ライフサイエンスコーパス: Polycomb group

1 as a trithorax group factor that counteracts Polycomb group action in Arabidopsis (Arabidopsis thalia

2 this screen, CAT7, regulates expression and polycomb group binding at the MNX1 locus during early ne

3 The polycomb group complex regulates downstream factors, e.g

4 Previously, we showed that a Polycomb group complex, PRC1, remains continuously assoc

5 rabidopsis thaliana) is under control of the polycomb group complex, which includes Fertilization Ind

6 , we find that subunits of the PRC1 and PRC2 polycomb group complexes are similarly required for DSB-

7 Deregulation of polycomb group complexes polycomb repressive complex 1 (

8 d repressive histone modifications) bound by Polycomb group complexes PRC1 (Polycomb-repressive compl

9 Here we report that Piwi interacts with Polycomb group complexes PRC1 and PRC2 in niche and germ

10 components of the Trithorax/COMPASS-like and Polycomb group complexes together with histone arginine

11 E2F6 is a component of polycomb group complexes, which bind to silenced chromat

12 Polycomb-group complexes repress the locus in lung tumor

13 e genes, characterized by recruitment of the polycomb group enhancer of zeste homolog 2 methyltransfe

14 The Polycomb group family member Bmi1 is overexpressed in nu

15 Bmi-1 is a member of the Polycomb group family of proteins that function in the e

16 The polycomb group family protein BMI-1 is overexpressed by

17 ndings underscore the importance of Asxl1 in Polycomb group function, development, and hematopoiesis.

18 Deregulation of the polycomb group gene BMI-1 is implicated in the pathogene

19 1 gene on chromosome 7p15 to 3' exons of the Polycomb group gene JJAZ1/SUZ12 on chromosome 17q11 and

20 Mouse embryos lacking the polycomb group gene member Yin-Yang1 (YY1) die during th

21 mouse modelling data demonstrating that the polycomb group gene SUZ12 functions as tumour suppressor

22 CLF is a Polycomb Group gene, and the clf-59 mutant protein conta

23 re, we extend the connection between OGT and Polycomb group genes from flies to mammals, showing Poly

24 la polyhomeotic (ph) is one of the important polycomb group genes that is linked to human cancer.

25 e FERTILIZATION-INDEPENDENT SEED (FIS) class Polycomb group genes, the endosperm fails to cellularize

26 xpression in response to the derepression of Polycomb group genes.

27 mors and caused a rapid decrease in the Ezh2 Polycomb group histone H3K27 methyltransferase and an in

28 tion-sequencing (RIP-seq), we identified the Polycomb-group histone methyltransferase EZH2 as a p53 m

29 mutations affect BAP1 interactions with the Polycomb group-like protein, ASXL2, using combinations o

30 ific miRNAs are either tightly controlled by polycomb group-mediated H3K27me3 or maintained in a semi

31 tin conformation within IRER is regulated by polycomb group-mediated histone modifications.

32 alysis of Polycomblike revealed that loss of Polycomb group-mediated repression of the Hox gene Abdom

33 s a plant-specific gene that participates in Polycomb group-mediated transcriptional repression of ta

34 in NBs, unlike NSC differentiation, requires Polycomb-group-mediated repression.

35 over an early developmental function for the Polycomb group member Bmi1 in supporting PrE lineage for

36 We show that polycomb group members are recruited by poly(ADP ribose)

37 BMI1 is a member of the Polycomb group of chromatin-modifier proteins that is es

38 The Polycomb group of epigenetic enzymes represses expressio

39 x 2 (PRC2) comprises specific members of the Polycomb group of epigenetic modulators.

40 The Polycomb group of proteins (PcG) is important for transc

41 ene expression programmes established by the Polycomb group of proteins and to promote and maintain a

42 Scml2 is a member of the Polycomb group of proteins involved in epigenetic gene s

43 s, including activation of miR-190, miR-214, polycomb group of proteins, as well as DNA methylation.

44 Members of the Polycomb group of repressors and trithorax group of acti

45 insertion region-1 (BMI1) is a member of the polycomb group of transcription repressors, which functi

46 The Trithorax and Polycomb groups of chromatin regulators are critical for

47 Here, we show that Polycomb-group (Pc-G) proteins, which mediate epigenetic

48 maintenance of these patterns depends on the Polycomb group (PcG) and trithorax group (trxG) complexe

49 Polycomb group (PcG) and trithorax Group (trxG) proteins

50 The Polycomb Group (PcG) and Trithorax Group (TrxG) proteins

51 Polycomb Group (PcG) and Trithorax Group (TrxG) proteins

52 Polycomb group (PcG) and trithorax group (trxG) proteins

53 The highly-conserved Polycomb group (PcG) and trithorax group (trxG) proteins

54 estion of how noncoding RNAs are involved in Polycomb group (PcG) and Trithorax group (TrxG) regulati

55 We identify silencers of the Polycomb group (PcG) as principal contributors to this m

56 The genomic binding sites of Polycomb group (PcG) complexes have been found to cluste

57 activity of EZH2, a component of repressive Polycomb Group (PcG) complexes like PRC2, is increased o

58 Polycomb group (PcG) complexes PRC1 and PRC2 are well kn

59 Polycomb group (PcG) complexes such as PRC1 mediate tran

60 emodeling complexes counteract repression by Polycomb group (PcG) complexes to sustain active express

61 upports a model in which CpG islands recruit Polycomb group (PcG) complexes; however, which subset of

62 erference (RNAi) protein Argonaute-1 (AGO1), Polycomb group (PcG) component EZH2, and tri-methyl hist

63 Here, we show that a Polycomb group (PcG) component, Enhancer of Zeste [E(z)]

64 nt is mediated by the opposing activities of Polycomb group (PcG) factors and trithorax group (trxG)

65 table repression of these domains depends on Polycomb Group (PcG) functions, which include trimethyla

66 Trithorax group (trxG) and Polycomb group (PcG) gene products are part of an evolut

67 The polycomb group (PcG) genes encode a family of proteins t

68 Here, we uncover a role of Polycomb Group (PcG) genes in the temporally precise rep

69 ing of terminal differentiation genes by the Polycomb group (PcG) machinery is emerging as a key feat

70 pmental gene silencing through the so-called Polycomb Group (PcG) mechanism.

71 The Polycomb Group (PcG) of chromatin modifiers regulates pl

72 The polycomb group (PcG) of proteins are epigenetic represso

73 s of development and differentiation are the Polycomb group (PcG) of proteins, organized in the nucle

74 g cell senescence; shed light on the role of polycomb group (PcG) protein Bmi-1 in senescence.

75 miR-31 was accompanied by repression of the polycomb group (PcG) protein BMI1 and induction of cellu

76 The Polycomb group (PcG) protein BMI1 is a key factor in reg

77 The Polycomb group (PcG) protein Bmi1 is an essential epigen

78 The Polycomb group (PcG) protein BMI1 is essential for the a

79 histone methyltransferase and component of a Polycomb group (PcG) protein complex, represses Ink4a/Ar

80 nconventional mechanism of repression by the Polycomb group (PcG) protein Enhancer of zeste [E(Z)], w

81 F1 was previously shown to interact with the Polycomb group (PcG) protein Ezh2, a histone methyltrans

82 analysis we identified SLIT2 as a target of polycomb group (PcG) protein EZH2.

83 The Polycomb group (PcG) protein family is a well-known grou

84 ed by epigenetic regulators belonging to the Polycomb Group (PcG) protein family.

85 mphoma Mo-MLV insertion region 1 (Bmi1) is a Polycomb Group (PcG) protein important in gene silencing

86 ere found most often in association with the polycomb group (PcG) protein Polycomb (Pc), a subunit of

87 er that is remarkably similar to that of the Polycomb group (PcG) protein Suz12.

88 Conditional knock-out (KO) of Polycomb Group (PcG) protein YY1 results in pro-B cell a

89 of this approach is demonstrated by using a Polycomb group (PcG) protein, Enhancer of Zeste (EZH2),

90 ion of Ezh2, a histone methyltransferase and Polycomb group (PcG) protein.

91 nscriptional regulator, while EMF2 encodes a Polycomb group (PcG) protein.

92 monstrated that DFO1 interacts with the rice polycomb group (PcG) proteins (OsMSI1 and OsiEZ1).

93 Polycomb group (PcG) proteins are a group of evolutionar

94 Polycomb group (PcG) proteins are best known for their r

95 Polycomb Group (PcG) proteins are crucial for epigenetic

96 Polycomb Group (PcG) proteins are epigenetic repressors

97 The Polycomb group (PcG) proteins are epigenetic suppressors

98 Polycomb group (PcG) proteins are epigenetic transcripti

99 Polycomb group (PcG) proteins are essential for accurate

100 Polycomb Group (PcG) proteins are essential regulators o

101 Polycomb group (PcG) proteins are important epigenetic r

102 Polycomb group (PcG) proteins are key chromatin regulato

103 The Polycomb group (PcG) proteins are key regulators of deve

104 Among the distinct factors, Polycomb group (PcG) proteins are major negative regulat

105 Polycomb group (PcG) proteins are required for maintaini

106 Polycomb group (PcG) proteins are required for the epige

107 Polycomb group (PcG) proteins are responsible for mainta

108 As key epigenetic regulators, polycomb group (PcG) proteins are responsible for the co

109 Polycomb group (PcG) proteins are transcriptional repres

110 Polycomb group (PcG) proteins are transcriptional repres

111 Polycomb Group (PcG) proteins assemble a chromatin state

112 d developmental genes through cobinding with Polycomb group (PcG) proteins at transcriptional start s

113 In addition, both tumors overexpress the polycomb group (PcG) proteins BMI-1 and EZH2, which cont

114 in concert to directly repress expression of Polycomb group (PcG) proteins CBX7, embryonic ectoderm d

115 sheds light on how nuclear organization and Polycomb group (PcG) proteins contribute to epigenetical

116 Polycomb group (PcG) proteins control the epigenetic inh

117 Polycomb group (PcG) proteins exert essential functions

118 chromatid cohesion and segregation, and the Polycomb group (PcG) proteins for their roles in epigene

119 Polycomb Group (PcG) proteins form memory of transient t

120 The Polycomb Group (PcG) proteins form several complexes wit

121 Polycomb group (PcG) proteins function as chromatin-base

122 Polycomb group (PcG) proteins initiate the formation of

123 For example, the Polycomb Group (PcG) proteins maintain developmental gen

124 A prevailing paradigm posits that Polycomb Group (PcG) proteins maintain stem cell identit

125 Polycomb Group (PcG) proteins maintain transcriptional r

126 Polycomb Group (PcG) proteins mediate heritable gene sil

127 The Polycomb group (PcG) proteins modulate nucleosomes to ma

128 Polycomb Group (PcG) proteins organize chromatin at mult

129 Polycomb group (PcG) proteins play an important role in

130 Polycomb group (PcG) proteins play critical roles in the

131 Polycomb group (PcG) proteins play important roles in re

132 Polycomb group (PcG) proteins play vital roles in plant

133 The Polycomb group (PcG) proteins regulate stem cell differe

134 Polycomb group (PcG) proteins repress master regulators

135 Polycomb group (PcG) proteins silence gene expression by

136 Regulatory decisions in Drosophila require Polycomb group (PcG) proteins to maintain the silent sta

137 regulation is the balanced activities of the Polycomb group (PcG) proteins within the PRC1 and PRC2 c

138 y, increasing evidence has demonstrated that polycomb group (PcG) proteins, a subset of histone-modif

139 h INK4A and MIR31HG genomic regions and with Polycomb group (PcG) proteins, and that MIR31HG is requi

140 The polycomb group (PcG) proteins, Bmi-1 and Ezh2, are impor

141 that regulate genome architecture, including Polycomb group (PcG) proteins, form subnuclear structure

142 In arsenic-induced transformed cells, polycomb group (PcG) proteins, including BMI1 and SUZ12,

143 A growing body of evidence suggests that Polycomb group (PcG) proteins, key regulators of lineage

144 ental regulators, and bind to the repressive Polycomb group (PcG) proteins, often in the context of b

145 ax (TRX) antagonizes epigenetic silencing by Polycomb group (PcG) proteins, stimulates enhancer-depen

146 s regulated gene silencing is carried out by Polycomb group (PcG) proteins, which must be correctly r

147 d Pol II and enriched with promoter-proximal Polycomb Group (PcG) proteins, yet lacking the classical

148 tion of both histone deacetylases (HDAC) and polycomb group (PcG) proteins.

149 Evidence is presented that Polycomb group (PcG) repressors can influence paused Pol

150 ation at both TSS regions and gene bodies of Polycomb group (PcG) target developmental genes, while D

151 l modulator that maintains downregulation of Polycomb Group (PcG) target genes in lhp1 mutants, while

152 latory genes require stable silencing by the polycomb group (PcG) to prevent misexpression during dif

153 anscriptional target genes are also bound by Polycomb group (PcG) transcriptional repressor proteins

154 The first genes composing the Polycomb group (PcG) were identified 50 years ago in Dro

155 Sex Comb on Midleg (Scm) is a member of the Polycomb group (PcG), a set of transcriptional repressor

156 (SCM) is a transcriptional repressor in the Polycomb group (PcG), but its molecular role in PcG sile

157 Polyhomeotic (Ph), a member of the Polycomb Group (PcG), is a gene silencer critical for pr

158 neral, are also sensitive to activity of the Polycomb Group (PcG), suggesting that PcG attenuation up

159 e recently described group of embryonic cell Polycomb group (PcG)-marked genes that may be predispose

160 Polycomb group (PcG)-mediated gene silencing is a common

161 Polycomb group (PcG)-mediated repression is an evolution

162 We identify removal of Polycomb group (PcG)-mediated repression on stage-specif

163 ansitions between trithorax-group (TrxG) and polycomb-group (PcG) chromatin states are vital for the

164 Polycomb-group (PcG) complexes are multiprotein, evoluti

165 pe characteristic of males with mutations in Polycomb-group (PcG) genes.

166 Polycomb-group (PcG) proteins are highly conserved epige

167 Polycomb-group (PcG) proteins function to ensure correct

168 with facultative heterochromatin mediated by Polycomb-group (PcG) proteins has been reported as well.

169 -binding of histone deacetylases (HDACs) and Polycomb-group (PcG) proteins.

170 ved a common pattern of up regulation of the polycomb group PRC2 and enrichment for the histone mark

171 Here, we analyzed Polycomb group protein (PcG) complex integrity in respon

172 ction of methylation-prone genes compared to Polycomb group protein (PcG) marking in embryonic stem c

173 m chromatin and found candidates that impact polycomb group protein (PcG)-regulated gene expression i

174 The Polycomb group protein Bmi-1 is an essential regulator o

175 The polycomb group protein BMI1 is an important regulator of

176 Polycomb group protein BMI1 plays an important role in c

177 ruiting not only MLL complexes, but also the polycomb group protein Bmi1.

178 The polycomb group protein CBX2 is an important epigenetic r

179 PRC1-class Polycomb group protein complexes are essential for devel

180 Here we show that the polycomb group protein EED, a core component of PRC2, ph

181 sferase EHMT2 (also known as G9A) or for the Polycomb group protein EED, involved in repressive H3K9m

182 ast cancer with heightened expression of the Polycomb group protein Enhancer of Zeste Homolog 2 (EZH2

183 Although the polycomb group protein Enhancer of Zeste Homolog 2 (EZH2

184 The Polycomb group protein enhancer of zeste homolog 2 (EZH2

185 Molecular analyses establish that the polycomb group protein EZH2 (enhancer of zeste homolog 2

186 en-responsive elements (ARE) and dictated by Polycomb group protein EZH2 and repressive chromatin rem

187 ever, constitutive repression of CCN3 by the Polycomb group protein EZH2 disrupted this negative feed

188 4) in Genes & Development of the role of the polycomb group protein Ezh2 in muscle stem cells, and di

189 Polycomb group protein Ezh2 is a histone H3 Lys-27 histo

190 The polycomb group protein Ezh2 is a histone methyltransfera

191 inase in FLB1 and a differentially localized Polycomb group protein Ezh2, which is mostly nuclear in

192 AR activation recruits the polycomb group protein EZH2, which subsequently catalyze

193 DNA methyltransferase MET1, and/or the core Polycomb group protein FIE.

194 ng protein homologous to Drosophila SFMBT, a Polycomb group protein involved in epigenetic regulation

195 We identify the polycomb group protein Pcgf1 as an epigenetic regulator

196 n of alternative fate genes by retaining the Polycomb Group protein Pleiohomeotic at Ubx targeted gen

197 3 and is essential for proper recruitment of Polycomb group protein Rnf2.

198 epress reporter gene expression and bind the Polycomb group protein SUZ12 and the DNA methyltransfera

199 s including age-specific hypermethylation in polycomb group protein target genes and the upregulation

200 The specificity of polycomb group protein targeting is incompletely underst

201 First, we show that SCML2, a Polycomb group protein that associates with PRC1.2 (cont

202 Psc encodes a Polycomb group protein that functions as a central compo

203 The CBX7 gene encodes a polycomb group protein that is known to be downregulated

204 was correlated with higher levels of Bmi1, a polycomb group protein that is known to regulate the Ink

205 ransferase, Ezh2 (enhancer of zeste 2), is a Polycomb group protein that plays important roles in man

206 CBX7 is a polycomb group protein, and despite being implicated in

207 ogenesis is to suppress transcription of the Polycomb group protein, EZH2, thereby de-repressing gene

208 is study investigates the effect of Bmi-1, a polycomb group protein, on radiation-induced senescence

209 ver faster at sites for trithorax-group than polycomb-group protein binding, suggesting that nucleoso

210 ng of DAB2IP is a key mechanism by which the polycomb-group protein histone-lysine N-methyltransferas

211 strate that p53 influences expression of the Polycomb-group protein PHC1, which functions as a transc

212 g activity depends on a binding site for the Polycomb-group protein Pleiohomeotic (Pho) and on pho ge

213 is a mammalian homolog of Drosophila SCM, a Polycomb-group protein that associates with PRC1.

214 ingle-cell genome-wide interaction data on a polycomb-group protein, RING1B, and the associated trans

215 ue of Molecular Cell) have demonstrated that Polycomb group proteins (PcG) and the Kcnq1ot1 regulator

216 Polycomb group proteins (PcG) are required for proper de

217 Polycomb group proteins (PcG) are transcriptional repres

218 Polycomb group proteins (PcG) function as transcriptiona

219 Polycomb group proteins (PCGs) are involved in repressio

220 The Polycomb group proteins (PcGs) play a vital role through

221 complex 1 (PRC1) comprise a core assembly of Polycomb group proteins and additional factors that incl

222 Polycomb group proteins and associated histone marks are

223 se genes are subjected to repression by both Polycomb group proteins and SetDB1, and loss of either r

224 The Polycomb group proteins and the associated H3K27me3 hist

225 generation of ChIP-seq data for SWI/SNF and Polycomb group proteins and the transcriptional represso

226 Polycomb group proteins are critical to maintaining gene

227 Polycomb group proteins are essential regulators of deve

228 Trithorax and polycomb group proteins are generally thought to antagon

229 Polycomb group proteins are important for maintaining ge

230 Polycomb group proteins are required for long-term repre

231 Polycomb group proteins are transcriptional repressors r

232 The Polycomb group proteins are transcriptional repressors t

233 acetylglucosamine transferase (OGT), and the polycomb group proteins ASXL1 and ASXL2 in vivo.

234 MUC1-C regulated nuclear localization of the polycomb group proteins BMI1 and EZH2, which formed comp

235 suggest, more generally, that Trithorax and Polycomb group proteins can cooperate with one another t

236 Polycomb group proteins control a hierarchy of gene expr

237 The Polycomb group proteins foster gene repression profiles

238 uces dorsal mesoderm by releasing repressive polycomb group proteins from chromatin, bound to the Sta

239 Recently, the role of Polycomb group proteins has been studied in the specific

240 Polycomb group proteins have an essential role in the ep

241 silent set of miRNA genes is co-occupied by Polycomb group proteins in ES cells and shows tissue-spe

242 miR-16 levels down-regulated BMI1 and other polycomb group proteins like RING1A, RING1B, EZH2 and al

243 How polycomb group proteins repress gene expression in vivo

244 ubtypes and multiple myeloma, linked several polycomb group proteins that could be targeted by small

245 me3 modifications catalyzed by Trithorax and Polycomb group proteins, respectively.

246 results indicate that combined modulation of polycomb group proteins, such as EZH2, along with TrxG p

247 on the mechanism of histone modification via Polycomb Group Proteins, which evolved in tandem with th

248 he mark trimethyl H3K27, we examined whether Polycomb group proteins, which methylate H3K27, were pre

249 genes previously epigenetically silenced by Polycomb group proteins.

250 of chromatin-remodeling complexes, including Polycomb group proteins.

251 glycosylases and repressive targeting by the Polycomb group proteins.

252 lation of histone H3 on lysine 27 (H3K27) by Polycomb group proteins.

253 keletal or chromatin tethers as well as with polycomb group proteins.

254 paternal and maternal genomes as well as by Polycomb group proteins.

255 H3 at lysine 27 (H3K27me) as directed by the Polycomb group proteins.

256 core ES transcriptional circuitry, including Polycomb group proteins.

257 tions, expanding the regulatory diversity of polycomb group proteins.

258 rs and epigenetic gene silencing mediated by Polycomb group proteins.

259 ransferases and repressing proteins, such as Polycomb group proteins; upon differentiation, DNMT acti

260 Polycomb-group proteins control many fundamental biologi

261 eversible chromatin interactions mediated by Polycomb-group proteins play an important role in these

262 tioning in Arabidopsis thaliana We show that Polycomb-group proteins repress nucellus degeneration be

263 Polycomb-group proteins silence gene expression through

264 ypermethylation, recruitment, and binding of polycomb-group proteins, and histone heterochromatin mod

265 HSI2 and HSL1 recruit components of polycomb-group proteins, including CURLY LEAF (CLF) and

266 ensitive silencing are related properties of Polycomb-group proteins, whereas their activities are ge

267 ppression as an alternative to regulation by Polycomb-group proteins, which coordinate embryonic germ

268 e been identified that mediate the action of Polycomb-group proteins.

269 basis of epigenetic maintenance mediated by Polycomb-group proteins.

270 Polycomb Group regulation in Arabidopsis (Arabidopsis th

271 other findings suggest that KIS antagonizes Polycomb group repression by facilitating ASH1-dependent

272 Recent studies linking polycomb group repression complexes (PRC1 and PRC2) to t

273 tes transcription elongation and counteracts Polycomb group repression via distinct mechanisms.

274 Such genes are also often targets of the polycomb group repressive complexes in embryonic cells.

275 We also extensively discuss polycomb-group repressive complexes (PRCs), which freque

276 ionally suppressed E-cadherin expression via polycomb group-repressive complexes.

277 Arabidopsis polycomb-group repressor complex2 (PRC2) protein MEDEA (

278 G proteins are bound to DNA fragments called Polycomb group response elements (PREs).

279 ounteract silencing mediated by an engrailed Polycomb-group response element.

280 In Drosophila, DNA fragments called Polycomb-group response elements (PREs) have been identi

281 la, PcG proteins are recruited to the DNA by Polycomb-group response elements (PREs), regulatory sequ

282 n or closely linked to the promoter proximal Polycomb-group response elements.

283 homolog 1/scm-like with 4 mbt domains 2 and polycomb group ring finger (Pcgf) 2/ Pcgf5, displayed an

284 We show that the expansion of the Polycomb Group RING Finger (PCGF) protein family, an ess

285 Here, we show that the noncanonical Polycomb group RING finger 3/5 (PCGF3/5)-PRC1 complex in

286 id analysis revealed that p47 interacts with polycomb group ring finger 5 (PCGF5) protein, Src protei

287 ear-containing ARF binding protein 1 (GGA1), polycomb group ring finger 5 (PCGF5), actin gamma 1 (ACT

288 Here, we show that the PRC1 component polycomb group ring finger 6 (Pcgf6) is required to main

289 ecruitment of the TRP120-interacting protein polycomb group ring finger protein 5 (PCGF5) to the incl

290 rast, regions associated with the repressive Polycomb-Group showed low turnover in ESCs.

291 Epigenetic events and the upregulation of polycomb group silencing proteins including Bmi1 have be

292 nment and that hypermethylation of stem cell polycomb group target genes is an epigenetic hallmark of

293 using on promoter CpG sites that localize to Polycomb group target genes that are unmethylated in 11

294 profile among 13 CpG loci, characterized by polycomb group target genes, mammalian interspersed repe

295 effects on gene expression, particularly of polycomb group target genes.

296 average methylation among CpG loci found in polycomb group target genes; developmentally related tra

297 Here, we compare these with known polycomb group targets to show that approximately 47% of

298 The Polycomb group transcriptional repressor Bmi-1 often ove

299 tion in euchromatic regions and overlap with Polycomb Group transcriptional silencing loci.

300 the human homolog of the Drosophila L(3)MBT polycomb group tumor suppressor gene, is located on chro