ライフサイエンスコーパス: Pro

1 Pro accumulation in plants is a well-documented physiolo

2 Pro in P1' and Iso in P1 are typical residues in peptide

3 Pro(8)-OXT produces more potent and efficacious response

4 Pro- and anti-quorum-sensing molecules can be covalently

5 Pro-AG can likewise effectively edit large plasmids or s

6 Pro-angiogenic GPCR ligands were expressed by patient-de

7 Pro-apoptotic BCL-2 proteins oligomerize at the mitochon

8 Pro-aromatic and volatile 1-methyl-1,4-cyclohexadiene (M

9 Pro-arrhythmogenic pacing protocols were applied to init

10 Pro-atherogenic lipids and atherosclerosis are greater i

11 Pro-atherogenic TGRL were enriched in eicosapentaenoic a

12 Pro-B cell proliferation and small pre-B cell differenti

13 Pro-cognitive effects of DMXB-A may result from transien

14 Pro-glacial melange (a mixture of sea ice, icebergs, and

15 Pro-healing stent coatings may facilitate reendotheliali

16 Pro-IL1beta cleavage was only moderately enhanced by sim

17 Pro-inflammatory (TNF-alpha, IL-6) and pro-fibrotic (TGF

18 Pro-inflammatory cytokine profile and multiple markers o

19 Pro-inflammatory cytokine stimulation increased the cell

20 Pro-inflammatory cytokines are important mediators of is

21 Pro-inflammatory cytokines were lower while anti-inflamm

22 Pro-inflammatory cytokines, specifically IL-1 and TNF-al

23 Pro-inflammatory family members (IL-1alpha, IL-1beta, IL

24 Pro-inflammatory responses during sepsis are characteriz

25 Pro-inflammatory stimuli lead to endothelial inflammatio

26 Pro-inflammatory stimuli led to increased endothelial CD

27 Pro-inflammatory T(RM) cells accumulated in the mucosa o

28 Pro-opiomelanocortin (ARC(POMC)) neurons are viewed as t

29 Pro-oxidants are considered as major constituents of veh

30 Pro-Pro endopeptidase-1 (PPEP-1) is a secreted metallopr

31 Pro-spermatogonia (SG) serve as the gateway to spermatog

32 Pro-TH2 cytokines prevent oral tolerance.

33 Pro-tumorigenic M2 macrophage activation was diminished

34 Pro-urban inequalities were mostly affected by neighbour

35 Pro-vitamin A biofortified (yellow) cassava has the pote

36 based on a cis- or trans-configured Glu(18)-Pro(19) peptide bond.

37 that PIN1 binds the phosphorylated Thr(187)-Pro motif in p27 and reduces p27's interaction with cycl

38 We therefore suggest that Val(3)Pro(8)OXT and Pro(8)OXT are functional variants, which m

39 cacious on Gq and beta-arrestin, while Val(3)Pro(8)OXT showed reduced relative efficacy toward beta-a

40 ls, the Cebidae Pro(8)OXT and Saguinus Val(3)Pro(8)OXT taxon-specific variants act as equi-efficaciou

41 obic contacts between FtsZ residues Ile-374, Pro-375, and Leu-378 with ZapD residues Leu-74, Trp-77,

42 l states that are the result of a key Ser(4)-Pro(5) cis-trans isomerization.

43 With nearly 40% Pro, RePRP is induced by water deficit and abscisic acid

44 The cis conformation at the Cys(6)-Pro(7) peptide bond was essential for alpha3beta4 nAChR

45 and isomerization of, Kv4.2 at the pThr(607)-Pro motif, leading to the dissociation of the Kv4.2-DPP6

46 AMs) of right-handed helical (l-proline)(8) (Pro(8)) and corresponding peptides, N-terminal conjugate

47 of three amino acids in CsGA1ox/ds, Phe(93), Pro(106), and Ser(202), with those typically conserved a

48 n Ala-to-Val mutation at SP1 residue 1 and a Pro-to-Ala mutation at CA residue 157 within the major h

49 from which it is derived was identified as a Pro-Ser-X-X-X-Val motif.

50 No association was found between a Pro-vegetarian dietary pattern and BCC.

51 (Arabidopsis thaliana; AtCGL20), which is a Pro-rich, ~10-kD protein that is targeted to mitochondri

52 the protein backbone at the Calpha atom of a Pro residue to produce 2-hydroxyproline (2-Hyp).

53 anism of folding induced by the binding of a Pro-rich peptide ligand to the SH3 domain of phosphatidy

54 cognizing their N-terminal Pro residues or a Pro at position 2, in the presence of distinct adjoining

55 bear either the N-terminal Pro residue or a Pro at position 2, together with adjacent sequence motif

56 rein we report that the matrikine acetylated Pro-Gly-Pro (PGP) stimulates vascular inflammation throu

57 Crystal structures of Gly-AMP, Pro-AMP, betaPro-AMP and Phe-AMP bound to RNase A as cry

58 Because Val-17, Gly-22, Leu-25, Asn-26, and Pro-29 are predicted to reside along the same surface of

59 o acid substitutions (Cys(27), Gly(608), and Pro(671)) within the full-length molecule.

60 inus at the peptide bond joining Asp(80) and Pro(81) Cleavage at this site was predicted to separate

61 Approaches to Stop Hypertension (DASH), and Pro-vegetarian dietary pattern] with the risk of BCC, co

62 on between ATP binding by the CBS domain and Pro-sigma(K) cleavage by the membrane domain.

63 of proteins, named for conserved Pro-Glu and Pro-Pro-Glu motifs in their N termini.

64 Both Leu(8)-OXT and Pro(8)-OXT produce a less efficacious response than AVP

65 e therefore suggest that Val(3)Pro(8)OXT and Pro(8)OXT are functional variants, which might have been

66 ients) in the negative regulatory region and Pro-Glu-Ser-Thr-rich domains, the same two hotspots seen

67 Induction of P5CS1 transcription and Pro accumulation during phosphate deficiency was conside

68 ons to providers were generated using ArcGIS Pro (Esri).

69 absence of the fibrin inhibitor Gly-Pro-Arg-Pro.

70 dipeptides: Ala-Arg (AR), Arg-Ala (RA), Arg-Pro (RP), Arg-Glu (RE), and Glu-Arg (ER); and two non-ar

71 A nanobody containing an Asn-Pro-Phe peptide within the complementarity-determining r

72 their ability to be seeded, with variants at Pro(301) and Ser(320) showing robust aggregation with se

73 ith no apparent dephasing over the augmented Pro(8)PZn(n) length scales, showing that spin currents m

74 ities and Ca(2+) signaling responses of AVP, Pro(8)-OXT and Leu(8)-OXT at human, macaque, and marmose

75 Upon interaction with the AVPR1a, Pro(8)OXT and the common Leu(8)OXT yielded similar signa

76 lts reveal a previously unknown link between Pro metabolism and phosphate nutrition and show that Pro

77 with a sequence comprising a central block (Pro-Hyp-Gly) and two positively charged domains (Pro-Arg

78 a role for posttranslational modification by Pro hydroxylation in the regulation of CLE40 formation a

79 The second cleavage is prevented by Pro hydroxylation, resulting in the formation of mature

80 to potently inhibit the R(N) stimulation by Pro and Ala but not PEP.

81 Folded C-Pro domains then template the formation of triple helice

82 ng mutations within the collagen-alpha2(I) C-Pro domain.

83 sis network directly engages the misfolded C-Pro domain itself to prevent secretion and initiate clea

84 cognition and quality control of misfolded C-Pro domains is mediated by recognizing stalled assembly

85 Numerous C-Pro missense variants that disrupt or delay triple-helix

86 folding of ~30-kDa C-terminal propeptide (C-Pro) domains.

87 We first show that "C-Pro-only" constructs recapitulate key aspects of the beh

88 cal domains or by direct engagement of the C-Pro itself.

89 Pro-His-DPhe-Arg-Trp-Asn-Ala-Phe-DPro] and c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro], and may be further d

90 equence in the AGRP active loop derivative c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro], where Xxx was the nat

91 incorporated into the peptide macrocycles c[Pro(1)-Arg(2)-Phe(3)-Phe(4)-Xaa(5)-Ala(6)-Phe(7)-dPro(8)

92 ed nanomolar agonist potency at the mMC4R, c[Pro-His-DPhe-Arg-Trp-Asn-Ala-Phe-DPro] and c[Pro-His-DPh

93 [(13)C2]Ala and [(13)C2]Pro were the most abundant and rapidly labeled amino aci

94 found in most placental mammals, the Cebidae Pro(8)OXT and Saguinus Val(3)Pro(8)OXT taxon-specific va

95 Common to the series is a central Pro-Xaa sequence, where Pro is either l- or d-proline, w

96 in degrading the neutrophil chemoattractant Pro-Gly-Pro (PGP) and rationalized that the failure of c

97 nts, which trace their genesis to the chiral Pro(8) moiety, propagate with no apparent dephasing over

98 IVFB, an intramembrane protease that cleaves Pro-sigma(K) , releasing sigma(K) into the MC.

99 als that the hexapeptide H(2)N-(CH(2))(4)-CO-Pro-Leu-Arg-Phe-Gly-Ala-NH-CH(2)-Fc is the optimal probe

100 nd Cys, which are similar in size to cognate Pro.

101 N-terminal pro-peptide of type III collagen (Pro-C3) than placebo.

102 N-terminal propeptide of type III collagen (Pro-C3; -22% and -33%) and enhanced liver fibrosis score

103 s modifies with high specificity a conserved Pro, shares with the deacetylation reaction the same act

104 PE families of proteins, named for conserved Pro-Glu and Pro-Pro-Glu motifs in their N termini.

105 RhsA and RhsB effectors of ECL both contain Pro-Ala-Ala-Arg (PAAR) repeat domains, which bind the be

106 on Pro-rich proteins or proteins containing Pro-rich binding domains involved in cellular signaling.

107 1, the fourth gluconeogenic enzyme, contains Pro at position 2; Gid4 directly or indirectly recognize

108 (P5CS1) gene was previously shown to control Pro biosynthesis in such adverse conditions.

109 Two compounds 19 (c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-Agm) and 38 (c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NE

110 -Pro-Agm) and 38 (c(Bua-Cpa-Thi-Val-Asn-Cys)-Pro-d-Arg-NEt(2)) have been selected for clinical develo

111 ast, an Abc3 mutant in which an inverted Cys-Pro motif had been replaced with Ala residues fails to b

112 vered a four-residue pi-clamp motif (Phe-Cys-Pro-Phe) for regio- and chemoselective arylation of cyst

113 nlike traditional beta-turn motifs such as d-Pro-Gly, both the 2-Abz and d-Phe rings may be further f

114 se insights led to the identification of H-d-Pro-Pip-Glu-NH2 as a highly reactive and stereoselective

115 uces their degradation by the Gid4-dependent Pro/N-degron pathway.

116 (ITC), we studied a series of d-Phe/d-DiPhe-Pro-(amino)pyridines.

117 Hyp-Gly) and two positively charged domains (Pro-Arg-Gly) at both N- and C-termini.

118 trate the newly introduced cylindrical FAIMS Pro device coupled with an Orbitrap Eclipse enables anal

119 troduced cylindrical FAIMS device (the FAIMS Pro) coupled with a Thermo Fusion Lumos mass spectromete

120 resolution could be achieved, especially for Pro-containing protein regions in the alpha subunit of H

121 with a half-life time as short as 2.4 h for Pro-AMP in ethylimidazole-containing buffer at 37 degree

122 se in the MC ATP level was not necessary for Pro-sigma(K) cleavage by SpoIVFB, based on analysis of m

123 PPEP-1 exhibits a unique specificity for Pro-Pro peptide bonds within the consensus sequence VNP

124 Measured Hall voltages for Pro(8)PZn(1-3) substantially exceed that determined for

125 1 channels extends seven helical turns, from Pro-405 to Phe-431, and is flanked by unstructured loops

126 Bio-affinity layers of protein-G (Pro-G) at GO-Ru(II) electrode interface promotes the loc

127 Some acquired residues (e.g. Pro(52) and Asp(55)) are conserved in naturally efficien

128 We further demonstrate that Gag-Pro is not the main driver of this association, suggesti

129 systemically boosted with ALVAC-SIV(M766)Gag/Pro/gp120-TM and SIV(M766&CG7V) gD-gp120 proteins formul

130 o-acid insertion (Leu583-Ala586DelInsSer/Gln/Pro) within the JH2 domain of JAK2.

131 ditional cases of Leu583-Ala586DelInsSer/Gln/Pro, allowing for complete characterization of this uniq

132 hat variation surrounding the C-terminal Glu-Pro-Ile-Tyr-Ala (EPIYA) motifs as well as the number of

133 tions in ClC-Ka that change Ser(cen) to Gly, Pro, or Thr have only minor effects on anion selectivity

134 Examination of aza-Gly-Pro and aza-Phe-Pro analogs 2a and 2b in a murine preter

135 ence and absence of the fibrin inhibitor Gly-Pro-Arg-Pro.

136 To our knowledge, the peptides Gly-Pro-Ala-Val, Val-Cys, and Phe-Phe have not been previous

137 ading the neutrophil chemoattractant Pro-Gly-Pro (PGP) and rationalized that the failure of conventio

138 report that the matrikine acetylated Pro-Gly-Pro (PGP) stimulates vascular inflammation through activ

139 activates the chemotactic tripeptide Pro-Gly-Pro.

140 ition, several compatible solutes (glycerol, Pro, and Suc) accumulated to high levels in high salt-gr

141 d conformation on the stereoselectivity of H-Pro-Pro-Xaa-NH2-type peptidic catalysts in conjugate add

142 NA-seq to compare both V. vinifera and P1/HC-Pro N. benthamiana host responses to GLRaV-3 infection.

143 pin with a flexible loop and a conserved His-Pro-Asp motif required for ATP hydrolysis by Hsp70s) and

144 que pentasaccharide attached to hydroxylated Pro-143 within its C-terminal F-box-binding domain.

145 sing TM4SF40-TM4SF20 chimeras, we identified Pro-29 of TM4SF20 as another important element required

146 This includes a Leu-Lys-Ile-Pro sequence (residues 125-128 of AKAP79) that occupies

147 +) -dependent complex with EB3 via Ser-x-Ile-Pro aminoacid motif and that disruption of STIM2-EB3 int

148 sphate starvation led to gradual increase in Pro content in wild-type Arabidopsis plants as well as t

149 ce, deletion of the Neuropilin-2 receptor in Pro-opiomelanocortin neurons disrupted their projections

150 Greater reductions in Pro-C3, ELF, and cT1, but not in liver fat content, 7alp

151 additional steps of modification, including Pro hydroxylation, Hyp glycosylation, and/or Tyr sulfati

152 in selectivities increase with an increasing Pro(8)PZn(1-3) N-terminal conjugation.

153 Interpretation: Pro-inflammatory cytokine production had a dose-dependen

154 Due to its Pro-preference and resistance to low pH, we conclude tha

155 ', second fixation, (optional) Proteinase K (Pro-K) or sonication treatment, antibody staining, clear

156 Reductive cleavage of an L-Pro-L-Trp dipeptide from the MalG non-ribosomal peptide

157 uestiomycin A, cyclo (l-Pro-l-Val), cyclo (l-Pro-l-Tyr), bikaverin, kojic acid and 3-nitropropionic a

158 year 2012, oxaline, questiomycin A, cyclo (l-Pro-l-Val), cyclo (l-Pro-l-Tyr), bikaverin, kojic acid a

159 st a potential semiochemical role of cyclo(L-Pro-L-Pro) and a modulating effect of cyclo(L-Leu-L-Pro)

160 when presented with the synthesised cyclo(L-Pro-L-Pro) chemical blend, compared to the controls, the

161 c dipeptides, cyclo(L-Leu-L-Pro) and cyclo(L-Pro-L-Pro), from the complex mixture of a chemical signa

162 wo volatile cyclic dipeptides, cyclo(L-Leu-L-Pro) and cyclo(L-Pro-L-Pro), from the complex mixture of

163 compared to the controls, the cyclo(L-Leu-L-Pro) blend, or a combined blend with both cyclic dipepti

164 ro) and a modulating effect of cyclo(L-Leu-L-Pro) that may depend on the relative concentration of bo

165 iring modifications (alpha)N-methyl Gln or l-Pro at key positions within betaHP.

166 otential semiochemical role of cyclo(L-Pro-L-Pro) and a modulating effect of cyclo(L-Leu-L-Pro) that

167 presented with the synthesised cyclo(L-Pro-L-Pro) chemical blend, compared to the controls, the cyclo

168 ptides, cyclo(L-Leu-L-Pro) and cyclo(L-Pro-L-Pro), from the complex mixture of a chemical signal in t

169 ctedly, we found that 346 TSF sequences lack Pro-1, of which 85% are present in the malonate semialde

170 In budding yeast, CDK substrates with Leu/Pro-rich (LP) docking motifs are recognized by Cln1/2 cy

171 excom G4 Platinum and Abbott Freestyle Libre Pro CGMs during 28 inpatient days in 16 adults without d

172 ropical primates with a modified OXT ligand (Pro(8)-OXT), and this ligand shows significant coevoluti

173 M(Pro) is an attractive target for antiviral therapies to

174 stant of K(d) =0.14+/-0.03 muM, indicating M(Pro) has a strong preference to dimerize in solution.

175 ent molecules that allosterically regulate M(Pro) activity.

176 andomly assigned clusters (1:1) with MapInfo Pro (version 11.0) to either the control or intervention

177 n component (N-recognin) of the GID-mediated Pro/N-degron pathway.

178 The middle Pro residue within the tripeptides was replaced with ana

179 Using misacylated Pro-tRNAPhe and Phe-tRNAPro, we show that the imino acid

180 At the mOTR, Pro(8)-OT was more efficacious than Leu(8)-OT in measure

181 Peptides carrying multiple Pro and Gly (residues with lowest helical propensity) re

182 isotopic offsets among AAs (e.g. Delta(15) N(Pro-Phe) ), to explore the allocation of endogenous vers

183 The value of emperor penguin Delta(15) N(Pro-Phe) was higher in yolk and albumen than in muscle,

184 res; in comparison, the value of Delta(15) N(Pro-Phe) was similar across muscle and egg tissue in pre

185 y, vacuolar localization is required for NIa-Pro's ability to enhance aphid reproduction on host plan

186 nges were due to a single viral protein, NIa-Pro.

187 Here we show that NIa-Pro responds to the presence of the aphid vector during

188 ed fibroblasts, we identified multiple novel Pro-rich genes in addition to collagens, such as Ltbp2 (

189 NT-Pro-BNP was elevated in the S-group compared with the R-

190 n test to evaluate the difference between NT-Pro-BNP before and after PH therapy produced evidence th

191 ectal surgical patients, and the level of NT-Pro-BNP is associated with CPC.

192 existed between the median pre- and post-NT-Pro-BNP (-387.0 (IQR: -1373.0-109), p = 0.0495).

193 In addition, to examine if preoperative NT-Pro-BNP can predict the risk for postoperative CPC.

194 Preoperative NT-Pro-BNP predicted CPC [odds ratio (confidence interval):

195 The primary outcome for this study was NT-Pro-BNP changes and its association with fluid therapy a

196 e helix unit through sequential additions of Pro-Hyp-Gly triads, we achieved sub-angstrom tuning over

197 ofold coincident with increasing cleavage of Pro-sigma(K) , and the FS ATP concentration does not dec

198 for the interaction but not for cleavage of Pro-sigma(K) Chemical cross-linking and mass spectrometr

199 of folding in collagen peptides composed of Pro-Hyp-Gly triplet repeats, allowing for truncation to

200 Deletion of Pro-10 had little effect on CXCL12 binding to the CXCR4

201 he hOTR, neither the potency nor efficacy of Pro(8)-OT and Leu(8)-OT differed with respect to G(q) si

202 The inclusion of Pro contributes significantly to the development of CCK2

203 Mutagenesis of Pro(81) abolished the fragmentation, and low pH and redu

204 In the model, the Proregion of Pro-sigma(K) loops into the membrane domain of SpoIVFB,

205 membrane domain of SpoIVFB, and the rest of Pro-sigma(K) interacts extensively with the linker and t

206 s and unique residues, including the role of Pro(301) in inhibiting Tau aggregation.

207 ccurate er sensing of 85 scalemic samples of Pro, Met, Cys, Ala, methylpyrrolidine, 1-(2-naphthyl)ami

208 appears to play a role distinct from that of Pro in the known HP1beta CSD-PXVXL complexes.

209 The inhibitory effects of amino acids on Pro- and Ala-stimulated R(N) were mitigated by inhibitio

210 pecially promising for structural studies on Pro-rich proteins or proteins containing Pro-rich bindin

211 His, Lys, Arg, or Pro residues prohibit cleavage when found at the P1 posi

212 it has native support for the LSF, SGE, PBS Pro, and Slurm job schedulers and can scale up to thousa

213 acids) identified phosphoenolpyruvate (PEP), Pro, and Ala as the most potent stimulators of plant lea

214 mic neurons expressing the anorectic peptide Pro-opiomelanocortin (Pomc) regulate food intake and bod

215 Examination of aza-Gly-Pro and aza-Phe-Pro analogs 2a and 2b in a murine preterm labor model fe

216 The d-Phe-Pro beta-turn of the cyclic beta-hairpin antimicrobial d

217 of the decapeptide Gramicidin S cyclo(d-Phe-Pro-Val-Orn-Leu-)2 (GS).

218 for proline in the eighth residue position (Pro(8)-OT).

219 We found that at least five PPE (Pro-Pro-Glu) proteins are targets for T-cell recognition

220 The full extent of proline (Pro) hydroxylation has yet to be established, as it is l

221 Gid4 recognized the N-terminal proline (Pro) residue and the 5-residue-long adjacent sequence mo

222 n = 740 with Sapien 3; n = 188 with Evolut R/Pro; n = 106 with others).

223 both groups (Sapien 3=85.7% versus Evolut R/Pro=84.4%; P=0.821).

224 on 2; Gid4 directly or indirectly recognized Pro at position 2 of Pck1, contributing to its targeting

225 sp-47 and the catalytic site with the region Pro-49-Arg-56, which includes the highly conserved DPGR

226 cytoplasm, but the role of ATP in regulating Pro-sigma(K) cleavage has been unclear, as has the impac

227 cently we demonstrated that increased renal (Pro)renin receptor (PRR) expression in diabetes contribu

228 (PRP) family, composed of tandemly repeated Pro-Hyp-Val-X-Lys pentapeptide motifs, is found primaril

229 not affect RAT of TM4SF20, whereas replacing Pro-29 together with either Leu-25 or Val-17 of TM4SF20

230 onally constrained and turn-inducing residue Pro accelerated IAPP self-assembly.

231 el CXC chemokine, deletion of the X residue (Pro-10) had little to no impact on the folded chemokine

232 n structure that recognizes the proline-rich Pro-Pro-x-Tyr (PPxY) motif contained in specific target

233 e but prevails when serine in a QSP (Gln-Ser-Pro) motif is replaced by glutamate [RS1-Reg(S20E)].

234 D comprises the repeated Tyr-Ser-Pro-Thr-Ser-Pro-Ser motif with potential epigenetic modification sit

235 subsequent CDK12 phosphorylation at two Ser-Pro sites (S65 and T70) that control the exchange of 4E-

236 The CTD comprises the repeated Tyr-Ser-Pro-Thr-Ser-Pro-Ser motif with potential epigenetic modi

237 The AMO WhiteStar Signature Pro machine (Abbott Medical Optics) with the Ellips FX h

238 tt Medical Optics' (AMO) WhiteStar Signature Pro with the Ellips FX handpiece.

239 s spectrometry of purified, inactive SpoIVFB-Pro-sigma(K) complex indicated residues of the two prote

240 ethyne-bridged (porphinato)zinc structures (Pro(8)PZn(n)), were interrogated via magnetic conducting

241 kely reduced transmission and the subsequent Pro(323)Leu mutation in the RNA-dependent RNA polymerase

242 ucleotide polymorphism rs1143678 substitutes Pro(1146) for Ser in the integrin alphaM cytoplasmic tai

243 Substituting Pro-29 alone did not affect RAT of TM4SF20, whereas repl

244 illus subtilis IP SpoIVFB with its substrate Pro-sigma(K) depends on particular residues in the inter

245 Though Decon2LS and MASH Suite Pro have been available to provide intraspectrum charge

246 This "pro-active" genetic system (Pro-AG) functionally inactivates an antibiotic resistanc

247 n of ADAM10 or delivery of a competitive TAT-Pro-ADAM10709-729 peptide in R6/2 mice prevents N-CAD pr

248 enic enzymes that bear either the N-terminal Pro residue or a Pro at position 2, together with adjace

249 ets proteins by recognizing their N-terminal Pro residues or a Pro at position 2, in the presence of

250 II/IV, RVESRI, and log NT-proBNP (N-Terminal Pro-B-Type Natriuretic Peptide) were retained (chi(2), 6

251 Relationships between NT-proBNP (N-terminal Pro-B-type natriuretic peptide), systolic blood pressure

252 nsitive troponin-T and NT-proBNP [N-terminal Pro-B-type natriuretic peptide]) at baseline (pre-ERT) a

253 fusion of a long, defined-length, N-terminal Pro/Ala/Ser (PAS) random-coil polypeptide with IL-1Ra.

254 re potent and modestly more efficacious than Pro(8)-OT in inducing hyperpolarization.

255 bolism and phosphate nutrition and show that Pro biosynthesis is target of cross talk between ABA sig

256 Based on structural modeling suggesting that Pro-205 in green cone opsin could prevent entry and bind

257 ng additional hydrogen-bonding capacity, the Pro-->2-Hyp conversion alters the active site and enhanc

258 a germline-encoded Trp is used to engage the Pro in NPNA beta-turns, but here the Trp interacts with

259 substantially exceed that determined for the Pro(8) control and increase dramatically as the conjugat

260 nor role for G(i/o) activation; however, the Pro(8)-OT response in mOTR and hOTR cells was PTX insens

261 cogen synthase kinase (GSK3beta) site in the Pro/Ala-rich linker of C0-C2 did not significantly affec

262 can function as a specific N-recognin of the Pro/N-degron pathway.

263 the GID-based proteolytic system termed the Pro/N-end rule pathway.

264 ist sensitivity at room temperature than the Pro to Gln substitution in the extracellular segment of

265 We applied PRT to the Pro/N-end rule pathway, whose substrates include the sho

266 fferences appear not only in cases where the Pro-Xaa loop-region is altered, but also when seemingly

267 This Pro-Phe Met relay may constitute a structural switch tha

268 -portion residues, and hairpin-loop of three Pro and one Ser residues, as well as the absence of an N

269 ty in a trapped ion mobility device (timsTOF Pro) to devise a scan mode that samples up to 100% of th

270 le time-of-flight mass spectrometer (timsTOF Pro).

271 accommodated into the ribosome and bound to Pro-tRNA(Pro), productive synthesis of the peptide bond

272 Through a facile Gly to Pro substitution, we have altered backbone dynamics, com

273 ant, comprising two disulfides and an Ile-to-Pro mutation of Env from strain BG505.

274 I(T)-state, which contains a nonnative trans Pro-32, has been shown to be a key precursor of WT-beta(

275 s and inactivates the chemotactic tripeptide Pro-Gly-Pro.

276 A(Leu), the mitochondrial tRNA(Val) and tRNA(Pro)) were strongly associated with the observed race di

277 es of the bacterial ribosome containing tRNA(Pro) bound to either cognate or slippery codons to deter

278 be present in the peptidyl site, e.g., tRNA(Pro).

279 The absence of m(1)G37 in tRNA(Pro) causes +1 frameshifting on polynucleotide, slippery

280 of m(1)G37 destabilize interactions of tRNA(Pro) with the P site of the ribosome, causing large conf

281 m(1)G37 stabilizes the interactions of tRNA(Pro) with the ribosome in the context of a slippery mRNA

282 ated into the ribosome and bound to Pro-tRNA(Pro), productive synthesis of the peptide bond occurs.

283 s isomerization about a highly conserved Trp-Pro imide bond in a region of the TAD that is required f

284 Tyr-Pro had the highest ACE inhibitory activity (ACE IC50=5.

285 We describe here a so far unknown Pro hydroxylation activity which occurs in active sites

286 ce to glyphosate also contains an unreported Pro-106-Thr EPSPS target-site mutation.

287 ajority of amino acids were composed of Val, Pro, Tyr, Met, Leu, Trp, Phe, Lys and Glu.

288 Val-Pro had the highest ORAC activity (19.45+/-2.15mumol of

289 the validation of the Comprehensive In vitro Pro-Arrhythmia Assay (CiPA).

290 series is a central Pro-Xaa sequence, where Pro is either l- or d-proline, which was chosen to favor

291 of the two major HLA-B*51 subpeptidomes with Pro-2 and Ala-2, the former one was significantly reduce

292 p10 and the differential susceptibility of X-Pro and X-Ala bonds to ERAP1 trimming and together resul

293 Moreover, we found that the X-Pro amide bonds in the inter-cysteine loop are rigidly c

294 revealed that the conformation around the X-Pro bonds (cis-trans) plays an important role in recepto

295 catalysts have been developed that bear Xaa-Pro amide bonds.

296 Both Xaa-Pro aminopeptidase and mitochondrial processing activiti

297 we found that these enzymes are genuine Xaa-Pro aminopeptidases, which hydrolyze peptides with proli

298 nds and fast cis- trans isomerization of Xaa-Pro bonds are crucial for the stability and folding rate

299 Trans/cis isomerization of Xaa-Pro bonds is key for the structure and function of sever

300 lectropermeabilization state, verified by Yo-Pro-1 uptake.