ライフサイエンスコーパス: Px

1 Px and control rats then underwent a 40-h fast followed

2 Px and isoprenaline had contrasting effects on cardiac s

3 Px animals acutely administered insulin exhibited furthe

4 Px rats after 1 week developed mild to severe hyperglyce

5 Px rats developed different degrees of hyperglycemia; lo

6 Px resulted in stable hyperglycemia, hypoinsulinemia, de

7 Px was not associated with kidney allograft survival (P

8 Px was transcribed in vitro by the sigmaA holoenzyme and

9 ociated in univariate analysis with the B*35 Px alleles (OR, 0.29; 95% CI, 0.08-0.99; P=.037), which

10 AIDS was completely attributable to HLA-B*35-Px alleles, some of which differ from HLA-B*35-PY allele

11 en total CTL activity and HIV RNA among B*35-Px carriers differed significantly from that among B*35-

12 did not differ between patients bearing B*35-Px genotypes and those bearing B*35-PY genotypes.

13 The association with the B*35-Px group was less strong than with HLA-B*53 alone.

14 specificity to some HLA-B*35 subtypes (B*35-Px group).

15 on 9; and the more broadly reactive HLA-B*35-Px group, which also binds epitopes with proline in posi

16 vity and viral load was observed in the B*35-Px group.

17 ent consequences of HLA-B*35-PY and HLA-B*35-Px in terms of disease progression highlight the importa

18 Here, we show that the B*35-Px molecule B*3503 binds with greater affinity to immuno

19 can present identical HIV-1 epitopes as B*35-Px molecules.

20 allelic variants B*3502/3503/3504/5301 (B*35-Px) progress more rapidly to AIDS than do those with B*3

21 A subset of HLA-B*35 alleles, B*35-Px, are strongly associated with accelerated HIV-1 disea

22 als with B*35-PY, but not in those with B*35-Px.

23 -thirds in ZF rats made hyperglycemic by 60% Px.

24 wofold increase in islets of 14-day post-60% Px Sprague-Dawley rats that hyperexpress beta-cell PPARg

25 s observed upon glycemic adaptation post-60% Px, in hyperglycemic 90% Px rats, islet PPARy, and PPARy

26 al pancreatectomy (Px) and hyperglycemic 90% Px rat models.

27 adaptation post-60% Px, in hyperglycemic 90% Px rats, islet PPARy, and PPARy targets SetD7 and Pdx1 w

28 PPARy agonist pioglitazone treatment in 90% Px rats partially restored glucose homeostasis and B-cel

29 found that it decreased from 35 microm at a Px of -0.5 MPa to 6 microm at -8 MPa.

30 In addition, islets isolated 3-7 d after Px showed higher IDX-1 protein expression than control i

31 y detected in these ducts 1 and 7 days after Px or sham Px but was easily detected at 2 and 3 days af

32 ut was easily detected at 2 and 3 days after Px.

33 ts but was strong in ducts at 2-3 days after Px.

34 was extracted from rats 4 and 14 weeks after Px or sham Px surgery.

35 sc., 10 days) was administered 5 weeks after Px with the aim of inducing cardiomyopathy, and cardiac

36 in between Px at stomatal closure (Pg12) and Px at 50% loss of conductivity.

37 These were in the HLA-B35-Px epitope and the HLA-B27-KK10 epitope.

38 There was no apparent interaction between Px and Iso treatment.

39 cavitation was defined as the margin between Px at stomatal closure (Pg12) and Px at 50% loss of cond

40 , we used the empirical relationship between Px and Df to model the freeze-thaw response in conifer s

41 We found that individually both Px and isoprenaline suppressed cardiac mitochondrial res

42 The gene controlled by Px has been called antE.

43 Nephropathy was induced by Px combined with uninephrectomy (Px-UNx).

44 Compared with sham-operated controls, Px-UNx induced albuminuria and increased urine markers o

45 Conversely, Px in combination with UNx resulted in several clinical

46 In conclusion, the EndoPredict-Px score accurately and early predicted in-hospital mort

47 y was to create and validate the EndoPredict-Px score for early in-hospital mortality prediction in p

48 a functioning kidney allograft, the need for Px for symptoms and radiological findings is not rare (3

49 ed with open flap debridement procedures for Px and Bx.

50 The level of GLUT2 mRNA from Px islets was 24 +/- 4% of that of islets from sham-oper

51 25 cm H2O in the three high-pressure groups (Px).

52 ased 60-fold and glutathione peroxidase (GSH Px) approximately 2.7-fold.

53 Their mRNA levels of bcl-2, bax, and GSH-Px essentially were unchanged.

54 8-OHdG and GSH-Px in saliva in both periodontitis groups were significa

55 The addition of exogenous GSH-Px led to restoration of platelet inhibition by NO.

56 Upregulation of GSH-Px and depletion of GSH indicate a reparative process of

57 ed with an increase in concentrations of GSH-Px and SOD, and a decrease in IL-6 and TNF-alpha.

58 Moreover, the mRNA levels of GSH-Px were significantly elevated.

59 Glutathione peroxidase (GSH-Px) activity was decreased in the patients' plasmas comp

60 ies of catalase, glutathione peroxidase (GSH-Px) and glutathione reductase (GSH-Rd) in the liver.

61 2, bax, p53, and glutathione peroxidase (GSH-Px) genes.

62 zyme activity of glutathione peroxidase (GSH-Px) were analyzed with enzyme-linked immunosorbent assay

63 oncentrations of glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), interleukin-6 (IL-6), t

64 utase (SOD), and glutathione peroxidase (GSH-Px), while decreasing serum malondialdehyde (MDA) levels

65 (Cu/Zn SOD) and glutathione peroxidase (GSH-Px).

66 thione peroxidase/glutathione reductase (GSH-Px/GSSG-R) functions, protein expression of gamma-glutam

67 Nrf2-Keap1 antioxidant genes (CAT, SOD, GSH-Px) and improved cellular redox balance by increasing re

68 than those in the DEX group, whereas the GSH-Px and SOD were higher (P < 0.05).

69 Perifused islets isolated from hyperglycemic Px rats showed reduced insulin responses to GLP-1 and GI

70 ange in beta-cell phenotype of hyperglycemic Px rats resulted in a reduced sensitivity to the beta-ce

71 In Px rats, the mechanism is an increase in the beta-cell i

72 In Px, the degree of suppression with fasting was similar,

73 In contrast, in Px the insulin response to GLP-1 tripled in association

74 Hyperglycemia in Px rats also led to activation of nuclear factor-kappaB

75 BCM increased in Px mice from 2 days onwards and was approximately 68% of

76 respiration, but that this was preserved in Px rats receiving isoprenaline.

77 degree of hyperglycemia and were reversed in Px rats by 2-week treatment with phlorizin (treatment th

78 and protected myocardial energetic status in Px rat hearts.

79 ast, the increase was less than threefold in Px, reaching an insulin response at 16.7 mM glucose that

80 a showed that the preferred binding motif is Px(P/A)xPR.

81 ern blot analysis of homogenates of isolated Px islets also showed a reduction in GLUT2 protein; dens

82 cies that maintain relatively high gs at low Px, thereby maintaining carbon assimilation, albeit at t

83 Moreover, Px increased heart and LV weights and dimensions and cau

84 Moreover, Px rats were protected against isoprenaline-induced mort

85 43), all of which match the consensus motif (Px[S/T]P) for phosphorylation by mitogen-activated prote

86 uit (kL) declined with increasingly negative Px.

87 significantly between the Px (n = 39) and no-Px groups, except for a higher proportion of females in

88 raft pancreatectomy (Px) and 196 did not (no-Px).

89 Isoprenaline treatment, but not Px, decreased ejection fraction and induced LV fibrosis.

90 GLUT2 immunofluorescence in the beta-cell of Px rats was greatly reduced.

91 Furthermore, beta-cells of Px rats were not vulnerable to apoptosis when further ch

92 tly different for common pancreatic ducts of Px, sham Px, and unoperated rats and did not change with

93 y reverses the changes in gene expression of Px rats at 4 weeks, the changes at 14 weeks were only pa

94 d altered ketone metabolism in the hearts of Px rats, but enhanced capacity for glucose uptake and me

95 The superimposition of Px and UNx increased GFR, indicating hyperfiltration.

96 ecreased in islets of 90% pancreatectomized (Px) hyperglycemic rats, with recovery when glucose level

97 on in islets of partially pancreatectomized (Px) rats.

98 eas in rats 4-6 wk after 90% pancreatectomy (Px) and sham-operated controls.

99 strate metabolism in the 90% pancreatectomy (Px) rat model of type 1 diabetes.

100 After 90% pancreatectomy (Px), the adult pancreas regenerates in a process recapit

101 e Sprague Dawley rats by 90% pancreatectomy (Px).

102 hese, 50 underwent allograft pancreatectomy (Px) and 196 did not (no-Px).

103 c regeneration after partial pancreatectomy (Px) and (2) define the involvement of the PI3K/Akt pathw

104 in normoglycemic 60% partial pancreatectomy (Px) and hyperglycemic 90% Px rat models.

105 4 weeks after 85-95% partial pancreatectomy (Px) when beta-cells have impaired glucose-induced insuli

106 4 weeks after a 90% partial pancreatectomy (Px), a well-characterized model of hyperglycemia.

107 5 days following 60% partial pancreatectomy (Px).

108 c rats 4 weeks after partial pancreatectomy (Px).

109 way in pancreatic regeneration after partial Px was assessed by effects of a pharmacologic PI3K inhib

110 generation and pAkt expression after partial Px were significantly decreased with aging.

111 educed pancreatic regeneration after partial Px.

112 Following partial Px, pancreatic regeneration and activation of the PI3K p

113 ugh a direct point (Pd), a cross-body point (Px), or a familiar symbolic gesture (S).

114 ta-cell clusters/small islets at 2 days post-Px contributed substantially to BCM augmentation, follow

115 ), thereby maintaining high water potential (Px; isohydric), from those species that maintain relativ

116 diameter across a range of xylem pressures (Px) in the conifers Pinus contorta and Juniperus scopulo

117 ment learning model (exceedance probability, Px = .92) and had increased exploratory behavior compare

118 Promoter Px is turned on at the same time as promoter P3 during e

119 The transcript from promoter Px codes for a small protein with partial homology to th

120 A Bacillus subtilis promoter, Px, that functions in a convergent manner with the sigA

121 /-)), normoglycemic 60% pancreatectomy rats (Px), normoglycemic and hyperglycemic Zucker fatty (ZF) r

122 and loss of conductivity at minimum seasonal Px, respectively.

123 in these ducts 1 and 7 days after Px or sham Px but was easily detected at 2 and 3 days after Px.

124 ed from rats 4 and 14 weeks after Px or sham Px surgery.

125 rent for common pancreatic ducts of Px, sham Px, and unoperated rats and did not change with time aft

126 cific messages were reduced, we analyzed the Px islets for the pancreas-duodenum-specific transcripti

127 teristics differed significantly between the Px (n = 39) and no-Px groups, except for a higher propor

128 duced (approximately 80%) in islets from the Px rats.

129 The most common presentation in the Px group was abdominal pain.

130 pt for a higher proportion of females in the Px group.

131 rglycemia; low hyperglycemia was assigned to Px rats with fed blood glucose levels less than 150 mg/d

132 phenotype, in islets from phlorizin-treated Px rats.

133 Treating Px rats with phlorizin normalized hyperglycemia without

134 induced by Px combined with uninephrectomy (Px-UNx).

135 Whereas Px and isoprenaline separately produced clinical endpoin

136 showing loss of conductivity (embolism) with Px down to -8 MPa were generated with versus without sup

137 frican-American female, patient (proband X, [Px]) reported with a chief complaint of tooth mobility a