ライフサイエンスコーパス: Q fever

1 ellular bacterium and the causative agent of Q fever.

2 f developing a peptide mimic vaccine against Q fever.

3 eloping a safe and effective vaccine against Q fever.

4 differently modulated in men and women with Q fever.

5 ver but are lacking in patients with chronic Q fever.

6 a lions may be a risk factor for contracting Q fever.

7 l pathogen responsible for acute and chronic Q fever.

8 ich is associated with a case of human acute Q fever.

9 oonotic bacterial pathogen that causes human Q fever.

10 r bacterium and the causative agent of human Q fever.

11 d by or nonreactive in subjects with chronic Q fever.

12 he design of new generation vaccines against Q fever.

13 d the etiological agent of the human disease Q fever.

14 iella burnetii, the causative agent of human Q fever.

15 the clinical illness seen in human cases of Q fever.

16 he etiological agent of the zoonotic disease Q fever.

17 differential diagnosis of acute and chronic Q fever.

18 lular bacterium and the etiological agent of Q fever.

19 rnetii, the rickettsial organism that causes Q fever.

20 in the absence of additional data of chronic Q fever.

21 ck and humans with an acute disease known as Q fever.

22 iella burnetii, the causative agent of human Q fever.

23 g dynamic during early stages of human acute Q fever.

24 logical evolution and progression to chronic Q fever.

25 oms and/or serological confirmation of acute Q fever.

26 e etiological agent of the emerging zoonosis Q fever.

27 r Gram-negative bacterium which causes human Q fever.

28 iphospholipid dosages in patients with acute Q fever.

29 sorders have been described in patients with Q fever.

30 4 at the French National Referral Center for Q fever.

31 ith predisposition to development of chronic Q fever.

32 iella burnetii can lead to acute and chronic Q fever.

33 n an increased likelihood to develop chronic Q fever.

34 e bacterium that causes the zoonotic disease Q fever.

35 MYD88 (-938C>A) were associated with chronic Q fever.

36 contribute to the increased risk of chronic Q fever.

37 et need for a safe and effective vaccine for Q-fever.

38 tracellular parasite and the cause of query (Q) fever.

39 ntracellular bacterium that causes query, or Q fever, a disease that typically manifests as a severe

40 The phase I form is responsible for Q fever, a febrile illness with flu-like symptoms that o

41 ar Gram-negative bacterium that causes human Q fever, a flu-like disease that can progress to chronic

42 Coxiella burnetii causes human Q fever, a zoonotic disease that presents with acute flu

43 Coxiella burnetii is the causative agent of Q fever, a zoonotic disease that threatens both human an

44 Q fever AAAs and atherosclerotic AAAs contained similar

45 as used to investigate local inflammation in Q fever AAAs compared to atherosclerotic AAAs in aorta t

46 Finally, Q fever AAAs did not contain any well-defined granulomas

47 Furthermore, Q fever AAAs showed an increase in both the number of CD

48 However, in Q fever AAAs, the number of CD68(+)CD206(+) M2 macrophag

49 ed for the pathogen using PrioCHECK Ruminant Q Fever AB Plate ELISA kit.

50 The Q fever agent Coxiella burnetii uses a defect in organel

51 suspected patient-to-patient transmission of Q fever among pregnant women in a high-risk pregnancy un

52 ellular bacterial pathogen that causes human Q fever, an acute debilitating flu-like illness that can

53 lla burnetii is the bacterial agent of human Q fever, an acute, flu-like illness that can present as

54 neumonia (CAP) is the major manifestation of Q fever, an emerging disease in French Guiana.

55 The outcome of Q fever, an infectious disease caused by Coxiella burnet

56 tients treated in our center, 1797 had acute Q fever and 48 had acute Q fever endocarditis.

57 en Coxiella burnetii, the causative agent of Q fever and a federal select agent.

58 Of the 759 patients with acute Q fever and available echocardiographic results, 9 (1.2%

59 ver vaccine in treated patients with chronic Q fever and demonstrated that they successfully mounted

60 Intervals between acute Q fever and diagnosis of chronic infection can reach mor

61 We determined the interval between acute Q fever and diagnosis of chronic infection, assessed wha

62 a valuable technique in diagnosis of chronic Q fever and during follow-up, often leading to a change

63 nt aortic vegetation in a patient with acute Q fever and high levels of IgG anticardiolipin antibodie

64 were genotyped in 139 patients with chronic Q fever and in 220 controls with cardiovascular risk-fac

65 ligate intracellular bacterium, causes human Q fever and is considered a potential agent of bioterror

66 s were associated with the activity of acute Q fever and Q fever endocarditis, respectively.

67 First, we describe our experience on Q fever and Tropheryma whipplei infection management bas

68 vely collected data from patients with acute Q fever and valvular injury.

69 ntibiotic prophylaxis in patients with acute Q fever and valvulopathy has never been validated in a c

70 important in the pathophysiology of clinical Q fever and/or the induction of protective immunity.

71 We investigated brucellosis, Q-fever and leptospirosis in the venous blood of 216 mal

72 ma, were up-regulated in patients with acute Q fever, and the expression levels of the late genes ALO

73 Cases of chronic Q fever are extremely rare and most often manifest as cu

74 to Coxiella burnetii, the causative agent of Q fever, are uncommon in the United States.

75 burnetii, the biothreat pathogen that causes Q fever, as in vitro propagation of this organism leads

76 gnostic value of (18)F-FDG PET/CT in chronic Q fever at diagnosis and during follow-up.

77 The Q fever bacterium Coxiella burnetii replicates inside ho

78 In some cases, Q fever becomes chronic, leading to endocarditis that ca

79 omas are present in patients with resolutive Q fever but are lacking in patients with chronic Q fever

80 th Coxiella burnetii, the causative agent of Q fever, can result in life-threatening persistent infec

81 Q fever case report forms submitted during 1999-2015 wer

82 As Q fever, caused by Coxiella burnetii, is a major health

83 Current practice for diagnosis of Q fever, caused by the intracellular pathogen Coxiella b

84 s used as a new diagnostic tool for previous Q fever, circumventing most of these drawbacks.

85 Linking a single dairy-goat farm to a human Q-fever cluster, we show widespread transmission, massiv

86 ntly (P = .01) increased in males with acute Q fever compared with healthy volunteers.

87 Acute Q fever could be associated with an increased prevalence

88 e, we sought to determine how commonly acute Q fever could cause valvular vegetations associated with

89 igate intracellular bacterial agent of human Q fever, Coxiella burnetii, has a remarkable ability to

90 The causative agent of human Q fever, Coxiella burnetii, is highly adapted to infect

91 The intracellular bacterial agent of Q fever, Coxiella burnetii, translocates effector protei

92 to 2014 French National Referral Center for Q fever database.

93 -5% of all acute Q fever infections, chronic Q fever develops, mostly manifesting as endocarditis, in

94 Persistent infection (chronic Q fever) develops in 1%-5% of patients.

95 lop classic serological criteria for chronic Q fever diagnosis in the absence of additional data of c

96 To test if increased IgG aCL at acute Q fever diagnosis is associated with an increased risk o

97 ith classic serological criteria for chronic Q fever diagnosis remained asymptomatic despite no speci

98 ria: (1) patients aged >=18 years; (2) acute Q fever diagnosis, defined as suggestive symptoms in the

99 e I IgG titers >=1:1024 6 months after acute Q fever diagnosis, was assessed.

100 e I IgG titers >=1:1024 6 months after acute Q fever diagnosis.

101 Serology is essential for Q fever diagnostics, a disease caused by the bacterial p

102 r even many years after an outbreak or acute Q fever disease.

103 tes of Coxiella burnetii, the cause of human Q fever, display different phenotypes with respect to in

104 reases in fetal death and malformation after Q fever during pregnancy.

105 lla burnetii is the causative agent of human Q fever, eliciting symptoms that range from acute fever

106 U]) were independently associated with acute Q fever endocarditis (odds ratio [OR], 2.7 [95% confiden

107 Acute Q fever endocarditis (OR, 5.2 [95% CI, 2.6-10.5]; P < .0

108 que opportunity for early diagnosis of acute Q fever endocarditis and for the prevention of persisten

109 fevers for 14 months who was diagnosed with Q fever endocarditis based on an extremely high antibody

110 of clinical and epidemiological features of Q fever endocarditis collected through passive surveilla

111 Some cases of apparent Q fever endocarditis could not be classified by CSTE lab

112 ssess the clinical spectrum and magnitude of Q fever endocarditis in the United States.

113 There are few descriptive analyses of Q fever endocarditis in the United States.

114 No cases of Q fever endocarditis nor other persistent focalized infe

115 The prevention of Q fever endocarditis through the use of systematic echoc

116 Q fever endocarditis was defined according to recently u

117 (TTE) identified a valvular lesion of acute Q fever endocarditis without underlying valvulopathy.

118 We identified a new clinical entity, acute Q fever endocarditis, defined as valvular lesion potenti

119 ults, 9 (1.2%) were considered to have acute Q fever endocarditis, none of whom had a previously know

120 iated with the activity of acute Q fever and Q fever endocarditis, respectively.

121 were specifically increased in patients with Q fever endocarditis.

122 ter, 1797 had acute Q fever and 48 had acute Q fever endocarditis.

123 ut did not meet the CSTE case definition for Q fever endocarditis.

124 02) were independently associated with acute Q fever endocarditis.

125 at least 6 months' follow-up after the acute Q fever episode.

126 onsidered in the management of patients with Q fever, especially those with persistent focalized infe

127 Coxiella burnetii, the causative agent of Q fever, establishes a unique lysosome-derived intracell

128 perform microbiological testing for chronic Q fever even many years after an outbreak or acute Q fev

129 About 90% of patients with chronic Q fever failed to form granulomas.

130 will develop chronic fatigue, referred to as Q fever fatigue syndrome (QFS).

131 uman cases and occurred in a region that was Q-fever free before 2009, providing a unique quasi-exper

132 d in the French National Referral Center for Q fever from January 2007 to December 2011 were included

133 iella burnetii, the causative agent of human Q fever, has been considered a prototypical obligate int

134 Coxiella burnetii, the etiological agent of Q fever, has two phase variants.

135 During acute Q fever, high IgG aCL prevalence has been reported, but

136 vealed a 23.66% and 27.23% seroprevalence of Q fever in cattle and buffalo, respectively.

137 the Gram-negative bacterium responsible for Q fever in humans and coxiellosis in domesticated agricu

138 Coxiella burnetii causes acute Q fever in humans and occasional chronic infections that

139 haride (LPS), is highly virulent, and causes Q fever in humans and pathology in experimental animals.

140 rRNA gene of Coxiella burnetii, the agent of Q fever in humans, contains an unusually high number of

141 , the etiological agent of acute and chronic Q fever in humans, is a naturally intracellular pathogen

142 Coxiella burnetii, the etiological agent of Q fever in humans, is an intracellular pathogen that rep

143 ular bacterium that causes acute and chronic Q fever in humans.

144 tive bacterium that causes acute and chronic Q fever in humans.

145 ides new insights into the seroprevalence of Q fever in large ruminants across seven studied district

146 practices for the prevention and control of Q fever in large ruminants in the region.

147 s is considered to be a late complication of Q fever in patients with preexisting valvular heart dise

148 follow-up period for a patient with chronic Q fever in the United States.

149 ween seropositivity of feral swine and human Q fever incidence.

150 was to describe the natural history of acute Q fever, including its clinical and serological evolutio

151 ection control guidelines are sufficient for Q fever-infected women in similar settings.

152 ignificant disabilities, related to an acute Q fever infection, without other somatic or psychiatric

153 In 1%-5% of all acute Q fever infections, chronic Q fever develops, mostly man

154 a, Coxiella burnetii, the etiologic agent of Q fever, inhabits a spacious acidified intracellular vac

155 syndrome with valvular vegetations in acute Q fever is a new clinical entity.

156 Q fever is a worldwide zoonosis caused by Coxiella burne

157 Q fever is a zoonosis caused by Coxiella burnetii, a uni

158 Chronic Q fever is a zoonosis caused by the bacterium Coxiella b

159 Acute Q fever is a zoonotic disease caused by the obligate int

160 Q fever is a zoonotic disease of worldwide significance

161 Q fever is an infection caused by Coxiella burnetii.

162 Q fever is caused by Coxiella burnetii, a bacterium that

163 Human Q fever is caused by the intracellular bacterial pathoge

164 Acute human Q fever is characterized by flu-like symptoms that, in s

165 istent focalized infection forms after acute Q fever is extremely low and does not justify the use of

166 The prevalence of Q fever is higher in men than in women.

167 Although Q fever is mainly transmitted by aerosol infection, stud

168 Human Q fever is mainly transmitted by aerosol infection.

169 Acute Q fever is often self-limiting, presenting as a febrile

170 Chronic Q fever is still being diagnosed and mortality keeps occ

171 Q-fever is a flu-like illness caused by Coxiella burneti

172 Coxiella burnetii, the etiological agent of Q fever, is a Gram-negative bacterium transmitted to hum

173 Coxiella burnetii, the etiological agent of Q fever, is a gram-negative obligate intracellular bacte

174 Coxiella burnetii, the causative agent of Q fever, is a human intracellular pathogen that utilizes

175 Coxiella burnetii, the etiological agent of Q fever, is a small, Gram-negative, obligate intracellul

176 Coxiellosis, also known as Q fever, is a zoonotic disease caused by Coxiella burnet

177 Coxiella burnetii, the causative agent of Q fever, is a zoonotic disease with potentially life-thr

178 Coxiella burnetii, the cause of human Q fever, is an aerosol-borne, obligate intracellular bac

179 Coxiella burnetii, the causative agent of Q fever, is an emerging pathogen that has the potential

180 Coxiella burnetii, the etiological agent of Q fever, is an obligate intracellular bacterium prolifer

181 Coxiella burnetii, the causative agent of Q fever, is an obligate intracellular bacterium.

182 Growth of Coxiella burnetii, the agent of Q fever, is strictly limited to colonization of a viable

183 were comparable to those seen in human acute Q fever, making this an accurate and valuable animal mod

184 Humans with Q fever may experience an acute flu-like illness and pne

185 strated that individuals treated for chronic Q fever mount a broader ex vivo response to class II epi

186 lla burnetii, the etiological agent of human Q fever, occupies a unique niche inside the host cell, w

187 lar survival are poorly defined and a recent Q fever outbreak in the Netherlands emphasizes the need

188 Successful host cell colonization by the Q fever pathogen, Coxiella burnetii, requires translocat

189 g the LPA delivery system to study pulmonary Q fever pathogenesis as well as designing vaccine counte

190 ected biomarkers were assessed in blood from Q fever patients by real-time reverse transcription poly

191 An excess risk of DLBCL and FL was found in Q fever patients compared with the general population (S

192 A significant proportion of acute Q fever patients develop classic serological criteria fo

193 Systematic TTE in acute Q fever patients offers a unique opportunity for early d

194 ) probable, and 125 (24.1%) possible chronic Q fever patients were identified.

195 Q fever patients with persistent focalized infection wer

196 les a dynamic approach for the evaluation of Q fever patients.

197 ted biomarkers and tested their relevance in Q fever patients.

198 ) of proven and 3 (3.7%) of probable chronic Q fever patients.

199 ncept of M1/M2 polarization is applicable to Q fever patients.

200 urately identifies patients with low risk of Q fever pneumonia and may help physicians to make more r

201 bjectives were to estimate the prevalence of Q fever pneumonia and to build a prediction rule to iden

202 a prediction rule to identify patients with Q fever pneumonia for empirical antibiotic guidance.

203 -one patients with CAP were included and the Q fever pneumonia prevalence was 24.4% (95% confidence i

204 th a predictive score </=3 had a low risk of Q fever pneumonia with a negative predictive value of 0.

205 st prediction rule to identify patients with Q fever pneumonia.

206 >185 mg/L were independently associated with Q fever pneumonia.

207 onal transmission patterns associated with a Q-fever point source.

208 A meta-analysis of 136 Q fever pregnancies, including 4 new cases and 7 populat

209 ellular bacterial pathogen Coxiella burnetii Q fever presents with acute flu-like and pulmonary sympt

210 ogenesis and genetics and aid development of Q fever preventatives such as an effective subunit vacci

211 Chronic Q fever-related complications and mortality were assesse

212 Chronic Q fever-related complications occurred in 216 patients (

213 Chronic Q fever-related mortality occurred in 83 (26.5%) of prov

214 Q fever-related mortality rate in patients with and with

215 effective new generation vaccine to prevent Q fever remains an important public health goal.

216 Coxiella burnetii, the etiologic agent of Q fever, replicates in an intracellular phagolysosome wi

217 xiella burnetii (Cb), the causative agent of Q fever, replicates within host macrophages by modulatin

218 We review all cases of chronic Q fever reported in the United States and discuss import

219 unity against a murine model of experimental Q fever requires MHC-II-restricted, CD4(+) T cell-depend

220 ion by Coxiella burnetii, the cause of human Q fever, requires pathogen-directed biogenesis of a larg

221 A need exists in Q fever research for animal models mimicking both the ty

222 human patients who had recovered from acute Q fever, respectively, revealed both unique SCV/LCV anti

223 exas, which have low and high rates of human Q fever, respectively.

224 llular pathogens that cause diseases such as Q fever, rickettsioses, brucelloses, tularemia, and othe

225 Coxiella burnetii, the causative agent of Q fever, secretes bacterial effector proteins via its Ty

226 The incidence of seroconversion to a chronic Q fever serological pattern, defined as phase I IgG tite

227 is, with directed serological testing (i.e., Q fever serology, Bartonella serology) in culture-negati

228 Q fever should be considered in patients with prosthetic

229 t (ELISpot) assays, individuals with chronic Q fever showed strong class II epitope-specific response

230 Although the name "chronic Q fever" suggests otherwise, rapid evolution (<1 month)

231 We observed a lymphoma in a patient with Q fever that prompted us to investigate the association

232 odel for inhalation to determine the risk of Q fever through tap water.

233 The evolution from acute Q fever to endocarditis is associated with age and valvu

234 Rapid progression from acute Q fever to endocarditis is associated with high levels o

235 A screening-level risk assessment of Q fever transmission through drinking water produced fro

236 Chronic Q fever usually develops within 2 years after primary in

237 epitopes for a novel T-cell targeted subunit Q fever vaccine in treated patients with chronic Q fever

238 de implementation of the only licensed human Q fever vaccine.

239 can be exploited for a new-generation human Q fever vaccine.

240 ular complications, we aimed to detect acute Q fever valvular injury to improve therapeutic managemen

241 The date of acute Q fever was known in 200 patients: in 45 (22.5%), the in

242 To understand the pathogenicity of Q fever, we investigated the roles of immune components

243 In the French national reference center for Q fever, we prospectively collected data from patients w

244 single-nucleotide polymorphisms and chronic Q fever were assessed by means of univariate logistic re

245 ological follow-up was performed after acute Q fever were diagnosed less often after this 2-year inte

246 from an endemic area with a risk for chronic Q fever were enrolled.

247 From 2007 to 2018, patients with chronic Q fever were included from 45 participating hospitals.

248 he French National Referral Center for acute Q fever were included in a cohort study.

249 s with possible, probable, or proven chronic Q fever were included.

250 ls treated for persistent infection (chronic Q fever) whether they recognize the same set of epitopes

251 ll adult Dutch patients suspected of chronic Q fever who were diagnosed since 2007 were retrospective

252 Approximately 20% of patients with acute Q fever will develop chronic fatigue, referred to as Q f