ライフサイエンスコーパス: QTc interval

1 QTc interval >/=500 ms increased the risk of cardiac eve

2 QTc interval prolongation was defined as QTc interval >5

3 QTc intervals were analyzed according to age (< 16 or >

4 QTc intervals were measured in 241 patients with heart f

5 QTc intervals were prolonged (>440 ms) in 122 (51%) pati

6 C) runs (sertraline: 13.1%; placebo: 12.9%), QTc interval greater than 450 milliseconds at end point

7 At a QTc interval threshold of 500 milliseconds, the 6-lead E

8 nts receiving hydroxychloroquine developed a QTc interval of 500 ms or greater, but the proportion of

9 ed the DSEC were more likely to experience a QTc interval increase of at least 30 milliseconds vs pla

10 en) and were 1.4 times more likely to have a QTc interval above 500 ms.

11 erval: 1.52 to 3.54, p < 0.001) for having a QTc interval >/=99th percentile (>/=458 ms).

12 Having a QTc interval lower than the first percentile (</=372 ms)

13 th 0.8% of clinic visits (4 of 489) having a QTc interval of 500 milliseconds or more.

14 ed trial participants were excluded due to a QTc interval greater than 450 milliseconds.

15 pregnant women) with cardiac parameters, all QTc intervals were within normal limits, with no signifi

16 ypoxia correlated significantly with altered QTc intervals (p < 0.001).

17 Although QTc interval prolonged in 100% of patients, T-wave chang

18 ed abbreviated QRS duration (P = 0.0003) and QTc interval (P = 0.0006) in EV-treated DSG2mt/mt mice.

19 onship between piperaquine concentration and QTc interval throughout pregnancy can inform effective,

20 , PR intervals (P = 0.014), QRS duration and QTc interval (both P = 0.003), but Normal-VLDL did not.

21 Median PR interval, QRS duration, and QTc interval were 156, 88, and 402 ms, respectively.

22 ts (PR interval, QRS axis, QRS duration, and QTc interval) were evaluated for single-nucleotide polym

23 higher dose therapy increased lethality and QTc interval prolongation.

24 Tc) on drug therapy, the magnitude of QT and QTc interval prolongation, and the change in T(peak) to

25 eviation; PR interval, QRS duration, QT, and QTc interval; P, Q, R, S, and T amplitudes in 12 leads;

26 n, estimated glomerular filtration rate, and QTc interval.

27 dy and heart weights, prolonged PR, QRS, and QTc intervals, and reduced %EF and %FS at normoxia compa

28 ogram demonstrated slightly prolonged QT and QTc intervals and normal sinus rhythm.

29 ificantly greater symptoms, increased QT and QTc intervals and QTc dispersion, ventricular tachycardi

30 The RR, QT and QTc intervals and the high frequency component of heart

31 Both QT and QTc intervals are longer during sleep.

32 048 segments showed mean (+/- SD) RR, QT and QTc intervals of 830 +/- 100, 407 +/- 23 and 445 +/- 16

33 ith control, AM and SR increased RR, QT, and QTc intervals (P<0.0001 for all).

34 sinus slowing and increased PR, QRS, QT, and QTc intervals, as seen with azithromycin overdose.

35 QTc interval prolongation was defined as QTc interval >500 ms or increase in QTc of >/=60 ms from

36 dults with delirium in the ICU with baseline QTc interval less than 550 ms.

37 dy, a J-shaped association was found between QTc interval duration and risk of AF.

38 luding in patients with normal or borderline QTc intervals (F1 score, 0.70 [95% CI, 0.40-1.00]; sensi

39 quine concentration and Fridericia corrected QTc interval was identified.

40 red with baseline, the heart rate-corrected (QTc) interval was prolonged by 30 to 60 milliseconds in

41 In patients receiving multiple courses, QTc intervals returned to pretreatment levels before the

42 he findings of this trial suggest that daily QTc interval monitoring during antipsychotic use may hav

43 -1.57; P = .78) was associated with next-day QTc intervals.

44 cated by increased PR interval and decreased QTc interval.

45 l hypercholesterolemia, electrocardiographic QTc interval for long QT syndrome, and glycosylated hemo

46 ine levels and a longer electrocardiographic QTc interval than did the sham group.

47 he phenotype (prolonged electrocardiographic QTc interval).

48 icant shortening of the electrocardiographic QTc interval and reduction of left ventricular systolic

49 athy, including cardiac isoenzyme elevation, QTc interval prolongation, and rapidly reversible cardia

50 ate during exercise, making the end-exercise QTc interval dependent on peak work load achieved.

51 iables predicts patients at highest risk for QTc interval prolongation and may be useful in guiding m

52 ed to a patient at moderate or high risk for QTc interval prolongation, a computer alert appeared on

53 Female gender, QTc interval > or =500 ms, and interim syncopal events d

54 95% upper confidence limit for the mean 24-h QTc interval was 452 ms (men 439 ms, women 461 ms).

55 sh/wk had a 29.2% lower likelihood of having QTc intervals >0.45 s (P=0.03).

56 binary outcome meta-analyses (human height, QTc interval and gallbladder disease); all previous repo

57 In the 50 patients analyzed with IE, QTc interval prolonged in 50 of 50 (100%) patients (from

58 Mean change in QTc interval did not differ significantly from placebo w

59 For mean increase in QTc interval from baseline, a nonsignificant difference

60 refractory period, and 4% to 6% increases in QTc interval.

61 ipants experienced a significant increase in QTc intervals during hypoxia using Bazett's (from 402 +/

62 mouse models show similar problems including QTc interval prolongation and hypothermia.

63 c repolarization disturbances with increased QTc intervals in both patients and controls, but with a

64 ing of the heart rate-corrected QT interval (QTc interval) in Kir2.1-transduced animals (n = 4) and a

65 ll patients developed corrected QT interval (QTc interval) prolongation (median QTc interval 504 ms,

66 1A (QRS duration), NOS1AP, KCNH2, and KCNQ1 (QTc interval).

67 They review the evidence linking QTc interval prolongation, potassium channels, and torsa

68 prevalence and factors associated with long QTc interval in a cohort of opioid-dependent HIV-infecte

69 trophy (77% versus 58%; P=0.02) and a longer QTc interval (466+/-36 versus 453+/-41 milliseconds; P=0

70 Compared with men, women exhibit a longer QTc interval and an increased propensity toward torsade

71 Carriers of 2 mutations had longer QTc intervals (527+/-54 versus 489+/-44 ms; P<0.001); al

72 Device patients had longer QTc intervals (p = 0.03) and more symptoms (p < 0.001).

73 ne and lansoprazole had significantly longer QTc intervals (up to 12 ms in white men) and were 1.4 ti

74 The association with respect to longer QTc intervals was stronger for the outcome of lone AF, a

75 consumption of fish is associated with lower QTc interval in free-eating people without any evidence

76 The average maximal QTc interval was 495 +/- 21 ms and the average QTc range

77 uals receiving the DSEC had a longer maximal QTc interval (mean [SD], 419.4 [11.8] vs 396.1 [15.7] mi

78 nt Metabolife 356 increased the mean maximal QTc interval and SBP.

79 The maximal QTc interval over 24 h in normal subjects is longer than

80 The maximal QTc interval was > or = 500 ms in 6 subjects and > or =

81 Mean time to maximal QTc interval prolongation, changes in T-wave polarity, >

82 riability between hourly minimal and maximal QTc intervals reached their circadian peak shortly after

83 ntipsychotics vs placebo on next-day maximum QTc interval, adjusting for prespecified baseline covari

84 The maximum QTc interval provides incremental prognostic information

85 The maximum QTc interval recorded before age 10 was the strongest pr

86 Mean QTc interval was prolonged by 2.4 ms.

87 was 70 mg/day (range 15-250 mg/day) and mean QTc interval was 438 +/- 34 ms.

88 +/- 23 and 445 +/- 16 ms, respectively (mean QTc interval for men 434 +/- 12 ms, 457 +/- 10 ms for wo

89 d relatives, men exhibited the shortest mean QTc interval in chromosome 7q- and 11p-linked blood rela

90 The mean QTc interval in genotype-negative blood relatives (n = 2

91 hadone dose was 397 +/- 283 mg, and the mean QTc interval was 615 +/- 77 msec.

92 ayo Clinic evaluation, 22 +/- 14 years; mean QTc interval, 427 +/- 25 milliseconds) were dismissed as

93 The mean QTc intervals were longer at peak exercise in patients (

94 This surpassed expert-measured QTc intervals in detecting LQTS (F1 score, 0.84 [95% CI,

95 ent with mexiletine was 22 years, and median QTc interval before therapy 509 ms.

96 interval (QTc interval) prolongation (median QTc interval 504 ms, IQR: 477 to 568 ms) within 24 h of

97 Baseline median QTc intervals across the groups were similar: haloperido

98 In all 74 patients analyzed with MUSE, QTc interval prolonged from 423 +/- 25 ms to 455 +/- 34

99 In nonathletes, QTc interval abnormalities comprised the majority (52%)

100 n the JLNS family described here have normal QTc intervals (0.43 and 0.44 seconds, respectively).

101 Monitoring of QTc interval is mandated in different clinical condition

102 to evaluate the prevalence and predictors of QTc interval prolongation and incidences of LTA during h

103 QT-prolonging drugs and reduces the risk of QTc interval prolongation in hospitalized patients with

104 The role of QTc interval prolongation in heart failure remains poorl

105 by examining dose dependency, the percent of QTc intervals higher than 500 msec, and the risk of drug

106 Nevertheless, intra-subject variability of QTc intervals reduces the clinical utility of QTc monito

107 SNPs previously identified as modulators of QTc-interval in genome-wide association studies in the g

108 ed risk of QTc prolongation and the postdose QTc intervals progressively decreased.

109 Prolonged QTc interval (>450 ms) was documented in 33 of 91(36.3%)

110 Prolonged QTc interval and life-threatening arrhythmias (LTA) are

111 Prolonged QTc interval is a strong, independent predictor of adver

112 Prolonged QTc interval was an independent predictor of posttranspl

113 7%]), Q waves (2 athletes [1.2%]), prolonged QTc interval (2 athletes [1.2%]), and frequent premature

114 A prolonged QTc interval and Q wave were related to post-transplant

115 isdiagnosis or overdiagnosis was a prolonged QTc interval secondary to vasovagal syncope (n = 87; 30%

116 Cirrhotics had a prolonged QTc interval, a Q wave, abnormal QRS axis deviation, ST

117 family members, none of whom had a prolonged QTc interval.

118 On multivariate analysis, prolonged QTc interval was an independent predictor of all-cause d

119 nt cardiac arrest and dramatically prolonged QTc interval who were both born to healthy parents.

120 rent syncopal events and a greatly prolonged QTc interval.

121 95% CI, 1.23 to 4.68), and pre-HCT prolonged QTc interval (HR, 2.55; 95% CI, 1.38 to 4.72) were indep

122 score comprising renal impairment, prolonged QTc interval, and age older than 52 was developed for pr

123 s with shared clinical features of prolonged QTc interval (range 505-725 ms) and documented ventricul

124 wing in recent years, and cases of prolonged QTc interval and torsades de pointes have been described

125 The prevalence of prolonged QTc interval in opioid-dependent HIV-infected patients o

126 (</= 440 ms [n = 469]), LQTS with prolonged QTc interval (> 440 ms [n = 1,392]), and unaffected fami

127 iver transplantation together with prolonged QTc interval.

128 Prolonged QTc intervals and life-threatening arrhythmias (LTA) are

129 implantation in 3) and excessively prolonged QTc intervals in 8 (6.7%) (dosage reduced or discontinue

130 ly, both these family members have prolonged QTc intervals and would have been classified as Romano-W

131 ificantly lower than in those with prolonged QTc intervals (15%) (p < 0.001) but higher than in unaff

132 r ACA or SCD only in patients with prolonged QTc intervals (female age > 13 years, hazard ratio: 1.90

133 bradycardia; palpitation; changing PR, QRS, QTc intervals in electrocardiogram; heart failure) for t

134 d >/=120 ms (1.75, 1.17-2.62); corrected QT (QTc) interval >/=450 ms in men or >/=460 ms in women (1.

135 The rate-corrected QT (QTc) interval association with serum PDGF was tested in

136 The Bazett-corrected QT (QTc) interval during exercise has been used as a marker

137 gender differences in the rate-corrected QT (QTc) interval in the presence of a QT-prolonging gene.

138 stigate whether the heart rate-corrected QT (QTc) interval on the electrocardiogram (ECG) is associat

139 Corrected QT (QTc) interval prolongation (defined as QTc>500 ms or an

140 icant bradycardia or excessive corrected QT (QTc) interval prolongation.

141 Female gender, corrected QT (QTc) interval, LQT2 genotype, and frequency of cardiac e

142 ects on weight, prolactin, and corrected QT (QTc) interval.

143 and variability of the QT and corrected QT (QTc) intervals over 24 h and to assess their pattern and

144 genes with normal or prolonged corrected QT (QTc) intervals.

145 QT syndrome (LQTS) with normal corrected QT (QTc) intervals.

146 hisms (SNPs) that modulate the corrected QT (QTc)-interval and the occurrence of cardiac events in 63

147 ontrols; however, resting heart rates and QT/QTc intervals were similar at baseline.

148 SCD in patients with LQTS with normal-range QTc intervals (4%) was significantly lower than in those

149 ors ACA or SCD in patients with normal-range QTc intervals included mutation characteristics (transme

150 the baseline, the mean, and the most recent QTc interval recorded before age 10, were less significa

151 subjects, the QTc gender difference reflects QTc interval shortening in men during adolescence.

152 the LQT group had a 24% reduction in resting QTc interval (from 617 +/- 92 to 469 +/- 23 ms, P = .004

153 remodeling in response to MI, with shortened QTc intervals, fewer VT episodes, and higher survival ra

154 Besides shortening QTc interval, mexiletine caused a major reduction of lif

155 h the mutation was associated with a shorter QTc interval (P<0.05) and a reduced occurrence of cardia

156 rol (4.8+/-0.30 and 4.5+/-0.23), and shorter QTc intervals (167+/-2.6 versus 182+/-6.4).

157 of African origin had significantly shorter QTc intervals than Caucasians (p < 0.001).

158 favorable treatment outcome and significant QTc-interval prolongation (QTc >=500 ms or >=60 ms incre

159 during adolescence included recent syncope, QTc interval, and sex.

160 1 (95% CI, 0.80-0.85), which was better than QTc interval-based detection (AUC, 0.74; 95% CI, 0.69-0.

161 The QTc interval and QTc variability reach a peak shortly af

162 The QTc interval prolongs in 100% of patients with early tra

163 +/-6 versus 115+/-11 beats/min; P=0.54), the QTc interval had prolonged significantly more in patient

164 To better understand it, we analyzed the QTc interval duration in patients with heart failure wit

165 Both the QTc interval and the variability between hourly minimal

166 and 13 patients with no CAD to correlate the QTc interval respectively.

167 If the QTc interval exceeds 500 ms, consider discontinuing or r

168 COMMENDATION 4 (RISK STRATIFICATION): If the QTc interval is greater than 450 ms but less than 500 ms

169 partially reversed, with enhancements in the QTc interval and ST segment height.

170 t, or for clinically relevant changes in the QTc interval.

171 ed a high degree of daily variability in the QTc interval.

172 rocardiogram for all patients to measure the QTc interval and a follow-up electrocardiogram within 30

173 4) and a 16.7% +/- 1.8% prolongation of the QTc interval (n = 3) in Kir2.1AAA-transduced animals 72

174 Risk factors for prolongation of the QTc interval are chronic hepatitis C-induced cirrhosis,

175 n (n = 44; 15%), or misinterpretation of the QTc interval as a result of inclusion of the U-wave (n =

176 T prolongation, and misinterpretation of the QTc interval) increases awareness and provides critical

177 p < 0.001) as significant predictors of the QTc interval; and heart rate (p < 0.001), genotype (p <

178 gs that cause torsade de pointes prolong the QTc interval and bind to the potassium rectifier channel

179 opic drugs have been reported to prolong the QTc interval and increase the risk of ventricular dysrhy

180 ic trioxide does not permanently prolong the QTc interval.

181 shows that arsenic trioxide can prolong the QTc interval.

182 Transmural ischemia prolonged the QTc interval (using the Bazett's formula) in 100% of pat

183 Concern regarding the QTc interval in human immunodeficiency virus (HIV)-infec

184 However, recent studies indicate that the QTc interval is nonlinear with respect to heart rate dur

185 art Study were inversely correlated with the QTc interval (P<0.001).

186 ear relationship between GRS(NOS1AP) and the QTc-interval (P=4.2x10(-7)).

187 pectedly large effects of NOS1AP SNPs on the QTc-interval and a trend for effects on risk of cardiac

188 an analysis for quantitative effects on the QTc-interval, 3 independent SNPs at NOS1AP (rs10494366,

189 .6x10(-7)) were strongly associated with the QTc-interval with marked effects (>12 ms/allele).

190 tensive care units (ICUs), may contribute to QTc interval prolongation.

191 0001) in QRS duration but was not related to QTc interval or Sokolow-Lyon index.

192 Similar to QTc intervals, women had JTc, and JTpc intervals longer

193 Height was not associated with QTc interval or the Sokolow-Lyon index.

194 up and upward, the risk of AF increased with QTc interval duration in a dose-response manner, reachin

195 val: 1.24 to 1.66, p < 0.001) for those with QTc intervals >/=99th percentile (>/=464 ms).