ライフサイエンスコーパス: RBE

1 RBE of ~1.48 in the SOBP and ~1 in the plateau were meas

2 RBE showed more effective inhibition of polyphenol oxida

3 RBE thus acts to maintain two different types of spatial

4 Both ch-19 RBE and trs elements have been shown to be essential for

5 Rep discriminate between these and the ch-19 RBE sequence?

6 Co-transfection of the pTZU6+27 RBE(apt) plasmid with HXBDeltaBgl, or pNL4-3, at a weigh

7 were observed on all substrates containing a RBE sequence, but never on DNA lacking an RBE.

8 Additionally, WT G, but not a RBE epitope mutant, could dissociate from F upon ephrinB

9 e AAV2 inverted terminal repeat or the AAVS1 RBE sequence elements neither enhances nor severely comp

10 e correlations have been extended to acquire RBE-weighted dose distributions and calculated, along wi

11 a RBE sequence, but never on DNA lacking an RBE.

12 showed that the interactions between PPI and RBE affected the secondary and tertiary structure of PPI

13 restingly, Rep interactions with the RBE and RBE' during nicking seem to be functionally distinct.

14 investigate the contribution of the RBE and RBE' during this process.

15 iral effect of an HIV-1 Rev-binding aptamer [RBE(apt)] could be enhanced by a ribozyme directed again

16 Although the 22-bp RBE contains the GAGC motifs that have been found in all

17 .1, EMBL accession number ) or the rat brain RBE-2 (NCX1.5, GenBank(TM) accession number ) Na(+)-Ca(2

18 The anti-HIV activity of the CMV RBE(apt) construct was non-specific, because co-transfec

19 y of linear substrates containing a complete RBE with hairpinned substrates and found that linear sub

20 We find that the concatenated RBEs can facilitate the cytoplasmic transport of viral m

21 Despite this, a constant RBE of 1.1 is still applied as a standard in proton ther

22 ancies between experimental data and current RBE models.

23 emonstrate that, early in petal development, RBE represses the transcription of a suite of CIN-TCP ge

24 RABBIT EARS (RBE) encodes a C2H2 zinc finger transcriptional represso

25 The RABBIT EARS (RBE) gene has been identified as a regulator of petal de

26 criptional repressor encoded by RABBIT EARS (RBE) regulates the expression of all three miR164 genes.

27 transcription factor, AT5G06070/RABBIT EARS (RBE), is responsible for the rbe-d phenotype.

28 al muscle known as the repeated-bout effect (RBE).

29 ethod to enhance the radiobiological effect (RBE) of ionizing radiation (IR) by increasing mitochondr

30 g similar relative biological effectiveness (RBE) between the two modalities.

31 Relative biological effectiveness (RBE) factors for surrogate cancer endpoints in cell cult

32 Relative biological effectiveness (RBE) is the ratio of the effects generated by high LET r

33 amage and relative biological effectiveness (RBE) of a clinically relevant antiproton beam.

34 , and the relative biological effectiveness (RBE) of carbon-ion beams over X-rays.

35 ty to the relative biological effectiveness (RBE) of proton beams.

36 that the relative biological effectiveness (RBE) of protons is variable, with dependence on factors

37 rmine the Relative Biological Effectiveness (RBE) of VHEE.

38 as a high Relative Biological Effectiveness (RBE) when delivered as a single treatment, but how it in

39 reported relative biological effectiveness (RBE).

40 in their Relative Biological Effectiveness (RBE).

41 -specific relative biological effectiveness (RBEs) between space radiation and gamma radiation.

42 n, 50 Gy (relative biological effectiveness [RBE]) versus 70 Gy (RBE), on visual outcomes was analyze

43 ly 40 Gy (relative biological effectiveness [RBE], 5) as a nephrotoxic dose, as no such histologic fi

44 metrics (relative biological effectiveness, RBE, and radiation effects ratio, RER, relative to y ray

45 Both a Rep DNA binding element (RBE) and a nicking site essential for AAV replication pr

46 An AAV Rep binding element (RBE) and terminal resolution site (trs) identical to the

47 e high affinity Rev protein binding element (RBE) has been determined at 2.1-A resolution.

48 pete with the wild-type Rev-binding element (RBE) in vitro, it was not known whether they would be ab

49 The p5 Rep binding element (RBE) is essential in RMSSI and Rep-dependent replication

50 es based on the minimal Rev Binding Element (RBE) of HIV-1.

51 Two Rev binding element (RBE) RNA oligonucleotides were used as model systems in

52 ide which contained the Rep binding element (RBE) within the A stem of the TR.

53 sequence elements, the Rep binding element (RBE), a small palindrome that comprises a single tip of

54 ence composed of an AAV Rep binding element (RBE), a spacer, and a nicking site.

55 ear 22-bp sequence, the Rep binding element (RBE), that is within both the terminal repeat (TR) and t

56 hesized concatemers of Rev-binding elements (RBEs) that fold to form multiple, discrete, high-affinit

57 e of several redundant Rep binding elements (RBEs) within the p5 promoter or within the terminal repe

58 al entry, and its receptor binding-enhanced (RBE) epitope was temperature-dependent, suggesting that

59 t that a new species, Roussin's Black Ester (RBE), may be formed, in which one or more of the sulfide

60 Dosimetry estimates (RBE, 5) per 37 kBq administered for tumors and kidneys w

61 onstrated that AAV4 Rep68 bound the expanded RBE with a sixfold-greater affinity than the human RBE.

62 with the guanine nucleotides of the expanded RBE, thus providing a biochemical basis for the increase

63 ays to determine the effect of this expanded RBE sequence on the Rep-RBE interaction and AAV targeted

64 but the effects of repeated blast exposure (RBE) on SOF brain health are incompletely understood.

65 etanin, the red pigment in red beet extract (RBE), is susceptible to degradation under acidic conditi

66 nd commercially defatted rice bran extracts (RBE and CDRBE) were evaluated for their ability to inhib

67 were used to extract two rice bran extracts (RBE) from rice bran.

68 dictated by differential Rep affinities for RBE sites.

69 ield was used as the biological endpoint for RBE calculation, with values found to be consistent with

70 phenomenological and mechanistic models for RBE have been shown to produce comparable results with s

71 uble mutants supports an additional role for RBE in organ separation.

72 diagnostic test to detect brain injury from RBE.

73 -thirds (70.4%) of patients receiving 50 Gy (RBE) and nearly half (45.1%) of patients receiving 70 Gy

74 A radiation dose reduction from 70 to 50 Gy (RBE) did not seem to increase the proportion of patients

75 re observed in prior studies at the 20.7-Gy (RBE, 5) renal dose level.

76 ly half (45.1%) of patients receiving 70 Gy (RBE) retained 20/200 or better vision 5 years after trea

77 iological effectiveness [RBE]) versus 70 Gy (RBE), on visual outcomes was analyzed.

78 On the other hand, RBE' contacts seem to be required primarily for TR unwin

79 This high RBE may lead to unexpected synergies for combinations of

80 base damage, which contributes to the higher RBE of high LET radiation-induced cell killing.

81 -1 cells, functions analogously to the human RBE and provide further evidence for a developing model

82 th a sixfold-greater affinity than the human RBE.

83 Recently, identical RBE sequences have been identified at other locations in

84 odel system which found that ferulic acid in RBE and p-coumaric acid in CDRBE were active in enzymati

85 tigated complex formation between betanin in RBE with pea protein isolate (PPI) to improve the stabil

86 Five phenolic compounds in RBE and CDRBE (protocatechuic acid, vanillic acid, p-cou

87 ally, two Rep mutants that were deficient in RBE binding and transactivation but positive for p5 repr

88 adiation revealed significant differences in RBE at any cell surviving fraction: e.g., at a surviving

89 es was found to increase with an increase in RBE concentration.

90 During the early phase of petal initiation, RBE regulates a microRNA164-dependent pathway that contr

91 as also shown to be predictive of carbon ion RBE (R (2) = 0.77).

92 ere chronic nephrotoxicity (41.4 Gy/592 kBq; RBE, 5).

93 nd others demonstrated that the cell-killing RBE is involved in the interference of high LET radiatio

94 The mechanistic model found a large RBE for misrepair, which phenomenological models are una

95 C cells, but not KRAS-mutant cells, show low RBE.

96 erature-dependent, suggesting that the Mab45 RBE epitope on G may be involved in triggering F.

97 The Mab45 RBE epitope was mapped to the base of the globular domai

98 targeted integration; specifically, how many RBE sequences are in the human genome?

99 ic analysis confirmed that overexpression of RBE represses secondary growth, while the rbe-2 mutant i

100 We also show that the role of RBE in sepal and petal development is mediated in part t

101 These results indicate that one role of RBE is to fine-tune miR164 expression to regulate the CU

102 In the development of second-whorl organs, RBE acts in the same pathway and downstream of UNUSUAL F

103 stributions and calculated, along with other RBE models, on a treatment plan.

104 for ch-19 is not distinct compared to other RBEs in the human genome when utilizing naked DNA.

105 In the absence of the TR, the p5 RBE and the p19 Sp1 site at position -50 are essential f

106 ss this possibility, we replaced both the p5 RBE and the p19 Sp1 site with GAL4 binding sites.

107 is suggested that the primary role of the p5 RBE and the p19 Sp1 sites was to act as a scaffold for b

108 d that in the presence of adenovirus, the p5 RBE represses p5 transcription while the RBE in the TR a

109 However, both the TR RBE and the p5 RBE transactivate the p19 and p40 promoters.

110 acetyltransferase constructs in which the p5 RBE was inserted at different locations upstream or down

111 replication; however, replacement of the p5 RBE with either the AAV2 inverted terminal repeat or the

112 Rep repression of p5 is specific for the p5 RBE, as other p5 promoter elements do not support this a

113 The fact that the p5 RBE-Rep complex can transactivate p19 and p40 while repr

114 roton beam, 1.9 x 10(6) neutron captures per RBE weighted Gray Equivalent dose (GyE) occurred within

115 p are present to interact with all potential RBE sites.

116 irmed that PPI proteins were involved in PPI-RBE interactions.

117 Furthermore, the size of PPI-RBE particles was found to increase with an increase in

118 to the RBE control, this indicates that PPI-RBE complexes could expand the applicability of betanin

119 As the PPI-RBE complex had improved antioxidant activity and long-t

120 (d) alone may not adequately indicate proton RBE.

121 stablished experimental findings that proton RBE increases with LET(d).

122 use of microdosimetric spectrum to quantify RBE requires a cell line-specific mechanistic model.

123 To understand how the Rep-RBE complex within p5 activated p19, we considered the p

124 ect of this expanded RBE sequence on the Rep-RBE interaction and AAV targeted integration.

125 to determine the characteristics of the Rep-RBE interaction.

126 ticulum-retained mutants, CsA did not rescue RBE-2/F913-->Stop, an endoplasmic reticulum-retained fun

127 or gene therapy reagents that target the Rev:RBE interaction.

128 ar factors do not directly influence the Rev:RBE interaction.

129 Evaluation of stilbene-containing RNA RBE sequences of varying length for their ability to bin

130 addition of the anti-env ribozyme to the RSV RBE(apt) did not enhance its antiviral activity.

131 The RSV RBE(apt) plasmid co-transfected with either HIV clone, a

132 However, the simian RBE is expanded, having five perfect directly repeated G

133 In vivo, integration targeted to the simian RBE was demonstrated by PCR analysis of latently infecte

134 these experiments establish that the simian RBE, identified in CV-1 cells, functions analogously to

135 n of footprints on both the human and simian RBEs revealed nearly identical protection; however, MI a

136 , no such changes were detected with soluble RBE epitope mutants or short-stalk G mutants.

137 tagenesis analysis suggested that the A-stem RBE contains only a single Rep binding site rather than

138 to efficient nicking at the trs: the A-stem RBE, the secondary structure element which consists of t

139 ive to sequence manipulations of the p5 TATA/RBE/YY1+1 core structure in a manner that reflects the f

140 Biochemical analyses confirmed that RBE binds directly to the promoter of WUSCHEL-related ho

141 Furthermore, we demonstrate that RBE directly interacts with the promoter of MIR164c and

142 Our results indicate that RBE inhibits cambium proliferation and thereby impacts s

143 utations on petal lamina growth suggest that RBE is also required to regulate later developmental eve

144 The RBE acted like a repressor element at most positions in

145 The RBE by itself or in combination with the YY1+1 initiator

146 The RBE gene is expressed in the procambium and cambium regi

147 The RBE of VHEE was quantified as the relative doses require

148 The RBE(apt) and anti-env ribozyme genes were inserted into

149 n: e.g., at a surviving fraction of 0.1, the RBE was 0.97 +/- 0.03 in group 1 and 1.16 +/- 0.04 in gr

150 of repression increased dramatically as the RBE was inserted closer to the p19 promoter.

151 the G-G base pair is required to assume the RBE conformation present in the NMR model of the complex

152 in the NMR model of the complex between the RBE and the Rev peptide.

153 model that proposes individual roles for the RBE and the spacer and nicking site elements.

154 e Rev responsive, it may be possible for the RBE to readily mutate in response to drugs or gene thera

155 Finally, since sequences distinct from the RBE are found to be Rev responsive, it may be possible f

156 termine if ECM remodeling is involved in the RBE, we conducted a second study by use of a repeated-bo

157 d that ephrinB2 binding to WT G, but not the RBE-epitope mutants, could trigger F.

158 Here we investigate the contribution of the RBE and RBE' during this process.

159 al, with nucleotides at the periphery of the RBE having the least effect on binding affinity and thos

160 terations in the polarity or position of the RBE relative to the trs greatly inhibit Rep nicking.

161 ents in which two adjacent base pairs of the RBE were substituted simultaneously with nucleotides tha

162 Thus, the effect of the RBE(apt) was strongly dependent on the promoter of the t

163 w and was independent of the presence of the RBE(apt).

164 tripartite cleavage signal comprised of the RBE, the RBE', and the trs.

165 Rev-responsive element (RRE) in place of the RBE.

166 te cleavage signal comprised of the RBE, the RBE', and the trs.

167 ey would be able to functionally replace the RBE in vivo.

168 We concluded that the RBE by itself was not a conventional upstream activation

169 -term refrigerated stability compared to the RBE control, this indicates that PPI-RBE complexes could

170 ur data indicate that Rep is tethered to the RBE in a specific orientation during trs nicking.

171 e p19 Rep proteins, which do not bind to the RBE, can eliminate repression of the p5 promoter by Rep7

172 ve activity that appear to contribute to the RBE.

173 p5 RBE represses p5 transcription while the RBE in the TR activates p5.

174 Interestingly, Rep interactions with the RBE and RBE' during nicking seem to be functionally dist

175 Rep contacts with the RBE appear necessary for both the DNA helicase and trs c

176 lowing specific nucleotide contacts with the RBE' and directing nicking to the trs.

177 rence patterns on the two strands within the RBE and the relative contributions of the individual bas

178 Substitutions within the RBE' also reduce Rep specific activity, but to a lesser

179 focus on the roles of these proteins and the RBEs in controlling transcription during a productive in

180 within this region that did not exhibit this RBE epitope were also non-fusogenic despite their abilit

181 analysis confirmed that WOX4 is epistatic to RBE in secondary growth.

182 However, both the TR RBE and the p5 RBE transactivate the p19 and p40 promote

183 le tip of an internal hairpin within the TR (RBE'), and the trs.

184 amers that were different from the wild-type RBE in terms of both primary sequence and secondary stru

185 level by 35%, while the expression of the U6 RBE(apt) did not affect p24 production.

186 In contrast to the NMR model of the unbound RBE, an asymmetric G-G pair with N2-N7 and N1-O6 hydroge

187 eatment image change analysis, of a variable RBE.

188 linical interest in incorporating a variable RBE.

189 ations offer an alternative path to variable RBE compared to the more standard phenomenological model

190 Using these values, VHEE RBE was measured as 0.93 (D(0.5)) and 0.99 (D(0.1)) for

191 The in vivo RBE for space radiation was estimated to be approximatel

192 ntial to detect brain injury associated with RBE in active-duty SOF.