ライフサイエンスコーパス: RCT

1 RCTs may also lack external validity and have limited ge

2 RCTs of >=24 wk were included and data were analyzed usi

3 RCTs were eligible if they aimed to compare immediate ad

4 RCTs without available data from ClinicalTrials.gov, pub

5 RCTs, including cross-over trials, assessing children of

6 One SR, 1 RCT, and 4 cohort studies were included.

7 We included 10 RCTs (n = 3,788) comprising 26 arms (active arm [n = 2,4

8 In total, 37 publications were included-10 RCTs, 4 non-RCT interventions, and 23 observational stud

9 We included 125 RCTs (12,541 patients).

10 and norepinephrine reuptake inhibitors (126 RCTs in 3 systematic reviews).

11 eports were identified, and 243 OPSs and 153 RCTs were eligible for analysis after exclusion based on

12 ated that iNPWT reduced wound dehiscence (16 RCTs, n = 3058, RR 0.78, 95% CI: 0.64-0.94).

13 isk ratio [RR], 0.61 [95% CI, 0.47-0.78]; 17 RCTs [n = 3094]; I2 = 39.0%).

14 cross the primary and secondary outcomes; 18 RCTs for a total of 933 participants were included in th

15 In total, 19 RCTs with 1100 participants were identified and included

16 al age and 21 (representing 19 cohorts and 2 RCTs) were included for birth weight.

17 Meta-analyses of 2 RCTs showed no effect on child cognitive [mean differenc

18 A total of 21 RCTs and 12 observational studies evaluating 51 085 pati

19 included in the qualitative analysis, and 23 RCTs were included as part of the network meta-analysis.

20 A total of 4,590 patients enrolled in 26 RCTs published between 2006 and 2019 were analyzed.

21 A total of 26 RCTs and 47 observational studies were identified.

22 We included 27 RCTs (n=1070), and the treatment components included hig

23 28 RCTs with available adverse events were analysed (18 pla

24 All 28 RCTs were rated as having unclear risk of bias.

25 vidence indicated that iNPWT reduced SSI [28 RCTs, n = 4398, relative risk (RR) 0.61, 95% confidence

26 tion reduced maternal thyroglobulin and in 3 RCTs, it prevented or diminished the increase in materna

27 l searches identified 1617 citations, and 31 RCTs were systematically reviewed for eligibility.

28 In final, we included eligible 35 RCTs (21047 patients).

29 ith missing data were documented in 26 (37%) RCTs.

30 1-year follow-up visit (IRIS Registry 81.4%, RCT 89.2%, P = .011).

31 ntified 10,596 unique articles, of which 403 RCTs met inclusion criteria.

32 A total of 42 RCTs were involved in the meta-analysis.

33 50 RCTs totalling 6681 patients were included.

34 evant PRO domains were specified in 36 (51%) RCTs.

35 We identified 597 RCTs, comprising 108 664 participants, that met the incl

36 oled ARD, 0.20% [95% CI, -1.13% to 1.53%]; 6 RCTs, n = 6307).

37 ow-up visits completed (IRIS Registry 85.6%, RCT 96.1%, P < .001) and in the probability of having a

38 total of 3678 records were assessed, and 71 RCTs, enrolling 24 701 patients, were included in our sy

39 e [ARD], -1.44% [95% CI, -3.31% to 0.43%]; 8 RCTs, n = 7571) or any delivery before 37 weeks (pooled

40 Risk of death at 2 years (n = 1,477, 8 RCTs) was similar between the 2 groups (RR: 0.84; 95% CI

41 ive treatment compared with placebo across 8 RCTs.

42 Out of the 84 RCTs with effect size information, 49 (58.3%) had a rela

43 After 3 years of follow-up (n = 1,775, 9 RCTs), all-cause mortality was significantly lower in th

44 d relative risk, 0.80 [95% CI, 0.73-0.87]; 9 RCTs [n = 12 551]; I2 = 0%).

45 From 241 results, 9 RCTs and 598 eyes were included.

46 uded 20 systematic reviews and 13 additional RCTs.

47 Two additional RCTs reported on DOACs for thromboprophylaxis in ambulat

48 periodontal treatment in the aforementioned RCT were selected for clinical and microbiological evalu

49 atabase search was conducted to identify all RCTs published in nursing journals from January 2016 to

50 A cross-sectional database search of all RCTs published in nursing journals was conducted.

51 Although RCTs may provide a useful starting point to think about

52 However, the compliance among RCTs published in nursing field is unknown.

53 case study, the feasibility of conducting an RCT of the oft-cited issue of sodium reduction on cardio

54 sessment of the feasibility of conducting an RCT with hard clinical outcomes when such trials are una

55 vidence-based policy to determine whether an RCT with hard outcomes is needed before policy recommend

56 tant conceptual differences between CRTs and RCTs relating to design, analysis, and inference.

57 bservational data, consensus guidelines, and RCTs.

58 e meta-analysis of observational studies and RCTs separately.

59 Two-arm RCTs were reviewed to see if sample size estimation was

60 , NCT04371419; American Economic Association RCT Registry, AEARCTR-0005789).

61 Agreement between RCT and RWE findings varies depending on which agreement

62 This study examined the association between RCT findings supporting or rejecting the trials' experim

63 t of active comparators, concordance between RCT and RWE findings is not guaranteed, partially becaus

64 advanced chronic kidney disease: the BiCARB RCT.

65 single-center, parallel-group, double-blind RCT and randomized into 4 arms (n = 23): HP-diet and bet

66 usses the most important challenges faced by RCTs in cardiac surgery and provides a list of suggestio

67 on optimal methods of PRO analysis in cancer RCTs, hindering interpretation of results.

68 estimate (SE), 95% confidence interval (CI): RCTs, 1.70, 1.33-2.16; observational studies, 1.32, 1.13

69 extensions for pragmatic trials and cluster RCTs when applicable, and should include detailed materi

70 accounting for the design effect of cluster RCTs.

71 he narrative review of which 19 were cluster RCTs and 20 were individual RCTs.

72 re, it may not always be feasible to conduct RCTs of public health interventions with hard outcomes d

73 Thirteen placebo-controlled RCTs and 1 meta-analysis assessed reductions in systolic

74 3 active-controlled and 7 placebo-controlled RCTs for replication.

75 tions to emulate those of each corresponding RCT.

76 was within the 95% CI from the corresponding RCT in 8 of 10 studies.

77 Current RCTs suggest that in mid-term follow-up prophylactic mes

78 in pooled analyses, additional well-designed RCTs are needed to define the efficacy of probiotics/syn

79 Well-designed RCTs, with child cognitive outcomes, are needed in pregn

80 In designing RCTs of EHR interventions, one should carefully consider

81 r the past 4 decades, results from well-done RCTs have repeatedly contradicted practices supported by

82 ions: The results of this first-ever eHealth RCT in IPF showed that a comprehensive home monitoring p

83 Eight RCTs of DAA therapy vs placebo or an outdated antiviral

84 Thirty-eight RCTs, including 1383 participants, were identified.

85 A total of 105 eligible RCTs were included.

86 studies screened, we identified 86 eligible RCTs; 52, with data from over 70 000 patients, were posi

87 icipant data (IPD) were sought from eligible RCTs.

88 ngs until July 8, 2020, to identify eligible RCTs.

89 -text articles, we identified three eligible RCTs (n = 5,161), and two contributed with IPD (n = 4,56

90 Despite attempts to emulate RCT design as closely as possible, differences between t

91 in high-impact medical journals and explore RCT characteristics associated with women as lead author

92 This is the first RCT comparing Kono-S anastomosis and standard anastomosi

93 This is the first RCT demonstrating that PFC with LVHR significantly impro

94 TAGS is the first RCT to compare medical versus surgical treatments for pa

95 Twenty-one studies (2'930 patients, five RCT, 16 observational studies) were retained for the ana

96 Five RCTs totaling 792 patients were included in our meta-ana

97 ding the waiting period by 4 weeks following RCT has no influence on the oncological outcomes of T3/T

98 Heterogeneity was moderate to none for RCT but moderate to high for quasi-experiments.

99 For RCTs with effect size, sample sizes were recomputed and

100 For RCTs, we computed medication effects on any drinking and

101 NAHL), and PsycINFO on February 21, 2020 for RCTs comparing IOL at 41 weeks with expectant management

102 fferences in effect estimates were found for RCTs where second-generation sulfonylureas were used as

103 Data and safety monitoring for RCTs of EHR interventions should be conducted to guide i

104 ched CENTRAL, Medline and Web of Science for RCTs comparing minimally invasive to OPD for adults with

105 MBASE and Cochrane Library were searched for RCTs and health economic evaluations.

106 base, and Cochrane Library were searched for RCTs.

107 Cochrane Collaboration risk of bias tool for RCTs and select items from the Newcastle-Ottawa Scale fo

108 udies and the Cochrane Risk of Bias Tool for RCTs.

109 Ninety-four RCTs were included (N = 52 174).

110 Ninety-four RCTs, for a total of 6,158 participants, were included i

111 Two hundred twenty-four RCTs and 3 observational studies including more than 240

112 base were searched, and a meta-analysis from RCT was performed comparing DCB with non-DCB devices (su

113 ysis (MA) was performed to include data from RCTs for which IPD was not available.

114 causal MR analyses, together with data from RCTs, do not support a beneficial role of vitamin D supp

115 Consequently, average results from RCTs can disproportionately affect the treatment choices

116 Future RCTs that focus on the potential clinical benefits of HI

117 searched MEDLINE, EMBASE, and CINAHL for HF RCTs published in journals with an impact factor >=10 be

118 Women are under-represented as authors of HF RCTs, with no change in temporal trends.

119 sidered inherently biased vs. a hypothetical RCT.

120 A Phase III RCT is underway to further investigate safety and effica

121 veloping CVDs after influenza vaccination in RCT studies was 0.55 (95% CI 0.41-0.73), which was signi

122 re effective and appeared as effective as in RCTs.

123 Women had lower odds of lead authorship in RCTs that were multicenter (odds ratio [OR]: 0.58; 95% C

124 Women had lower odds of lead authorship in RCTs that were multicenter, were coordinated in North Am

125 combination with reperfusion therapy, but in RCTs that only included feasibility or safety outcomes.

126 Quality of PRO reporting was higher in RCTs citing the Consolidated Standards of Reporting Tria

127 usual-care regimens for asthma management in RCTs.

128 in the laboratory, and drinking outcomes in RCTs, such that medications that reduced stimulation, se

129 e determination are inadequately reported in RCTs published in nursing journals.

130 ypes, whereas an increased risk of stroke in RCTs (SE: 1.14, 95% CI: 1.04-1.25) and a decreased risk

131 PARP inhibition versus placebo treatment in RCTs.

132 The risk of bias of included RCTs was assessed using the Cochrane Collaboration's ris

133 The mean age of participants in the included RCTs was 42.6 +/- 9.3 years, and 42% were male.

134 her exploration with more research including RCT and/or MR analyses with more valid instruments.

135 19 were cluster RCTs and 20 were individual RCTs.

136 ption until Nov 22, 2019 for non-inferiority RCTs comparing different systemic antibiotic therapies.

137 orting quality of antibiotic non-inferiority RCTs.

138 Parallel-group, open-label RCT conducted at the National Hospital in Guinea-Bissau.

139 This was a parallel-group, open-label RCT conducted at the National Hospital in Guinea-Bissau.

140 eceived ivermectin as part of the open-label RCT.

141 erformed a meta-analysis of English language RCTs comparing the use of prophylactic NPWT to standard

142 In contrast, m-RCT remained unchanged in HAPOB100 Tg (human APOB100 tra

143 cate that, besides the major HDL-dependent m-RCT pathway via SR-BI (scavenger receptor class B type 1

144 B type 1) to the liver, a CETP-independent m-RCT path exists, in which LDL mediates the transfer of c

145 aining lipoproteins is unable to stimulate m-RCT.

146 We investigated LDL contributions to the m-RCT pathway in hypercholesterolemic mice.

147 and its potential impact in supporting the m-RCT pathway in vivo both remain unknown.

148 The m-RCT rates of the LDLr (LDL receptor)-KO (knockout), LDLr

149 In vivo, m-RCT was evaluated in mouse models of hypercholesterolemi

150 ften and in what contexts RWE findings match RCTs.

151 Most RCTs (n=65 [92%]) had PRO measures as a secondary or exp

152 Most RCTs found that supplementation reduced maternal thyrogl

153 Most RCTs used as basis for the current USPSTF guidelines eit

154 with IPF.Methods: We performed a multicenter RCT in newly treated patients with IPF.

155 In this blinded, multicenter RCT, patients scheduled for elective LVHR (hernia defect

156 thma assessment and treatment in multicenter RCTs and was associated with attaining and maintaining g

157 ven (23%) of 31 observational studies and no RCTs were at low risk of bias according to Cochrane's Ri

158 37 publications were included-10 RCTs, 4 non-RCT interventions, and 23 observational studies.

159 of randomized controlled trials (RCTs), non-RCT interventions, and observational studies was conduct

160 randomised controlled trials (RCTs) and non-RCTs of psychological and pharmacological treatments for

161 Nine non-RCTs were included.

162 The mean age of participants in the non-RCTs was 40.6 +/- 9.4 years, and 47% were male.

163 mic models for these sequential processes of RCT enrollment, information generation, and the resultin

164 ontrolled trials (RCTs) and meta-analyses of RCTs published between June 1, 2016, and January 24, 202

165 ontrolled trials (RCTs) and meta-analyses of RCTs published from August 1, 2014, through December 4,

166 ifty systematic reviews and meta-analyses of RCTs were eligible for review.

167 In this meta-analysis of RCTs comparing TAVR versus SAVR in low-risk patients, TA

168 nsive systematic review and meta-analysis of RCTs to assess the effect of swallowing exercises in HNC

169 Quality assessment of RCTs and observational studies was conducted using the J

170 Given the dearth of RCTs, the vascular benefits of MICT are discussed with a

171 rcome limitations in the generalizability of RCTs are required to provide screening guidelines that a

172 , may guide future analyses and reporting of RCTs.

173 amples of differences between the results of RCTs and CRTs on the same topic are given.

174 uestion, we conducted a systematic review of RCTs that evaluated the addition of a CPI to chemotherap

175 lled trials (RCTs) and systematic reviews of RCTs published from 1966 through October 17, 2019.

176 Despite the prominent role of RCTs in health care, it may not always be feasible to co

177 g" approach, wherein a model is developed on RCT data by incorporating a term for treatment assignmen

178 hich only five observational studies and one RCT were included for quantitative analysis; these studi

179 to -1%, I2 : 69%, p=0.03) when pooling only RCT (792 patients).

180 lity observational studies (642 patients) or RCT (527 patients), significance was lost.

181 A double-blind, parallel RCT (n = 115; age 63 +/- 7 y; 68% male; body mass index

182 Based on the 18 placebo RCTs (n=7307 patients), PARP inhibitors significantly in

183 ere analysed (18 placebo and ten non-placebo RCTs), with 5693 patients in PARP inhibitor groups and 3

184 Future high-quality RCTs need to be carried out.PROSPERO registration: CRD42

185 of the mid or lower rectum who had received RCT (45-50 Gy with 5-fluorouracil or capecitabine) were

186 ark lowers all-cause mortality, but a recent RCT found no effect of BCG-Russia.

187 nces were often not established or reported, RCTs were not powered to assess important harms, few dat

188 g is frequently undertaken despite no robust RCT evidence of efficacy.

189 Seven RCTs including 1845 subjects >12 years treated with dupi

190 Sixteen RCTs reported the outcomes of PSP modification therapy w

191 rolled trials (RCTs) in medical specialties, RCTs in cardiac surgery face specific issues.

192 adhere to the recommendations of a specific RCT within their field of expertise, even when included

193 last 20 years, the number of cardiac surgery RCTs has declined significantly.

194 the successful completion of cardiac surgery RCTs particularly challenging.

195 ful design and completion of cardiac surgery RCTs.

196 Ten RCTs including 1620 subjects aged 12 to 75 years old tre

197 sense and clinical observation, rather than RCTs, should be the preferred method to generate evidenc

198 The RCT DUPLICATE initiative (Randomized, Controlled Trials

199 closely as possible, differences between the RCT and corresponding RWE study populations remained.

200 with very low certainty of evidence for the RCT) or congenital anomalies (OR 1.69 [95% CI 0.83-3.41]

201 with very low certainty of evidence for the RCT).

202 Twenty-seven were included in the RCT and 27 in the OLT.

203 Of the patients enrolled in the RCT, 43% entered this study (n = 10/control and 15/test

204 tched that of the target population when the RCT was conducted.

205 n though the distribution of risk within the RCT matched that of the target population when the RCT w

206 The RCTs that treated patients with a topical NSAID and asse

207 Kaplan-Meier estimates in the RCTs were compared with restricted mean survival time.

208 The study populations in the RCTs were older and had more underlying diseases than th

209 Around 36% of the RCTs published in nursing journals did not report how th

210 te the quality of PRO reporting across these RCTs.

211 Three RCTs addressed child neurodevelopment; only 1 was adequa

212 Three RCTs with a total of 224 patients were included.

213 Two hundred and twenty-three RCTs were included in this study, and 143 (64.1%) studie

214 of risk across those categories at the time RCT results are reported or the different rate of change

215 Concerns about traditional RCT models are legitimate, but randomization remains a c

216 with preventive than conventional treatment [RCT: 364 days (95% confidence interval [CI] = 223-535) v

217 One randomized clinical trial (RCT) (n = 4005) examined the direct effect of screening

218 (N = 9986), one randomized controlled trial (RCT) (N = 367), and 29 retrospective cohort studies (N =

219 Randomized controlled trial (RCT) at a tertiary referral institution.

220 d-wedge cluster-randomised controlled trial (RCT) comparing CQI to usual standard of antenatal care (

221 o ensure that a randomized controlled trial (RCT) has enough power to detect any statistical differen

222 s of an ongoing randomized controlled trial (RCT) of LPG stove and fuel distribution in 3,200 househo

223 ta, there is no randomized controlled trial (RCT) on the effects of high protein (HP)-diet and/or bet

224 A randomized controlled trial (RCT) was undertaken to determine the effect of negative

225 parallel-group, randomised controlled trial (RCT) with 3-month follow-up, conducted in 23 primary car

226 an open-label, randomized controlled trial (RCT), consecutive patients with ACLF diagnosed with HRS

227 ial (UPBEAT), a randomised controlled trial (RCT), of a lifestyle intervention (low glycaemic index (

228 evaluated in a randomized controlled trial (RCT), PFC compared to bridged repair would improve patie

229 , fully powered randomised controlled trial (RCT), retention could be improved by conducting assessme

230 1:1 ratio in a randomized controlled trial (RCT).

231 7 cohorts and 1 randomized controlled trial (RCT)] were included for gestational age and 21 (represen

232 of a previously-published randomized trial (RCT) evaluating the 2-years effects of metronidazole (MT

233 d 17 studies (6 randomized controlled trial [RCT], 5 cohorts, and 6 case-control) with a total of 180

234 sults of many HF randomized clinical trials (RCT), and variable treatment responses even for proven t

235 tional studies or randomized control trials (RCT) aimed to assess mortality rate, duration of hospita

236 Randomized clinical trials (RCTs) and comparative observational studies that enrolle

237 f-selection into randomized clinical trials (RCTs) by patients with distributions of baseline risk di

238 dentify eligible randomized clinical trials (RCTs) reporting on the changes in GT and KT (primary out

239 y of traditional randomized clinical trials (RCTs), together with the widespread availability of real

240 inistration) and randomized clinical trials (RCTs).

241 age reports of randomised controlled trials (RCTs) and before-and-after studies investigating social

242 ies emulating randomized, controlled trials (RCTs) and compare results.

243 iew to include randomized controlled trials (RCTs) and meta-analyses of RCTs published between June 1

244 e searched for randomized controlled trials (RCTs) and meta-analyses of RCTs published from August 1,

245 tion Index for randomised controlled trials (RCTs) and non-RCTs of psychological and pharmacological

246 15, 2018, for randomised controlled trials (RCTs) and observational studies that reported adverse ev

247 ta-analysis of randomized controlled trials (RCTs) and observational studies was conducted to assess

248 for reviews of randomized controlled trials (RCTs) and quasi-experiments.

249 e searched for randomized controlled trials (RCTs) and systematic reviews of RCTs published from 1966

250 on-inferiority randomized controlled trials (RCTs) are used for approval of new antibiotics and makin

251 r hypothetical randomized controlled trials (RCTs) as gold standards.

252 cally reviewed randomised controlled trials (RCTs) comparing PARP inhibitor therapy versus control tr

253 atic review of randomised controlled trials (RCTs) comparing these radiotherapy approaches.

254 the results of randomized controlled trials (RCTs) conducted among patients undergoing laparotomy hav

255 port efficient randomized controlled trials (RCTs) designed to evaluate the effectiveness, safety, an

256 ta-analysis of randomised controlled trials (RCTs) evaluating venous thromboembolism prevention.

257 Several randomised controlled trials (RCTs) have assessed if induction of labour (IOL) in unco

258 Randomized controlled trials (RCTs) have demonstrated that BCG-Denmark lowers all-caus

259 Compared with randomized controlled trials (RCTs) in medical specialties, RCTs in cardiac surgery fa

260 ed to identify randomised controlled trials (RCTs) in Pubmed, Embase, Cochrane, and major conferences

261 However, randomised controlled trials (RCTs) investigating the impact of HIIT on the brain are

262 We included randomized controlled trials (RCTs) investigating the isocaloric effect of substitutin

263 lly identified randomized controlled trials (RCTs) investigating the safety and efficacy of systemic

264 r inclusion in randomised controlled trials (RCTs) involving patients with haematological malignancie

265 We included randomized controlled trials (RCTs) of health system interventions targeting adults wi

266 questions that randomized controlled trials (RCTs) of individual patients cannot answer.

267 e outcomes and randomised controlled trials (RCTs) of physical activity interventions in adults older

268 s at home, but randomized controlled trials (RCTs) on the effects of eHealth are scarce.Objectives: T

269 t failure (HF) randomized controlled trials (RCTs) published in high-impact medical journals and expl

270 including only randomized-controlled trials (RCTs) reporting on PSP outcomes was conducted to assess

271 Review of randomized controlled trials (RCTs) supported our findings showing no impact of vitami

272 e reviewed for randomized controlled trials (RCTs) that compared prophylactic mesh reinforcement vers

273 ta-analysis of randomized controlled trials (RCTs) to determine the effect of selenium supplementatio

274 ated in cancer randomised controlled trials (RCTs) to provide information about treatment risks, bene

275 ta-analysis of randomized controlled trials (RCTs) was undertaken.

276 ta-analyses of randomized controlled trials (RCTs) were eligible if they measured the effect of dieta

277 ies (OPSs) and randomised controlled trials (RCTs) were included.

278 ients from ten randomized controlled trials (RCTs) were ultimately included.

279 Randomized controlled trials (RCTs) with concealed allocation to the intervention were

280 to the lack of randomized controlled trials (RCTs) with hard clinical outcomes (eg, incident disease,

281 meta-analyses, randomized controlled trials (RCTs), and comparative observational studies published f

282 blications for randomized controlled trials (RCTs), focusing on the racial composition of their study

283 In randomized controlled trials (RCTs), HTE is typically examined through a subgroup anal

284 atic review of randomized controlled trials (RCTs), non-RCT interventions, and observational studies

285 al efficacy in randomised controlled trials (RCTs), where all patients had to receive reperfusion the

286 double-blind, randomised controlled trials (RCTs).

287 balloons from randomized controlled trials (RCTs).

288 DH), tested in randomized controlled trials (RCTs).

289 ol study and 8 randomized controlled trials (RCTs).

290 therapies (246 randomized controlled trials [RCTs] in 5 systematic reviews) and with selective seroto

291 een the TVT IRIS Registry cohort and the TVT RCT cohort in the percentage of follow-up visits complet

292 S Registry cohort and this cohort to the TVT RCT cohort.

293 line, whereas there had been none in the TVT RCT cohort.

294 istry cohort was inferior to that of the TVT RCT.

295 Of 1969 screened articles, twelve RCTs were included.

296 Two RCTs of direct oral anticoagulants (DOACs) for the treat

297 Furthermore, only two RCTs were eligible for the IPD-MA; thus, the possibility

298 favorable for 4 of 5 outcomes measured under RCT (eg, reduced opioid use; odds ratio [OR] = 0.70, con

299 Eligible articles were RCTs of cancer-directed therapy in adult patients with h

300 d is applied to disaggregate patients within RCTs to define risk-based variation in benefit, and an "