ライフサイエンスコーパス: RDE

1 RDE (II)-treated IgE cannot access its binding site on b

2 RDE experiments often make use of or require collection

3 RDE far exceeds the performance of six recent DNA-Transf

4 RDE is 99% accurate when aligning 250-length reads onto

5 RDE studies indicate that inhibition by cocaine, specifi

6 RDE-1 competes with other Argonautes for binding to 23H-

7 RDE-12 colocalizes with WAGO-1 in germline P granules an

8 RDE-3 (also known as MUT-2) is a ribonucleotidyltransfer

9 RDE-3 contains conserved domains found in the polymerase

10 RDE-4 is also required for loading 26G-RNAs into the Arg

11 RDE-4 preferentially binds long dsRNA, while TRBP binds

12 RDE-4 protein also interacts in vivo with DCR-1, RDE-1,

13 RDE-8 can cleave RNA in vitro and is needed for the prod

14 Each child underwent 1 RDE and 1 SADE dental cleaning, administered in randomiz

15 with peak current density of 16,000 A g(-1) (RDE) and 450 mW cm(-2) operated in air (MEA).

16 4 protein also interacts in vivo with DCR-1, RDE-1, and a conserved DExH-box helicase.

17 Genetic analysis indicates that the RDE-10/RDE-11 complex acts in parallel to nuclear RNAi.

18 The RDE-10/RDE-11 complex and the RNA-dependent RNA polymerase RRF-

19 Therefore, the RDE-10/RDE-11 complex is critical for amplifying the exogenous

20 The RDE-10/RDE-11 complex is essential for the amplification of RNA

21 cal approaches, we report a divergent RDE-10/RDE-11 complex that is required for RNAi in C. elegans.

22 ns suggest that ABC(RNAi) proteins and MUT-7/RDE-2 function together in parallel pathways and/or as m

23 E protein possesses sialate-O-acetylesterase RDE activity.

24 s the corresponding sialate-O-acetylesterase RDE activity.

25 tion of the PtNi nanoparticle catalyst after RDE testing revealed the development of hollows in a num

26 t recruited to target mRNA by upstream AGOs (RDE-1 and ERGO-1), where it promotes small RNA amplifica

27 However, the conductance (G) measured by an RDE depends on the depth (D) of the liquid below the pro

28 erited silencing is independent of SID-1 and RDE-1, but requires HRDE-1 and MUT-7.

29 findings suggest a model in which RDE-4 and RDE-1 function together to detect and retain foreign dsR

30 the ability of RDE-4 deletion constructs and RDE-4/TRBP chimeras to reconstitute Dicer activity sugge

31 stigations using a combination of cyclic and RDE linear sweep voltammetry suggest two plausible route

32 llective actions of both RDE-4-dependent and RDE-4-independent mechanisms to produce RNAi-inducing vi

33 ouble-stranded RNA is processed by Dicer and RDE-1/Argonaute into primary siRNA that guides target mR

34 he RNA interference (RNAi) pathway Argonaute RDE-1, thereby promoting secondary siRNA amplification a

35 germline requires SID-1, a primary Argonaute RDE-1, a secondary Argonaute HRDE-1, and an RNase D homo

36 hat bind with high affinity to the Argonaute RDE-1, but also to the microRNA (miRNA) pathway Argonaut

37 enzymatic activity of the primary Argonaute, RDE-1, is not required for silencing activity.

38 the dsRNA importer, SID-1 and the argonaute, RDE-1.

39 enous GlyR agonists (glycine, taurine) block RDE by preventing the closure of postsynaptic GlyRs.

40 lso demonstrated excellent stability in both RDE and membrane electrode assembly (MEA) testing.

41 ns depends on the collective actions of both RDE-4-dependent and RDE-4-independent mechanisms to prod

42 By RDE we mean modifying the emission of fluorophores or ch

43 complex with a dsRNA binding protein called RDE-4, and an RLR ortholog called DRH-1.

44 lating the product during chronoamperometric RDE experiments followed by mass spectroscopic analysis.

45 We found that a component of Dicer complex RDE-4 and a chromatin-related zinc finger protein ZFP-1,

46 During normal growth and development, RDE-3 pUGylates transposon RNAs to silence transposons a

47 iochemical approaches, we report a divergent RDE-10/RDE-11 complex that is required for RNAi in C. el

48 During RDE, GlyRs are less responsive to local glycine applicat

49 s (unilateral cover testing, Random Dot "E" [RDE] and Stereo Smile Test II [Stereo Optical, Inc., Chi

50 this phenomenon as rate-dependent efficacy (RDE).

51 erials show in both rotating disc electrode (RDE) and membrane electrode assembly (MEA) tests the wor

52 were studied using rotating disc electrode (RDE) measurements, Tafel slope and Koutecky-Levich plots

53 y was detected with rotating disk electrode (RDE) amperometry and an interdigitated array (IDA) elect

54 onoamperometric and rotating disk electrode (RDE) data.

55 Rotating disk electrode (RDE) experiments were carried out to study the catalytic

56 ned using classical rotating disk electrode (RDE) experiments.

57 onoamperometry, and rotating disk electrode (RDE) experiments.

58 was coupled to a Au rotating disk electrode (RDE) for monitoring at near-normal incidence the reflect

59 dip-type small diameter ring-disk electrode (RDE) is ideal for very small volumes.

60 GOae) modified on a rotating disk electrode (RDE) is presented.

61 vity using standard rotating disk electrode (RDE) measurements.

62 ere measured with a rotating disk electrode (RDE) technique.

63 n reaction (ORR) in rotating disk electrode (RDE) testing, which substantially outperformed commercia

64 further examined in rotating disk electrode (RDE) tests that minimized mass transfer limitations.

65 atinum catalysts in rotating disk electrode (RDE) tests.

66 -Levich model for a rotating disk electrode (RDE) to a general heterogeneous electrochemical kinetic

67 the ss-HSDNA/rGOae rotating disk electrode (RDE) toward AFB1 detection using FcCH2OH as the redox me

68 at the surface of a rotating disk electrode (RDE) used to measure chemical fluxes.

69 In vitro rotating disk electrode (RDE) voltammetry and in vivo microdialysis were used to

70 Rotating disk electrode (RDE) voltammetry at glassy carbon electrodes in 300- to

71 Rotating disk electrode (RDE) voltammetry is applied to the measurement of the tr

72 ss transport to the rotating disk electrode (RDE), the most widely employed hydrodynamic electrode in

73 electrodes (ME) or rotating disk electrodes (RDE) provide a means to analyze concentrations of redox

74 Caenorhabditis elegans RDE-4 facilitates cleavage of long dsRNA to small interf

75 that, in its natural context in C. elegans, RDE-3 adds pUG tails to targets of RNA interference, as

76 where a novel Reference-Free DNA Embedding (RDE) Transformer model generates vector embeddings of re

77 in the South Korean real driving emissions (RDE) certification route, consisting of urban, rural, an

78 leading to loss of repression of endogenous RDE-1 targets.

79 3 and the NYN domain-containing endonuclease RDE-8, thus bridging the enzymes that cleave and pUGylat

80 E-1 can instead recruit an endoribonuclease, RDE-8, to target RNA.

81 n fluorescence, radiative decay engineering (RDE).

82 t the commercial receptor-destroying enzyme (RDE) (II) from Vibrio cholerae culture fluid specificall

83 , and acted as a receptor-destroying enzyme (RDE) capable of eliminating the binding of HKU1-S1 to RD

84 se and acts as a receptor-destroying enzyme (RDE) for hCoV-HKU1.

85 Downstream of these events, RDE-12 forms an RNase-resistant (target mRNA-independent

86 tment at the recommended dose for expansion (RDE) established in the dose-escalation part.

87 ation of the recommended dose for expansion (RDE).

88 retinal detachment (retinal detachment eyes, RDE) and 5 healthy fellow eyes (HFE) of 5 patients (mean

89 retinal detachment (retinal detachment eyes, RDE) and five healthy fellow-eyes (HFE) of five patients

90 otein complex containing the new RNAi factor RDE-11, the known RNAi factors RSD-2 and ERGO-1, and oth

91 which are also regulated by the RNAi factor RDE-3.

92 Our findings reveal a role for RDE-4 as a critical determinant of small RNA loading spe

93 We found RDE-4 is important for ATP-independent and ATP-dependent

94 Furthermore, RDE-11 is required for mRNA degradation subsequent to ta

95 on black supported catalyst mixtures on a GC RDE and the electrocatalytic activity determined using t

96 In comparison to HFE, RDE showed highly irregular cone patterns in AO-OCT and

97 In comparison to HFE, RDE showed highly irregular cone patterns in AO-OCT and

98 We also describe how RDE can be applied to medical testing and biotechnology.

99 to establish the maximum tolerated dose (ie, RDE) of ceritinib in the fasted and fed states.

100 d 18dB in HFE and was significantly lower in RDE with 14.30dB at BL and 14.64dB at FUP.

101 18 dB in HFE and was significantly lower in RDE, with 14.30 dB at BL and 14.64 dB at FUP.

102 es, we present here a sophisticated inverted RDE (iRDE) cell design.

103 LSV-RDE points toward different CO2RR mechanisms at the samp

104 tammetry with a rotating disk electrode (LSV-RDE), sample-generation tip-collection mode of scanning

105 with an edgeless feature, and a custom-made RDE/RRDE working station was designed to provide unique

106 ata obtained using more typical, nongastight RDE cells.

107 Ai in C. elegans, the nucleotidyltransferase RDE-3 modifies the 3' termini of mRNAs with polyUG (pUG)

108 naptic GlyRs under all conditions, occluding RDE.

109 Additionally, analyses of the ability of RDE-4 deletion constructs and RDE-4/TRBP chimeras to rec

110 because DEPS-1 promotes the accumulation of RDE-4, a dsRNA-binding protein required for RNAi.

111 ed rde-10, and through proteomic analysis of RDE-10-interacting proteins, we identified a protein com

112 Cone density of RDE was significantly reduced and ranged between 200/mm(

113 Cone density of RDE was significantly reduced and ranged between 200/mm(

114 rts and gaseous analytes makes the design of RDE cells that allow for headspace analysis challenging

115 ynthesis by orchestrating the recruitment of RDE-10 and RRF-1 to primary siRNA-targeted mRNA in disti

116 and suggest possible models for the role of RDE-3 in the RNAi mechanism.

117 ther, these findings document the utility of RDE for the nonisotopic measurement of neurotransmitter

118 the complex with target mRNA is dependent on RDE-1 but not RRF-1, suggesting that target mRNA recogni

119 ), a method that is not compatible with open RDE cells.

120 virus, which redirects the Argonaute protein RDE-1 from its endogenous small RNA cofactors, leading t

121 s, ERAS is mediated by the Argonaute protein RDE-1/AGO2, is conserved in mammals and promotes ER-asso

122 he RdRP RRF-3, and the dsRNA-binding protein RDE-4 are required for the biogenesis of 26-nt small RNA

123 tis elegans, where the dsRNA-binding protein RDE-4 initiates silencing by recruiting an endonuclease

124 hich partners with the dsRNA binding protein RDE-4 to process dsRNA into viral siRNAs (viRNAs).

125 NAs is mediated by the dsRNA-binding protein RDE-4.(5)(,)(6)(,)(7) Here, we show that RDE-4 also faci

126 1 and the secondary siRNA biogenesis protein RDE-2.

127 ork, the Maelstrom domain-containing protein RDE-10, the intrinsically disordered protein MUT-16, and

128 an interactor of the RNAi-defective protein RDE-10, and ntl-9/CNOT9, one of several CCR4/NOT complex

129 and a conserved Vasa ATPase-related protein RDE-12.

130 s to the Caenorhabditis elegans RNAi protein RDE-4.

131 were randomized, with 83 children receiving RDE first and 80 children receiving SADE first.

132 ers potent antiviral silencing that requires RDE-1, an Argonaute protein essential for RNAi mediated

133 Overall, a 3.7 +/- 1.4 nm diameter PdNPs/rGO RDE exhibits high performance with a rather low limit of

134 ly ignored, and the 3.7 +/- 1.4 nm PdNPs/rGO RDE may be useful toward trace hydrazine detection, espe

135 These in situ SERRS-RDE data using labeled O(2) show that indeed a Fe(III)-O

136 In situ SERRS-RDE in the presence of 2-phenylpropionaldehyde indicates

137 esonance Raman spectroscopy technique, SERRS-RDE, is used to probe the species accumulated during ele

138 meras to reconstitute Dicer activity suggest RDE-4 promotes activity using its dsRNA-binding motif 2

139 to RNAs in heterologous expression systems, RDE-3 can add long stretches of alternating non-template

140 Taken together, we concluded that RDE (II) modulates the IgE structure and renders it unab

141 s are mechanistically based on the fact that RDE-4 binds cooperatively, via contributions from multip

142 We also find that RDE-8 promotes RdRP activity, thereby ensuring amplifica

143 ly reduced in rde-4 mutants, indicating that RDE-4 is broadly required for their formation or stabili

144 We also noted that RDE (II)-treated IgE could not induce passive cutaneous

145 We observed that RDE (II) treatment significantly reduced the binding of

146 We report that RDE-12, a conserved phenylalanine-glycine (FG) domain-co

147 We show that RDE-1 can instead recruit an endoribonuclease, RDE-8, to

148 We show that RDE-1 interacts with trigger-derived sense and antisense

149 ein RDE-4.(5)(,)(6)(,)(7) Here, we show that RDE-4 also facilitates the preferential loading of siRNA

150 These results suggest that RDE (II) specifically modulates branched glycans on IgE,

151 indings and our genetic studies suggest that RDE-12 is first recruited to target mRNA by upstream AGO

152 Our results suggest that RDE-12 promotes secondary siRNA synthesis by orchestrati

153 This result suggests that RDE contributes to long-term synaptic plasticity in the

154 The RDE kinetically resolves transmembrane transport with a

155 The RDE method also allows observation of outward transport

156 The RDE of ceritinib was established as 510 mg/m(2) (fasted)

157 The RDE tests showed that the limiting current of the AC wit

158 The RDE was established on the basis of the incidence of dos

159 The RDE was found to be able to measure dopamine and its met

160 The RDE-10/RDE-11 complex and the RNA-dependent RNA polymera

161 The RDE-10/RDE-11 complex is essential for the amplification

162 ur types) were treated with ceritinib at the RDE (13 patients at 510 mg/m(2) fasted and 42 patients a

163 Within a solution stirred by the RDE, both diffusion and hydrodynamic boundary layers are

164 By extending the RDE induction protocol to include 500 paired presynaptic

165 Calibration of the RDE using a tachometer shows that the rotation speed of

166 Genetic analysis indicates that the RDE-10/RDE-11 complex acts in parallel to nuclear RNAi.

167 Therefore, the RDE-10/RDE-11 complex is critical for amplifying the exo

168 ide a spreadsheet-based calculator where the RDE dimensions are the input parameters and the procedur

169 f GlyRs, either pharmacologically or through RDE, also lead to increased LTD.

170 itivity of membrane-inserted GlyRs underlies RDE.

171 ng infection of C. elegans with Orsay virus, RDE-3 adds pUG tails to viral RNAs, which converts these

172 measures were significantly lower in SADE vs RDE (Cohen d = -0.84 to -1.19).

173 When RDE-1 is depleted, these siRNAs are enriched in ALG-1 an

174 To reveal the mechanism by which RDE (II) interferes with IgE activity, we performed lect

175 Our findings suggest a model in which RDE-4 and RDE-1 function together to detect and retain f

176 ether, our findings suggest a model in which RDE-8 cleaves target mRNAs to mediate silencing, while g

177 f other mRNAs, perhaps by collaborating with RDE-3 to generate endogenous short interfering RNAs (end

178 ess during dental care in SADE compared with RDE (mean difference in skin conductance level, -1.22 [9

179 r viral pUGylation because it interacts with RDE-3 and the NYN domain-containing endonuclease RDE-8,

180 MS2 or 3.2 x 10(10) viral particles/mL with RDE amperometry.