ライフサイエンスコーパス: REM sleep

1 an open upper airway become hypotonic during REM sleep.

2 ay closure when asleep, in particular during REM sleep.

3 psychological disorders marked by fragmented REM sleep.

4 in REM sleep relative to quiet waking or non-REM sleep.

5 with larger responses during SWS than during REM sleep.

6 mechanism for upper airway hypotonia during REM sleep.

7 positively correlated across wakefulness and REM sleep.

8 active exclusively in the DOWN state of non-REM sleep.

9 um in cognitive functions and that of MCH in REM sleep.

10 ated in KO compared with OE mice in NREM and REM sleep.

11 context for memory consolidation during non-REM sleep.

12 ong-range correlations break down during non-REM sleep.

13 d maintain breathing automaticity during non-REM sleep.

14 on of GABAergic PPT neurons slightly reduced REM sleep.

15 presence and absence of dreaming in NREM and REM sleep.

16 s wakefulness and also reduces NREM and also REM sleep.

17 cephalon leads to decreases in both NREM and REM sleep.

18 kefulness from propofol anesthesia, NREM and REM sleep.

19 ed a key site for regulating wakefulness and REM sleep.

20 usands of downstates and spindles during non-REM sleep.

21 g, whereas lesions of the PPT in cats reduce REM sleep.

22 cingulate cortex (ACC) and the DLPFC during REM sleep.

23 , these long timescales are abrogated in non-REM sleep.

24 ally different gating mechanisms in NREM and REM sleep.

25 nd evoked delta activity, and an increase in REM sleep.

26 hat regulate the EEG and motor components of REM sleep.

27 cated neurons more selectively active during REM sleep.

28 t (REM) sleep, and to a lesser degree during REM sleep.

29 trol of locomotion, muscle tone, waking, and REM sleep.

30 to be a bihemispheric sleeper that expresses REM sleep.

31 T during NREM sleep was sufficient to induce REM sleep.

32 low-voltage fast desynchronized activity of REM sleep.

33 ay be involved in cognitive processes during REM sleep.

34 these neurons in sleep selectively promotes REM sleep.

35 l areas in non-rapid eye movement (NREM) and REM sleep.

36 in mice has shown that it can also occur in REM sleep.

37 n of hypoglossal motor neurons (HMNs) during REM sleep.

38 has shown that slow waves can also occur in REM sleep.

39 ring sleep, particularly rapid eye movement (REM) sleep.

40 tribute to forgetting in rapid eye movement (REM) sleep.

41 ep, in particular during rapid-eye-movement (REM) sleep.

42 eye movement (NREM) and rapid eye movement (REM) sleep.

43 hypopnea indices during rapid eye movement (REM) sleep.

44 s restricted primarily to periods of active (REM) sleep.

45 vioral states, including rapid eye-movement (REM) sleep.

46 y was related to time in rapid eye movement (REM) sleep.

47 cephalogram (EEG) during rapid eye movement (REM) sleep.

48 onic twitches of the whiskers during active (REM) sleep.

49 ine which species 'have' rapid eye movement (REM) sleep.

50 that are reactivated during REM, but not non-REM, sleep.

51 hat occur during non-rapid-eye-movement (non-REM) sleep(1-8) and whose disruption impairs spatial mem

52 Response thresholds were also greater in REM sleep (10 mW) compared to non-REM and waking (3 to 5

53 haviors, including rapid eye movement sleep (REM sleep), a sleep phase when the brain is as active as

54 rs exclusively and abundantly during active (REM) sleep, a particularly prominent state in early deve

55 Cholinergic REM Induction Test revealed that REM sleep abnormalities can be mimicked by administratio

56 ial for dream mentation, in both non-REM and REM sleep across mammals.

57 t they are both wake and rapid eye movement (REM)-sleep active.

58 REM sleep-active MCH neurons in the hypothalamus are thu

59 Wake- and REM sleep-active MCH neurons were distinct populations t

60 , these VTA GABAergic neurons were wake- and REM sleep-active.

61 ns, which were wake- and rapid eye movement (REM) sleep-active, produced wakefulness through projecti

62 mulations of LH MCH neural activity increase REM sleep after long-term withdrawal with important diff

63 ory machinery, and what may serve to improve REM sleep after withdrawal.

64 ABNs that are reactivated during subsequent REM sleep against a backdrop of overall reduced ABN acti

65 Compared to NREM sleep, IEDs location in REM sleep also showed a higher concordance with electrog

66 Moreover, REM sleep also strengthens and maintains newly formed sp

67 silencing of this sparse ABN activity during REM sleep alters the structural remodeling of spines on

68 d with non-REM sleep but stronger during non-REM sleep among deep-layer excitatory neurons.

69 ly, such a decline was associated with lower REM sleep amounts, supporting a role for REM sleep in ov

70 Almost all antidepressant agents suppress REM sleep and a time-and-dose-response relationship betw

71 g revealed dynamic network activation during REM sleep and activation of a subset of the neurons duri

72 led dynamic activation of MCH neurons during REM sleep and activation of a subset of the same neurons

73 n between cortical areas is disrupted in non-REM sleep and anesthesia.

74 By focusing on the components of REM sleep and discouraging continued reliance on a restr

75 Here, we explored whether FAA during REM sleep and during evening resting wakefulness is rela

76 evailing thought, the DLPFC is active during REM sleep and likely interacting with other areas.

77 de a causal link between ABN activity during REM sleep and memory consolidation.

78 beta activity before and during movements in REM sleep and NREM sleep.

79 ibition reduced breathing equally during non-REM sleep and quiet wake.

80 activity that occurs from wakefulness to non-REM sleep and reduces airway collapsibility.

81 ortex, naive participants were awakened from REM sleep and responded to a questionnaire on bodily sen

82 ely, there was no direct correlation between REM sleep and SCRs, indicating that REM may only modulat

83 olidation is differentially mediated by both REM sleep and SWS.

84 ls for the regulation of rapid eye movement (REM) sleep and non-REM sleep, how mutual inhibition betw

85 n of glycine-induced non-rapid eye movement (REM) sleep and shortened NREM sleep latency with a simul

86 0 mW compared to non-rapid eye movement (non-REM) sleep and wakefulness (each P < 0.05, n = 7).

87 o induce spindles during rapid-eye movement (REM) sleep and wakefulness-behavioral states that do not

88 eurons are active during rapid eye movement (REM) sleep and wakefulness.

89 were found to be synchronously active during REM sleep, and also during the exploration of novel obje

90 , with unihemispheric slow waves, suppressed REM sleep, and continuous bodily movement.

91 Results showed that FAA during REM sleep, and during evening resting wakefulness, predi

92 olidation), the neural circuits that control REM sleep, and how dysfunction of REM sleep mechanisms u

93 the number of oxygen desaturation events in REM sleep, and increased ventilation in non-REM and REM

94 d processing in the prefrontal region during REM sleep, and inhibited neural activation in the untrai

95 alcium spikes increased substantially during REM sleep, and the blockade of these calcium spikes prev

96 ence of dreams in human sleep, especially in REM sleep, and the detection of physiologically similar

97 Wakefulness, rapid eye movement (REM) sleep, and non-rapid eye movement (NREM) sleep are

98 uring quiet wake and non-rapid eye movement (REM) sleep, and to a lesser degree during REM sleep.

99 that dendritic calcium spikes arising during REM sleep are important for pruning and strengthening ne

100 et out to determine whether movements during REM sleep are processed by different motor networks than

101 Waking and rapid eye movement (REM) sleep are characterized by ongoing irregular activi

102 Although quiet wake and rapid eye movement (REM) sleep are characterized by similar, long timescales

103 R1-KO) mice showed no significant changes in REM sleep as a function of T(a), even with increased sle

104 hypothesize that the MCH system may modulate REM sleep as a function of T(a).

105 -eye-movement (NREM) and rapid-eye-movement (REM) sleep, as well as increased sleep fragmentation.

106 e anatomical, cellular and synaptic basis of REM sleep atonia control is a critical step for treating

107 EM neurons are regulated and in turn produce REM sleep atonia.

108 l Jouvet used the term paradoxical to define REM sleep because of the simultaneous occurrence of a co

109 Patients with Parkinson's disease (PD) and REM sleep behavior disorder (RBD) show mostly unimpaired

110 nsylvania Smell Identification Test (UPSIT), REM Sleep Behavior Disorder screening questionnaire (RBD

111 nephrine levels, slow resting heart rate, no REM sleep behavior disorder, and preserved smell.

112 certain phenomenological aspects observed in REM sleep behavior disorder.

113 valence, and survival of rapid eye movement (REM) sleep behavior disorder (RBD) in patients who devel

114 The presence of probable rapid eye movement (REM) sleep behavior disorder was strongly associated wit

115 During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strong

116 Idiopathic REM sleep behaviour disorder (iRBD) is a powerful early

117 We also hypothesized that isolated REM sleep behaviour disorder (iRBD) is a prodromal pheno

118 including obstructive sleep apnoea (apnea), REM sleep behaviour disorder (RBD) and narcolepsy with c

119 nderlie debilitating sleep disorders such as REM sleep behaviour disorder and narcolepsy.

120 Both patients with REM sleep behaviour disorder and Parkinson's disease dem

121 Individuals with REM sleep behaviour disorder are at significantly higher

122 ores, higher depression scores and increased REM sleep behaviour disorder symptoms compared to patien

123 d with Parkinson's disease--in patients with REM sleep behaviour disorder without Parkinson's disease

124 ients with polysomnography-proven idiopathic REM sleep behaviour disorder, 26 cases with early Parkin

125 with Parkinson's disease in individuals with REM sleep behaviour disorder, a condition associated wit

126 s of dementia and parkinsonism in idiopathic REM sleep behaviour disorder: a multicentre study' by Po

127 Rapid eye movement (REM) sleep behaviour disorder (RBD) is characterised by

128 ean (SD) 19.2 (12.7) vs 6.1 (5.7); p<0.001), REM-sleep behaviour disorder screening questionnaire (me

129 hat is specifically associated with restless REM sleep (beta = 0.31, P < 10(-26)).

130 developments in our current understanding of REM sleep biology and pathobiology.

131 This pattern is present during phasic REM sleep but not during tonic REM sleep, the latter res

132 n contrast, the E/I balance decreased during REM sleep but only after pre-sleep training, and the dec

133 was stronger during waking compared with non-REM sleep but stronger during non-REM sleep among deep-l

134 mice, that slow waves occur regularly during REM sleep, but only in primary sensory and motor areas a

135 ted in the generation of rapid eye movement (REM) sleep, but the underlying circuit mechanisms remain

136 spindles throughout the cerebral cortex and REM sleep by an "activated," low-voltage fast electroenc

137 on of negative delta (1-4 Hz) waves in human REM sleep by analyzing high-density EEG sleep recordings

138 ol the upper airway muscles are inhibited in REM sleep by the combination of monoaminergic disfacilit

139 has been identified with rapid eye-movement (REM) sleep, characterized by wake-like, globally 'activa

140 day SF procedure that selectively fragmented REM sleep, cholinergic output neurons (ChNs) in the mHb

141 llations were calculated during movements in REM sleep compared with movements in the waking state an

142 tentials revealed elevated beta power during REM sleep compared with NREM sleep and beta power in REM

143 nots, and more on the diverse expression of REM sleep components over development and across species

144 interrogation of brain circuitry linked with REM sleep control, in turn revealing how REM sleep mecha

145 mone (MCH) neurons play an important role in REM sleep control.

146 on regulation, we hypothesized that restless REM sleep could interfere with the overnight resolution

147 ent whole-brain networks across the wake-non-REM sleep cycle.

148 263397 increased waking and reduced NREM and REM sleep, decreased gamma power during wake and NREM, a

149 ormance gains independent of learning, while REM sleep decreases plasticity to stabilize learning in

150 This REM sleep-dependent elimination of new spines facilitate

151 ing of complex representations necessary for REM sleep-dependent memory consolidation.SIGNIFICANCE ST

152 Total sleep or REM sleep deprivation also prevented MD- and FC-induced

153 s significantly reduced after total sleep or REM sleep deprivation.

154 in deep NREM sleep and, importantly, also in REM sleep, despite the recovery of wake-like neural acti

155 nerated movements produced during active (or REM) sleep, differ from wake movements in that they reli

156 results not only demonstrate that selective REM sleep disturbance leads to hyperactivity of mHb ChNs

157 tify a key molecular substrate through which REM sleep disturbance may alter affect regulation.

158 Here we show that chronic REM sleep disturbance, achieved in mice by chronic sleep

159 Sleep disturbance, particularly REM sleep disturbance, profoundly impacts emotion regula

160 rating movement and bodily sensations during REM sleep dreaming.

161 lness is related to affective experiences in REM sleep dreams.

162 waking life but also to rapid eye movement (REM) sleep dreams.

163 r trauma exposure was sufficient to increase REM sleep duration during both the Light and Dark Phase,

164 U0453595 attenuated age-related decreases in REM sleep duration in aged wildtype mice.

165 at wild-type (WT) mice dynamically increased REM sleep durations specifically during warm T(a) pulsin

166 H system in the dynamic output expression of REM sleep during T(a) manipulation.

167 d within species, the potential functions of REM sleep (e.g., memory consolidation), the neural circu

168 Stimulations during REM sleep elicited significantly reduced responses at po

169 Recently, restless rapid-eye-movement (REM) sleep emerged as a robust signature of sleep in ins

170 We therefore propose that, in REM sleep, endogenously generated processes compete with

171 corporated in the network over the following REM sleep epoch.

172 spatio-temporal physiological signatures of REM sleep, especially in humans.

173 Although wake and rapid eye movement (REM) sleep exhibit long timescales, these long-range cor

174 the discovery of REM sleep, the diversity of REM sleep expression across and within species, the pote

175 ed with T(a) warming, showing an increase in REM sleep expression beyond what T(a) warming in yellow

176 rol and function of this temperature-induced REM sleep expression have remained unknown.

177 tween the hippocampus and the BLA during non-REM sleep following training.

178 REM sleep frontal high delta power was a negative correl

179 um (PPT) and laterodorsal tegmentum (LDT) in REM sleep generation.

180 e hypoglossal motor nucleus (MoXII) restores REM sleep genioglossus activity, highlighting the import

181 Together, these findings indicate that REM sleep has multifaceted functions in brain developmen

182 hanisms and functions of rapid-eye-movement (REM) sleep have occurred over the past decade.

183 on of rapid eye movement (REM) sleep and non-REM sleep, how mutual inhibition between specific pathwa

184 In REM sleep, however, this relationship was reversed.

185 During quiet wake or non-REM sleep, hypercapnia increased both breathing frequenc

186 ncy (fR ) and tidal volume (VT ) whereas, in REM sleep, hypercapnia increased VT exclusively.

187 inhibited by glycinergic transmission during REM sleep, hypoglossal motoneurons that control the uppe

188 p regulates emotional memory, and persistent REM sleep impairment after cocaine withdrawal negatively

189 A recent study shows that restless REM sleep impedes this overnight process, providing insi

190 eficient for neurotensin exhibited increased REM sleep, implicating the involvement of the neuropepti

191 dual antagonists, MK-1064 increases NREM and REM sleep in dogs without inducing cataplexy.

192 al, giving clinical relevance to the role of REM sleep in emotion regulation in insomnia, depression,

193 Given the role of REM sleep in emotion regulation, we hypothesized that re

194 These findings reveal an important role of REM sleep in experience-dependent synapse elimination an

195 (REM) sleep prompts interest in the role of REM sleep in hippocampal-dependent episodic memory.

196 erefore, delta waves are an integral part of REM sleep in humans and the two identified subtypes (saw

197 from the ventral medulla powerfully promotes REM sleep in mice.

198 likely to play a role in the suppression of REM sleep in odontocete cetaceans.

199 Atypical REM sleep in other species, such as African elephants an

200 wer REM sleep amounts, supporting a role for REM sleep in overnight emotional processing.

201 des evidence that nocturnal movements during REM sleep in Parkinson's disease (PD) patients are not p

202 motor task is learned, indicating a role for REM sleep in pruning to balance the number of new spines

203 on a template derived from the expression of REM sleep in the adults of a small number of mammalian s

204 Our findings provide evidence for a role for REM sleep in the maintenance of cellular representations

205 ring NREM sleep and reward processing during REM sleep in the reward group but not in the no-reward g

206 kefulness and suppresses rapid-eye movement (REM) sleep in mice and rats and reduces cataplexy in two

207 ovement (NREM) sleep and rapid eye movement (REM) sleep, in six medication-refractory focal epilepsy

208 ep, and increased ventilation in non-REM and REM sleep, independently of metabolic effects.

209 eam mentation occurs during both non-REM and REM sleep, indicates that all mammals have the potential

210 he lateral hypothalamus (LH), which regulate REM sleep initiation and maintenance.

211 M) cycling, REM sleep reduction or loss, and REM sleep instruction in wakefulness.

212 These findings indicate that REM sleep is a spatially and temporally heterogeneous st

213 d in healthy adult individuals, we show that REM sleep is characterized by prominent delta waves also

214 The brain circuitry governing REM sleep is located in the pontine and medullary brains

215 ing signal for postural muscle atonia during REM sleep is thought to originate from glutamatergic neu

216 this sudden amelioration of motor control in REM sleep is unknown, however.

217 Rapid eye movement (REM) sleep is a distinct brain state characterized by ac

218 Rapid eye movement (REM) sleep is a recurring part of the sleep-wake cycle c

219 Although rapid eye movement (REM) sleep is also associated with diminished arousal le

220 Rapid eye movement (REM) sleep is an important component of the natural slee

221 during the second half, rapid eye movement (REM) sleep is more predominant.

222 We conclude that sleep, especially REM sleep, is causal to successful consolidation of dang

223 arcolepsy, a disorder of rapid eye movement (REM) sleep, is characterized by excessive daytime sleepi

224 pheric slow wave sleep (USWS) and suppressed REM sleep, it is unclear whether the mysticete whales sh

225 t, which is dominated by rapid eye movement (REM) sleep, led to better discrimination between fear-re

226 Initial hopes that these abnormalities of REM sleep may serve as differential-diagnostic markers f

227 dy suggest that baseline rapid eye movement (REM) sleep may serve a protective function against enhan

228 ith REM sleep control, in turn revealing how REM sleep mechanisms themselves impact processes such as

229 at control REM sleep, and how dysfunction of REM sleep mechanisms underlie debilitating sleep disorde

230 During both NREM and REM sleep, mice showed large increases in cerebral blood

231 able entrainment of spindle power during non-REM sleep, nor of theta power during resting wakefulness

232 ic stimulation promotes both wakefulness and REM sleep, optogenetic stimulation of these neurons in s

233 ow wave sleep (SWS) differs from that during REM sleep or waking states.

234 preferentially increases rapid eye movement (REM) sleep over non-REM (NREM) sleep across species.

235 motor responses were specifically reduced in REM sleep (P < 0.001).

236 may not be continuously available during non-REM sleep, permitting the cortex to control thalamic spi

237 Except in REM sleep, phasic RTN stimulation entrained and shortene

238 ults indicate that higher baseline levels of REM sleep predict reduced fear-related activity in, and

239 rence of dreaming during rapid eye movement (REM) sleep prompts interest in the role of REM sleep in

240 Here we show that REM sleep prunes newly formed postsynaptic dendritic spi

241 these neurons selectively in sleep enhances REM sleep quality and quantity after long-term withdrawa

242 p compared with NREM sleep and beta power in REM sleep reached levels similar as in the waking state.

243 ession after sleep deprivation and expedites REM-sleep recovery.

244 movement - rapid eye movement (REM) cycling, REM sleep reduction or loss, and REM sleep instruction i

245 The findings suggest that restless REM sleep reflects a process that interferes with the ov

246 Notably, rapid eye movement (REM) sleep regulates emotional memory, and persistent RE

247 understood how cocaine experience may alter REM sleep regulatory machinery, and what may serve to im

248 cataplexy, nighttime sleep disturbances, and REM-sleep-related phenomena (sleep paralysis, hallucinat

249 ccurred in all recorded neurons (n = 106) in REM sleep relative to quiet waking or non-REM sleep.

250 matergic neurons are maximally active during REM sleep (REM-max), while the majority of GABAergic neu

251 wake cycle, yet the mechanisms that regulate REM sleep remain incompletely understood.

252 underlying mechanisms of rapid eye movement (REM) sleep remain unclear.

253 In both NREM and REM sleep, reports of dream experience were associated w

254 enuated by 47% and 36% during NREM sleep and REM sleep, respectively.

255 As previously reported in our analysis of REM sleep responses, we found different patterns of chan

256 ) warming completely blocked the increase in REM sleep seen in YFP controls.

257 alidated to be a specific proxy for restless REM sleep (selective fragmentation: R = 0.57, P < 0.001;

258 Rapid eye movement (REM) sleep serves an important function for processing a

259 related to EEG oscillatory parameters of non-REM sleep serving as markers of sleep-dependent memory c

260 Sawtooth waves, which are exclusive to REM sleep, share many characteristics with ponto-genicul

261 received auditory cueing during NREM but not REM sleep showed impaired fear memory upon later present

262 of electroencephalographic activation during REM sleep similar to that observed during the performanc

263 th widely distributed, but locally regulated REM sleep slow oscillations.

264 pectral slope discriminates wakefulness from REM sleep solely based on the neurophysiological brain s

265 oglossal motor output in-vivo and identifies REM sleep specific suppression of net motor excitability

266 REM sleep-specific optogenetic silencing of LH(vgat) cel

267 REM sleep state-dependent inhibition of MCH neurons impa

268 eye movement (NREM) and rapid eye movement (REM) sleep, strongly consolidating the waking state for

269 tion between complexity and motor indices in REM sleep suggests drastically different gating mechanis

270 and-dose-response relationship between total REM sleep suppression and therapeutic response to treatm

271 levels and provide a possible mechanism for REM sleep suppression of upper airway muscle activity.SI

272 vity was greater in exploratory behavior and REM sleep than in quiet wakefulness and slow wave sleep,

273 enioglossus activity from wakefulness to non-REM sleep that occurred on the placebo night.

274 part of the brain - may function to control REM sleep, the brain state that underlies dreaming.

275 s the historical origins of the discovery of REM sleep, the diversity of REM sleep expression across

276 during phasic REM sleep but not during tonic REM sleep, the latter resembling relaxed wakefulness.

277 ives wakefulness, whereas inhibition reduces REM sleep theta activity.

278 an increase of REM density, as well as total REM sleep time.

279 during training enhanced rapid eye movement (REM) sleep time, increased oscillatory activities for re

280 Yet until now, cortical activity during REM sleep was thought to be homogenously wake-like.

281 While rapid eye movement (REM) sleep was marked by decreased hippocampal firing an

282 a period of rapid eye movement (REM) and non-REM sleep, was absent in all animals in which 5-HT defic

283 nce, that dream mentation only occurs during REM sleep, we conclude that it is unlikely that monotrem

284 This finding may help explain why, during REM sleep, we remain disconnected from the environment e

285 st activity map of individual neurons during REM sleep, we use deep-brain calcium imaging in unrestra

286 When dreaming during rapid eye movement (REM) sleep, we can perform complex motor behaviors while

287 Compared to NREM sleep, IEDs during REM sleep were of significantly shorter duration and spa

288 slow-wave sleep and some limited recovery in REM sleep when individuals with AUD stop drinking.

289 neural circuits to opportunistically express REM sleep when the need for thermoregulatory defense is

290 by non-rapid eye movement (NREM) sleep or by REM sleep, whether it results from plasticity increases

291 show mostly unimpaired motor behavior during REM sleep, which contrasts strongly to coexistent noctur

292 cortex interferes with dream movement during REM sleep, which is consistent with a causal contributio

293 rimarily occurred during rapid-eye movement (REM) sleep, which is notable because REM is associated w

294 ostasis, KO mice accrued only half the extra REM sleep wild-type (WT) littermates obtained during rec

295 ing, non-rapid eye movement sleep [NREM] and REM sleep) within an ultradian cycle.

296 ur results suggest that elevated submentalis REM sleep without atonia appears to be a potentially use

297 r operating characteristic curves determined REM sleep without atonia cutoffs distinguishing synuclei

298 ted wakefulness and reduced both REM and non-REM sleep without inducing hyperlocomotion.

299 utility of quantitative rapid eye movement (REM) sleep without atonia analysis in the submentalis an

300 Spindles and SWRs were initiated during non-REM sleep, yet the changes were incorporated in the netw