ライフサイエンスコーパス: RING finger domain

1 vely modulated GATA4 transactivation via its RING finger domain.

2 breviated as E3 activity) is mediated by its RING finger domain.

3 -700 on Cbl, and also requires an intact Cbl RING finger domain.

4 adation of cdc34 and its binding to the ICP0 ring finger domain.

5 UbcH6 E2-conjugating enzymes mapping to the ring finger domain.

6 functions as an E3 ligase independent of the RING finger domain.

7 IAP repeat (BIR) domain and a COOH-terminal RING finger domain.

8 tivation of GCKR by TRAF2 required the TRAF2 RING finger domain.

9 perty of Vmw110 and more particularly of its RING finger domain.

10 ding a 7-amino acid insert within the TRAF2A RING finger domain.

11 r nuclear localization as the amino-terminal ring finger domain.

12 ion, which encodes a transcript containing a RING finger domain.

13 s C-terminal cysteine-rich motif is indeed a RING finger domain.

14 components requires BRCA1's BRCT but not the ring finger domain.

15 on of similarity between these proteins is a RING finger domain.

16 lates protein sumoylation independent of the RING finger domain.

17 i-spanning membrane protein with a cytosolic RING finger domain.

18 tin ligase activity harbored within the MDM2 RING finger domain.

19 his required the PML N terminus and the MDM2 RING-finger domain.

20 ivation of p53 by PIAS1 does not require the RING-finger domain.

21 RAF, DTRAF2, that contains an amino-terminal Ring-finger domain.

22 UMO-interacting motif (SIM) and a C-terminal RING-finger domain.

23 t, in a manner that was dependent upon PML's RING-finger domain.

24 amino acids of Slx8, but not its C-terminal RING-finger domain.

25 e sequence homology between their respective RING finger domains.

26 dent on its variant SRC homology 2 (SH2) and RING finger domains.

27 binding is a generally proposed function of RING finger domains.

28 irus IAP repeats (BIRs) and carboxy-terminal RING finger domains.

29 ally defined by a C4HC3 consensus similar to RING finger domains.

30 es a conserved protein with zinc knuckle and RING finger domains.

31 CDCrel-1, interacts with Parkin through its ring-finger domains.

32 In this study, we identified PHD and Ring Finger Domains 1 (PHRF1) as an important ATR activa

33 is required for ubiquitin-like with PHD and RING finger domains 1 (UHRF1) E3 ubiquitin ligase activi

34 or ubiquitin-like protein containing PHD and RING finger domains 1 (uhrf1) in zebrafish leads to a re

35 Ubiquitin-like with PHD and RING finger domains 1 (UHRF1) is an essential regulator

36 or ubiquitin-like with plant homeodomain and RING finger domains 1 (Uhrf1) is essential for maintenan

37 Ubiquitin-like, containing PHD and RING finger domains 1 (uhrf1) is regulated at the transc

38 mutations in the ubiquitin-like with PHD and ring finger domains 1 (uhrf1) or DNA methyltransferase 1

39 DNMT1) and ubiquitin-like containing PHD and RING finger domains 1 (UHRF1) proteins.

40 enetic regulator ubiquitin-like with PHD and ring finger domains 1 (UHRF1), exhibits altered expressi

41 ng protein Ubiquitin-like containing PHD and RING finger domains 1 (UHRF1).

42 regulator Ubiquitin-like containing PHD and RING finger domains 1 (UHRF1).

43 ork, with UHRF1 (ubiquitin-like with PHD and RING finger domains 1) as a central node, links genetic

44 n ligase UHRF1 (Ubiquitin-like, with PHD and RING finger domains 1) directly participates in the inte

45 UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) has a well-established role in ep

46 port that UHRF1 (ubiquitin-like with PHD and RING finger domains 1) interacts with TIP60 both in vitr

47 UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is a multi-domain protein associa

48 UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1) is required for maintenance methy

49 in UHRF1 (ubiquitin-like, containing PHD and RING finger domains 1), also known as NP95 in mouse and

50 E3 ligase UHRF1 (ubiquitin-like with PHD and RING finger domains 1), which is commonly upregulated in

51 by Uhrf1 (Ubiquitin-like, Containing PHD and RING Finger Domains 1).

52 Ubiquitin-like, containing PHD and RING fingers domains 1 (UHRF1) plays a pivotal role in r

53 UHRF1 (ubiquitin-like, containing PHD and RING finger domains, 1) recruits DNMT1 to hemimethylated

54 lecular adaptor, ubiquitin-like with PHD and RING finger domains-1 (UHRF1), was determined in human C

55 olecular adaptor ubiquitin-like with PHD and RING finger domains-1 (UHRF1), was measured in human HCC

56 e identified the ubiquitin-like with PHD and ring finger domains 2 (UHRF2) gene as an important media

57 Ubiquitin-like, containing PHD and RING finger domains 2 (UHRF2) regulates cell cycle and b

58 a protein of 581 amino acids that contains a RING finger domain, a B-box, and two coiled-coil regions

59 gase containing three domains, an N-terminal RING finger domain, a central coiled-coil domain, and a

60 TRIM37 contains a RING finger domain, a hallmark of E3 ubiquitin ligases,

61 entral proline-rich region; and a C-terminal RING finger domain, a motif often found in ubiquitin-pro

62 tion occurred even though hRAD18 possesses a RING finger domain, a structure that is generally associ

63 diate these processes, it requires its C3HC4 RING finger domain, a tertiary structural fold that is c

64 , revealed the presence of an amino-terminal RING finger domain, a zinc binding motif found in a vari

65 protein family, which contain a cluster of a RING-finger domain, a B box/coiled-coil domain and a SPR

66 (2+)-chelating ability of its amino-terminal RING finger domain abolished TRAC-1's ligase activity an

67 Further truncations, which delete the RING finger domain, abrogated the negative regulatory ef

68 ons of the zinc coordination residues of the RING finger domain abrogates TGF-beta resistance, but no

69 As a result, the juxtaposition of PA and RING finger domains across a lipid bilayer facilitates t

70 Our studies suggest that both the RING finger domain activity and the specific binding of

71 ults are consistent with the notion that the RING finger domains allosterically activate E2.

72 Deletion of the enzyme's N-terminal RING-finger domain almost completely abolishes fiber for

73 Alleles of SLX8 that express the RING-finger domain alone show almost complete complement

74 In contrast, the RING finger domain (amino acids 116 to 156) and surprisi

75 n, and a divergent SH2 domain) followed by a RING finger domain and a proline-rich C-terminus.

76 rotein designated as TRAF7, which contains a RING finger domain and a zinc finger domain that are mos

77 , as it possesses a conserved amino terminal RING finger domain and an acidic carboxyl domain.

78 MEX3A, a dual-function protein containing a RING finger domain and an RNA-binding domain, was critic

79 Bmi-1 to the rim of the nucleus requires the RING finger domain and correlates with its ability to tr

80 is a unique TRAF protein because it lacks a RING finger domain and is predominantly expressed in act

81 ted) at Lys-446, which is located within the RING finger domain and plays a critical role in Mdm2 sel

82 sis to determine the importance of the MSL-2 RING finger domain and second cysteine-rich motif.

83 rophobic pocket can be regulated through the RING finger domain and that increases in pocket affinity

84 n assay also showed that both the N-terminal RING finger domain and the intact coiled-coil region of

85 The Slx5 and Slx8 proteins contain RING finger domains and coimmunoprecipitate from cell ex

86 hock protein 90 and did not require the MDM2 RING-finger domain and p53 ubiquitination.

87 tyrosine kinase binding domain, a catalytic RING finger domain, and a C-terminal proline-rich domain

88 is reduced by MKRN3 mutations affecting the RING finger domain, and that these mutations compromised

89 iquitin ligase activity of the purified RAG1 RING finger domain, and the tertiary structure of the do

90 ctivate JNK, DTRAF1 lacks an amino-terminal 'Ring-finger' domain, and overexpression of a truncated D

91 Although the RING finger domains are necessary for dimerization, they

92 These results establish the RING finger domain as an essential element in Cbl-mediat

93 Mapping of Not4 identified the RING finger domain as essential for H3K4me3, suggesting

94 a 1.9-kb open reading frame that contains a RING finger domain at its N-terminus and an alanine-rich

95 Delta-PRAJA, which has a deleted RING finger domain at the C terminus, abolishes ubiquiti

96 The intact RING finger domain at the Mdm2 COOH terminus (amino acid

97 This activity requires a functioning MDM2 ring finger domain because the MDM2(C464A) mutant was un

98 d GAL4/PML fusion proteins that retained the RING finger domain but lacked the intact coiled-coil reg

99 strong sequence homology to ICP0 within the RING finger domain but limited similarity elsewhere.

100 UbcH7 interacted with the wild-type c-Cbl RING finger domain but not with a RING finger domain tha

101 similar mechanism or pathway involving their RING finger domain but that their intrinsic activities a

102 ncludes the evolutionarily conserved TKB and RING finger domains but lacks the less conserved C-termi

103 We demonstrate that disruption of the ORF61p RING finger domain by amino acid substitution (Cys19Gly)

104 of 49 patients; all of these cases harbored RING finger domain c-Cbl mutations.

105 n vitro studies, which demonstrated that its RING finger domain can autoubiquitylate and monoubiquity

106 known motifs; EF-hand domains (CGR11) and a ring-finger domain (CGR19), suggestive of function.

107 ICP0 contains a RING finger domain characteristic of a class of E3 ubiqu

108 tin-like (UBL) domain, a zinc knuckle, and a RING finger domain characteristic of some ubiquitin liga

109 indicates that checkpoint with forkhead and ring finger domains (CHFR), a recently identified mitoti

110 ese studies provide evidence that C-terminal RING finger domains, contained within both of these prot

111 ked InsP3R ubiquitination, suggesting that a RING finger domain-containing E3 is also involved in thi

112 the ubiquitin ligase ubiquitin-like PHD and RING finger domain-containing protein 1 (UHRF1) and its

113 omain (PHD) of UHRF1 (ubiquitin-like PHD and RING finger domain-containing protein 1) operates as a f

114 Specifically, we identified a RING finger domain-containing protein, RINCK (for RING-f

115 ed ubiquitin ligase complex comprising three RING finger domain-containing proteins (Pex2, Pex10 and

116 TRIM21 is a RING finger domain-containing ubiquitin E3 ligase whose

117 Mutations in Z that unfolded its RING finger domain eliminated its inhibitory activity, b

118 trate-independent ubiquitination system, the RING finger domain encoded by exon 2 of ICP0 binds cdc34

119 ciated with the really interesting new gene (RING) finger domain encoded by exon 2.

120 in the outer mitochondrial membrane with its RING finger domain facing the cytoplasm.

121 Flag-gp78), but not Flag-gp78 mutated in its RING-finger domain (Flag-RINGmut) with deficient ubiquit

122 ximity to their N termini that consists of a RING finger domain, followed by one or two B box domains

123 The three ring finger domains form a cytosolic tower, with ring fi

124 The Mdm2 ring finger domain has been shown to possess E3 ligase a

125 A protein lacking the SH2 and RING finger domains has no activity, but a chimeric prot

126 The ring finger domain in Chfr is required for the ligase ac

127 polymerase-associated domain in PolH and the RING finger domain in Pirh2.

128 Recent results implicate the RING finger domain in specific ubiquitination events; it

129 nesis of cysteine residues within a putative RING finger domain in the amino acid sequence of HCF-1 a

130 ibosylation factor domain protein 1), with a RING finger domain in the N-terminal region, two predict

131 een suggested to bind zinc(II) in an unusual RING finger domain in which Thr 455 was postulated as a

132 ubiquitinase activity of MKRN3 required its RING finger domain, in order to repress the promoter act

133 Dominant negative c-Cbl lacking the ring finger domain inhibited PAR(2) ubiquitination and i

134 any RING finger proteins, by virtue of their RING finger domain, interact with E2 ubiquitin-conjugati

135 nd an in vitro binding assay, that the c-Cbl RING finger domain interacts with UbcH7, a ubiquitin-con

136 A TRAF2 mutant lacking its N-terminal RING finger domain is a dominant-negative inhibitor of T

137 nd increased p53 transactivation by the MdmX ring finger domain is discussed.

138 hemical analyses further show that the yBre1 RING finger domain is essential for H2B ubiquitylation b

139 as with the other target proteins, the ICP0 RING finger domain is essential.

140 dition, we demonstrate that an intact ORF61p RING finger domain is necessary for E3 ubiquitin ligase

141 GCK, and the highly related kinase GCKR, the RING finger domain is needed for their activation.

142 riptional suppression whereas the N-terminal RING finger domain is not required.

143 Thus, a correctly folded RAG1 RING finger domain is required for normal V(D)J recombin

144 nfection, (v) ICP0 carrying mutations in the RING finger domain is stable both early and late in infe

145 key function of ICP0 that requires an intact RING finger domain is that of an ubiquitin E3 ligase: IC

146 The RING-finger domain is a novel zinc-binding Cys-His prote

147 s association with microtubules, whereas the RING-finger domain is required for microtubule stabiliza

148 Ubiquitination of lysines in Hrd1's RING-finger domain is required for substrate retrotransl

149 by the BARD1 protein (residues 8-142), whose RING finger domain itself lacked Ub ligase activity in v

150 We show that Lys65 in the RING finger domain, Lys160 in the B1 Box, and Lys490 in

151 ructural and functional asymmetry of dimeric RING finger domains may be a general feature of E3 ligas

152 In contrast, the C381A Ring finger domain mutant functions like WT c-Cbl.

153 effect induced by expression of a MEKK1 PHD/RING finger domain mutant were consistent with a higher

154 The RING finger domain of c-Cbl has been shown recently to e

155 xpression of Cbl-Grb2/SH2 fusions containing RING finger domain of Cbl restores normal ubiquitylation

156 Furthermore, deletion of the COOH-terminal RING finger domain of HdmX completely reversed the resis

157 ues required for the interaction between the RING finger domain of ICP0 and UBE2D1, and we report tha

158 t (i) consistent with previous findings, the RING finger domain of ICP0 is required for the activatio

159 etion of ICP0 or mutations in the N-terminal RING finger domain of ICP0 results in the absence of ICP

160 The RING finger domain of ICP0 was required for degradation

161 m2 is an E3 ubiquitin ligase for p53 and the RING finger domain of mdm2 is critical for ligase activi

162 oteolytic cleavage removes the COOH-terminal RING finger domain of mdm2, resulting in the loss of RNA

163 quitination-dependent degradation by the PHD/RING finger domain of MEKK1, which exhibited E3 ubiquiti

164 Point mutations disrupting the RING finger domain of p28 completely abolish its E3 liga

165 The RING finger domain of PIAS1 was essential for its E3 lig

166 1-PIASy interaction but do not depend on the RING finger domain of PIASy.

167 yeast system, and deletion of the N-terminal RING finger domain of PML abolished the interaction.

168 t interaction between IE1 and the N-terminal RING finger domain of PML may inhibit oligomerization an

169 In vitro, the RING finger domain of RAG1 acts as a ubiquitin ligase th

170 main (CRD) of frizzled and the intracellular RING finger domain of RNF43.

171 Here, we showed that purified RING finger domain of ROC1, an essential subunit of SKP1

172 We find that the RING finger domain of SLI-1 is partially dispensable.

173 conserved cysteine residue to glycine in the RING finger domain of the 1863 amino acid BRCA1 protein.

174 xperimentally-induced mutations in the C3HC4 RING finger domain of the Bmi-1 oncoprotein block its ab

175 ed a novel protein, BAP1, which binds to the RING finger domain of the Breast/Ovarian Cancer Suscepti

176 n an N-terminal zinc finger and a C-terminal RING finger domain of the C3HC4 subclass, but show no ho

177 t a mutation that specifically disrupted the ring finger domain of the HUL-2 site had no effect on th

178 f MTA1, whereas MTA1 binds to the N-terminal ring finger domain of the MAT1.

179 The RING finger domain of topors is homologous to a similar

180 r motif common to IKKalpha, IKKbeta, and the RING finger domain of TRAF2, and either IKKalpha or IKKb

181 h the amino-terminal portion of TANK and the ring finger domain of TRAF2.

182 We found that a structurally intact RING finger domain of TRAF3 is required for inhibition o

183 The RING finger domain of Vmw110 (but not the C-terminal reg

184 Using mutant Vmw110 viruses we show that the RING finger domain of Vmw110 is essential for the induce

185 The RING finger domain of Yvh1, but not its phosphatase doma

186 Tyrosine kinase binding and RING finger domains of Cbl are essential for Cbl-mediate

187 Intact tyrosine kinase-binding and RING finger domains of Cbl were found to be essential fo

188 effect by targeting cysteine residues in the RING finger domains of histone E3 ubiquitin ligase, ther

189 und that arsenite could bind directly to the RING finger domains of RNF20 and RNF40 in vitro and in c

190 ity, but a chimeric protein with the SH2 and RING finger domains of SLI-1 replaced by the equivalent

191 We raised antibody against Ring-finger domain of BRCA1.

192 The RING-finger domains of RIN2 and RIN3 encode ubiquitin li

193 r a Cys point mutation within the N-terminal RING finger domain or a small deletion (of positions 281

194 nd could physically interact with either the RING finger domain or central acidic region of full-leng

195 s reduced by wild type Cbl; mutations of the RING finger domain or its deletion abrogated this effect

196 Mutations in the Cbl family RING finger domain or linker sequence constitute importa

197 The second, designated HUL-2, maps to the RING finger domain present in ICP0 encoded by exon 2.

198 hat single point mutations in the human MDM2 RING finger domain prevent the interaction of MDM2 with

199 DM2 defective either in Rb interaction or in RING finger domain, promotes cell cycle S phase entry in

200 ized genes are a cell growth regulatory with ring finger domain protein (CGR19, Hs.59106), an RB-asso

201 heckpoint with Forkhead-associated (FHA) and RING finger domain protein (CHFR), an E3 ubiquitin ligas

202 The ubiquitin-like, containing PHD and RING finger domains protein 1 (UHRF1) is essential for m

203 Because many RING-finger domain proteins appear to function as E3 ubi

204 , and activated MDM2 binding to its internal RING finger domain, providing evidence for a conformatio

205 In addition, a PIAS1 mutant without the RING-finger domain required for sumoylation could still

206 We report here that full-length ARD1 or the RING finger domain (residues 1-110) produced polyubiquit

207 Recent studies have shown, however, that the ring-finger domain (RFD) of MDM2, where the ubiquitin E3

208 Since MdmX also possesses a ring finger domain that allows MdmX to associate with Md

209 endent degradation and that mutations in its RING finger domain that disrupt ubiquitin ligase activit

210 The N-terminus of the BRCA1 protein bears a RING finger domain that functions as an E3 ubiquitin lig

211 The central region of Pirh2 harbors a RING finger domain that is critical for its ubiquitin li

212 ins (except for TRAF1) contain an N-terminal RING finger domain that is essential for their functions

213 domain of p53, and (iii) a C-terminal C2H2C4 RING finger domain that is required for E2 enzyme-bindin

214 type c-Cbl RING finger domain but not with a RING finger domain that lacks the amino acids that are d

215 otein interactions via its TRAF domain and a RING finger domain that possesses non-conventional E3 ub

216 Mib1 regulates CE through its RING Finger domains that have been implicated in substra

217 n addition, DIAP2 also requires a functional RING finger domain to block cell death and target drICE

218 ignaling by a form of TRAF2, which lacks the ring finger domain (TRAF2DeltaN), increases activities o

219 ith the heterodimeric complex of BRCA1/BARD1 RING-finger domains uncovers a common architecture for a

220 protein kinase activation, and an intact Cbl RING finger domain was required for this functional effe

221 s the essential Really Interesting New Gene (RING)-finger domain was sufficient to bind p105, conjuga

222 l half of the protein, including the TKB and RING finger domains, was sufficient to mediate negative

223 Because Chfr contains a RING-finger domain, we tested whether Chfr inhibits chro

224 ed around the first zinc-binding site of the RING finger domain were conserved in a Drosophila virili

225 Both proteins contain an N-terminal zinc RING-finger domain which confers E3 ubiquitin ligase act

226 rved cysteine residues or a histidine in the RING finger domain, which are required for zinc binding,

227 terminal half of Nrdp1 possesses an atypical RING finger domain, which is required for enhancing ErbB

228 The TOPORS RING finger domain, which mediates ubiquitination, is re

229 ICP0 has a RING finger domain with E3 ubiquitin ligase activity tha

230 dogenous Hdm2, Mdm2:X fusions containing the ring finger domain with or without the zinc finger domai

231 echanism that involves an interaction of the RING finger domain with UbcH7.

232 oteins between Mdm2 and MdmX by swapping the ring finger domains with or without the zinc finger doma