ライフサイエンスコーパス: RNA decay

1 to be critical for initiation of trp leader RNA decay.

2 oly(A) tail and preventing the initiation of RNA decay.

3 recedes a kinetically distinct commitment to RNA decay.

4 d interacts with the exosome to regulate frq RNA decay.

5 d sRNA-mRNA annealing and the role of Hfq in RNA decay.

6 inetic model can account for a triphasic HCV RNA decay.

7 localized in specialized bodies involved in RNA decay.

8 ate protein expression via nonsense-mediated RNA decay.

9 ames that are resistant to nonsense-mediated RNA decay.

10 and the mechanisms and regulation of nuclear RNA decay.

11 ase activities that might be involved in HBV RNA decay.

12 ) were likely to result in nonsense-mediated RNA decay.

13 ch RNase E may exercise overall control over RNA decay.

14 ut it is now known to have a general role in RNA decay.

15 ylated 5' terminus needed to stimulate rapid RNA decay.

16 an unusual mode of core exosome-independent RNA decay.

17 splicing, ribosome assembly, translation and RNA decay.

18 transcription factor XBP1s and of regulated RNA decay.

19 specified by LSM1-dependent pericentromeric RNA decay.

20 re in linking transcription, translation and RNA decay.

21 ptionally to repress translation and promote RNA decay.

22 nded with the activation of RNase L-mediated RNA decay.

23 ly controlled at different levels, including RNA decay.

24 not sensitive to nonsense-mediated messenger RNA decay.

25 m(7)G cap that promotes rather than inhibits RNA decay.

26 ists in tissues due to XRN-1 stalling during RNA decay.

27 ine modifications leading to YTHDF2-mediated RNA decay.

28 n endoribonuclease required for ZAP-mediated RNA decay.

29 th for circle formation, likely representing RNA decay.

30 iency due to activation of nonsense mediated RNA decay.

31 messenger RNA by nonsense-mediated messenger RNA decay.

32 on termination is followed by TRAMP-mediated RNA decay.

33 FH1 RNA half-life and had no effect on HJ3-5 RNA decay.

34 ive sequences may have unexpected effects on RNA decay.

35 suppresses the output of P(R2) by eliciting RNA decay.

36 ant implications for the role of RNase J1 in RNA decay.

37 y, akin to polyadenylation-induced messenger RNA decay(10).

38 spite the absence of the major, Pi-dependent RNA decay activity of PNPase.

39 n of HUSH promotes a condition favoring NEXT RNA decay activity.

40 We found that nonsense-mediated messenger RNA decay acts on this element in a conformation-specifi

41 yed an important role in the analysis of HCV RNA decay after the initiation of antiviral therapy.

42 at Rrp47 and Mpp6 stimulate exosome-mediated RNA decay, albeit with unique dependencies on elements w

43 Genome-wide RNA decay analysis revealed that stable mRNAs are enrich

44 quence on the RUBY transcript triggers No-Go RNA Decay and cleavage of the RUBY mRNA.

45 fy human immunodeficiency virus (HIV) type 1 RNA decay and dolutegravir (DTG) concentrations in the s

46 ein Pir1, to control gene expression through RNA decay and facultative heterochromatin assembly.

47 e are in turn associated with alterations in RNA decay and global transcript abundance profiles that

48 RNase L executes regulated RNA decay and halts global translation.

49 il is a rate-limiting step that precedes the RNA decay and is primarily mediated by the CARBON CATABO

50 This method has great potential in RNA decay and metabolic regulation studies via individua

51 Thus, nuclear RNA decay and nuclear-cytosolic RNA sorting actively pro

52 ible mechanism for the dynamic regulation of RNA decay and processing by inhibitory RNase binding pro

53 Arc synthesis, whereas translation-dependent RNA decay and proteasomal degradation strictly limit the

54 effector protein for small-molecule-directed RNA decay and provide a general URID framework for disco

55 that contributes to cytoplasmic and nuclear RNA decay and quality control.

56 decay and the crosstalk that occurs between RNA decay and ribosome rescue.

57 of the principal enzymes mediating messenger RNA decay and RNA processing-RNase E, an endoribonucleas

58 hlight the intersecting pathways involved in RNA decay and the crosstalk that occurs between RNA deca

59 g hub" (HUSH) complexes, involved in nuclear RNA decay and the epigenetic silencing of TEs, respectiv

60 and mRNA quality control, including exosomal RNA decay and transcript retention triggered by defectiv

61 The rates of RNA decay and transcription determine the steady-state l

62 ul for elucidating the factors that regulate RNA decay and transcriptional elongation in vivo.

63 ite its well-known roles in rRNA processing, RNA decay, and cleavage of sRNA-mRNA duplexes.

64 However, it remains unknown how widespread RNA decay, and consequent changes in the translatome, pr

65 ases with essential roles in RNA maturation, RNA decay, and gene silencing.

66 us (HBV) replication through promoting viral RNA decay, and the ZAP-responsive element (ZRE) of HBV p

67 Both transcription and RNA decay are critical for normal gene regulation.

68 brain disorders, suggesting that defects in RNA decay are linked to impaired neural development.

69 Our findings reveal RNA decay as a key component of RNA metabolism upon cell

70 Our study reveals m(6)A-dependent RNA decay as a previously unidentified maternally driven

71 ted RNase J1 in the initiation of trp leader RNA decay as well as in the subsequent steps leading to

72 of the Aptima assay in the detection of HIV RNA decayed as background uninfected PBMC counts increas

73 Finally, in vitro RNA decay assay demonstrates that CUGBP2 is functionally

74 In contrast, RNA decay assays demonstrated that there was no signific

75 RNA decay assays indicate that poorly structured 3' UTRs

76 In vivo RNA decay assays suggest that active forms of this prote

77 In RNA decay assays, ARE(bcl-2) transcripts were protected

78 Using RNA immunoprecipitation and RNA decay assays, we demonstrate that ZAP directly and s

79 asmic HuR levels inhibits c-fos ARE-mediated RNA decay but has little effect on rapid decay directed

80 transcription involves impaired splicing and RNA decay, but occurs in the absence of chromatin remode

81 Hfq also plays a key role in bacterial RNA decay by binding tightly to polyadenylate [poly(A)]

82 l transcripts to a monophosphate can trigger RNA decay by exposing the transcript to attack by 5'-mon

83 A-like ER kinase or membrane-bound messenger RNA decay by inositol-requiring enzyme 1.

84 antiviral IFN responses and monitor nuclear RNA decay by sensing cytosolic escape of IIIRs.

85 r4 is a eukaryotic RNA helicase required for RNA decay by the nuclear exosome.

86 f mammalian cells and triggers intracellular RNA decay by the pseudokinase and endoribonuclease RNase

87 tes is mediated in part through catalysis of RNA decay by the, interferon-regulated 2-5A system.

88 urprisingly, Upf1 recruitment and subsequent RNA decay can be antagonized by retroviral RNA elements

89 been challenged by the recent discovery that RNA decay can be triggered by a prior non-nucleolytic ev

90 The human ARD-1 (activator of RNA decay) cDNA sequence can rescue mutations in the Esc

91 RNA decay characteristics of the B. subtilis pnpA mutant

92 How RNA decay contributes to brain development is largely un

93 tin remodelling, transcription, splicing and RNA decay control, enhancer function, and epigenetic reg

94 al RNase J1 cleavage site resulted in faster RNA decay, depending on its location.

95 a large multisubunit complex that initiates RNA decay during critical nuclear transactions including

96 Understanding the control of RNA decay during development has been somewhat neglected

97 Analysis of HIV-1 RNA decay dynamics during the initiation of highly activ

98 nisms, including nonsense-mediated messenger RNA decay, endoplasmic reticulum-associated protein degr

99 rains lacking the RNA helicase, DBP2, or the RNA decay enzyme, XRN1, we find that the GAL lncRNAs spe

100 expression machinery by triggering a massive RNA decay event via a virally encoded endoribonuclease,

101 Rather, RNA decay experiments showed that SRSF2 is required to m

102 ity was not affected by RA, as determined by RNA decay experiments.

103 ynthetic lethal with deletion of the nuclear RNA decay factor, RRP6, pointing to a global role for Db

104 diversity of new mechanisms by which nuclear RNA decay factors finely tune the expression of protein-

105 and DNA breaks, and show that RNA export and RNA decay factors work collaboratively to maintain genom

106 and enhancer of mRNA decapping 3 (EDC3) (two RNA decay factors), phosphorylated adaptor for RNA expor

107 m responsible for the recruitment of several RNA decay factors.

108 Completed HIV RNA decayed faster than initiated or 5'-elongated HIV RN

109 UPF1 ATPase mutants accumulate 3' RNA decay fragments harbouring a ribosome stalled during

110 Accumulation of 3' RNA decay fragments is determined by both RNA sequence d

111 hinery and terminating ribosomes based on 3' RNA decay fragments that accrue in UPF1 ATPase mutants.

112 dings show that PPR10 serves as a barrier to RNA decay from either the 5' or 3' direction and that a

113 w, neuronal role for UPF1, distinct from its RNA decay functions, in regulating transport and/or tran

114 d quantify the effect of RNase E scarcity on RNA decay, gene regulation and cell growth.

115 This process of nonsense-mediated RNA decay has been most comprehensively studied in the y

116 oth of which are required for STAU1-mediated RNA decay, however, did not have differentiation effects

117 luence mRNA stability, leading to subgenomic RNA decay imbalance.

118 l prevalence and features of cotranslational RNA decay in a plant transcriptome.

119 Messenger RNA decay in Bacillus subtilis is accomplished by a comb

120 Comparable HIV-1 RNA decay in BP, SP, and RF was observed between DTG + 3

121 at the specific ENE structure inhibits rapid RNA decay in cis by engaging in a limited set of base-pa

122 ul approach to single-molecule assessment of RNA decay in living cells by exploiting the ability of f

123 differentiation and reveal the importance of RNA decay in maintaining pluripotency.

124 RNA molecules (2-5A) that activate regulated RNA decay in mammalian tissues.

125 their ability to induce rapid and widespread RNA decay in order to gain access to host resources.

126 Measurement of LmGT2 RNA decay in promastigotes and axenic amastigotes treate

127 bout mechanisms of quality control and small RNA decay in RNA interference (RNAi) pathways.

128 nitude of human immunodeficiency virus (HIV) RNA decay in semen.

129 The exoribonuclease Rrp6p is critical for RNA decay in the nucleus.

130 eir presence is predictive of the pattern of RNA decay in vivo during heat shock.

131 both 5'-->3' and 3'-->5' exoribonucleolytic RNA decay in vivo, to study the degradation pathway of p

132 They also suggest a model of "programmed" RNA decay in which endonucleolytically generated RNA fra

133 A sequencing in mutants defective in nuclear RNA decay including the exosome to reassess the existenc

134 and nonadditive effects on the rate of viral RNA decay, indicating that miR-122 protects HCV RNA from

135 at lowering RNase Y concentration may affect RNA decay indirectly via an effect on RNase J1, which is

136 distribution measurements demonstrate rapid RNA decay inside P-bodies, which is further supported by

137 technique was developed and used to analyze RNA decay intermediates.

138 RNA decay is a crucial mechanism for regulating gene exp

139 Messenger RNA decay is an essential step in gene expression to set

140 rmal conditions, we show that stress-induced RNA decay is dependent on XRN1 but does not depend on de

141 The polyadenylation- and exosome-mediated RNA decay is involved in the degradation of plant RNAs i

142 As, we show that the mechanism of trp leader RNA decay is not dependent on TRAP binding.

143 The role of miR16 in ARE-RNA decay is sequence-specific and requires the ARE bind

144 RNA decay is vital for regulating mRNA abundance and gen

145 mutant plants indicates that cotranslational RNA decay is XRN4 dependent.

146 all peptide release during nonsense-mediated RNA decay, is critical for assembly of stalled polysomes

147 This study reveals compartmentalized RNA decay kinetics, establishing RIDR as a pivotal tool

148 tigate the degradosome's proposed role as an RNA decay machine, we used DNA microarrays to globally a

149 ted mRNA decay (NMD) by engaging with mRNAs, RNA decay machinery and the terminating ribosome.

150 protects from and exploits the host nuclear RNA decay machinery for proper expression of its genes.

151 ot only serves as a scaffold for the central RNA decay machinery in gram-negative bacteria but also m

152 cerebral cortex and demonstrate that intact RNA decay machinery is essential for corticogenesis in v

153 f mRNA, we investigated whether the 5' to 3' RNA decay machinery participated in the regulation of th

154 Eukaryotic cells have a powerful RNA decay machinery that plays an important and diverse

155 Viral RNAs must successfully evade this host RNA decay machinery to establish a productive infection.

156 via physical interaction and recruitment of RNA decay machinery to the AU-rich elements within the 3

157 ruses to both engage and escape the cellular RNA decay machinery underscores the influence these path

158 exoribonuclease component of the cytoplasmic RNA decay machinery.

159 omplex, a major component of the cytoplasmic RNA decay machinery.

160 by RNA-sequencing, RNA immunoprecipitation, RNA decay measurement, and proximity ligation assays, fu

161 Messenger RNA decay measurements are typically performed on a popu

162 A decay (NMD) is an evolutionarily conserved RNA decay mechanism that has emerged as a potent cell-in

163 Here, we show that RNA decay mechanisms involving upstream frameshift 1 (UP

164 Messenger RNA decay mediated by the c-fos major protein coding-reg

165 overexpression of HuD dramatically inhibits RNA decay mediated by the full-length MYCN 3'-untranslat

166 We combined nonsense-mediated RNA decay microarrays and array-based comparative genomi

167 Unlike typical RNA decay models in normal conditions, we show that stre

168 megakaryocytes, and demonstrate that linear RNAs decay more rapidly than circRNAs in platelet prepar

169 Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA

170 Nonsense-mediated RNA decay (NMD) is a highly conserved and selective RNA

171 Nonsense-mediated RNA decay (NMD) is a highly conserved RNA turnover pathw

172 Nonsense-mediated RNA decay (NMD) is a highly conserved RNA turnover pathw

173 Nonsense-mediated RNA decay (NMD) is a highly conserved RNA turnover pathw

174 While nonsense-mediated RNA decay (NMD) is an established mechanism to rapidly d

175 Nonsense-mediated RNA decay (NMD) is an RNA control mechanism that has als

176 e have recently shown that nonsense-mediated RNA decay (NMD) is inhibited by cellular stresses genera

177 Nonsense-mediated messenger RNA decay (NMD) is triggered by premature translation te

178 3B-dependent branch of the nonsense-mediated RNA decay (NMD) pathway is critical for human cognition.

179 ly conserved and selective nonsense-mediated RNA decay (NMD) pathway remain murky.

180 essential component of the nonsense-mediated RNA decay (NMD) pathway, in 13 of 15 pulmonary IMT sampl

181 UPF3B--is critical for the nonsense-mediated RNA decay (NMD) pathway, while its autosomal counterpart

182 the core component of the nonsense-mediated RNA decay (NMD) pathway.

183 One hypothesis holds that nonsense-mediated RNA decay (NMD) protects the organism by preventing the

184 Nonsense-mediated RNA decay (NMD) rapidly degrades both mutated mRNAs and

185 recently demonstrated that nonsense-mediated RNA decay (NMD), a mechanism that rapidly degrades selec

186 istent DNA damage inhibits nonsense-mediated RNA decay (NMD), an RNA surveillance and gene-regulatory

187 ls by inhibiting nonsense-mediated messenger RNA decay (NMD).

188 se' RNA messages is termed nonsense-mediated RNA decay (NMD).

189 radation of their mRNAs by nonsense-mediated RNA decay (NMD).

190 Moreover, although pulse-labeled RNA decays normally in orn mutant cells under nonpermiss

191 We also tested the involvement in trp leader RNA decay of the more recently discovered endonuclease R

192 low FAS expression due to nonsense-mediated RNA decay or protein instability, resulting in defective

193 aintain Chl homeostasis through processes of RNA decay or translation.

194 domains that mediate conditional expression, RNA decay, or cap-independent initiation.

195 e SMG6 endonuclease of the nonsense-mediated RNA decay pathway are key regulators that control which

196 L gene functions in the interferon-inducible RNA decay pathway known as the 2-5A system.

197 ase L functions in the interferon-inducible, RNA decay pathway known as the 2-5A system.

198 nse-mediated mRNA decay (NMD) is a conserved RNA decay pathway that degrades aberrant mRNAs and direc

199 RNase-L is the terminal component of an RNA decay pathway that is an important mediator of IFN-i

200 In this work we report on a Dbr1p-dependent RNA decay pathway that limits the accumulation of splice

201 Here, we characterize a genome-wide RNA decay pathway that reduces the half-lives of mRNAs b

202 ked oligoadenylates (2-5As) that initiate an RNA decay pathway to impair viral replication.

203 in sorghum by means of the nonsense-mediated RNA decay pathway.

204 This pro-viral role was not associated with RNA decay pathways but instead, we established that PB c

205 Most studies investigate the RNA decay pathways in the cytosol or nucleoplasm but nev

206 posure to at least two host-mediated nuclear RNA decay pathways, the PABPN1- and PAPalpha/gamma-media

207 dation by at least two host-mediated nuclear RNA decay pathways, the PABPN1- and poly(A) polymerase a

208 partly, due to the exhaustion of alternative RNA decay pathways.

209 HIV-1 RNA decay patterns were compared in individuals receivin

210 inding protein LSM1-mediated major satellite RNA decay plays a central role in the preferential incor

211 Messenger RNA decay plays a central role in the regulation and sur

212 merase alpha/gamma (PAPalpha/gamma)-mediated RNA decay (PPD) pathway and an ARS2-dependent decay path

213 ays, the PABPN1- and PAPalpha/gamma-mediated RNA decay (PPD) pathway and an ARS2-mediated decay pathw

214 es may represent a model system for studying RNA decay process in plant tissues.

215 ism that is part of or synergise the classic RNA decay processes to maintain intracellular RNA levels

216 review discusses the role of RNA silencing, RNA decay, PTI, and effector-triggered immunity as antiv

217 at all YTHDFs work redundantly to facilitate RNA decay, raising questions about the exact functions o

218 , human, chick, and zebrafish Bmp2 synthetic RNAs decay rapidly in extracts from cells not expressing

219 , and it is not clear whether the bulk HIV-1 RNA decay rate actually represents a composite of the de

220 The HIV-1 RNA decay rate was assessed using nonlinear mixed-effect

221 In SP, the HIV-RNA decay rate with RPV was as fast as with EVGcobi; by

222 or without romidepsin enhanced plasma HIV-1 RNA decay rates compared to ART only.

223 s that shape the transcriptome by regulating RNA decay rates.

224 s we demonstrate nonsense mediated messenger RNA decay, reduced levels of OPA1 protein, and impairmen

225 the enhanced CLIP-seq (eCLIP) datasets of 37 RNA decay related RBPs in two human cell lines.

226 stricts RVFV replication, and this increased RNA decay results in the loss of visible RNA granules, i

227 lead to translational repression, messenger RNA decay, ribosome rescue, and/or nascent protein degra

228 cing, pre-rRNA processing, RNA transport and RNA decay, scanning is facilitated by helicase activity.

229 It promotes RNA decay, sequestration, or stability, influencing geno

230 that following its escape from KSHV-induced RNA decay, SHFL acts as a potent antiviral factor, restr

231 s and in xrn1(-) yeast defective in decapped RNA decay, showing that increased RNA1 stability was not

232 study establishes 3' oligouridylation as an RNA decay signal for Dis3l2, and identifies the first ph

233 ation of the YTHDF2-mRNA complex to cellular RNA decay sites.

234 Staufen 1 (STAU1)-mediated messenger RNA decay (SMD) involves the degradation of translationa

235 together with recent insights into bacterial RNA decay, suggest a unifying model for the biogenesis o

236 We show that a key nonsense-mediated RNA decay switch exon (NSE) in ATM is repressed by U2AF,

237 Using a cell-free RNA decay system, we demonstrate that the mammalian exos

238 k of UPF1 in MNs and uncovers a link between RNA decay, TDP-43 dysfunction, and ALS neurodegeneration

239 sider another potential role for large-scale RNA decay that has emerged from studies of stress-induce

240 hat cellular stress induces prevalent 5' end RNA decay that is coupled to translation and ribosome oc

241 In addition to initiating RNA decay that is necessary for mitochondrial fitness, Y

242 etween yeast and mammalian nonsense-mediated RNA decay, these data suggest that the two pathways use

243 CD1), CXCR4, and SOX10, leading to increased RNA decay through the m(6)A reader YTHDF2.

244 cts as the typical organization platform for RNA decay (TTP) and RNA preservation (ELAV/HuR) factors

245 ce upstream of the expanded repeats enhances RNA decay via the nuclear reader YTHDC1, and the antisen

246 erved surfaces, and the structural basis for RNA decay, we report the X-ray structure determination f

247 However, small RNAs and 5'-3' RNA decay were not essential for recovery of the transcr

248 These defenses include RNA silencing and RNA decay, which target viral RNA and inhibit virus accu

249 ion levels that involves splicing coupled to RNA decay, which we refer to as spliceosome-mediated dec

250 and Rrp47 each contribute to Mtr4-dependent RNA decay, with maximal Mtr4-dependent decay observed wi

251 nd cellular stress sensing, the mechanism of RNA decay within the nucleolus is not completely underst

252 Multiple pathways of RNA decay work together to establish and maintain hetero