ライフサイエンスコーパス: RNA interference

1 ker honey bees to knock down these genes via RNA interference.

2 d in hNPCs and Drosophila melanogaster using RNA interference.

3 RNA binding and RNA associated proteins with RNA interference.

4 echanisms that have been collectively called RNA interference.

5 ses, whereas Csx28 enhances, Cas13b-mediated RNA interference.

6 via adeno-associated virus (AAV) 9-mediated RNA interference.

7 es were manipulated pharmacologically and by RNA interference.

8 uence- and site-specific manner analogous to RNA interference.

9 infection, these genes were knocked down by RNA interference.

10 ated by receptor knockdown experiments using RNA interference.

11 Sir4-mediated gene silencing and the loss of RNA interference.

12 of MT1A, 1B and 2A expression was induced by RNA interference.

13 lar to eukaryotic RNAPs that are involved in RNA interference(6,7), although most of the phi14:2 RNAP

14 erived from protein and RNA binding studies, RNA-interference, a murine smoking model, and expression

15 Depleting SRSF10 by RNA interference affected viral splicing and, like 1C8,

16 cultured cells using both overexpression and RNA interference along with cell-spreading assays to inv

17 cell death, and silencing of both genes via RNA interference also leads to dwarfism, mild cell death

18 Small interfering RNA and small hairpin RNA interference and adenovirus transfection were adopte

19 Thus we silenced selected CYPs via RNA interference and analyzed the effect on PCB 28-deriv

20 tient samples from 14 different cancers, and RNA interference and CRISPR screens in 290 cancer cell l

21 Previous studies using RNA interference and CRISPR showed that concurrent elimi

22 ene replacement, antisense oligonucleotides, RNA interference and CRISPR-based gene editing.

23 vel but is dispensable for cleavage-mediated RNA interference and for the association of the AGO3 eff

24 We found that fly mutants for RNA interference and immune deficiency (Imd), but not To

25 Honey bee antiviral responses include RNA interference and immune pathway activation, but thei

26 hrough the use of marker-assisted selection, RNA interference and potentially gene editing.

27 oprecipitation, transcriptional silencing by RNA interference and virus-induced gene silencing (VIGS)

28 in the next 1-2 years and virally delivered RNA interference and zinc finger transcriptional repress

29 protein turnover and ubiquitination assays, RNA-interference and gene expression analyses to examine

30 eens using CRISPR-Cas9-mediated knockout and RNA interference, and found that the RecQ DNA helicase W

31 ime PCR, Western blotting, small interfering RNA interference, and kinase inhibitors were used to stu

32 food production, including those involved in RNA interference, and those encoding prolixicin and hexa

33 uch as the use of nonsubstitutive therapy as RNA interference, anti-tissue factor pathway inhibitor,

34 Using genetic and RNA interference approaches, we show that the activity o

35 Antisense oligonucleotides (ASOs) and RNA-interference approaches are emerging as attractive t

36 elegans, RDE-3 adds pUG tails to targets of RNA interference, as well as to transposon RNAs.

37 RNA interference assays showed that suppression of AP2M1

38 research has been demonstrated by conducting RNA interference assays.

39 submitted EGFR-dependent HNSCC cell lines to RNA interference-based functional genomics screens to id

40 This siRNA design may enable RNA interference-based gene silencing in the CNS for the

41 Further analysis demonstrated that the RNA interference-based knockdown of the unconventional m

42 Our RNA interference-based screen identified FBXW7 as a key

43 For example, RNA interference can efficiently knockdown RNAs, but it

44 as largely abolished by targeting PHGDH with RNA interference, CRISPR/Cas9 KO, or small-molecule PHGD

45 the expression of immune effector genes, osa RNA interference decreased the expression of a large gro

46 ges overexpress Cp and its downregulation by RNA interference decreases markers of glomerular proinfl

47 d ROCR (regulator of chondrogenesis RNA), by RNA interference disrupted MSC chondrogenesis, concomita

48 Depletion of cdc-42 by RNA interference does not suppress the premature or elev

49 and invasion in vitro, and GBP2 silencing by RNA interference exhibits opposite effects.

50 Knocking down P10 by RNA interference for males reduced the percentage of DcR

51 BEAS-2B knockdown with RNA interference for MUC4 (small interfering RNA [siRNA]

52 xpressed in testis, enriched for meiosis and RNA interference functions and are frequently targeted b

53 hundreds of endogenous genes, including the RNA-interference genes rde-11 and sid-1.

54 ibition of mitochondrial transport by Milton RNA interference had no influence on anterograde DCV run

55 reducing DHX33 levels through short hairpin RNA interference has the same effect.

56 in which ispdiA3 has been knocked down using RNA interference have decreased spirochete colonization

57 HBV core inhibitors, HBV cccDNA transcripts RNA interference, HBV cell apoptosis inducers, HBV RNA,

58 We validated an RNA interference high throughput assay that successfully

59 Silencing these proteases by RNA interference impairs correct plug processing and slo

60 hat is required for transposon silencing and RNA interference in Caenorhabditis elegans(1-4).

61 ific promoter to decrease NTRC expression by RNA interference in developing tomato fruits by 60% to 8

62 Argonaute (Ago) proteins are key players in RNA interference in eukaryotes, where they function as R

63 Knockdown of AQP1 by RNA interference in HT29 cells significantly impairs Li(

64 tigation of p47 transcription levels through RNA interference in I. scapularis limited Kenny accumula

65 sRNA delivery could increase the efficacy of RNA interference in insect pest species.

66 s not found when S100A12 was knocked down by RNA interference in keratinocytes.

67 e gamma1 subunit of clathrin adaptor AP-1 by RNA interference in MDCK cells disrupted apical localiza

68 139) human C2 domain-containing proteins by RNA interference in neuroendocrine cells.

69 ytokine signaling 3 or either T-bet or STAT1 RNA interference in STAT3 LOF cells partially rescued IL

70 Nanoparticle-mediated RNA interference in the haematopoietic niche could be us

71 Using a Drosophila RNA interference in vitro screen, we identified a set of

72 silencing mRNA expression of the channel by RNA interference, inhibit Alternaria-evoked ATP release.

73 tion of components of the exocyst complex by RNA interference inhibited the formation of Listeria pro

74 1, in insulin-secreting MIN6 beta-cells with RNA interference inhibits SOCE and ATP-sensitive K(+) (K

75 unctional significance, as GLDC depletion by RNA interference inhibits the proliferation and tumorige

76 In response to RNA interference, insect viruses have convergently evolv

77 Methods to introduce RNA interference into adult neurons, in vitro or in vivo

78 lation, such as conditional gene expression, RNA interference, knock-in and knock-out, lack sufficien

79 RNA interference knockdown and mutant clone analyses sho

80 RNA interference knockdown experiments demonstrated the

81 RNA interference knockdown of Arf6 reduced the amount of

82 RNA interference knockdown of MAPK7 reduces proliferatio

83 d adeno-associated virus (AAV)-mediated Ac45 RNA interference knockdown to study the function of Ac45

84 orthogonal methods such as CRISPR knockout, RNA interference knockdown, and small-molecule inhibitor

85 of a putative tomato ORE1 as target gene for RNA interference knockdown.

86 The RNA interference lines and the T-DNA insertional mutant

87 the colonization of CASTOR/POLLUX and CCaMK RNA interference lines by L. bicolor was reduced.

88 Metabolite profiling of NTRC-RNA interference lines revealed increased organic and am

89 floral organs into leaves in the most severe RNA interference lines suggest redundant and additive GR

90 ressing lines, in contrast to those of BBX19 RNA interference lines, display ABA hypersensitivity, al

91 n and development through hijacking the host RNA-interference machinery that involves ARGONAUTE 1.

92 Silencing Hs-Tyr by RNA interference made the treated nematodes less virulen

93 een the suppressor and distorter through the RNA interference mechanism.

94 in a way that is dependent on the canonical RNA interference mechanism.

95 RNA interference -mediated-downregulation of AADC1 in gr

96 statin, induced NEAT1 up-regulation, whereas RNA interference-mediated depletion of NEAT1 exacerbated

97 ciently reduced porphyrin accumulation after RNA interference-mediated downregulation of ALAS2 in hum

98 Results demonstrate that vCA1-targeted RNA interference-mediated GLP-1R knockdown increases mot

99 in myogenesis using the C2C12 cell line with RNA interference-mediated knockdown and CRISPR-Cas-media

100 al associated non-coding RNA (PRANCR), using RNA interference-mediated knockdown and phenotypic analy

101 ng pathways in such inhibitory actions using RNA interference-mediated knockdown assays and monocyte

102 RNA interference-mediated knockdown of endogenous AKAP15

103 asis modulate stem cell behavior in vivo via RNA interference-mediated knockdown of factors involved

104 In human hepatocytes, an RNA interference-mediated knockdown of OR10J5 increased

105 Moreover, RNA interference-mediated knockdown of SOT1 in gray popl

106 RNA interference-mediated Parkin depletion attenuates CD

107 ator of DENV and ZIKV infection and that its RNA interference-mediated silencing inhibits the formati

108 RNA interference-mediated silencing of AgTRIO in A. gamb

109 RNA interference-mediated silencing of pixr, or immunity

110 tion has mostly been studied through gene or RNA interference, more recent approaches to degrade prot

111 ple, mutagenesis, CRISPR-based gene editing, RNA interference, morpholinos or pharmacological inhibit

112 extensively studied in Drosophila, in which RNA interference, NF-kappaB, and JAK-STAT pathways under

113 with small-molecule chemical inhibitors and RNA interference of 5-HT(2)R endocytic machinery, includ

114 Both nanoparticle-mediated RNA interference of endothelial QKI expression and palbo

115 Moreover, the transient overexpression and RNA interference of FaTA are positively associated with

116 netic techniques, we demonstrate that either RNA interference of hsf-1 or use of an hsf-1(sy441) muta

117 Isoflavonoid biosynthesis was silenced via RNA interference of isoflavone synthase in soybean hairy

118 6), upon treatment with a PAK4 inhibitor and RNA interference of PAK4.

119 ain nitrate concentration and yield, whereas RNA interference of TaNRT2.5 has the opposite effects.

120 or chemogenetic) and chronic downregulation (RNA interference) of MCH communication to the vHP increa

121 nematode Caenorhabditis elegans, we applied RNA interference on mutants to inactivate two genes, use

122 In addition, targeting SOX11 directly by RNA interference or indirectly by IL-21 treatment induce

123 acetylase 1 (HDAC1) or HDAC2 was depleted by RNA interference or inhibited by the HDAC inhibitor vori

124 ation since knocking down GBF1 expression by RNA interference or inhibiting its activity by treatment

125 RNA interference or mutation of MtRRB3, the RRB-encoding

126 Blocking this interaction by RNA interference or selective inhibitors reduced SARS-Co

127 Downregulation of p38 MAPK activity via RNA interference or small molecule inhibitor led to cell

128 an be inhibited by targeting HIF-1alpha with RNA interference or the small-molecule inhibitor YC-1.

129 vels and further inhibited PU.1 using either RNA interference or, to our knowledge, first-in-class sm

130 adult mice through PHD2 enzyme silencing by RNA interference, or inducible recombination of floxed a

131 Using RNA interference, Ov-tsp-2 and tsp-3 mRNA expression was

132 n primordial germ cells loses competence for RNA-interference over several generations and accumulate

133 regions are processed into small RNAs by the RNA interference pathway, and are subject to silencing t

134 protein modifications and turnover; and the RNA interference pathway, which recognizes and degrades

135 nal silencing and degradation as part of the RNA interference pathway.

136 inhibited in myeloid cells by harnessing the RNA interference pathway.

137 scripts that are processed by the endogenous RNA-interference pathway into mature miRNA molecules, wh

138 uctural similarity, we propose that eukaryal RNA interference polymerases have their origins in phage

139 Using small molecules, RNA interference reagents, and mutant forms of MDMX, we

140 knockdown in human coronary artery VSMCs by RNA interference reduced lipid accumulation and increase

141 1.A3 and BnROD1.C3 in a double mutant, or by RNA interference, reduced the PUFA content of the oil to

142 MicroRNA (miRNA)-mediated RNA interference regulates many immune processes, but ho

143 RNA interference represents a potent intervention for ca

144 RNA interference repression of AcMYB123, AcbHLH42, AcF3G

145 down-regulation of P311 levels by lentiviral RNA interference reproduced the deficits seen in P311(-/

146 induction time and that knockdown of MT with RNA interference resulted in a loss of bioactivity.

147 -A1 or reduction in its transcript levels by RNA interference resulted in chlorosis and reduced Pst s

148 Dmrt1 knockdown in ZZ embryos by RNA interference resulted in male to female sex reversal

149 ich RNA sequencing, immunoblot analysis, and RNA interference revealed to be dependent on p21(WAF1/Ci

150 Importantly, isoform-specific RNA-interference revealed that HDAC isoforms regulate di

151 Germline expression of RNA-Interference (RNA-i) constructs against G-proteins,

152 Enoxacin is a small molecule that stimulates RNA interference (RNAi) and acts as a growth inhibitor s

153 ur protocol offers a flexible choice between RNA interference (RNAi) and CRISPR-Cas9 genome editing f

154 cesses known to control RNA viruses, such as RNA interference (RNAi) and Imd pathways.

155 neration in two different neuron types using RNA interference (RNAi) and mutants.

156 The RNA interference (RNAi) and PIWI-interacting RNA (piRNA)

157 iscuss the implications of recurrent loss of RNA interference (RNAi) and/or heterochromatin component

158 Therefore, an RNA interference (RNAi) approach was adopted to reduce t

159 pen (Populus tremula x tremuloides) using an RNA interference (RNAi) approach.

160 w generation of insect control methods using RNA interference (RNAi) are being developed.

161 rda Using a viral complementation system and RNA interference (RNAi) assays, we found that ESCRT-I an

162 onaute (AGO) proteins are core components of RNA interference (RNAi) but the mechanisms of their regu

163 The initiation of RNA interference (RNAi) by topically applied small inter

164 Previously, we have shown that RNA interference (RNAi) can prevent aflatoxin accumulati

165 We transformed two RNA interference (RNAi) constructs, PTG and its matrix-a

166 RNA interference (RNAi) enables flexible and dynamic int

167 ed RNA (dsRNA)] together with the endogenous RNA interference (RNAi) factor ERI-6/7, a homolog of MOV

168 Gene silencing by RNA interference (RNAi) has emerged as a powerful treatm

169 um, Snodgrassella alvi, to induce eukaryotic RNA interference (RNAi) immune responses.

170 represent potential targets for therapeutic RNA interference (RNAi) in both early and late presentat

171 An example is antiviral RNA interference (RNAi) in insects: the host RNAi machin

172 While the use of RNA interference (RNAi) in molecular biology and functio

173 RNA interference (RNAi) in transgenic maize has recently

174 RNA interference (RNAi) is a conserved eukaryotic mechan

175 RNA interference (RNAi) is a gene-silencing pathway that

176 RNA interference (RNAi) is a highly specific gene-silenc

177 RNA interference (RNAi) is a natural process through whi

178 RNA interference (RNAi) is a valuable reverse genetics t

179 RNA interference (RNAi) is a valuable technique to deter

180 RNA interference (RNAi) is an antiviral pathway common t

181 RNA interference (RNAi) is an effective way of combating

182 Because RNA interference (RNAi) is increasingly explored for com

183 RNA interference (RNAi) is known for its high catalytic

184 In arthropods, RNA interference (RNAi) is responsible for antiviral def

185 Paradoxically, CD44 knockdown by RNA interference (RNAi) led to increased alpha-SMA expre

186 ypes of two SUFB mutants, laf6 and hmc1, and RNA interference (RNAi) lines with reduced SUFB expressi

187 nt RNAs are differentially recognized by the RNA interference (RNAi) machinery.

188 RNA interference (RNAi) of SE51385 prevented down-regula

189 m that regulates the core steps of antiviral RNA interference (RNAi) pathway in plants and animals.

190 s previously been characterized in Entamoeba RNA interference (RNAi) pathway proteins, including Argo

191 The RNA interference (RNAi) pathway regulates mRNA stability

192 NA (piRNA) function and the germline nuclear RNA interference (RNAi) pathway, as well as MET-2 and SE

193 Inactivation of the RNA interference (RNAi) pathway, which suppresses TE mov

194 l noncoding RNAs (sRNAs) associated with the RNA interference (RNAi) pathway.

195 al models of the biological mechanism of the RNA interference (RNAi) pathway.

196 viral immunity in insects is mediated by the RNA interference (RNAi) pathway.

197 Nuclear RNA interference (RNAi) pathways work together with hist

198 YAB5 resulted in similar phenotypes as CsIVP-RNA interference (RNAi) plants, including disturbed vasc

199 In plants, RNA interference (RNAi) plays a pivotal role in growth a

200 The RNA interference (RNAi) process encompasses the cellular

201 en in nematodes defective in their antiviral RNA interference (RNAi) response, and is neither lethal

202 In Caenorhabditis elegans, RNA interference (RNAi) responses can transmit across ge

203 Depleting these factors from cells using RNA interference (RNAi) results in myosin II-dependent u

204 Inhibition of TTBK paralogues by RNA interference (RNAi) revealed a specific requirement

205 ity of STING was identified in a genome-wide RNA interference (RNAi) screen and confirmed in primary

206 From an RNA interference (RNAi) screen for regulators of intesti

207 Here, we describe a large-scale RNA interference (RNAi) screen in adult Schistosoma mans

208 Systematic RNA interference (RNAi) screening of 40 mosquito-specifi

209 We adapted pooled RNA interference (RNAi) screening technology for use in

210 s of this pathway, we performed whole-genome RNA interference (RNAi) screens in physiologically relev

211 paced short palindromic repeats (CRISPR) and RNA interference (RNAi) screens, and these have provided

212 ransgenic Arabidopsis (Arabidopsis thaliana) RNA interference (RNAi) seeds with lower transcript expr

213 Plant-mediated RNA interference (RNAi) shows great potential in crop pr

214 RNA interference (RNAi) targeted to the SmedTV sequence

215 at meg-3/4 mutant animals exhibit defects in RNA interference (RNAi) that are transgenerationally dis

216 Inclisiran (ALN-PCSsc) is a long-acting RNA interference (RNAi) therapeutic agent that inhibits

217 Fitusiran, an investigational RNA interference (RNAi) therapy that targets antithrombi

218 In this study we investigate the use of RNA interference (RNAi) to control two dipteran pests, M

219 The application of RNA interference (RNAi) to mammalian cells has provided

220 Using RNA interference (RNAi) to suppress isoprene emission, w

221 on during dendrite regeneration, postmitotic RNA interference (RNAi) was performed and dendrites or a

222 RNA interference (RNAi), a cellular process through whic

223 Plant and invertebrate cells utilise mostly RNA interference (RNAi), an RNA-based mechanism, for cel

224 tor DRH-1 promotes defense through antiviral RNA interference (RNAi), but less is known about its rol

225 ugh biotechnological alternatives, including RNA interference (RNAi), have been proposed in recent ye

226 ads to the mortality of WCR larvae by DvSSJ1 RNA interference (RNAi), we characterized transgenic pla

227 dings into preclinical applications using an RNA interference (RNAi)-based approach.

228 RNA interference (RNAi)-based gene regulation platforms

229 Large-scale RNA interference (RNAi)-based screens have identified ne

230 The RNA interference (RNAi)-based therapeutic ARC-520 for ch

231 Nucleation proceeded normally at the RNA interference (RNAi)-dependent element cenH but subse

232 The RNA interference (RNAi)-induced transcriptional silencin

233 We demonstrate that RNA interference (RNAi)-mediated AeAmt1 protein knockdow

234 RNA interference (RNAi)-mediated downregulation of SlLHP

235 RNA interference (RNAi)-mediated gene silencing revealed

236 oval of the first siRNA-derived therapeutic, RNA interference (RNAi)-mediated gene therapy is undergo

237 e of this rapid transcriptional change using RNA interference (RNAi)-mediated knock-down of genes bel

238 To explore the potential of utilizing RNA interference (RNAi)-mediated resistance against shea

239 are negatively affected by dicer-2-mediated RNA interference (RNAi).

240 e when beta(2)-m expression was inhibited by RNA interference (RNAi).

241 pest insects by a cellular mechanism called RNA interference (RNAi).

242 non-coding regulatory molecules that induce RNA interference (RNAi).

243 evade host defenses, specifically antiviral RNA interference (RNAi).

244 ed specific virulence proteins that suppress RNA interference (RNAi).

245 an attractive alternative option to mediate RNA interference (RNAi).

246 ants help to protect and modify them through RNA interference (RNAi).

247 ssed the effects of 15 candidate genes using RNA interference (RNAi): all affected life span and/or m

248 We performed an unbiased RNA interference screen and identified PAC (TMEM206) as

249 Here, we performed an RNA interference screen for cell surface molecules and i

250 Here we use an RNA interference screen in the cec-4 background and iden

251 W 264.7 macrophages and performed a targeted RNA interference screen of genes encoding chromatin-modi

252 An RNA interference screen of genes for anterior-posterior

253 In this study, we conducted an RNA interference screen of the Caenorhabditis elegans nu

254 An in vivo RNA interference screen of translational regulators reve

255 Furthermore, an RNA interference screen revealed functional roles for se

256 An RNA interference screen using APP-CTF [99-residue CTF (C

257 myosin II (NMII) we performed an image-based RNA interference screen using stable Drosophila melanoga

258 Next, using an RNA interference screen, fluorescence correlation spectr

259 With an RNA interference screen, we found that the E3 ubiquitin

260 Using a focused RNA interference screen, we identified 22 host genes tha

261 Here, using an RNA interference screen, we identify cytohesin 1 (CYTH1)

262 Using a whole-genome RNA interference screen, we uncovered 26 novel regulator

263 We performed an open, unbiased RNA-interference screen of mammalian chemokines in co-cu

264 High-content image analysis coupled to RNA interference screening offers opportunities to explo

265 RNA interference screening revealed 26 genes that both i

266 terogeneity, we performed genome-wide pooled RNA interference screens and identified genes conferring

267 cells, we previously conducted genome-scale RNA interference screens to identify candidate host fact

268 Using computational and pooled in vivo RNA interference screens, we identify the transcription

269 Rh50 inactivation by RNA interference selectively in muscle cells caused musc

270 MEK5 knockdown by RNA interference sensitizes prostate cancer cells to ion

271 inhibition by a pharmacological inhibitor or RNA interference significantly reduced the autophagic re

272 Overexpression and RNA interference silencing of GmMYB29A2 increased and de

273 to bridge this gap in knowledge by combining RNA interference specific for LRRC8A with patch-clamp an

274 Initial RNA-interference studies in rats suggested a role in neu

275 RNA interference suppression of Ma1 expression in 'McInt

276 RNA interference suppression of NaSIPP in Nicotiana spp.

277 ), CENP-C(Mif2), and Aurora B(Ipl1) When the RNA interference system was introduced to knock down all

278 nthases, adenosine deaminases acting on RNA, RNA interference systems, and other proteins containing

279 In particular, RNA interference targeting either both of the CPP syntha

280 egies include antisense oligonucleotides and RNA interference targeting mRNA, and zinc finger transcr

281 By using RNA interference technique, we found that ZxAKT1-silence

282 ighting CCD by targeting the IAPV-IRES using RNA-interference technology are underway, and the struct

283 Givosiran is an investigational RNA interference therapeutic agent that inhibits hepatic

284 e mechanism of lumasiran, an investigational RNA interference therapeutic for primary hyperoxaluria t

285 cy of long-term treatment with patisiran, an RNA interference therapeutic that inhibits TTR productio

286 BM siRNA therapy, which may have utility for RNA interference therapy of other tumors or brain diseas

287 When Alix was silenced by RNA interference, TnBVANK1 was no longer able to cause a

288 We used RNA interference to examine the effects of AURKA overexp

289 the SEC2 system in plants, we used inducible RNA interference to knock down SCY2 in Arabidopsis.

290 We used virally mediated RNA interference to locally downregulate SERT expression

291 Using RNA interference to partially deplete KIFC1 from rat neu

292 Here, we employed RNA interference to silence the CAM isogene PPC1 in Kala

293 b server, the plant-specific small noncoding RNA interference tool pssRNAit, which can be used to des

294 rage products was only moderately changed in RNA interference transgenics.

295 A non-transgenic approach based on RNA interference was employed to induce protection again

296 RNA interference was performed to block BCL11B.

297 Using transcriptomic analyses and RNA interference, we characterize and functionally valid

298 Here, using genome editing and RNA interference, we examine transcription factor intera

299 e, using loss-of-function screening based on RNA interference, we show that environmental oxygen leve

300 eals similarities between Csm and eukaryotic RNA interference, which also uses RNA-guided RNA targeti