ライフサイエンスコーパス: RNA splicing

1 e with the ability to activate pre-messenger RNA splicing.

2 ene expression, chromatin accessibility, and RNA splicing.

3 chromatin remodeler could indirectly affect RNA splicing.

4 vesicular trafficking, DNA damage repair and RNA splicing.

5 reviously implicated in the control of HIV-1 RNA splicing.

6 ydroxyvitamin D (1,25(OH)2D) with subsequent RNA splicing.

7 etain function due to their direct impact on RNA splicing.

8 w role for this central kinase in regulating RNA splicing.

9 B cell receptors (BCRs) through alternative RNA splicing.

10 ived from this individual show altered UPF3B RNA splicing.

11 while not impairing full-length SON-mediated RNA splicing.

12 proteins involved in nucleotide binding and RNA splicing.

13 abundance of several proteins that regulate RNA splicing.

14 ticipated in rapalog-induced deregulation of RNA splicing.

15 ld maintain function through their impact on RNA splicing.

16 cripts resulting from erroneous SON-mediated RNA splicing.

17 nELAVL target binding, and altered neuronal RNA splicing.

18 nition factor U2AF1 alter its normal role in RNA splicing.

19 liceosome before the first catalytic step of RNA splicing.

20 d, and many disease-causing mutations affect RNA splicing.

21 nd-to-last nucleotide of exon 2 and possibly RNA splicing.

22 omplex genes, via aberrant transcription and RNA splicing.

23 ir C termini as a consequence of alternative RNA splicing.

24 of RNA metabolism that control premessenger RNA splicing.

25 l role in RNA metabolism by facilitating pre-RNA splicing.

26 tophagy, global transcriptional control, and RNA splicing.

27 trimethylation, nucleosome positioning, and RNA splicing.

28 hibiting T cell activation and by modulating RNA splicing.

29 failure, presumably through altering cardiac RNA splicing.

30 icases, we examined cancer-specific roles in RNA splicing.

31 ylation at splice acceptor sites may inhibit RNA splicing.

32 o humans that are reported to have a role in RNA splicing.

33 ns are orthologues of proteins implicated in RNA splicing.

34 ed to regulate gene expression by modulating RNA splicing.

35 support the potential link between HDACs and RNA splicing.

36 nt both SRSF3 degradation and alterations in RNA splicing.

37 ugh coordinated effects on the epigenome and RNA splicing.

38 the complex and tightly regulated process of RNA splicing.

39 in the same RNA sequence when joined through RNA splicing.

40 expression cassette to prevent its loss from RNA splicing.

41 , introns are removed through the process of RNA splicing.

42 AR-FL and AR-V proteins without altering AR RNA splicing.

43 -requiring enzyme 1alpha-dependent messenger RNA splicing (activation) of X-box-binding protein-1 (XB

44 n human disease and defects in pre-messenger RNA splicing/alternative splicing are accumulating.

45 ct failed to splice reporter RNA in in vitro RNA splicing analyses.

46 intronic and 3' UTR binding regulates human RNA splicing and abundance.

47 d leukemia (AML) and crucial for maintaining RNA splicing and AML survival.

48 -mutant tumours have significantly disrupted RNA splicing and an excess of 5' cryptic splicing events

49 s (RTs) function in both intron mobility and RNA splicing and are evolutionary predecessors of retrot

50 are predicted to influence gene expression, RNA splicing and cell proliferation.

51 Integrative analyses of RNA splicing and chromatin occupancy, combined with chro

52 rylation sites involved in transcription and RNA splicing and decreased abundance of enzymes in lipid

53 f histone/protein modifications and HDACs in RNA splicing and discuss the convergence of two parallel

54 rewiring of the transcriptome that involved RNA splicing and enriched for targets of RNA binding pro

55 ovel pathways in MDS pathogenesis, including RNA splicing and epigenetic regulation of gene expressio

56 e data identify a specific role for ZRSR2 in RNA splicing and highlight dysregulated splicing of U12-

57 While the association between RNA splicing and histone modifications is beginning to b

58 s and reduced synaptic signaling and between RNA splicing and increased oligodendrocyte development a

59 criptase, which function together to promote RNA splicing and intron mobility via reverse splicing of

60 role in the regulation of malarial parasite RNA splicing and is essential for the survival of blood

61 ermined that RBFox1 is a potent regulator of RNA splicing and is required for a conserved splicing pr

62 itination at damaged DNA, but also regulates RNA splicing and mitotic spindle formation in its integr

63 as cellular maintenance pathways, including RNA splicing and nuclear-cytoplasmic transport have been

64 These tumor-specific mutations alter UPF1 RNA splicing and perturb NMD, leading to upregulated lev

65 ysis discovered disruptions in mitochondria, RNA splicing and phosphoprotein gene pathways.

66 lions of protein variants due to alternative RNA splicing and post-translational modifications, and v

67 These mutations induce defects in RNA splicing and represent a new class of mutations in m

68 in a variety of cellular processes including RNA splicing and resistance to agents that cause DNA int

69 large, autocatalytic ribozymes that catalyze RNA splicing and retrotransposition.

70 The chloroplast RNA splicing and ribosome maturation (CRM) domain is a R

71 An analysis of RNA splicing and RNA editing of selected RNA species dem

72 f a deep connection between the mechanism of RNA splicing and small-RNA-mediated gene silencing, the

73 ved in other functions such as modulation of RNA splicing and specific regulation of gene expression,

74 RNA splicing and spliceosome assembly in eukaryotes occu

75 complexes that are crucial to pre-messenger RNA splicing and telomere maintenance, respectively.

76 Genetic variants regulating RNA splicing and transcript usage have been implicated i

77 of IMP1, which corrects the defects in IGF2 RNA splicing and translation.

78 insights into cell type-specific control of RNA splicing and underscores the importance of consideri

79 ng causes of aberrant HDACs and dysregulated RNA splicing and, thus, further support the potential li

80 r with its pre-mRNA and regulate alternative RNA splicing and/or A-to-I RNA editing.

81 ively, these studies reveal ZMAT3 as a novel RNA-splicing and homeostasis regulator and a key compone

82 utionalized' for non-conflict roles, e.g. in RNA-splicing and in RNAi systems (e.g. in kinetoplastids

83 Three variants were not predicted to alter RNA splicing, and 13 essential splice dinucleotide, nons

84 DNA replication and repair to transcription, RNA splicing, and metabolism.

85 sequencing confirmed the effect of hDBR1 on RNA splicing, and metabolite profiling supported the obs

86 at multiple levels, including transcription, RNA splicing, and mRNA stability.

87 imate link across telomere biology, aberrant RNA splicing, and myeloid progenitor differentiation.

88 d minor spliceosome, the factors controlling RNA splicing, and the role of alternative splicing in ca

89 enhance our understanding of transcription, RNA splicing, and translation.

90 roteins resulting in disruption of messenger RNA splicing; and (ii) licensing of expanded C9orf72 pre

91 ifferent components of the initiation or the RNA-splicing apparatus(5,6).

92 Alterations in RNA splicing are associated with cancer, but it is not c

93 t the regulations of cellular mRNA decay and RNA splicing are compromised by Zika virus infection as

94 ions, genomic rearrangements, and defects in RNA splicing are included among the most sensitive acces

95 al process of gene regulation, and errors in RNA splicing are known to be associated with a variety o

96 how such somatic non-coding mutations affect RNA splicing are largely unexplored.

97 The double mutant knocks out the RNA-splicing arm of the UPR signaling pathway.

98 Misregulated alternative RNA splicing (AS) contributes to the tumorigenesis and p

99 Alternative RNA splicing (AS) regulates proteome diversity, includin

100 oding RNA binding proteins, particularly the RNA splicing-associated SR genes.

101 to downregulate gene expression or to modify RNA splicing, but antisense technology has not previousl

102 ols (odds ratio 1.26-1.9); it did not affect RNA splicing, but it was in strong linkage disequilibriu

103 at inhibition of transcription initiation or RNA splicing, but not translation, leads to spindle defe

104 RNA and influences both gene expression and RNA splicing, but these actions do not appear to be link

105 provide new insights into the regulation of RNA splicing by Akt isoforms through phosphorylation of

106 also establish a role for Myc in regulating RNA splicing by controlling the incorporation of nonsens

107 ogether, this study identifies regulation of RNA splicing by RBFox1 as an important player in transcr

108 The effect of the c.5461-10T-->C variant on RNA splicing by reverse-transcription polymerase chain r

109 Dysregulation of RNA splicing by spliceosome mutations or in cancer genes

110 d trigger an alteration of exon usage during RNA splicing, causing the enamel malformations.

111 anscriptional regulation, DNA damage repair, RNA splicing, cell differentiation, and metastasis.

112 l program and activating genes essential for RNA splicing, cell migration, controlled cellular prolif

113 nt lessons learned in this emerging field of RNA splicing chemistry and chemical biology.

114 MCPs of RPL13, a ribosomal gene and SON, an RNA splicing cofactor, reduced proliferation and differe

115 ing chromatin modification, DNA methylation, RNA splicing, cohesin complex, transcription factors, ce

116 Analogously, an HDAC-RNA splicing connection suggests that splicing is regula

117 egulatory proteins controlling pre-messenger RNA splicing contain serine:arginine (SR) repeats.

118 Consistent with the central role of CWC15 in RNA splicing, cwc15 mutants are embryo lethal and additi

119 arget of FUS-R521C-associated DNA damage and RNA splicing defects in mice.

120 re, we characterize previously uncategorized RNA splicing defects involving widespread intron retenti

121 r RNA foci and correlated with a plethora of RNA splicing defects.

122 The sequestration of MBNL1 results in RNA-splicing defects that contribute to disease.

123 tions, typically affecting genes involved in RNA splicing, dictate future trajectories of disease evo

124 ons of cancer cell lines to include genetic, RNA splicing, DNA methylation, histone H3 modification,

125 identified mutations in genes implicated in RNA splicing, DNA modification, chromatin regulation, an

126 ion-induced joined neoantigen (NINJA), using RNA splicing, DNA recombination and three levels of regu

127 s, including kinase signaling, cytoskeleton, RNA splicing, DNA repair, and nuclear lamina.

128 trates and is involved in DNA transcription, RNA splicing, DNA repair, cell differentiation, and meta

129 P1), as a prominent regulator of alternative RNA splicing during heart failure.

130 ght RNA ligase that catalyzes unconventional RNA splicing during the mammalian UPR.

131 SRSF3 expression was similarly decreased and RNA splicing dysregulated in mouse models of NAFLD and N

132 been shown to sequester proteins involved in RNA splicing, editing, nuclear export and nucleolar func

133 ere, we uncover sequence-specific changes in RNA splicing enforced by mutant p53 which enhance KRAS a

134 We identified two RNA splicing enhancers and their binding proteins (U2AF6

135 al protein kinase (PK)/ribonuclease, IRE1, a RNA splicing enzyme, and another involving membrane-asso

136 ited number of cellular processes, including RNA splicing, epigenetic and traditional transcriptional

137 624+4A>T, c.3190+5G>A, and c.3491-3C>G), and RNA splicing errors were confirmed for 7.

138 ce variants demonstrated a key role for this RNA splicing event in the resistance of cells to anoikis

139 we identify novel genome-wide, race-specific RNA splicing events as critical drivers of PCa aggressiv

140 covering and quantifying circular and linear RNA splicing events at both annotated and un-annotated e

141 TP53 undergoes multiple RNA-splicing events, resulting in at least nine mRNA tra

142 A methylation of RNA has profound effects on RNA splicing, export, stability, and translation.

143 SF3B1 is the most commonly mutated RNA splicing factor in cancer(1-4), but the mechanisms b

144 round Variants in the cardiomyocyte-specific RNA splicing factor RBM20 have been linked to familial c

145 L4-33K is a virus-encoded alternative RNA splicing factor which activates splicing of viral la

146 , we report that SON, previously known as an RNA splicing factor, controls MLL complex-mediated trans

147 PER 17 (bZIP17), and the membrane-associated RNA splicing factor, INOSITOL REQUIRING ENZYME1 (IRE1).

148 st report suggesting that MCM7 is a critical RNA splicing factor, thus giving significant new insight

149 n Prp40A, a homologue of Prp40, an essential RNA-splicing factor in the budding yeast.

150 olyglutamine-binding protein 1 (PQBP1) is an RNA-splicing factor that, when mutated, in humans causes

151 ancer-associated mutations in genes encoding RNA splicing factors (SFs) commonly occur in leukemias,

152 Mutations in RNA splicing factors are the single most common class of

153 QKI-7 expression is tightly controlled by RNA splicing factors CUG-BP and hnRNPM through direct bi

154 ontaining non-coding mutations in well-known RNA splicing factors exhibit similar gene expression sig

155 is no functional evidence that mutations in RNA splicing factors initiate leukaemia.

156 me-wide screen revealed that depletion of 14 RNA splicing factors leads to a specific defect in centr

157 These toxic RNAs alter the activities of RNA splicing factors resulting in alternative splicing m

158 Genes encoding the RNA splicing factors SF3B1, SRSF2, and U2AF1 are subject

159 Oncogenic mutations in the RNA splicing factors SRSF2, SF3B1, and U2AF1 are the mos

160 Under ADT conditions, recruitment of several RNA splicing factors to the 3' splicing site for AR-V7 w

161 f TOP1 to RNAPIIo and for the recruitment of RNA splicing factors to the actively transcribed chromat

162 The loss of genes that encode RNA splicing factors weakens cancer cells in a way that

163 he primary cell affected by mutations in the RNA splicing factors, and these changes occur at an earl

164 uncovered recurrent somatic mutations within RNA splicing factors, including SF3B1, SRSF2, U2AF1 and

165 relatively few genes and typically focus on RNA splicing factors.

166 3/Las1 as a unique member of the RNaseL/Ire1 RNA splicing family.

167 nalyses revealed that both drugs altered E1A RNA splicing (favoring the production of 13S over 12S RN

168 n with global effects on gene expression and RNA splicing fidelity.

169 Although its function in RNA splicing for effective cell cycle progression and ge

170 s, severely crippling or ablating the native RNA splicing function.

171 Mutations in the RNA splicing gene SF3B1 are found in >80% of patients wi

172 (45% of primary cohort), while mutations in RNA splicing genes are rare (2% of primary cohort).

173 matic mutations in epigenetic regulators and RNA splicing genes frequently constitute isolated diseas

174 natural product and synthetic modulators of RNA splicing has opened new access to this field, allowi

175 osome assembly; however, its precise role in RNA splicing has remained unclear.

176 discovery in 1977, the study of alternative RNA splicing has revealed a plethora of mechanisms that

177 ng factors contributing to HPV18 alternative RNA splicing have been discovered in this study for the

178 Together, these data demonstrate a role for RNA splicing homeostasis in dietary restriction longevit

179 equencing and analysis of global alternative RNA splicing identified that the mRNA splicing of cytopl

180 termines strain-specific differences in cell RNA splicing.IMPORTANCE Efficient viral replication requ

181 ous mutations in SMC3 or SMC1A that affected RNA splicing in 2 independent patients with combined CdL

182 rations of H3K36me3 associated with aberrant RNA splicing in a SETD2 mutant RCC and SETD2 knockout ce

183 ue U1 snRNP pathology and implicate abnormal RNA splicing in AD pathogenesis.

184 KDM5B, modulates RNAPII elongation rates and RNA splicing in ES cells.

185 Considering the importance of RNA splicing in gene regulation, alterations in this pat

186 ich underscore the importance of fine-tuning RNA splicing in hematopoiesis.

187 d demonstrate the importance of SON-mediated RNA splicing in human development.

188 Furthermore, secondary motifs regulate RNA splicing in neuronal development and in neuronal sub

189 ere are many important examples of regulated RNA splicing in Saccharomyces cerevisiae Here, we report

190 e, there are important examples of regulated RNA splicing in Saccharomyces cerevisiae, such as splici

191 ine-rich (SR) proteins involved in messenger RNA splicing, including the splicing factor SRm300 (SRRM

192 Consistent with a role for PfCLK3 in RNA splicing, inhibition resulted in the down-regulation

193 after treating virus-infected cells with the RNA splicing inhibitor spliceostatin A to prevent M2 mRN

194 In nuclear pre-messenger RNA splicing, introns are excised by the spliceosome, a

195 RNA splicing is a fundamental mechanism contributing to

196 RNA splicing is a highly regulated process dependent on

197 RNA splicing is a key mechanism linking genetic variatio

198 RNA splicing is a major contributor to total transcripto

199 The evolution of RNA splicing is a prime example of the Darwinian functio

200 RNA splicing is an essential part of eukaryotic gene exp

201 RNA splicing is an essential process that governs many a

202 Alternative RNA splicing is an essential process to yield proteomic

203 onclude post-transcriptional control of Xist RNA splicing is an essential regulatory step of Xist ind

204 ur laboratory previously reported that Bcl-x RNA splicing is dysregulated in a large percentage of hu

205 n generating transcriptome diversity through RNA splicing is independently unmasked by two studies in

206 We suggest that RNA splicing is of particular importance for plant respo

207 RNA splicing is primarily altered by non-coding mutation

208 e propose a model wherein a modest effect on RNA splicing is sufficient to mediate the CD33 associati

209 The RNA splicing landscape of PCa across racial populations

210 action networks to describe the formation of RNA splicing machinery complexes and splicing processes

211 The dependence of adenovirus on the host pre-RNA splicing machinery for expression of its complete ge

212 s affecting genes encoding components of the RNA splicing machinery in hematological malignancies.

213 ic mutations of SF3B1 and other genes of the RNA splicing machinery in patients with myelodysplastic

214 dary-type AML carrying mutations in genes of RNA splicing machinery, TP53-mutated AML, or de novo AML

215 in SRRM2 (also called SRm300) is part of the RNA splicing machinery.

216 Here, we provide an overview of RNA splicing mechanisms followed by a discussion of dise

217 tronic mutation as the molecular basis for a RNA splicing-mediated RAF inhibitor resistance mechanism

218 suggest a novel model wherein SNP-modulated RNA splicing modulates CD33 function and, thereby, AD ri

219 udemycin E is an analog of the pre-messenger RNA splicing modulator FR901464 and its derivative splic

220 nd are mediators of molecular functions like RNA splicing, mRNA decay, and translation control.

221 s, chromatin, long noncoding RNAs (lncRNAs), RNA splicing, nuclear topology and the 3D conformation o

222 When messenger RNA splicing occurs co-transcriptionally, the potential

223 We investigated the effect on pre-messenger RNA splicing of 14 ATP8B1 mutations at exon-intron bound

224 In this manuscript, we demonstrated that RNA splicing of AR-V7 in response to ADT was closely ass

225 ore, we investigated whether the alternative RNA splicing of Bcl-x pre-mRNA was modulated by MDA-7/IL

226 en 1q21-amplified ILF2 and the regulation of RNA splicing of DNA repair genes may be exploited to opt

227 es important observations on how alternative RNA splicing of HPV18 pre-mRNAs is subject to regulation

228 vide the first evidence that the alternative RNA splicing of HPV18 pre-mRNAs is subject to regulation

229 osis that was associated with alterations in RNA splicing of known SRSF3 target genes.

230 onucleotide drug that modifies pre-messenger RNA splicing of the SMN2 gene and thus promotes increase

231 RNA splicing of U12-type introns functions in human cell

232 n of HPV18 genes is regulated by alternative RNA splicing of viral polycistronic pre-mRNAs to produce

233 te degradation of target mRNAs or to inhibit RNA splicing or translation of several genes of P. falci

234 e disease patients suggests that identifying RNA splicing outliers is particularly useful for determi

235 Here, we show that alterations in RNA splicing patterns across the human transcriptome tha

236 Based on this finding, we hypothesized that RNA splicing plays a role in mediating vWF expression in

237 ear protein that regulates transcription and RNA splicing, plays an important role in tumorigenesis b

238 Using RNA splicing prediction as well as digit classification

239 first time a chemical-based interrogation of RNA splicing processes.

240 n/cytoskeletal protein binding, RNA binding, RNA splicing/processing, chromatin modifying, intracellu

241 or up to three months, redistribution of the RNA-splicing protein muscleblind-like splicing regulator

242 f RALY and hnRNP-C increased levels of viral RNA splicing, protein abundance and progeny production d

243 n a random forest classifier that integrates RNA splicing, protein structure, and evolutionary conser

244 aling, chromatin, and epigenomic regulation; RNA splicing; protein homeostasis; metabolism; and linea

245 Alternative RNA splicing provides an important means to expand metaz

246 S69 connects histone H3.3K36me3 to regulated RNA splicing, providing significant, important insights

247 es DDX5 and RNA helicase A (RHA) that alters RNA-splicing ratios.

248 3ss) is an essential early step in mammalian RNA splicing reactions, but the processes involved are u

249 Traditionally recognized as an RNA splicing regulator, heterogeneous nuclear ribonucleo

250 d identified a muscle-specific isoform of an RNA splicing regulator, RBFox1 (also known as A2BP1), as

251 We further identify BS69 association with RNA splicing regulators, including the U5 snRNP componen

252 with mutations in genes encoding chromatin, RNA-splicing regulators, or both (in 18% of patients); A

253 In a yeast strain in which the RNA splicing-related functions of Mss116p are dispensabl

254 ng factors contributing to HPV18 alternative RNA splicing remain unknown.

255 Alternative pre-messenger RNA splicing remodels the human transcriptome in a spati

256 rated as two isoform families by alternative RNA splicing, represented by VEGF-A165a and VEGF-A165b.

257 identified in cardiomyopathy patients alter RNA splicing, representing a 50% increase in the numbers

258 RNA splicing represents a post-transcriptional mechanism

259 gle intra-otic dose of ASO corrects harmonin RNA splicing, restores harmonin protein expression in se

260 y while studying transcription, translation, RNA splicing, ribosome biogenesis, and more recently, di

261 fect genetic instability, promoter activity, RNA splicing, RNA stability, and neurite mRNA localizati

262 Driver mutant genes include those of RNA splicing (SF3B1, SRSF2, U2AF1, and ZRSR2), DNA methy

263 tes evolved from DNA encoding a pre-existing RNA splicing signal, effectively linking dosage compensa

264 m(6)A is thought to regulate RNA splicing, stability, translation, and secondary stru

265 Minigene RNA splicing studies in BV2 microglial cells established

266 ntially makes it vulnerable to modulators of RNA splicing, such as digoxin and digitoxin.

267 activation disrupts RNA metabolism including RNA splicing, surveillance and transport pathways.

268 in processes such as chromatin modification, RNA splicing, T- and B-cell activation, and NF-kappaB si

269 atio-temporally coordinated, indicating that RNA splicing takes place in the context of chromatin.

270 ed additional changes in gene expression and RNA splicing that may underlie the effects of this mutat

271 ting to transcript type, gene expression and RNA splicing that would be lost with other approaches us

272 During pre-RNA splicing, the 5' and 3' termini of exon(s) can be co

273 RNA splicing, the spliceosome-catalyzed process by which

274 data demonstrating the influence of HYAL2 on RNA splicing, these findings begin to explain the broad

275 ntiation from neural stem cells and mediates RNA splicing through interactions with polypyrimidine tr

276 pre-mRNAs that are regulated by alternative RNA splicing to produce a repertoire of viral transcript

277 uman TACI undergoes alternative messenger (m)RNA splicing to produce isoforms with 1 or 2 ligand-bind

278 ous mechanisms by which cancer cells exploit RNA splicing to promote tumor growth and the current the

279 ted role of RBM3 in linking stress-regulated RNA splicing to tumorigenesis, with potential prognostic

280 f which match human known motifs involved in RNA splicing, transcription or translation.

281 Here by using a combination of RNA splicing, transcription, and protein chemistry techn

282 protein synthesis, ARSs are also involved in RNA splicing, transcriptional regulation, translation, a

283 fect promoter activity, genetic instability, RNA splicing, translation, and neurite mRNA localization

284 arious molecular phenotypes such as aberrant RNA splicing, transport, and stability.

285 Histone modifications and RNA splicing, two seemingly unrelated gene regulatory pr

286 V1), RHOA/cytoskeleton remodeling (ARHGEF3), RNA splicing (U2AF1), T-cell receptor signaling (PTPRN2,

287 suggest that a conserved role in chloroplast RNA splicing underlies the physiological defects describ

288 rine carotid arteries by posttranscriptional RNA splicing unique to platelets.

289 open reading frame usage, and translation of RNA splicing variants) has been reported, and autoreacti

290 ion of Bcl-x(L) is regulated at the level of RNA splicing via alternative 5' splice site selection wi

291 lation of proteins associated with messenger RNA splicing via the spliceosome.

292 NA editing profiles, while Htr2c alternative RNA splicing was unchanged.

293 involved in regulation of transcription and RNA splicing were enriched in the group of cell types wi

294 of protein-coding messenger RNAs (mRNAs) via RNA splicing, whereby the spliceosome removes non-coding

295 esses in eukaryotic gene expression, such as RNA splicing, which can cause a pre-mRNA to produce one

296 a rapid change in alternative pre-messenger RNA splicing, which is later followed by changes in over

297 One of the key processes in eukaryotes is RNA splicing, which readies mRNA for translation.

298 scores how strongly genetic variants affect RNA splicing, whose alteration contributes to many disea

299 ic mechanisms linking aberrant pre-messenger RNA splicing with liver damage, fibrosis, and HCC.

300 pores, exposing the dynamics and patterns of RNA splicing without biases introduced by amplification.