ライフサイエンスコーパス: RNA synthesis

1 rminators after they are incorporated during RNA synthesis.

2 and regulate RdRp activity at every step of RNA synthesis.

3 enes are transcribed in episodic "bursts" of RNA synthesis.

4 r binding, bending and melting, and abortive RNA synthesis.

5 uncoated particles were active in initiating RNA synthesis.

6 ased DLPs and their efficiency in initiating RNA synthesis.

7 dentify residues that are critical for viral RNA synthesis.

8 two to three nucleotides after kilobases of RNA synthesis.

9 polymerase (RdRp) (3D(pol)) catalyzes viral RNA synthesis.

10 iral polymerase NS5 to initiate minus-strand RNA synthesis.

11 e for RNA capping and a polymerase for viral RNA synthesis.

12 the viral replicase complex to boost progeny RNA synthesis.

13 iomyocytes, indicative of impaired ribosomal RNA synthesis.

14 Inhibition is relieved upon 6S RNA-templated RNA synthesis.

15 to modestly enhance viral pregenomic 3.5-kb RNA synthesis.

16 the promoter DNA while moving downstream for RNA synthesis.

17 were interchangeable without affecting viral RNA synthesis.

18 R101A) or completely destroyed (G12L) viral RNA synthesis.

19 polymerase uses it as the template for viral RNA synthesis.

20 which is required for ribozyme activity and RNA synthesis.

21 of nascent transcript during negative-strand RNA synthesis.

22 fically impede intracellular influenza virus RNA synthesis.

23 g general transcription factors to stimulate RNA synthesis.

24 disperse based on the presence or absence of RNA synthesis.

25 tide-mediated excision reaction that rescues RNA synthesis.

26 S selection involves DNA scrunching prior to RNA synthesis.

27 ength TRIM56 by specifically targeting viral RNA synthesis.

28 virus, that has a unique mechanism of viral RNA synthesis.

29 viruses suggests that the CP also regulates RNA synthesis.

30 structural analyses of spherules engaged in RNA synthesis.

31 al replication machinery for efficient viral RNA synthesis.

32 1, which plays important regulatory roles in RNA synthesis.

33 vitro TBSV replication, including (-) and (+)RNA synthesis.

34 protein in PRRSV infection to regulate viral RNA synthesis.

35 viral polyprotein, but is required for viral RNA synthesis.

36 s of RNA polymerase II to DNA and consequent RNA synthesis.

37 g activities and plays a vital role in viral RNA synthesis.

38 ational drug design efforts to inhibit viral RNA synthesis.

39 rus, encodes a V protein that inhibits viral RNA synthesis.

40 The P protein of MuV is critical for viral RNA synthesis.

41 stood process that makes the RdRp capable of RNA synthesis.

42 ng the fraction of HCV genomes available for RNA synthesis.

43 asmic membranes that serve as sites of viral RNA synthesis.

44 while increasing the fraction available for RNA synthesis.

45 phosphatidylethanolamine in asymmetrical (+)RNA synthesis.

46 (TopA), inhibiting both DNA replication and RNA synthesis.

47 th elongating RNAPII and the leading edge of RNA synthesis.

48 at controls both the abortive and productive RNA synthesis.

49 d result in changes in virus replication and RNA synthesis.

50 iscrimination against 2'-fluoro-dNTPs during RNA synthesis.

51 and a short template sequence for subgenomic RNA synthesis.

52 sit into the elongation phase for processive RNA synthesis.

53 A complex, the functional template for viral RNA synthesis.

54 anslation, eliminates miR-122 stimulation of RNA synthesis.

55 losteric site is not always available during RNA synthesis.

56 the NP-RNA complex, thereby regulating viral RNA synthesis.

57 ng that telaprevir exerts a direct effect on RNA synthesis.

58 e the requirements of nsp3 domains for viral RNA synthesis.

59 al oligomerization domain and enhances viral RNA synthesis.

60 ing the RdRp greatly affects its ability for RNA synthesis.

61 mplish the initiation and then elongation of RNA synthesis.

62 osphorylation plays a critical role in viral RNA synthesis.

63 SV polymerase to engage the RNA template for RNA synthesis.

64 nclear which RO element(s) accommodate viral RNA synthesis.

65 , consistent with changes in the fidelity of RNA synthesis.

66 nds our mechanistic understanding of the RSV RNA synthesis.

67 abinonucleotides are effective templates for RNA synthesis.

68 tes reovirus-induced necroptosis by limiting RNA synthesis.

69 ould carry out both de novo and primer-based RNA synthesis.

70 to control both inclusion body formation and RNA synthesis.

71 for template RNA recruitment and (-) and (+)RNA synthesis.

72 uggest a role of G3BP during negative-strand RNA synthesis.

73 sembly, viral polymerase activity, and viral RNA synthesis.

74 Knockdown of sigma3 does not impact reovirus RNA synthesis.

75 RNA, which is the product of polyA-templated RNA synthesis.

76 and represses the RNA Pol II elongation and RNA synthesis.

77 consider the unique mechanism of their viral RNA synthesis.

78 viral infectivity by attenuating subgenomic RNA synthesis.

79 ductive RNA synthesis as opposed to abortive RNA synthesis.

80 release of paused polymerase into productive RNA synthesis.

81 intrinsic Pol II promoters to induce de novo RNA synthesis.

82 ed host mRNAs to be used as primers in viral RNA synthesis.

83 constraints on codon usage to balance viral RNA synthesis.

84 f 2-thiouridine-an intermediate of prebiotic RNA synthesis.

85 lting in alteration of the activity of viral RNA synthesis.

86 a vital role in the maintenance of faithful RNA synthesis activity (fidelity) of FMDV 3D(pol), sugge

87 A-binding protein Rim1 severely inhibits the RNA synthesis activity of Rpo41, but not the Rpo41-Mtf1

88 pound does not inhibit back priming, another RNA synthesis activity of the RSV polymerase.

89 f repair DNA synthesis) and RRS (recovery of RNA synthesis after DNA damage).

90 Thus, endogenous HSATII RNA synthesis after herpesvirus infections appears to ha

91 ular membranes that provide niches for viral RNA synthesis and a platform for interactions with host

92 establish DMVs as the central hub for viral RNA synthesis and a potential drug target in CoV infecti

93 scontinuous to continuous extension of PRRSV RNA synthesis and also offer a new potential anti-PRRSV

94 function in the TH form as a general acid in RNA synthesis and as a general base in RNA hydrolysis.

95 two mutations (G37L and P112A) reduced viral RNA synthesis and blocked virion assembly.

96 RABV systems, we show that the loop governs RNA synthesis and capping during the dynamic stop-start

97 these substitutions result in aberrant viral RNA synthesis and correlate with patient outcome.

98 thematical model of the kinetic interplay of RNA synthesis and CTS and parameterized it with diverse

99 We studied RNA synthesis and degradation at the transcription start

100 but lacks information about the dynamics of RNA synthesis and degradation.

101 icular stomatitis virus reveal insights into RNA synthesis and distinctive mRNA capping mechanisms of

102 te that Spt5 is crucial for a normal rate of RNA synthesis and distribution of RNAPII over transcript

103 y, we establish a spatial link between viral RNA synthesis and diverse host factors of unprecedented

104 egrity of the nucleolus, impairing ribosomal RNA synthesis and evoking the ribosomal protein-dependen

105 h initiates growth by increasing protein and RNA synthesis and fatty acid metabolism, while decreasin

106 life cycle such as the entry process, viral RNA synthesis and gene expression, as well as morphogene

107 2 sub-domain is required for efficient viral RNA synthesis and growth of SVV, but not for IRES functi

108 The precise roles of the TL/TH in RNA synthesis and hydrolysis remain unclear.

109 ances our understanding of influenza A virus RNA synthesis and identifies the initiation platform of

110 ances our understanding of Influenza A virus RNA synthesis and identifies the initiation platform of

111 of 10-del ZIKV may be due to decreased viral RNA synthesis and increased sensitivity to type-1-interf

112 glycolytic pathway dramatically reduced DENV RNA synthesis and infectious virion production, revealin

113 d with ATM-dependent repression of ribosomal RNA synthesis and large-scale reorganization of nucleola

114 RNA requires the temporal synchronization of RNA synthesis and ligand binding-dependent conformationa

115 linkages occur sporadically in non-enzymatic RNA synthesis and may have aided prebiotic RNA replicati

116 3, which is critically involved in ribosomal RNA synthesis and mRNA translation.

117 of a variety of tools and methods for guide RNA synthesis and mutant identification.

118 interaction and abrogate both viral genomic RNA synthesis and N-mediated translation strategy withou

119 ATAD2 depletion also reduced global RNA synthesis and nascent DNA-associated RNA.

120 eoli is required for inhibition of ribosomal RNA synthesis and nucleolar segregation in response to r

121 tein (RNP) complexes that are substrates for RNA synthesis and packaging into virus particles.

122 Our results explain how p58C participates in RNA synthesis and primer length counting and also indica

123 h of our knowledge about the fundamentals of RNA synthesis and processing come from ensemble in vitro

124 s a significant role in regulating ribosomal RNA synthesis and processing, ribosome export into the c

125 involved in cell adhesion, cytoskeleton, and RNA synthesis and processing.

126 ere acute respiratory syndrome (SARS)-CoV an RNA synthesis and proofreading pathway through associati

127 facilitated a comparative analysis of viral RNA synthesis and revealed two novel transcription junct

128 Recent studies show the processes of RNA synthesis and RNA processing to be spatio-temporally

129 RPs influence error catastrophe: fidelity of RNA synthesis and RNA recombination.

130 udies did not distinguish between changes in RNA synthesis and RNA turnover and did not address the r

131 hrough a process that required de novo viral RNA synthesis and shifted the ratio of viral dsRNA/ssRNA

132 results show that ATM and p53 regulate both RNA synthesis and stability as well as enhancer element

133 nstrate that our compounds can block de novo RNA synthesis and that effect is dependent on a chemical

134 s into the molecular mechanisms of norovirus RNA synthesis and the sequences that determine the recog

135 75, and R376, contributes to the fidelity of RNA synthesis and to efficient sexual RNA replication me

136 on, PIs and APHIs can block NS3 functions in RNA synthesis and virus assembly, in addition to inhibit

137 NTR sequences regulate RNA synthesis and, by analogy with other segmented negat

138 Promoters initiate RNA synthesis, and enhancers stimulate promoter activity

139 transcription levels via impacts on enhancer RNA synthesis, and interacts with the rRNA producing/pro

140 polymerase VP1 mediates all stages of viral RNA synthesis, and it requires the core shell protein VP

141 g, cellular uptake of nucleoside for DNA and RNA synthesis, and nucleoside-derived anticancer and ant

142 interaction is a positive regulator of viral RNA synthesis, and that the interfaces mediating it are

143 implications of our findings for nairovirus RNA synthesis are discussed.IMPORTANCE Nairoviruses are

144 rporated at position i, the inhibitor caused RNA synthesis arrest at position i + 3.

145 pyrophosphorolysis occurs during productive RNA synthesis as opposed to abortive RNA synthesis.

146 e viral polymerase and is required for viral RNA synthesis, as well as the assembly of replication co

147 We report an in vitro RNA synthesis assay for the RNA-dependent RNA polymerase

148 (EM) autoradiography revealed abundant viral RNA synthesis associated with DMVs in cells infected wit

149 pite genomic deletions but that the impaired RNA synthesis associated with terminally deleted viruses

150 1 polymerase and shows diminished growth and RNA synthesis at 39 degrees C compared to that at 31 deg

151 of TSs, we directly correlate TF binding and RNA synthesis at a specific promoter.

152 to UV, which supports the notion that faulty RNA synthesis at damaged sites is harmful to the cell fi

153 erate RPR evolution, and allow RPR-catalysed RNA synthesis at near physiological (>/=1 mM) Mg(2+) con

154 eprogrammed upon stress, we measured nascent RNA synthesis at nucleotide-resolution, and profiled his

155 f RDV-TP at position i caused termination of RNA synthesis at position i+3.

156 s form a large complex that is necessary for RNA synthesis at replication sites.

157 NA bubble and enters into abortive cycles of RNA synthesis before escaping the promoter to transit in

158 nB P1 open complex, scrunching occurs before RNA synthesis begins.

159 cell death was cell autonomous and required RNA synthesis but not viral DNA replication.

160 ly the most widespread technique for DNA and RNA synthesis but suffers from scalability limitations a

161 ral mRNA or full-length copies and initiates RNA synthesis by binding the conserved 3' and 5' vRNA en

162 cleotide addition, can stimulate translesion RNA synthesis by Escherichia coli RNAP without altering

163 RNA synthesis by even a single virus particle can initia

164 Thus, RNA synthesis by even a single, uncoated particle can in

165 largely responsible for inhibition of viral RNA synthesis by generating recombinant viruses that lac

166 elet aggregation and tissue factor messenger RNA synthesis by monocytes.

167 Detection of increased negative-strand RNA synthesis by real time RT-PCR for the NS3:N570A muta

168 severely compromise transcription and block RNA synthesis by RNA polymerase (RNAP), leading to subse

169 ive transcription is a non-canonical form of RNA synthesis by RNA polymerase in which a ribonucleotid

170 ays a critical role in V inhibition of viral RNA synthesis by the N-terminal domain.

171 RNA synthesis by the prototype coronavirus mouse hepatit

172 ce is sufficient for the initiation of viral RNA synthesis by the recombinant MNV RNA-dependent RNA p

173 on of ddhCTP causes premature termination of RNA synthesis by the RNA-dependent RNA polymerase of som

174 le-based blocking of Hsp70 function inhibits RNA synthesis by the tombusvirus RdRp in vitro.

175 We detected RNA synthesis by uncoated particles as early as 15 min a

176 Transcription (positive-strand RNA [+RNA] synthesis) by VP1 occurs within double-layered part

177 ize to viroplasms, which are the sites of RV RNA synthesis, by expressing the mutant form as a green

178 ells, coronaviruses assemble a multi-subunit RNA-synthesis complex of viral non-structural proteins (

179 Coupling of nsP and RNA synthesis complicates analysis of viral RNA replicat

180 Long RNA synthesis (constrained to be single round) occurs on

181 RNA synthesis could not be linked to DMSs or any other c

182 mplate N are also required for initiation of RNA synthesis, extending our knowledge of ribonucleoprot

183 presents a prime example for the coupling of RNA synthesis, folding, and regulation.

184 ic defect of VCP/p97 enhance the recovery of RNA synthesis following UVR, whereas both VCP/p97 and pr

185 lusion bodies (IBs) are cytoplasmic sites of RNA synthesis for a variety of negative-sense RNA viruse

186 Here we characterize RNA synthesis from single-copy glucocorticoid receptor (

187 ome replication, by inhibiting initiation of RNA synthesis from the promoter.

188 to monitor template DNA translocation during RNA synthesis from the pyrG promoter and in vitro transc

189 lasma of rodents and humans, is critical for RNA synthesis, glycogen deposition, and many other essen

190 date, the mechanism of norovirus subgenomic RNA synthesis has not been characterized.

191 e promoter sequence and the mechanism of RSV RNA synthesis.IMPORTANCE As a major human pathogen, RSV

192 of the viral machinery required for VSV(IND) RNA synthesis.IMPORTANCE Interferons are important antiv

193 y the obligation of the NSV genome for viral RNA synthesis.IMPORTANCE Negative-strand RNA viruses (NS

194 Surprisingly, RNA pol II-mediated RNA synthesis in 24 hr-treated cells was upregulated, in

195 P2 functionally engage each other to mediate RNA synthesis in a test tube.

196 ltisubunit RNA polymerases (RNAPs) carry out RNA synthesis in all domains life.

197 ally, due to the error-prone nature of viral RNA synthesis in an individual patient, the EBOV genome

198 ynthesis of nonstructural proteins, or viral RNA synthesis in differentiated neurons.

199 eir close proximity by PLA demonstrates that RNA synthesis in individual cells resumes about 30-45 mi

200 ency of the compound, which suppressed viral RNA synthesis in infected cells.

201 "DNA scrunching" that occurs concurrent with RNA synthesis in initial transcription.

202 Using this approach, HDACi have induced HIV RNA synthesis in latently infected cells from some patie

203 nscription elongation complexes and modulate RNA synthesis in response to translation, processing, an

204 Depletion of GTP inhibits ribosomal RNA synthesis in T cells by inhibiting transcription ini

205 originated from the unique mechanism of NSV RNA synthesis in that the genomic RNA sequestered in the

206 bstrates required to fuel ribozyme-catalyzed RNA synthesis in the absence of a highly evolved metabol

207 This strategy is likely to avoid viral RNA synthesis in the cytosol that would rapidly lead to

208 rovide a tailored microenvironment for viral RNA synthesis in the infected cell.

209 at PB1 proline 651 is critical for efficient RNA synthesis in vitro and in cell culture.

210 ich enables a more efficiently elongation of RNA synthesis in vitro.

211 tive transcription is a noncanonical form of RNA synthesis in which a nucleotide specified by a singl

212 unifying, refined mechanism of RDV-mediated RNA synthesis inhibition in coronaviruses and define thi

213 ow the formation of spherules enhances viral RNA synthesis is also not understood, although it is ass

214 However, RNA synthesis is anything but monotonous: RNA polymerase

215 RSV RNA synthesis is catalyzed by a multifunctional RNA-depe

216 RNA synthesis is central to life, and RNA polymerase (RN

217 Coronavirus RNA synthesis is connected with the formation of double-

218 nable processive, accurate, and controllable RNA synthesis is emerging from complementary structural,

219 loop that is important for the initiation of RNA synthesis is fully retracted, which leaves space in

220 space of transcription intermediates during RNA synthesis is important to understand riboswitch func

221 Customized RNA synthesis is in demand for biological and biotechnol

222 viral ribonucleoproteins that catalyse viral RNA synthesis is inhibited, causing decreased viral prot

223 Coronavirus RNA synthesis is performed by a replication-transcriptio

224 Periods of active nascent RNA synthesis known as bursts represent individual gene

225 nduced transcriptional bursting in which the RNA synthesis leads to the buildup of torsion in DNA.

226 elements define boundaries for both DNA and RNA synthesis machineries.

227 nalyze the effects of mutations on the virus RNA synthesis machinery in cells of both mammalian (host

228 n-depth mechanistic understanding of the RSV RNA synthesis machinery remains a high priority among th

229 minates the assembly of the coronavirus core RNA-synthesis machinery, provides key insights into nsp1

230 those polymerases, and reveal the potential RNA synthesis mechanisms and models of highly conserved

231 nes that peak on day 2, 3, or 4 and regulate RNA synthesis, metabolic pathways, and cell division, re

232 For the initiation of RNA synthesis, most RdRps use either a primer-dependent

233 For the initiation of RNA synthesis, most RdRps use either a primer-dependent

234 but that template copying chemistry favored RNA synthesis; multiple rounds of replication may have l

235 After sigma70 binding, further RNA synthesis occurs as DNA is drawn (or 'scrunched') in

236 Rapid RNA synthesis of comprehensive single mutant libraries a

237 affect transcription and how the recovery of RNA synthesis of large genes are particularly delayed by

238 KSHV RTA may bind to MyD88 RNA, suppresses RNA synthesis of MyD88, and inhibits IL-1-mediated signa

239 MyD88 expression at the RNA level, inhibits RNA synthesis of MyD88, and may bind MyD88 RNA.

240 Mononegavirales mimic RNA synthesis of their eukaryotic counterparts by utiliz

241 The DRMs could support viral RNA synthesis on both the endogenous and exogenous templ

242 extensively activity at the stage of initial RNA synthesis on sigma(54)-regulated promoters.

243 termini of the V protein that inhibit viral RNA synthesis: one at the very N terminus of V and the s

244 These domains may play direct roles in RNA synthesis, or they may have evolved for other purpos

245 we found that TSS scanning does not require RNA synthesis, our results revealed that transcription i

246 edly potentiates the inhibition of ribosomal RNA synthesis, PCNA expression, and T-cell activation in

247 Understanding of RNA synthesis priming in eukaryotes is currently limited

248 er drugs requires a detailed analysis of DNA/RNA synthesis processes.

249 t it inhibits a step common to both of these RNA synthesis processes.

250 r QDE-1(Ncr) counterpart favoring processive RNA synthesis, QDE-1(Tte) and QDE-1(Mth) produce predomi

251 have been used to provide information about RNA synthesis rates in plants.

252 nificantly block initiation or elongation of RNA synthesis; rather, they block the transition from in

253 I2) do not block initiation or elongation of RNA synthesis; rather, they block the transition from th

254 ction poorly as templates in model prebiotic RNA synthesis reactions, raising the question of how a s

255 The kinetics of DNA repair and RNA synthesis recovery in human cells following UV-irrad

256 lethal mutations in cell division cycle and RNA synthesis related genes, revealing 660 suppressor in

257 ylation of the M2-1 protein upregulates hMPV RNA synthesis, replication, and pathogenesis in vivo IMP

258 shortly after virus entry but prior to viral RNA synthesis/replication.

259 As viral RNA synthesis requires large amounts of ATP, we conclude

260 x 10(-5)) indicate high accuracy/fidelity of RNA synthesis resembling those of replicative DNA polyme

261 TRIM25 inhibition of viral RNA synthesis results from its binding to viral ribonucl

262 stream binding factor recruitment, ribosomal RNA synthesis, ribonucleotide levels, and affects riboso

263 situ analyses of vesicular stomatitis virus RNA synthesis, specific activities of viral RNA synthesi

264 ication complex by NS5BDelta21, resulting in RNA synthesis stimulation by helicase.

265 e-sense (NNS) RNA virus and shares a similar RNA synthesis strategy with other members of NNS RNA vir

266 mAb114 and REGN-EB3 and inhibitors of viral RNA synthesis such as remdesivir and TKM-Ebola.

267 ces an increase in total precursor messenger RNA synthesis, suggesting an increased burden on the cor

268 n contrast, the APHI could partially inhibit RNA synthesis, suggesting that the allosteric site is no

269 e not well understood, in part because viral RNA synthesis takes place within enzyme complexes associ

270 rgest RNA viruses, have a complex program of RNA synthesis that entails genome replication and transc

271 we discuss the shared and unique features of RNA synthesis, the monomeric multifunctional enzyme L, a

272 the RNAP core is catalytically competent for RNA synthesis, the selectivity of transcription initiati

273 TRIM25 inhibits viral RNA synthesis through a direct mechanism that is indepen

274 al capsid and carry out endogenous messenger RNA synthesis through a transcriptional enzyme complex (

275 hat control gene regulatory mechanisms, from RNA synthesis to decay. In mammalian mitochondria, post-

276 polymerase remodel the nucleocapsid to allow RNA synthesis to occur efficiently.

277 nergy is generated per translocation step of RNA synthesis to overcome OC stability and drive escape.

278 which releases the stress and allows for the RNA synthesis to restart with the original rate.

279 monitoring steady-state RNA levels, rates of RNA synthesis, transcription initiation and RNA polymera

280 into preinitiation complexes that can begin RNA synthesis upon binding of NTPs (nucleoside triphosph

281 and RNA, inhibition of OGT impaired nascent RNA synthesis upon T cell activation.

282 gth of the RNA template for in vitro de novo RNA synthesis using the purified RSV polymerase as 8 nuc

283 The partial reduction of ECm during RNA synthesis was circumvented by the protection of the

284 related Lassa virus RdRp, and termination of RNA synthesis was not observed.

285 RNA synthesis, specific activities of viral RNA synthesis were correlated with the genomic RNA seque

286 f the coronavirus genome requires continuous RNA synthesis, whereas transcription is a discontinuous

287 mplete cycle of replication and asymmetrical RNA synthesis, which is a hallmark of (+)-strand RNA vir

288 mplete cycle of replication and asymmetrical RNA synthesis, which is a hallmark of (+)RNA viruses.

289 DSB-induced transcriptional promoters drives RNA synthesis, which stimulates phase separation of DDR

290 box binding protein (TBP) leads to increased RNA synthesis, which together with R-loop accumulation r

291 t-recruitment' roles in promoter melting and RNA synthesis, which were revealed by studying the pre-i

292 rus-induced replication complexes to promote RNA synthesis, while DnaJB6 associates with capsid prote

293 s mutations in the L segment decreased viral RNA synthesis, while those in the M segment delayed prog

294 An understanding of viral RNA synthesis will allow the design of better vaccines a

295 cess of RNA translation upon cell infection, RNA synthesis within a replication compartment, and viru

296 M) Mg(2+) concentrations, enabling templated RNA synthesis within membranous protocells.

297 To mimic the result of RNA synthesis within non-growing protocells, we co-encap

298 polymerase VP1 mediates all stages of viral RNA synthesis within the confines of subviral particles

299 prior to capsid assembly and double-stranded RNA synthesis within viral inclusion bodies (VIBs).

300 ells, dampening miR-122 stimulation of viral RNA synthesis without reducing the stability or translat