ライフサイエンスコーパス: RNA virus

1 y Rice stripe virus (RSV), a negative-strand RNA virus.

2 uses in the life cycle of a small pathogenic RNA virus.

3 type (VSV(IND)), a prototype negative-strand RNA virus.

4 Mosaic Virus (BMV), a T = 3 single stranded RNA virus.

5 ig industry, is a highly genetically diverse RNA virus.

6 ing antivirals against other negative-strand RNA viruses.

7 hinery remains a high priority among the NNS RNA viruses.

8 s, unrelated to any other taxonomic group of RNA viruses.

9 cal RNA synthesis, which is a hallmark of (+)RNA viruses.

10 factors and cellular pathways coopted by (+)RNA viruses.

11 available about SIE of plant negative-strand RNA viruses.

12 nostructures, such as the protein capsids of RNA viruses.

13 roved drugs restricts replication of diverse RNA viruses.

14 the role of recombination in positive-strand RNA viruses.

15 responses, including susceptibility to plant RNA viruses.

16 provide new opportunities for characterizing RNA viruses.

17 uppression comparable to those of vertebrate RNA viruses.

18 xual and sexual replication strategies among RNA viruses.

19 nuclear viral dsRNA sensor for both DNA and RNA viruses.

20 Tase domain in non-segmented negative strand RNA viruses.

21 ty and heterogeneous sequencing coverage for RNA viruses.

22 racellular trafficking of multiple unrelated RNA viruses.

23 d from integrations of DNA and nonretroviral RNA viruses.

24 ch works especially well for positive-strand RNA viruses.

25 lity to the investigation of potentially all RNA viruses.

26 recognition receptors in the defense against RNA viruses.

27 approach against pathogenic single-stranded RNA viruses.

28 yamines may facilitate attachment of diverse RNA viruses.

29 de selection mechanism operating in RdRps of RNA viruses.

30 may be applicable to other negative-stranded RNA viruses.

31 of capsid genes of eukaryotic positive-sense RNA viruses.

32 or infectivity of a wide variety of DNA and RNA viruses.

33 urce for designing therapeutics in targeting RNA viruses.

34 distinguish the ebolaviruses from other NNS RNA viruses.

35 l agents, especially against positive-strand RNA viruses.

36 inference of fast-evolving pathogens such as RNA viruses.

37 echanism of retroviruses and positive-strand RNA viruses.

38 t reticulon-like MPs are employed by diverse RNA viruses.

39 a) contribute to the pathogenesis induced by RNA viruses.

40 whether they occur for other positive-sense RNA viruses.

41 esurgence in DIP studies for negative-strand RNA viruses.

42 ay an antiviral role against negative-strand RNA viruses.

43 r surveillance and could be adapted to other RNA viruses.

44 is differentially manipulated by respiratory RNA viruses.

45 one of the broadest known host ranges among RNA viruses.

46 ep of gene expression by all positive-strand RNA viruses.

47 er was spent studying two diseases caused by RNA viruses, alphavirus encephalomyelitis and measles, a

48 colonies showed higher infection level with RNA viruses although infection levels were low compared

49 Nonsegmented negative-stranded (NNS) RNA viruses, among them the virus that causes rabies (RA

50 sis of inducible cell lines infected with an RNA virus and expressing either wild-type W or W lacking

51 (RSV) is a nonsegmented negative-sense (NNS) RNA virus and shares a similar RNA synthesis strategy wi

52 merase proteins of segmented negative-strand RNA viruses and for the search for antiviral compounds t

53 a principal determinant of immunity for most RNA viruses and have promise to reduce infection or dise

54 -intrinsic immunity to these positive-strand RNA viruses and identify previously unrecognized antivir

55 re infected with 4-thiouridine (4SU)-labeled RNA viruses and irradiated with 365 nm light to crosslin

56 table roadmap to guide functional studies of RNA viruses and other pharmacologically relevant RNA tra

57 erve as a paradigm for other positive-strand RNA viruses and provide a starting point for a comprehen

58 genomes generated during the replication of RNA viruses and the functions that they carry out.

59 , with metatranscriptomics better suited for RNA viruses and virion-enriched metagenomics largely ide

60 y microbiome that contained bacteria, fungi, RNA viruses, and DNA viruses in each patient.

61 ws broad-spectrum antiviral activity against RNA viruses, and previous studies with RdRps from Ebola

62 Since RNA elements guide function in most RNA viruses, and they represent potential drug targets,

63 RNA viruses are a major human health threat.

64 RNA viruses are capable of rapid host shifting, typicall

65 th this time-resolved analysis, we show that RNA viruses are diverse, abundant, and active in soil.

66 RNA recombination events among similar RNA viruses are frequent, although RNA recombination cou

67 These RNA viruses are transmitted by the bite of infected mosq

68 tripartite, single-stranded, negative-sense RNA viruses are transmitted from plant to plant by thrip

69 Positive-strand RNA [(+)RNA] viruses are important pathogens of humans, animals,

70 , known as nonsegmented negative-sense (NNS) RNA viruses, are a class of pathogenic and sometimes dea

71 ses, negative-sense single-strand tripartite RNA viruses, are a global public health threat.

72 viruses and many other families of enveloped RNA viruses, are not utilized by the Herpesviridae, at l

73 me structure-function interrelationships for RNA viruses, as informed by SHAPE structure probing, and

74 In contrast, single-stranded RNA viruses assemble their coat proteins around their ge

75 Single-stranded, positive-sense RNA viruses assemble their replication complexes in infe

76 Positive-strand RNA [(+)RNA] viruses assemble numerous membrane-bound viral repl

77 Chikungunya virus, a cytopathic RNA virus associated also with epidemics, required RelA,

78 the yield of Chandipura virus, a cytopathic RNA virus associated with human epidemics, by extending

79 Human pegivirus (HPgV) is a single-strand RNA virus belonging to the Flaviviridae.

80 therwise identical virions of a multipartite RNA virus, brome mosaic virus (BMV).

81 nosis of many infectious diseases, including RNA viruses, but is generally limited to settings with a

82 pens RIG-I-mediated immune signaling against RNA viruses by controlling RIG-I's association with its

83 s a regulatory factor for the replication of RNA viruses by differentially regulating the RIG-I- and

84 RelA promoted the growth of cytopathic RNA viruses by extending the life span of infected cells

85 identified that impact the recombination of RNA viruses by using single-cell yeast systems.

86 ll-to-cell movement of two positive-stranded RNA viruses by using trans-complementation assays.

87 " and applied it to cells challenged with an RNA virus called sindbis (SINV).

88 The large polymerase (L) proteins of NNS RNA viruses carry all of the enzymatic functions require

89 Ebola, a hypervariable RNA virus causing fatalities of up to 90% for recent out

90 Current models of cell-intrinsic immunity to RNA viruses centre on virus-triggered inducible antivira

91 Strain-level RNA virus characterization is essential for developing p

92 Like other RNA viruses, CHIKV has a high mutation rate and is capab

93 is an enveloped trisegmented negative-strand RNA virus classified within the Nairoviridae family of t

94 This review discusses mechanisms of RNA virus clearance and neurotoxicity during viral encep

95 Like other single-stranded RNA viruses, CMV is known to have a high potential for p

96 Negative-strand RNA viruses condense their genome into helical nucleocap

97 is a 7.2-kb positive-sense, single-stranded RNA virus containing three partially overlapping reading

98 Neurotropic RNA viruses continue to emerge and are increasingly link

99 Many RNA viruses create specialized membranes for genome repl

100 on.IMPORTANCE Replication of positive-strand RNA viruses depends on recruitment of host components in

101 tion of many positive-strand RNA viruses [(+)RNA viruses] depends on the cellular protein GBF1, but i

102 interfering RNAs (siRNAs) derived from viral RNA (virus-derived siRNAs) through gene silencing.

103 hina and identified more than 4,500 distinct RNA viruses, doubling the previously known set of viruse

104 r the first time, epistatic constraint in an RNA virus due to host range mutations themselves, which

105 compared with other enteric single-stranded RNA viruses (e.g., Echovirus 12, feline calicivirus) but

106 Genomic material from many neurotropic RNA viruses (e.g., measles virus [MV], West Nile virus [

107 Influenza virus is an RNA virus encapsulated in a lipid bilayer derived from t

108 age MS2 is a positive-sense, single-stranded RNA virus encapsulated in an asymmetric T = 3 pseudo-ico

109 Many RNA viruses encode a proof-reading deficient, low-fideli

110 RNA viruses encode the information required to usurp cel

111 estricted to DNA virus, as sindbis virus, an RNA virus, enhances the expression of this protein.

112 V behaves similarly to other negative-strand RNA viruses, even though there is no genetic similarity

113 ly recognized as a main genomic regulator of RNA virus evolution, which works especially well for pos

114 rease our understanding of the mechanisms of RNA virus evolution.

115 sly established five-branch structure of the RNA virus evolutionary tree, with no additional phyla.

116 RNA viruses exist as populations of genome variants.

117 Positive-stranded RNA viruses extensively remodel host cell architecture t

118 sociated RNA; the insect plus-strand RNA [(+)RNA] viruses Flock House virus and Nodamura virus; and t

119 Thus, CPO of an RNA virus for a mammalian host has paradoxical effects o

120 and used a novel Cre-inducible short-hairpin RNA virus for MSN-subtype-specific knockdown of Npas2 Ce

121 It is optimized for identifying RNA viruses from metagenomic data by combining an effect

122 Using a prototype of NNS RNA virus gene expression, vesicular stomatitis virus (V

123 mines its antiviral activity.IMPORTANCE Some RNA virus genomes are suppressed in the nucleotide combi

124 Most nonsegmented negative strand (NNS) RNA virus genomes have complementary 3' and 5' terminal

125 , including HIV-1, and introducing CpGs into RNA virus genomes inhibits their replication.

126 apsidates one of the largest single-stranded RNA virus genomes known.

127 s of CpG and UpA dinucleotides in most plant RNA virus genomes show degrees of suppression comparable

128 Chandipura virus (CHPV), a cytoplasmic RNA virus, has been implicated in several outbreaks of a

129 Only a few RNA viruses have been discovered from archaeological sam

130 actions between the insect immune system and RNA viruses have been extensively studied in Drosophila,

131 RNA viruses have evolved sophisticated strategies to dis

132 anslation and/or stability, and both DNA and RNA viruses have evolved to utilize epitranscriptomic mo

133 nd no support for the view that vector-borne RNA viruses have lower d (N)/d (S) ratios than non-vecto

134 om RSV and other nonsegmented negative-sense RNA viruses have provided insights into the overall NC a

135 Positive-sense RNA viruses hijack intracellular membranes that provide

136 In response to infection with RNA viruses, host nonself RNA sensors recognize virus-de

137 demonstrated that polyamines are crucial for RNA viruses; however, the mechanisms by which polyamines

138 grees C and 45 degrees C of RdRps from three RNA viruses, i.e. the double-stranded RNA bacteriophage

139 rally, they provide additional evidence that RNA virus IBs are important immunomodulatory complexes w

140 embly of functional viral factories in other RNA viruses.IMPORTANCE The rotavirus (RV) double-strande

141 nt plant and animal positive single-stranded RNA viruses.IMPORTANCE Uncapped viral RNAs often rely on

142 grassy stunt virus (RGSV), a negative-strand RNA virus in the Bunyavirales, causes developmental abno

143 s a nonenveloped, segmented, double-stranded RNA virus in the Reoviridae family.

144 However, very little is known about RNA viruses in an environmental context, and even less i

145 RNA viruses in aquatic environments remain poorly studie

146 p to explain the high potency of RDV against RNA viruses in cell-based assays.

147 ight be applicable to alphaviruses and other RNA viruses in general.

148 insights into the diversity and evolution of RNA viruses in mites, but also a solid knowledge base fo

149 required to implement diagnostic assays for RNA viruses in settings that lack traditional laboratory

150 Here we review the role of DVGs of RNA viruses in shaping outcomes of experimental as well

151 arge-scale study of known eukaryotic DNA and RNA viruses in stools from children, we evaluated fecall

152 rately tracks positive-sense single-stranded RNA virus inactivation without relying on culturing meth

153 nyavirales order of segmented negative-sense RNA viruses includes more than 500 isolates that infect

154 Their sequences share similarity to distinct RNA viruses, including bunyaviruses, narnaviruses, and s

155 NA synthesis for a variety of negative-sense RNA viruses, including Ebola virus.

156 nes that protect against multiple pathogenic RNA viruses, including hepatitis A and C viruses, dengue

157 ucleotides are suppressed in most vertebrate RNA viruses, including HIV-1, and introducing CpGs into

158 suppressed in the genomes of many vertebrate RNA viruses, including HIV-1.

159 Nonsegmented negative-strand RNA viruses, including measles virus (MeV), a member of

160 protein to permit virion assembly.IMPORTANCE RNA viruses, including poliovirus, evolve rapidly due to

161 tiviral activity against a number of DNA and RNA viruses, including severe acute respiratory syndrome

162 oad spectrum of antiviral activities against RNA viruses, including severe acute respiratory syndrome

163 itating RNA encapsidation.IMPORTANCE All NNS RNA viruses, including the human pathogens rabies, measl

164 We show that diverse RNA viruses, including the plant viruses tomato bushy st

165 he emergence of resistant viruses.IMPORTANCE RNA viruses, including Venezuelan equine encephalitis vi

166 tavirus (PUUV) infection represents a unique RNA virus-induced renal disease with significant protein

167 .5-5.5 kilo-base pair (kbp), double-stranded RNA virus infecting T. vaginalis.

168 re initially characterized in the context of RNA virus infection, evidence has now accumulated establ

169 emarkably, in response to dsRNA treatment or RNA virus infection, LGP2 is rapidly released from MAVS

170 s in response to nucleic acid sensing during RNA virus infection.

171 basis for the susceptibility of CHO cells to RNA virus infection.

172 the production of type I IFNs in response to RNA virus infection.

173 hat contribute to distinct phenotypes during RNA virus infection.

174 thin the intracellular response to dsRNA and RNA virus infection.

175 of NF-kappaB signaling during the course of RNA virus infections.

176 y may also be important in controlling other RNA virus infections.

177 Segmented negative-sense (SNS) RNA viruses initiate infection by delivering into cells

178 unravel an intriguing mechanism by which an RNA virus interrupts host DNA replication.

179 Genetic recombination in RNA viruses is a major force behind their rapid evolutio

180 (SARS-CoV-2), a novel evolutionary divergent RNA virus, is responsible for the present devastating CO

181 The life cycles of many highly pathogenic RNA viruses like influenza A virus (IAV) and Lassa virus

182 iral proteins, including the polymerase, but RNA viruses like influenza tend to become resistant to s

183 o human health posed by some single-stranded RNA viruses, little is understood about their assembly.

184 Comparing how RNA viruses manipulate the autophagy pathway reveals new

185 analogy with other segmented negative-sense RNA viruses, may direct activities such as virus assembl

186 Unlike RNA viruses, most DNA viruses replicate their genomes wi

187 lap on opposite strands, unprecedented among RNA viruses, motivates an exploration of the constraints

188 Positive-stranded RNA virus movement proteins (MPs) generally lack sequenc

189 ls of serial host range expansion.IMPORTANCE RNA viruses mutate rapidly and frequently expand their h

190 ure from other nonsegmented, negative-strand RNA viruses (NNSVs) that have been studied to date and h

191 Negative-strand RNA viruses (NSVs) include some of the most pathogenic h

192 ral RNA synthesis.IMPORTANCE Negative-strand RNA viruses (NSVs) include the most pathogenic viruses k

193 n enveloped, single-stranded, positive-sense RNA virus of the Flaviviridae family that has emerged as

194 Replication complexes of (+)RNA viruses of eukaryotes are associated with specialize

195 y describes paradoxical effects of CPO of an RNA virus on viral replication and the adaptive humoral

196 ses, like other non-enveloped, double-strand RNA viruses, package an RNA-dependent RNA polymerase (Rd

197 psid binding sites genome-wide within mature RNA virus particles, we have developed a Next-Generation

198 c RNA (RNA4) of Brome mosaic virus (BMV), an RNA virus pathogenic to plants, are distributed among th

199 ed 5' RNAs is a conserved feature of all SNS RNA virus polymerases, implying that promoter-specific R

200 cation of functional self-cleaving poxins in RNA-virus polyproteins.

201 The impacts of invertebrate RNA virus population dynamics on virulence and infection

202 dent RNA polymerases drives the diversity of RNA virus populations.

203 Nonsegmented negative-strand (NNS) RNA viruses possess a ribonucleoprotein template in whic

204 Although innate immune activation by RNA viruses preferentially occurs through intracellular

205 Some negative-sense RNA viruses prime mRNA transcription using host 5' cap s

206 The question as to whether RNA viruses produce bona fide microRNAs (miRNAs) during

207 error catastrophe.IMPORTANCE Positive-strand RNA viruses produce vast amounts of progeny in very shor

208 reverse-genetics system for an invertebrate RNA virus quasispecies.

209 isms that allow non-segmented negative sense RNA virus recognition and antagonism of RLRs.

210 facilitates investigation of potentially all RNA viruses, regardless of RNA sequence.

211 We previously discovered three RNA viruses related to nodaviruses and here describe a f

212 Three RNA viruses related to nodaviruses were previously descr

213 ex.IMPORTANCE Replication of negative-strand RNA viruses relies on two components: a helical ribonucl

214 ation in nucleotide substitution rates among RNA viruses remains unclear.

215 ost diversity that rival those of persistent RNA viruses [Renzette N, Bhattacharjee B, Jensen JD, Gib

216 Many RNA viruses replicate in cytoplasmic compartments (virus

217 ective viral genomes (DVGs) generated during RNA virus replication determine infection outcome by tri

218 al host pathways restricting positive-strand RNA virus replication in immortalized hepatocytes and id

219 fundamental gaps in our understanding of NNS RNA virus replication.

220 ype I interferon (IFN) induction and inhibit RNA virus replication.

221 ent a general strategy to interfere with NNS RNA virus replication.

222 lved a unique replication strategy among NNS RNA viruses resulting in 3' overhangs.

223 The replication of many positive-strand RNA viruses [(+)RNA viruses] depends on the cellular pro

224 Similar to other RNA viruses, SARS-CoV-2 must (1) enter a target/host cel

225 n the virulence of all currently known human RNA virus species.

226 nce of each of the 214 known human-infective RNA virus species.

227 FN) and cytokine responses to infection were RNA virus specific and differentially involved TLR7 and

228 immune responses, but the mechanism by which RNA viruses stimulate mtDNA release remains unknown.

229 Among the 21 RNA viruses studied, 18 showed a genome-average d (N)/d

230 perinatal Zika transmission as well as other RNA viruses such as coronavirus.

231 Infections by RNA viruses such as Influenza, HIV still pose a serious

232 onses are important against rapidly mutating RNA viruses, such as dengue (DENV), yet how viral divers

233 synthesis strategy with other members of NNS RNA viruses, such as measles, rabies virus, and Ebola vi

234 [KV]) and immune processes known to control RNA viruses, such as RNA interference (RNAi) and Imd pat

235 nce Riplet is known to be inhibited by other RNA viruses, such as such influenza A virus, this innate

236 Rapidly evolving RNA viruses, such as the GII.4 strain of human norovirus

237 for stable RNA folding is exceptional among RNA viruses, superseding even that of HCV, one of the mo

238 RNA virus survival depends on efficient viral genome rep

239 The triennial International Double-Stranded RNA Virus Symposium, this year organized by J.

240 RNA viruses synthesize new genomes in the infected host

241 pathogens, the non-segmented negative sense RNA viruses target the RLR pathway using a variety of me

242 ne responses and increased resistance to the RNA viruses tested.

243 irus (EBOV) is an enveloped, single-stranded RNA virus that can cause Ebola virus disease (EVD).

244 EBOV is a negative-sense RNA virus that can infect humans and non-human primates,

245 hikungunya virus (CHIKV) is a mosquito-borne RNA virus that causes febrile illness and debilitating a

246 member of the Arenaviridae, is an ambisense RNA virus that causes severe hemorrhagic fever with a hi

247 nfluenza is a negative-sense single-stranded RNA virus that encodes its own RNA-dependent RNA polymer

248 uenza B virus (IBV) is an acute, respiratory RNA virus that has been assumed to induce the eventual d

249 Herein we describe the discovery of an RNA virus that infects both freshwater and anadromous po

250 Hepatitis C virus (HCV) is a positive-sense RNA virus that interacts with the liver-specific microRN

251 llow Dwarf Virus (BYDV) is a positive strand RNA virus that lacks the canonical 5' 7-methylguanosine

252 Influenza A virus (IAV) is a lytic RNA virus that triggers receptor-interacting serine/thre

253 Alphaviruses are enveloped, positive-sense RNA viruses that are important causes of viral encephalo

254 Alphaviruses are positive-sense, enveloped RNA viruses that are important causes of viral encephalo

255 ed protein fold found in several plus-strand RNA viruses that binds to the small molecule ADP-ribose.

256 Alphaviruses are small enveloped RNA viruses that bud from the host cell plasma membrane.

257 iruses, which are highly organized enveloped RNA viruses that bud from the plasma membrane.

258 Coronaviruses (CoVs) are positive-sense RNA viruses that can emerge from endemic reservoirs and

259 Flaviviruses are vector-borne RNA viruses that can emerge unexpectedly in human popula

260 are enveloped, nonsegmented, negative-strand RNA viruses that cause a wide spectrum of human and anim

261 Human rhinoviruses (RVs) are positive-strand RNA viruses that cause respiratory tract disease in chil

262 P-defective mutants of two positive-stranded RNA viruses that have different movement strategies.

263 ussed.IMPORTANCE Nairoviruses are a group of RNA viruses that include many serious pathogens of human

264 RTANCE Nairoviruses are tick-borne enveloped RNA viruses that include several pathogens responsible f

265 idae are a diverse family of positive-strand RNA viruses that includes numerous human and veterinary

266 Coronaviridae is a family of positive-strand RNA viruses that includes SARS-CoV-2, the etiologic agen

267 es are a family of positive-strand enveloped RNA viruses that includes the severe acute respiratory s

268 For negative-sense RNA viruses that infect plants, the arthropod serves as

269 nts are frequently infected with cytoplasmic RNA viruses that persist for many generations through ne

270 ne viruses (arboviruses) are single-stranded RNA viruses, the most common of which include the mosqui

271 Different from most other RNA viruses, the transcription and replication of IAV oc

272 Like other positive-strand RNA viruses, the Turnip mosaic virus (TuMV) infection le

273 For positive-strand RNA [(+)RNA] viruses, the major target for antiviral therapies i

274 the Picornaviridae family of positive-strand RNA viruses, their successful replication cycles require

275 tained, particularly in the small genomes of RNA viruses, this should offer some advantages.

276 pleiotropic regulator of the replication of RNA viruses through regulation of RIG-I/MDA5-mediated si

277 Obstacles to convincingly linking RNA viruses to islet autoimmunity may be attributed to r

278 itically involved in regulating both DNA and RNA virus-triggered host defenses, in which activated ca

279 fic gene deletion of Traf3ip3 have increased RNA virus-triggered IFN-I production and reduced suscept

280 lta virus (HDV) is a human hepatitis-causing RNA virus, unrelated to any other taxonomic group of RNA

281 These samples were tested for DNA and RNA viruses using a real-time PCR and RT-PCR.

282 losses due to Deformed wing virus (DWV), an RNA virus vectored by the mite Varroa destructor.

283 In other RNA viruses, virus population diversity associates with

284 opagation of the DNA virus HSV-1 but not the RNA virus VSV.

285 The complete genome sequence of an RNA virus was assembled from RNA sequencing of virus par

286 ver, replication of single-stranded negative RNA viruses was not affected.

287 and by analogy for all other negative-strand RNA viruses, we show that directional sequencing must be

288 otein domains not previously detected in any RNA viruses were identified, such as the small ubiquitin

289 Orsay virus, a small RNA virus which specifically infects the laboratory mode

290 mechanism of replication of positive-strand RNA viruses, which are major pathogens of plants, animal

291 rge genus of positive-sense, single-stranded RNA viruses whose members cause a number of important an

292 It is a single stranded (-)RNA virus with a segmented genome.

293 Caliciviruses are single-stranded RNA viruses with 180 copies of capsid protein comprising

294 iruses have been described as positive-sense RNA viruses with a remarkably simple genome of ~3 kb, en

295 Like other RNA viruses with high mutation rates, CHIKV produces pop

296 Coronaviruses are a family of positive-sense RNA viruses with human and agricultural significance.

297 haviruses are emerging, mosquito-transmitted RNA viruses with poorly understood cellular tropism and

298 vast and diverse virome that is dominated by RNA viruses, with major additional contributions from re

299 st of this information comes from studies of RNA viruses, with relatively little known about evolutio

300 es tick-borne, trisegmented, negative-strand RNA viruses, with several members being associated with