ライフサイエンスコーパス: RPTP

1 RPTP-kappa also reduced epidermal growth factor-dependen

2 RPTP-kappa directly counters intrinsic EGFR tyrosine kin

3 RPTP-kappa expression in both GFP-labeled dorsal root ga

4 RPTP-kappa induction is dependent on activation of trans

5 RPTP-kappa is proteolytically processed to isoforms that

6 RPTP-kappa levels increased in keratinocytes as cells re

7 RPTPs are type-I integral membrane proteins which contai

8 RPTPs in general are still "orphan receptors" because, w

9 PTPmu is a RPTP that mediates cell aggregation and is expressed at

10 proteins with tyrosine phosphatase activity (RPTPs).

11 es that there are likely to be no additional RPTPs encoded in the fly genome.

12 cell in the leech, express high levels of an RPTP called HmLAR2 [6,7].

13 this is the first direct demonstration of an RPTP's influence on the actin cytoskeleton.

14 n particular by the family of Wnt kinase and RPTP phosphatase signaling pathways.

15 orting the model for regulation of CD45, and RPTPs in general.

16 complex signaling interplay between RTKs and RPTPs.

17 alytic activity is not fully understood, and RPTPs are generally not therapeutically targetable.

18 Interestingly, another RPTP, Ptp69D, promotes dendritic growth of C4da neurons

19 pends on the phosphatase activity of another RPTP, PTP69D.

20 ptor-type protein tyrosine phosphatase beta (RPTP-beta) specifically dephosphorylates Met and thereby

21 partially because the ligands recognized by RPTPs at growth cone choice points have not been identif

22 g cascade that could be modulated in vivo by RPTPs such as DPTP10D.

23 results suggest that in unstimulated cells, RPTP beta/zeta is intrinsically active and functions as

24 s the biological activity of a CD45 chimeric RPTP and the catalytic activity of an isolated RPTPsigma

25 lamus, are expanded in size; a complementary RPTP(delta) domain in ventral thalamus is correspondingl

26 ose, treatment of cells results in decreased RPTP retention, showing that galectin-1 binding contribu

27 tified cells throughout the CNS that display RPTP-kappa promoter activity.

28 ed with in ovo electroporation to knock down RPTP expression levels in the embryonic chick lumbar spi

29 tp4E is the only widely expressed Drosophila RPTP, and is the last of the six fly RPTPs to be genetic

30 has been demonstrated for certain Drosophila RPTPs.

31 Five of the six Drosophila RPTPs have C. elegans counterparts, and three of the six

32 Recent findings show that Drosophila RPTPs play key roles in guiding retinal axons and in pre

33 ein tyrosine phosphatase (PTP) family (i.e., RPTP kappa, RPTPmu, NU-3, SHP, and 3CH134) are completel

34 These results demonstrate that each RPTP exerts a unique regulatory fingerprint of RTK tyros

35 We observed that each RPTP induced a unique fingerprint of tyrosyl phosphoryla

36 the epidermal growth factor receptor (EGFR)-RPTP CD45 chimera (EGFR-CD45) in T cell signal transduct

37 ng those that do not normally express either RPTP, suggesting that the substrates involved in HmLAR-i

38 llel to its ability to inactivate endogenous RPTP beta/zeta, PTN sharply increases tyrosine phosphory

39 more, shRNA-mediated knockdown of endogenous RPTP-beta increases basal and HGF-stimulated Met phospho

40 l+neo (beta-geo) insertion in the endogenous RPTP-kappa gene, the consequent loss of RPTP-kappa's enz

41 ene's expression is driven by the endogenous RPTP-kappa promoter, distribution of the truncated RPTP-

42 Five highly expressed RPTPs (RPTP-beta, delta, kappa, mu, and xi) were functio

43 sophila RPTP, and is the last of the six fly RPTPs to be genetically characterized.

44 ne, by acting as an intracellular anchor for RPTP signalling at synaptic junctions.

45 lts suggest that PTN is a natural ligand for RPTP beta/zeta.

46 the first evidence of an essential role for RPTPs in epithelial organ development.

47 a scarcity of validated allosteric sites for RPTPs.

48 stall at an aberrant, abrupt border of high RPTP(delta) expression.

49 of the tandem D1 and D2 domains of the human RPTP LAR revealed that the tertiary structures of the LA

50 ree of the six are also orthologous to human RPTP subfamilies.

51 Most human RPTPs possess an extracellular receptor domain and tande

52 el mechanism of EGFR regulation and identify RPTP-kappa as a key molecular target for antioxidant pro

53 l interfering RNA (siRNA) screen to identify RPTPs in the human genome that serve as RTK phosphatases

54 as a new partner for the Drosophila Type IIa RPTP Lar.

55 In the vertebrate, type IIa RPTPs [protein tyrosine phosphatase (PTP)-delta, PTP-sig

56 s ortholog, Nephrin, binds to human Type IIa RPTPs.

57 ar region of RPTPmu, a prototypical type IIB RPTP.

58 ed the expression of mouse PTPRO, a type III RPTP with an extracellular region containing eight fibro

59 iments in our lab have identified a type III RPTP, CRYP-2/cPTPRO, specifically expressed during the p

60 te common-antigen-related)] and the type III RPTP, PTP receptor type O (PTPRO), have been implicated

61 eletions in the fly have shown that type III RPTPs are important in axon pathfinding, but nothing is

62 at competition between type IIa and type III RPTPs can regulate motor axon outgrowth, consistent with

63 ssion of wild-type or catalytically inactive RPTP-kappa reduced or enhanced, respectively, basal and

64 RPTPs are expressed in the brain, including RPTP-kappa which participates in homophilic cell-cell in

65 shRNA-mediated reduction of TGF-beta-induced RPTP-kappa significantly attenuates the ability of TGF-b

66 receptor protein tyrosine phosphatase kappa (RPTP-kappa) and the laminin receptor 1 (ribosomal protei

67 tor-type protein tyrosine phosphatase kappa (RPTP-kappa), and the interaction of the two proteins in

68 tor-type protein-tyrosine phosphatase-kappa (RPTP-kappa) dephosphorylates EGFR and thereby regulates

69 tor type protein tyrosine phosphatase-kappa (RPTP-kappa) specifically dephosphorylates EGFR, thereby

70 ative inhibition of receptor type PTP-kappa (RPTP-kappa).

71 nsion to our understanding of liprin and LAR RPTP function during synapse formation.

72 ependent study of synapse function after LAR-RPTP ablation.

73 In neurons, liprin-alpha and LAR-RPTP are enriched at synapses and coimmunoprecipitate wi

74 R-RPTP and tyrosine dephosphorylation by LAR-RPTP.

75 f cIAP1 reverts the apoptotic deficit of LAR-RPTP-deficient embryos.

76 receptor protein tyrosine phosphatases (LAR-RPTP) bind to liprin-alpha (SYD2) and are implicated in

77 We finally demonstrate that LAR-RPTP deficiency increases cIAP1 stability during apoptot

78 We report that LAR-RPTP is concentrated in mature synapses in cultured rat

79 that involves binding of liprin-alpha to LAR-RPTP and tyrosine dephosphorylation by LAR-RPTP.

80 In vivo, deletion of all LAR-RPTPs in the hippocampus at birth also did not alter syn

81 In cultured neurons, deletion of all LAR-RPTPs led to a reduction in synaptic NMDA-receptor EPSCs

82 ir localization at synaptic appositions, LAR-RPTPs are dispensable for presynapse structure and funct

83 Via these interactions, LAR-RPTPs are thought to function as synaptogenic wiring mol

84 Deletion of LAR-RPTPs decreased NMDA-receptor-mediated responses by a tr

85 Strikingly, deletion of LAR-RPTPs had no effect on synaptic connectivity in cultured

86 lice insert B in the Ig domain region of LAR-RPTPs, and mediate SALM5-dependent presynaptic different

87 To test the synaptogenic functions of LAR-RPTPs, we conditionally deleted the genes encoding all t

88 receptor protein tyrosine phosphatases (LAR-RPTPs) and that are implicated in presynaptic developmen

89 receptor protein tyrosine phosphatases (LAR-RPTPs) are cell-adhesion proteins that control synapse a

90 e receptor phosphotyrosine-phosphatases (LAR-RPTPs) are presynaptic adhesion molecules that interact

91 receptor protein tyrosine phosphatases (LAR-RPTPs; LAR, PTPdelta, and PTPsigma).

92 ynaptically interacting with presynaptic LAR-RPTPs and is important for the regulation of excitatory

93 n of postsynaptic SALM5 with presynaptic LAR-RPTPs.

94 Here we show that LAR-RPTPs act through cellular inhibitor of apoptosis protei

95 lly deleted the genes encoding all three LAR-RPTPs, singly or in combination, in mice before synapse

96 Thus, LAR-RPTPs are not essential for synapse formation, but contr

97 e after knockout of the three vertebrate LAR-RPTPs (PTPd, PTPo, and LAR) has not been tested.

98 ation inhibits the activity of a full-length RPTP in vivo.

99 on of vab-1 and ptp-3 suggests that LAR-like RPTPs and Eph receptors have related and partly redundan

100 experiments indicate a key role for LAR-like RPTPs in maintaining the integrity of the growth cone.

101 HmLAR2, one of two closely related LAR-like RPTPs in the embryonic leech, is expressed in a few cent

102 Here we report that two LAR-like RPTPs in the medicinal leech, HmLAR1 and HmLAR2, play ro

103 whether they normally express these LAR-like RPTPs.

104 which can be subdivided into receptor-like (RPTPs) and nonreceptor (NRPTPs).

105 these findings demonstrate that manipulating RPTP function via antibodies to the extracellular segmen

106 Most RPTPs are expressed at very low levels, whereas nonrecep

107 alytic domain (D1) of a typical RPTP, murine RPTP alpha.

108 isolation of mutations in the fourth neural RPTP, DPTP10D.

109 The neural RPTP DPTP99A can also induce gp150 dephosphorylation but

110 equires a specific subset of the five neural RPTPs.

111 lso show that elimination of all four neural RPTPs converts most noncrossing longitudinal pathways in

112 Syndecan (Sdc) as a ligand for the neuronal RPTP LAR.

113 n) as a candidate substrate for the neuronal RPTP Ptp52F by using a modified two-hybrid screen with a

114 onally inactivates the catalytic activity of RPTP beta/zeta.

115 Because cleavage of RPTP occurs at a target motif (RXK/RR) recognized by a f

116 The brain distribution of RPTP-kappa-expressing cells has not been determined, how

117 und that an active site-containing domain of RPTP beta/zeta both binds beta-catenin and functionally

118 educed and the normally graded expression of RPTP(delta) in that domain is no longer apparent.

119 Expression of RPTP-beta in human primary keratinocytes reduces HGF ind

120 Expression of RPTP-beta in primary human keratinocytes reduces both ba

121 Expression of RPTP-beta, but not other RPTP family members or catalyti

122 Co-expression of RPTP-kappa, but not other RPTPs, specifically reduced ba

123 y members or catalytically inactive forms of RPTP-beta, reduces hepatocyte growth factor (HGF)-stimul

124 The homology of RPTP-kappa's ectodomain to neural cell adhesion molecule

125 gh ligand-dependent receptor inactivation of RPTP beta/zeta to increase levels of tyrosine phosphoryl

126 Reversible, oxidative inactivation of RPTP-kappa activity by UV irradiation shifts the kinase-

127 "ligand-dependent receptor inactivation" of RPTP beta/zeta and disrupts its normal roles in the regu

128 Induction of RPTP-kappa by TGF-beta significantly decreases basal and

129 ptor kinase completely prevents induction of RPTP-kappa.

130 possibility that homophilic interactions of RPTP-kappa contribute to establishment of connections be

131 Furthermore, siRNA-mediated knockdown of RPTP-kappa increased basal and EGF-stimulated EGFR tyros

132 nous RPTP-kappa gene, the consequent loss of RPTP-kappa's enzymatic activity does not produce any obv

133 ast, an (inactivating) active-site mutant of RPTP beta/zeta also binds beta-catenin but fails to redu

134 n addition, the substrate-trapping mutant of RPTP-beta specifically interacts with Met in intact cell

135 ls reached confluency, and overexpression of RPTP-kappa in subconfluent keratinocytes reduced keratin

136 ot only shed light on the regulatory role of RPTP-D2 domains, but also provide a potentially useful t

137 ns may provide a basis for future studies of RPTP-kappa function.

138 tracellular ligands regulate the activity of RPTPs.

139 he first example of an allosteric agonist of RPTPs.

140 own natural ligands or selective agonists of RPTPs.

141 The D2 domain of RPTPs is believed to mostly play a regulatory function;

142 logists because the extracellular domains of RPTPs are similar to those of cell adhesion molecules (C

143 was clearly affected by dsRNA knock-down of RPTPs.

144 the development of allosteric inhibitors of RPTPs but a scarcity of validated allosteric sites for R

145 ported a general model for the regulation of RPTPs, derived from the crystal structure of the RPTPalp

146 This review focuses on the role of RPTPs in development of the nervous system in processes

147 To examine potential roles of RPTPs in axon growth and guidance in vivo, we used doubl

148 The domain structure of RPTPs comprises an extracellular region, a transmembrane

149 The LAR subfamily of RPTPs has been implicated in axon guidance and neural de

150 ith RTK signaling, the downstream targets of RPTPs.

151 Expression of RPTP-beta, but not other RPTP family members or catalytically inactive forms of R

152 s been established for RPTPalpha-D2 or other RPTP-D2 domains.

153 hemical probes targeting RPTPalpha and other RPTPs.

154 he catalytic activity of RPTPalpha and other RPTPs.

155 he regulation of CD45, and by homology other RPTPs, in which dimerization inhibits phosphatase activi

156 cytoplasmic region of CD45, like many other RPTPs, contains two homologous protein tyrosine phosphat

157 Co-expression of RPTP-kappa, but not other RPTPs, specifically reduced basal EGFR tyrosine phosphor

158 The known effects of other RPTPs in axon guidance could result from modulation of g

159 identify which neurons express a particular RPTP.

160 r), a receptor protein tyrosine phosphatase (RPTP) and the only known Drosophila HSPG receptor, for p

161 h the receptor protein tyrosine phosphatase (RPTP) beta/zeta in U373-MG cells.

162 that receptor protein tyrosine phosphatase (RPTP) beta/zeta is a physiological PTN receptor.

163 receptor-type protein tyrosine phosphatase (RPTP) CD148 is thought to have an inhibitory function in

164 find that the receptor tyrosine phosphatase (RPTP) Dlar and integrins are involved in organizing basa

165 three receptor protein tyrosine phosphatase (RPTP) ligands and a chemokine-like protein that binds to

166 brane receptor protein tyrosine phosphatase (RPTP) that functions in AVM to inhibit signaling through

167 f the receptor protein tyrosine phosphatase (RPTP), Dlar, and an associated intracellular protein, Dl

168 The receptor protein tyrosine phosphatase (RPTP)beta/zeta is a transmembrane tyrosine phosphatase w

169 e PTN/receptor protein tyrosine phosphatase (RPTP)beta/zeta signaling pathway.

170 s of receptor protein tyrosine phosphatases (RPTP) occur at high cell density and may have an importa

171 receptor-like protein tyrosine phosphatases (RPTPs) and has essential roles in immune functions.

172 IIB receptor protein tyrosine phosphatases (RPTPs) are bi-functional cell surface molecules.

173 Receptor tyrosine phosphatases (RPTPs) are essential for axon guidance and synaptogenesi

174 receptor-like protein tyrosine phosphatases (RPTPs) are essential for neural development.

175 ceptor-linked protein-tyrosine phosphatases (RPTPs) are essential regulators of axon guidance and syn

176 Receptor protein tyrosine phosphatases (RPTPs) are implicated as regulators of axon growth and g

177 Receptor protein tyrosine phosphatases (RPTPs) are important for growth-cone migration [1-5], bu

178 ceptor-linked protein tyrosine phosphatases (RPTPs) are key regulators of cell-cell communication thr

179 transmembrane protein tyrosine phosphatases (RPTPs) are not well understood.

180 Receptor protein tyrosine phosphatases (RPTPs) are of particular interest to developmental biolo

181 ays and receptor-like tyrosine phosphatases (RPTPs) are rarely considered in chemoattractant-mediated

182 Receptor-type protein tyrosine phosphatases (RPTPs) are required for appropriate growth of axons duri

183 ceptor-linked protein tyrosine phosphatases (RPTPs) are required for guidance of motoneuron and photo

184 onal receptor protein tyrosine phosphatases (RPTPs) as key determinants of axon pathfinding behavior.

185 Receptor protein tyrosine phosphatases (RPTPs) can play essential roles in the dephosphorylation

186 Receptor protein tyrosine phosphatases (RPTPs) comprise a family of proteins that feature intrac

187 receptor-like protein tyrosine phosphatases (RPTPs) contain two conserved phosphatase domains (D1 and

188 Receptor-like protein tyrosine phosphatases (RPTPs) continue to emerge as important signalling molecu

189 Receptor protein tyrosine phosphatases (RPTPs) control many aspects of nervous system developmen

190 Receptor-like protein-tyrosine phosphatases (RPTPs) form a diverse family of cell surface molecules w

191 receptor-type protein tyrosine phosphatases (RPTPs) have adhesion molecule-like extracellular segment

192 Receptor protein tyrosine phosphatases (RPTPs) have been shown to play key roles in regulating a

193 receptor-like protein tyrosine phosphatases (RPTPs) is not well understood.

194 h as receptor protein tyrosine phosphatases (RPTPs) mediate this process, but how they regulate the c

195 Receptor protein tyrosine phosphatases (RPTPs) play critical regulatory roles in mammalian signa

196 ceptor-linked protein tyrosine phosphatases (RPTPs) receive cues from the extracellular environment a

197 III receptor protein tyrosine phosphatases (RPTPs) regulate axon extension and pathfinding in Drosop

198 ceptor-linked protein tyrosine phosphatases (RPTPs) regulate axon guidance and synaptogenesis in Dros

199 receptor-type protein tyrosine phosphatases (RPTPs) such as CD45 from sites of receptor engagement.

200 s of receptor protein tyrosine phosphatases (RPTPs) that control axon guidance decisions in the Droso

201 Receptor-like protein-tyrosine phosphatases (RPTPs), like their non-receptor counterparts, regulate t

202 ila type III receptor tyrosine phosphatases (RPTPs), Ptp4E and Ptp10D.

203 ila type III receptor tyrosine phosphatases (RPTPs), Ptp4E and Ptp10D.

204 like receptor protein tyrosine phosphatases (RPTPs), which are reported to be highly expressed in the

205 n of receptor protein tyrosine phosphatases (RPTPs).

206 the receptor protein tyrosine phosphatases (RPTPs): LAR and RPTPsigma.

207 uppressed by dimerization, which may prevent RPTPs from accessing their RTK substrates.

208 agents that could be used as tools to probe RPTPs' signaling mechanisms or to manage cancers driven

209 The regulation of receptor-like PTP (RPTP) activity remains poorly understood, but based on t

210 Nine of 25 receptor PTPs (RPTPs) corresponded to human, nematode, or fly homologue

211 Purified RPTP-beta intracellular domain preferentially dephosphor

212 Purified RPTP-kappa preferentially dephosphorylated EGFR tyrosine

213 TGF-beta up-regulates RPTP-kappa mRNA and protein, in a dose and time dependen

214 tem, but also suggest a model for regulating RPTP dimerization and function.

215 ectopic expression of HmLAR1 and the related RPTP, HmLAR2 in the P and other neurons, including those

216 Five highly expressed RPTPs (RPTP-beta, delta, kappa, mu, and xi) were functionally a

217 studies of receptor tyrosine kinases (RTKs), RPTP activities have been reported to be suppressed by d

218 Several RPTPs are expressed in the brain, including RPTP-kappa w

219 We describe DPTP52F, the sixth RPTP to be discovered in Drosophila.

220 structure revealed that sea urchin-specific RPTPs including two, PTPRLec and PTPRscav, may act in im

221 e first demonstration that an Ig superfamily RPTP regulates the lamination of any neural tissue.

222 We report here that RPTP-kappa mediates functional integration of EGFR and T

223 Taken together, the above data indicate that RPTP-beta is a key regulator of Met function.

224 Taken together, the above data indicate that RPTP-kappa is a key regulator of EGFR tyrosine phosphory

225 The results also suggest that RPTP beta/zeta is a functional receptor for PTN; PTN sig

226 Our results indicate that RPTPs, and especially PTPRO, are required for axon growt

227 This suggests that RPTPs may have functions in development similar to CAMs.

228 The RPTP-kappa transmembrane P subunit interacts with and se

229 A small proportion of TCAs extend around the RPTP(delta) domain and reach the ventral thalamic-hypoth

230 tion of synapse growth and maturation by the RPTP LAR depends on catalytic phosphatase activity and o

231 ctly to and is an in vitro substrate for the RPTP DPTP10D.

232 The role of the RPTP CD45 in immune cell signaling is well known, but th

233 choice point pathway as an antagonist of the RPTP Dlar.

234 rst natural ligand identified for any of the RPTP family; its identification provides a unique tool t

235 It is a member of the RPTP R2B subfamily, which includes PTPkappa, PTPmu and P

236 lete understanding of the involvement of the RPTP subfamily in RTK tyrosyl dephosphorylation has not

237 demonstrate that PTPRU is unique amongst the RPTPs in possessing two pseudophosphatase domains.

238 Downregulation of Egfr signaling by the RPTPs is required for the construction of tubular lumens

239 sensitive to the sizes of the receptor, the RPTPs, and the antibody itself.

240 Remarkably, deficiency in either of these RPTPs influenced neutrophil GPCR responses in unique way

241 retinal lamination, we examined whether this RPTP could be regulating cell adhesion and migration wit

242 Three RPTPs, known as DLAR, DPTP69D, and DPTP99A, have been ge

243 PTP-delta together with PTPRO, or all three RPTPs combined, had less severe phenotypes than embryos

244 F-beta stimulates Smad3 and Smad4 binding to RPTP-kappa gene promoter.

245 del to map the distribution of the truncated RPTP-kappa/beta-geo fusion protein in the adult mouse br

246 appa promoter, distribution of the truncated RPTP-kappa/beta-geo fusion protein should reflect the re

247 Here, we report that two RPTPs, CD45 and CD148, previously shown to share redunda

248 egional and cellular expression of wild-type RPTP-kappa, and thus may identify sites where RPTP-kappa

249 -proximal catalytic domain (D1) of a typical RPTP, murine RPTP alpha.

250 Vertebrate RPTPs are now implicated in controlling axon outgrowth,

251 PTP-kappa, and thus may identify sites where RPTP-kappa is important.

252 The first step to investigate whether RPTPs influence axon growth in the more complex vertebra

253 between EGFR and TGF-beta pathways, in which RPTP-kappa functions to integrate growth-promoting and g

254 hedgehog-responsive gene MIM cooperates with RPTP to induce cytoskeletal changes.