ライフサイエンスコーパス: Rab protein

1 n homologue, and Sec4p, a vesicle-associated Rab protein.

2 th each specific step mediated by a distinct Rab protein.

3 re found to cofractionate with the exogenous rab protein.

4 signaling by specifically dephosphorylating Rab proteins.

5 b and does not interact with mono-prenylated Rab proteins.

6 to the same melanocyte/platelet subfamily of Rab proteins.

7 king of CXCR2 is differentially regulated by Rab proteins.

8 membrane at steady state and interacts with Rab proteins.

9 aracteristics that distinguish it from other Rab proteins.

10 y occurring in ras proteins but not in other rab proteins.

11 cmt-/- cells lacked the ability to methylate Rab proteins.

12 nzyme that attaches geranylgeranyl groups to Rab proteins.

13 at Vps9p recognizes sequence variation among Rab proteins.

14 strated that GDI-1 can operate with multiple Rab proteins.

15 selective interaction of GDI with individual Rab proteins.

16 Little is known about GEFs and GAPs for Ypt/Rab proteins.

17 roups to both cysteines at the C-terminus of Rab proteins.

18 al factor in the evolution of this subset of Rab proteins.

19 ates guanine nucleotide exchange on ARF1 and Rab proteins.

20 aradigm for studies on the mode of action of Rab proteins.

21 ggests that it may be specific for endosomal Rab proteins.

22 is to play a critical role in the binding of Rab proteins.

23 , which selectively dephosphorylates phospho-Rab proteins.

24 th the MHC-I complex and endosome-associated RAB proteins.

25 mutation result, but may connect to NET via RAB proteins.

26 ng events, which were regulated by different Rab proteins.

27 ylated alanine-rich C kinase substrate), and Rab proteins.

28 esearch on biological processes that involve Rab proteins.

29 ignaling by controlling dephosphorylation of Rab proteins.

30 RabGGTase) is responsible for prenylation of Rab proteins.

31 hat binds to prenylated inactive (GDP-bound) Rab proteins.

32 Gdi), which is involved in the activation of Rab proteins.

33 s to lysosomes by modulating the activity of Rab proteins.

34 the Golgi membrane through interactions with Rab proteins.

35 constitutively active forms of 31 Drosophila Rab proteins.

36 control the activity of membrane-associated Rab proteins.

37 and constitutively active forms of selected Rab proteins.

38 emporally regulated expression of Drosophila Rab proteins.

39 rab33b, the most commonly studied cisternal rab proteins.

40 icantly different in conformation from other Rab proteins.

41 and 14-3-3 proteins but not between ExoS and Rabs proteins.

42 eveloped highly sensitive sensors to monitor Rab protein activity in single dendritic spines undergoi

43 Rab proteins also act upstream of LRRK2 by controlling i

44 fied as a prenylation-dependent receptor for Rab proteins, also interacts with Ha-Ras, RhoA, TC21, an

45 ablishes a specific interaction between each Rab protein and its effectors.

46 nd for vesicle fusion at the PVC (the Vps21p rab protein and Vps45p SM (Sec1/Munc18) protein) are req

47 ces are highly homologous to other mammalian Rab proteins and also share homology with proteins of th

48 However, it has been unclear whether Rab proteins and effectors are sufficient for intermembr

49 The effects of ethanol exposure on rab proteins and Golgi function are discussed.

50 NOTCH4-dependent transcriptional control of RAB proteins and intracellular vesicle trafficking in au

51 P1), which is responsible for prenylation of Rab proteins and is essential for intracellular traffick

52 s of this protein family negatively regulate RAB proteins and modulate the signaling between RABs and

53 onal genetic data, the results indicate that Rab proteins and PI4P collaborate in the association of

54 f a stable complex between newly synthesized Rab proteins and Rab escort protein (REP).

55 has the ability to physically interact with Rab proteins and the nature of this interaction has led

56 ved to establish domains that contain unique Rab proteins and their cognate effectors, which drive al

57 Rab proteins and their effectors facilitate vesicular tr

58 enesis, the subcellular localization of some Rab proteins, and comparisons of the localization of wil

59 entified annexins, annexin-binding proteins, Rab proteins, and other proteins involved in membrane or

60 ty of LRRK2 to associate with phosphorylated Rab proteins, and phosphorylated Rab8A stimulates LRRK2

61 Yip1p function requires Rab-GDI and Rab proteins, and several mutations that abrogate Yip1p

62 A possible mechanism by which Rab proteins are digeranylgeranylated is suggested by th

63 Rab proteins are distributed across the entire surface a

64 While most Rab proteins are equally expressed in polarized and nonp

65 Rab proteins are geranylgeranylated on one or two C-term

66 Rab proteins are GTPases that cycle between an inactive

67 Although some Rab proteins are implicated in vesicle and organelle tra

68 icle budding from the donor compartment, Ypt/rab proteins are involved in the targeting of vesicles t

69 GppNHp, structural features common to active Rab proteins are observed.

70 The majority of Rab proteins are posttranslationally modified with two g

71 All nascent Rab proteins are prenylated by geranylgeranyltransferase

72 Rab proteins are Ras-related small GTPases that are dige

73 unclear how the expression and functions of Rab proteins are regulated in response to extracellular

74 Rab proteins are small GTP-binding proteins that form th

75 Rab proteins are small GTPases that are essential elemen

76 Rab proteins are small GTPases that play important roles

77 Rab proteins are small molecular weight GTPases that con

78 Rab proteins are thought to cycle on and off vesicle mem

79 Activated GTP-bound Rab proteins are thought to interact with effectors to e

80 small hydrolase enzymes (or GTPases) called Rab proteins, arranged on the cytoplasmic surface of its

81 nhibits the membrane localization of Rho and Rab proteins at statin doses as low as 200 nm, without a

82 timulates recruitment and phosphorylation of Rab proteins at the lysosome.

83 Rab proteins attach to membranes along the secretory pat

84 that several Ras-related proteins in brain (Rab) proteins become associated to phagosomes, little is

85 The cycling of Rab proteins between cytosol and intracellular membranes

86 nhibitor (GDI), which regulates the cycle of Rab proteins between membrane and cytosol, forms an incr

87 with the binding of Rab1B revealed that both Rab proteins bind preferentially to their respective res

88 ve, because the nucleotide-free forms of six Rab proteins bind with similar low efficiency to three S

89 This represents the first structure of a Rab protein bound to GDP.

90 change on ARF1 and on members of the related Rab proteins, but not on other small GTP binding protein

91 hanism for regulation of the GTPase cycle of Rab proteins by GDI proteins.

92 Posttranslational modification of Rab proteins by geranylgeranyltransferase type II requir

93 successive addition of two prenyl groups to Rab proteins by the homologous enzyme geranylgeranyltran

94 Together, our data demonstrate that a rab protein can bind directly to a specific cargo protei

95 Therefore, animal and fungi Rab proteins can be grouped in "Rab functional groups" a

96 ecific interactions of Myo5B with individual Rab proteins can lead to specificity in the regulation o

97 A glutamine residue of Rab proteins (cis-glutamine) that is essential for intri

98 Rab proteins constitute a second group of substrates tha

99 Rab proteins constitute the largest branch of the Ras GT

100 e experiments indicate that Golgi-associated Rab proteins contribute to the localization of PPM1H, an

101 Rab proteins cycle between inactive and active states as

102 Here, we examine Rab protein distributions during Drosophila epithelial t

103 nal homologs of the Saccharomyces cerevisiae Rab protein encoded by YPT1 and are differentially expre

104 Here, we systematically analyzed the Rab protein family and found 14 of them (Rab3A/B/C/D, Ra

105 and ability to bind multiple members of the Rab protein family.

106 ng on the LRRK2 interactors belonging to the Rab protein family.

107 Rab proteins form a nidus for the assembly of multiprote

108 d protein factor that can release prenylated Rab proteins from GDI.

109 g protein activity that regulates removal of Rab proteins from membranes.

110 t in Rab prenylation and REP cannot retrieve Rab proteins from the membranes.

111 Yop1p could also be coprecipitated with Rab proteins from total cellular lysates.

112 Moreover, individual Rab proteins function at specific sites within the cell,

113 he functional impact of this modification on RAB proteins has not been actively explored.

114 While many of the Rab proteins have been characterized in T. gondii, preci

115 A number of Rab proteins have been implicated in cancer development

116 While many Rab proteins have been previously linked to ciliogenesis

117 Recent studies of the functions of certain Rab proteins have revealed specific roles in mediating d

118 Small GTP-binding proteins (rab proteins) have recently been implicated in the regul

119 he classification of 30 out of 31 C. elegans Rab proteins identified here including Rab31/Rab50, a li

120 tor (GEF) that activates a subsequent acting Rab protein in a given pathway; this process has been te

121 of how GDI can be displaced efficiently from Rab protein in order to allow the necessary recruitment

122 along microtubules or actin, the role of any Rab protein in platelet biogenesis is unknown.

123 s the capability to physically interact with Rab proteins in a promiscuous manner; however, a genetic

124 when luciferase8-tagged D2R approached GFP2-Rab proteins in endosomal compartments.

125 To bind membranes, Rab proteins in fungal and animal cells must be isopreny

126 nd khc function, we determined Khc-dependent Rab proteins in glia and present evidence that Neurexin

127 Rab proteins in mammalian cells, or Ypt1p and Sec4p in y

128 However, by localizing specific Rab proteins in Paramecium cells, we found that paralogu

129 eal a redundant role for two tissue-specific Rab proteins in regulating transport to a tissue-specifi

130 a key role for the Rab38/Rab32 subfamily of Rab proteins in the biogenesis of melanosomes and potent

131 b-specific regions were used to identify new Rab proteins in the databases and suggest rules for nome

132 tide exchange factors (GEFs) for a subset of Rab proteins in the secretory pathway.

133 ith Golgi membranes that binds to prenylated Rab proteins in their GTP-bound state.

134 We have investigated the possible role of Rab proteins in this delivery process, and found Rab27b

135 olgi, suggesting a possible function for Ypt/rab proteins in vesicle budding as well.

136 d the GTPase activity of several other yeast Rab proteins including Ypt1p, Ypt7p, and Ypt51p but show

137 , little is known about how these phagosomal Rab proteins influence phagosome maturation.

138 Rab proteins influence vesicle trafficking pathways thro

139 In their active GTP-bound form, Rab proteins interact with proteins termed effector mole

140 ated by studying alpha1B-adrenergic receptor-Rab protein interactions, using Forster resonance energy

141 4 depletion occurs by segregation of the two Rab proteins into discrete domains that can separate.

142 ing for proteins that interact with Rab38, a Rab protein involved in the biogenesis of melanosomes an

143 ructed an activated allele of VPS21, a yeast Rab protein involved in vacuolar protein sorting, and de

144 of Vps21p, and Ypt7p, which is another yeast Rab protein involved in vacuolar protein transport.

145 pathogen-occupied vacuole by focusing on the Rab proteins involved in biogenesis and maintenance of t

146 ecent studies have revealed that a subset of RAB proteins involved in secretory and endocytic recycli

147 to and from thylakoids, similar to cytosolic Rab proteins involved in vesicle transport.

148 reveals that only a small pool of recycling Rab protein is essential for growth, and that the rates

149 that the double prenylation modification of Rab proteins is an important feature in the function of

150 fully understood how segregation of cargo or Rab proteins is maintained along the continuous endosoma

151 at there is a specific lipid requirement for Rab protein localization and function.

152 onservation and low redundancy of Drosophila Rab proteins make these transgenic lines a useful tool k

153 The dynamic redistribution of Rab proteins markedly decreased the Rab27A concentration

154 ization of internalized GPRC6A with selected Rab protein markers.

155 In light of recent evidence that rab proteins may act by promoting the stabilization of S

156 To fulfill their function, active Rab proteins need to localize to intracellular membranes

157 nd of membrane transport requires a cycle of Rab protein nucleotide binding and hydrolysis.

158 One gene, rab30 codes for a novel rab protein of 203 amino acids with minimal homology to

159 escribe a collaboration between two distinct Rab-protein-orchestrated trafficking circuits in bladder

160 Here, we tested the possibility that Rab protein overexpression might also have beneficial ef

161 d enhanced green fluorescent protein--tagged Rab proteins, pharmacological protein kinase C activatio

162 Rab proteins play a crucial role in the trafficking of i

163 Rab proteins play an essential role in regulating intrac

164 Rab proteins play an essential role in vesicle-mediated

165 ation-dependent expression suggest that this Rab protein plays a role in regulating the delivery of f

166 and scutellar bristle development to screen Rab proteins predicted to be substrates for ICMT (ste14

167 fusion event most likely involves SNARE and Rab proteins present on zymogen granules and cellular me

168 We have now determined that a related Rab protein, Rab10, can interact with myosin Va, myosin

169 Under the same conditions two other exocytic rab proteins, rab2 and rab8, remained membrane bound, an

170 factors including myosin Va and at least one Rab protein, Rab27a.

171 machinery interacts with cell type-specific Rab proteins, Rab38 and Rab32, to facilitate transport t

172 Among >40 rab proteins, rab38 has a unique COOH terminus which wou

173 Here we report that the endosomal Rab protein Rab4 orchestrates a GTPase cascade that resu

174 e of the extensively studied cisternal Golgi rab protein, rab6, is modulation of Golgi apparatus resp

175 an skin fibroblasts overexpressing endosomal Rab proteins (Rab7 or Rab9) showed a correction in the s

176 Rab proteins regulate polarized trafficking to the cell

177 Rab proteins regulate vesicular trafficking pathways, be

178 These findings indicate that the Rab protein regulator, AS160, stabilizes ENaC in a regul

179 everse step by stimulating GTP turnover of a Rab protein required for vesicle tethering/docking/fusio

180 -based sequence alignment of Rab9 with other Rab proteins reveals that its active site consists of re

181 These results indicate that an alternative Rab protein satisfies the Ypt1p requirement in Uso1p-dep

182 Comprehensive dominant-negative Rab protein screening identified Rab11 as an essential f

183 reported effectors of the secretory vesicle Rab protein Sec4, including the myosin-V Myo2, the exocy

184 Rab proteins Sec4 and Ypt11, receptors for essential tra

185 ctional upstream membrane traffic, activated rab protein Sec4p, and its guanine exchange factor Sec2p

186 ocyst complex and downstream effector of the rab protein Sec4p, in various mutants.

187 terminus encodes an exchange factor for the Rab protein Sec4p.

188 membrane in yeast requires the function of a Rab protein, Sec4p, and a set of v- and t-SNAREs, the Sn

189 Localization of adenoviral expressed Rab protein showed wild type Rab3D localized to zymogen

190 An equivalent Rab3A mutant (Rab3A[N135I]), a Rab protein specifically involved in regulated secretion

191 Biochemical screening of Rab protein substrates for RUTBC2 revealed highest GAP a

192 Biochemical screening of RUTBC1 Rab protein substrates revealed highest in vitro GTP hyd

193 specifically inhibit the phosphorylation of Rab protein substrates.

194 -complexed Rab3, and interacts with no other Rab protein tested.

195 Among the Rab proteins tested, we found that besides the previousl

196 Lastly, we tested if a different RAB protein that interacts with RILP, namely the Golgi-a

197 REP binds preferentially to Rab proteins that are in the GDP state, but the specific

198 vivo is exclusively confined to a subset of Rab proteins that are localized to the Golgi apparatus.

199 plexes represent a pool of active, recycling Rab proteins that can deliver Rabs to specific and disti

200 reted reporter protein, we have searched for Rab proteins that function in exocytosis.

201 CK) epithelial cells, belongs to a family of Rab proteins that includes Rab8 and Rab13.

202 As is the case for most other rab proteins, the precise molecular interactions by whic

203 A subset of Rab proteins, the Rab3 proteins are thought to play an i

204 Among 62 Rab proteins, the suppression of Rab5B most significantl

205 release of GDI, and the membrane-associated Rab protein then exchanges its bound GDP for GTP.

206 affinity to endogenous, LRRK2-phosphorylated Rab proteins, thereby blocking dephosphorylation seen up

207 itive factor attachment protein receptor and Rab proteins to "tether" vacuolar membranes before fusio

208 uble geranyl-geranyl groups are required for Rab proteins to correctly localize to their characterist

209 The targeting of various Rab proteins to different subcellular compartments appea

210 t Yip1p may function in the process by which Rab proteins translocate between cytosol and membranes.

211 The PEGylated Rab proteins undergo normal prenylation, underlining the

212 In this study, siRNA-based screening of Rab proteins using HBV-expressing cells showed that Rab5

213 Slp-4 binds vesicular Rab proteins via an N-terminal Slp homology domain, inte

214 at some of the effector domains can bind two Rab proteins via separate binding sites.

215 Membrane fusion also required the rab protein Vps21p.

216 the regulated cell line AtT-20, this tagged rab protein was found to colocalize with ACTH-containing

217 ermine whether the distribution of secretory rab proteins was altered by ethanol.

218 ntracellular trafficking of FVIIa, EPCR, and Rab proteins was evaluated by immunofluorescence confoca

219 , and the transport steps regulated by these rab proteins were unaffected.

220 short interfering RNA (siRNA) screening for Rab proteins, which are considered to act as molecular s

221 acilitates posttranslational modification of Rab proteins, which regulate intracellular trafficking i

222 Differing from Ras and Rab proteins, which require Mg(2+) for GDP and GTP bindi

223 ntain tightly localized domains of activated Rab proteins, which then serve to recruit other effector

224 The limited number of Rab proteins with defective membrane association in gm/g

225 rmed by the association of newly synthesized Rab proteins with Rab-escort-protein (REP), the choroide

226 The data suggest that the Rab protein Ypt1p transiently interacts with the t-SNARE

227 nteracts genetically and physically with the Rab protein Ypt1p, intra-Golgi SNARE molecules, as well

228 SNAREs Bos1p, Sec22p, Bet1p, Sed5p, and the Rab protein, Ypt1p, are distributed similarly but locali

229 nd biochemical tests revealed that a related Rab protein, Ypt6, might substitute for Ypt1p in ypt1Del