ライフサイエンスコーパス: Rho-associated kinase

1 ling pathways, myosin light chain kinase and Rho-associated kinase.

2 n of matrix metalloproteinase 15 (MMP15) and Rho-associated kinase 1 (ROCK1).

3 ets pretreated with a P2Y(1) antagonist or a Rho-associated kinase 1 inhibitor, confirming the crucia

4 Rho-associated kinases 1 and 2 (ROCK1/2) are Rho-GTPase

5 Rho-associated kinase 2 (ROCK2) recently was shown to be

6 Rho-associated kinase 2 (ROCK2) regulates the secretion

7 but also on well-known players such as PAR1, Rho-associated kinase 2, phospholipase C, and proteins r

8 ages by suppressing integrin alphaMbeta2 and Rho-associated kinase 2.

9 Inhibition of either beta(2) integrins or Rho-associated kinase, a kinase downstream from RhoA, gr

10 Furthermore, inhibition of the Rho-associated kinase, a regulator of cytokinesis, impro

11 ROCK or Rho-associated kinase, a serine/threonine kinase, is an

12 treated with FGF-2 and Y27632 (inhibitor of Rho-associated kinase) achieved an 84% recovery of the w

13 Both myosin light chain kinase and Rho-associated kinase acted as mediators of ERK1/2-depen

14 t extension that could be rescued by RhoA or Rho-associated kinase activation.

15 kinase, p140, which appears to be the major Rho-associated kinase activity in most tissues.

16 FLCN positively regulates RhoA activity and Rho-associated kinase activity, consistent with the only

17 distal cell edge, and the correct levels of Rho-associated kinase activity.

18 Inhibitors of Rho-associated kinase and PKC prevented the decline in G

19 ncreased actin polymerization in response to Rho-associated kinase and PKC signaling contributes sign

20 evering is partially slowed by inhibition of Rho-associated kinase and virtually abolished by direct

21 ted protein kinase, Src tyrosine kinase, and rho-associated kinase are required for initiation in bot

22 ivity was dependent on actin, Cav1, Src, and Rho-associated kinase as well as downstream protein kina

23 tide-based proteomic screen identified ROCK (Rho-associated kinase) as a putative substrate for SNRK,

24 Inhibition of PI-3K, PKCs, or Rho-associated kinase by pharmacologic inhibitors abroga

25 actin remodeling, myosin light chain kinase, Rho-associated kinase, calcium, and VEGF and its recepto

26 Selective inhibition of rho-associated kinase decelerated migration in response

27 and higher plateau retraction distances than Rho-associated kinase-dependent SFs located in the cell

28 neuropeptides and bioactive lipids (Rho- and Rho-associated kinase-dependent), tyrosine kinase recept

29 Here, we show that Drosophila Rho-associated kinase (Drok) works downstream of Fz/Dsh

30 r beta (TGF-beta) and the migratory proteins rho-associated kinase, focal adhesion kinase, and matrix

31 Inhibition of Rho-associated kinase had no effect.

32 dependently of its known associates, p53 and Rho-associated kinase I (ROCK I).

33 We found that RhoE inhibits ROCK I (Rho-associated kinase I) activity during genotoxic stres

34 bed regulation of the RhoA downstream target Rho-associated kinase I/II (ROCK), the patients' lymphoc

35 phosphorylation at Thr(697) and Thr(855) by Rho-associated kinase inhibited phosphatase activity and

36 is localized at the mitotic cell cortex, and Rho-associated kinase inhibition increases the degree of

37 No Rho-associated kinase inhibitor (ROCK-i), or centrifugat

38 ll as single-cell survival in the absence of Rho-associated kinase inhibitor (ROCKi).

39 Administration of the Rho-associated kinase inhibitor fasudil prevented renal

40 GTPase inhibitor C. difficile toxin B or the Rho-associated kinase inhibitor Y-27632 also blocked TGF

41 FAK to focal contacts and treatment with the Rho-associated kinase inhibitor Y-27632 did not prevent

42 phosphorylation, which was inhibited by the Rho-associated kinase inhibitor Y-27632.

43 istered ML-7 (a MLCK inhibitor) or Y27632 (a Rho-associated kinase inhibitor).

44 n, and pretreatment of HUVECs with Y27632, a Rho-associated kinase inhibitor, rescued TP-impaired ins

45 Recent studies using known Rho-associated kinase isoform 1 (ROCK1) inhibitors along

46 lial cells by selectively activating the Rho/Rho-associated kinase/LKB1/PTEN pathway.

47 o-effector protein kinase that is related to Rho-associated kinases of ROCK/ROK/Rho-kinase family.

48 sphorylation of MLC phosphatase (SMPP-1M) by Rho-associated kinase or endogenous SMPP-1M-associated k

49 Inhibition of Rho-associated kinases or Cdc42 caused male neutrophils

50 n of cell contractility through RhoA GTPase, Rho-associated kinase, or myosin light chain kinase rest

51 ere, we describe the purification of a novel Rho-associated kinase, p140, which appears to be the maj

52 Y-27632, an inhibitor of the Rho-associated kinase p160ROCK, diminished polyglutamine

53 The inhibition of a Rho-associated kinase, p160ROCK, decreased the traction

54 ltered the Ras homolog gene family, member A/Rho-associated kinase pathway with increased stress acti

55 arget the transforming growth factor-beta or Rho-associated kinase pathways converts embryonic fibrob

56 We found that Rho and its effector, Rho-associated kinase, preferentially regulated the amou

57 Rho-associated kinases (Rho kinases), which are downstre

58 Y-27632, an inhibitor of the Rho-associated kinase ROCK, is a therapeutic lead for Hu

59 The previously reported Rho-associated kinases ROCK I and II are ubiquitously ex

60 cyclin E acquires a high binding affinity to Rho-associated kinase (ROCK II), and physically associat

61 Ras-MAPK leads to loss of apically localized Rho-associated kinase (Rock) 2a, which results in failed

62 These events were dependent on Rho and Rho-Associated Kinase (ROCK) activation.

63 Although Rho-associated kinase (ROCK) activity has been implicate

64 Fasudil is a small molecule inhibitor of Rho-associated kinase (ROCK) and is approved for the tre

65 least partially depends on the activation of Rho-associated kinase (ROCK) and LIMK-1.

66 he interaction with its downstream effectors Rho-associated kinase (ROCK) and mDia.

67 Compaction, via activation of Rho-associated kinase (ROCK) and the stress kinase p38,

68 ation with inhibition of EMT by inclusion of Rho-associated kinase (ROCK) and transforming growth fac

69 n was only partially dependent on Rho kinase/Rho-associated kinase (ROCK) and was independent of RhoA

70 I3-kinase or phospholipase-C, but inhibiting Rho-associated kinase (ROCK) blocked only E13K-induced i

71 d endocytosis of TJ proteins was mediated by Rho-associated kinase (ROCK) but not myosin light chain

72 PKC and Rho-associated kinase (ROCK) Ca(2+)-sensitizing pathways

73 Rho-associated kinase (ROCK) has an essential role in go

74 ibition analysis revealed a critical role of Rho-associated kinase (ROCK) in AJC disassembly in calci

75 L-17 production by enhancing the activity of Rho-associated kinase (ROCK) in T cells.

76 In contrast, Rho-associated kinase (ROCK) inhibition blocked MLC phos

77 h WT and KO vessels were equally affected by Rho-associated kinase (ROCK) inhibition; however, augmen

78 cells could be rescued by treatment with the Rho-associated kinase (ROCK) inhibitor Y-27632 or introd

79 The Rho-associated kinase (ROCK) inhibitor Y-27632 permits h

80 ays, impedance-based assays with a selective Rho-associated kinase (ROCK) inhibitor, Galpha12/13 knoc

81 Activation of RhoA/Rho-associated kinase (ROCK) pathway and the associated

82 -I fiber orientation, inhibition of the RhoA/Rho-associated kinase (ROCK) pathway did not.

83 We investigated the involvement of the RhoA/Rho-associated kinase (ROCK) pathway in regulating ICAM-

84 s the thromboxane A2 receptor (TXAR) and the Rho-associated kinase (ROCK) pathway.

85 Inhibition of Rho-associated kinase (ROCK) prevented cytoskeletal defe

86 Rho-associated kinase (ROCK) regulates neural cell migra

87 ive phenotype was due, in part, to increased Rho-associated kinase (ROCK) signaling concomitant with

88 4c channel through its downstream Rap1A-RhoA-Rho-associated kinase (ROCK) signaling pathway for susta

89 eviously demonstrated that activation of the Rho-associated kinase (ROCK) signaling pathway promotes

90 Rho-associated kinase (ROCK) signaling plays a fundament

91 ould be regulated by serotonin via serotonin-Rho-associated kinase (ROCK) signaling.

92 ally exposed to high stress display elevated Rho-associated kinase (ROCK) signalling and an increased

93 he nocodazole-induced activation of RhoA and Rho-associated kinase (ROCK) that mediates phosphorylati

94 Sustained blockade of Rho-associated kinase (ROCK) with Y-27632 down-regulates

95 MLC phosphorylation in MKs is regulated by Rho-associated kinase (ROCK), and consistent with our mo

96 Claudins, E-cadherin, F-actin, myosin II, Rho-associated kinase (ROCK), and myosin light chain kin

97 Na,K-ATPase exocytosis was regulated by the Rho-associated kinase (ROCK), as preincubation with the

98 Rho GTPase and its downstream target, Rho-associated kinase (ROCK), have been implicated in di

99 inhibition of RhoA, its downstream effector, Rho-associated kinase (ROCK), or a microtubule-associate

100 ments show that Vangl2, as well as Daam1 and Rho-associated kinase (Rock), regulate apical constricti

101 in to direct the subcellular localization of Rho-associated kinase (Rock), which in turn drives chang

102 Its binding to Htt is regulated by the rho-associated kinase (ROCK), which phosphorylates profi

103 yosin cytoskeleton, through a Rho-GTPase and Rho-associated kinase (ROCK).

104 iven by myosin light chain kinase (MLCK) and Rho-associated kinase (ROCK).

105 nd actin cytoskeletal remodeling through the Rho-associated kinase (ROCK).

106 hibition of RhoA or its downstream effector, Rho-associated kinase (ROCK).

107 Targeted inhibition of Rho-associated kinase (ROCK)2 downregulates the proinfla

108 lastoma patients, and elevated expression of Rho-associated kinase (ROCK)2 is associated with poor pa

109 cognized that an increased expression of the Rho-associated kinase (ROCK-I), a downstream target of R

110 activating RhoA and its downstream effector Rho-associated kinase (ROCK/Rho-kinase).

111 Through these approaches, Rho-associated kinase ROCK1 emerged as a key molecule re

112 In contrast, inhibiting Rho-associated kinase ROCK1/2 increased migration and sc

113 The Rho-associated kinases ROCK1 and ROCK2 are critical for

114 appears necessary for downregulation of the Rho-associated kinase (ROCK1) that occurs during myogeni

115 Rho-associated kinases (ROCK1 and ROCK2) regulate the ac

116 We discovered that the Rho-associated kinase ROCK2 is required for CIE of MHCI

117 f inhibiting Rho or its downstream effector, Rho-associated kinase (ROCKII).

118 Rho-associated kinases (ROCKs) are critical molecules in

119 -induced STAT3 activation partly depended on Rho-associated kinase (ROK) and involved multiple effect

120 This synergy requires signaling via Rho-associated kinase (ROK) and p21-activated kinase (PA

121 muscle myosin II (Myo-II) by kinases such as Rho-associated kinase (Rok) is important to generate con

122 e myosin targeting subunit (MYPT1) by either Rho-associated kinase (ROK) or an unknown SMPP-1M-associ

123 hosphorylation of the targeting subunit at a Rho-associated kinase (ROK) phosphorylation site.

124 eously decreases RhoA affinity to its target Rho-associated kinase (ROK), a key mediator of neurite o

125 the activities of protein kinases, including Rho-associated kinase, that phosphorylate the myosin pho

126 the WERDS complex, which in turn, activates Rho-associated kinase to induce apical constriction.

127 ation and extracellular signal-regulated and Rho-associated kinases to regulate gene expression.

128 he fenestration structure, such as targeting Rho-associated kinase, VEGF-A, NF[Formula: see text]B, a

129 Moreover, inhibition of rho-associated kinase was distinguished by abrogation of

130 over, dominant-negative RhoA or inhibitor of Rho-associated kinase (Y27632) substantially negated the