ライフサイエンスコーパス: S phase checkpoint

1 rapidly signal fork stalling to activate the S phase checkpoint.

2 g that death was not preventable post the G1-S phase checkpoint.

3 OP blocking most, if not all, aspects of the S phase checkpoint.

4 syndrome 1 (NBS1), and is required for intra-S phase checkpoint.

5 is not induced by IR but also affects intra-S phase checkpoint.

6 A damage checkpoint independent of the intra-S phase checkpoint.

7 to ionizing radiation (IR) to activate intra-S phase checkpoint.

8 DNA replication forks and a mediator of the S phase checkpoint.

9 nding domain for recruitment to IRIF and the S phase checkpoint.

10 orks, but which is compromised for the intra-S phase checkpoint.

11 repair, telomere maintenance, and the intra-S phase checkpoint.

12 were associated with activation of the intra-S phase checkpoint.

13 by STAT3, leading to relaxation of the intra-S phase checkpoint.

14 transcription of ASE1, which depends on the S phase checkpoint.

15 This Top1-dependent process activates the S phase checkpoint.

16 e stability distinct from its role in the G1-S phase checkpoint.

17 a readout for activation of the ATR-mediated S phase checkpoint.

18 LL on damage to DNA, and thus compromise the S-phase checkpoint.

19 rigin activity and is modulated by the intra-S-phase checkpoint.

20 nto how cells recover from activation of the S-phase checkpoint.

21 d stalled replication forks during the intra-S-phase checkpoint.

22 iency in the forks required to establish the S-phase checkpoint.

23 complex (MRN) plays an essential role in the S-phase checkpoint.

24 ivate the signaling cascades involved in the S-phase checkpoint.

25 at Ser-343, which results in a defect in the S-phase checkpoint.

26 d cell cycle progression via an ATR-mediated S-phase checkpoint.

27 ependent cell survival required a functional S-phase checkpoint.

28 stranded breaks (DSBs) and activation of the S-phase checkpoint.

29 the ionizing radiation (IR)-inducible intra-S-phase checkpoint.

30 ion forks is a key step in activation of the S-phase checkpoint.

31 ingly, this accumulation is not dependent on S-phase checkpoint.

32 nates stalled forks, thereby attenuating the S-phase checkpoint.

33 be an important target of the Chk1-mediated S-phase checkpoint.

34 DNA damage, replication is inhibited by the S-phase checkpoint.

35 diol epoxide (BPDE) induces a Chk1-dependent S-phase checkpoint.

36 and functions upstream of rad-5/clk-2 in the S-phase checkpoint.

37 ed for normal recovery from the BPDE-induced S-phase checkpoint.

38 c25A is a major mechanism for damage-induced S-phase checkpoint.

39 ugh maintenance of an ATR and Chk1-dependent S-phase checkpoint.

40 ases polkappa and poleta in the BPDE-induced S-phase checkpoint.

41 hat loss of CDK2 activity activates an intra-S-phase checkpoint.

42 icularly enriched for genes that support the S-phase checkpoint.

43 at leads to this slowing is called the intra-S-phase checkpoint.

44 n radiosensitivity and a defect in the intra-S-phase checkpoint.

45 al for the efficient activation of the intra-S-phase checkpoint.

46 stream effector of ATM activity in the intra-S-phase checkpoint.

47 therapy, at least in part, by regulating the S-phase checkpoint.

48 ATRIP)-ATR complex, and this compromised the S-phase checkpoint.

49 (stalled fork) and is protected by the inter-S-phase checkpoint.

50 n and a potential role for PP2A in the intra-S-phase checkpoint.

51 to introduce a G2 in embryos that lacked an S-phase checkpoint.

52 tion licensing through the activation of the S-phase checkpoint.

53 ation forks and activates the Cds1-dependent S-phase checkpoint.

54 hase lengthens, which delays mitosis via the S-phase checkpoint.

55 nates DNA damage-induced G2/M, G1, and intra S phase checkpoints.

56 ce show defective recovery from BPDE-induced S-phase checkpoints.

57 that Cks overexpression abrogates the intra-S-phase checkpoint, a major barrier to oncogene-mediated

58 rikingly, phosphorylation of Mrc1 during the S phase checkpoint abolishes Pol2N binding, but not Pol2

59 The S-phase checkpoint activated at replication forks coordi

60 we report that Chk1p has a role in the intra-S-phase checkpoint activated when yeast cells replicate

61 Arrest was accompanied by DNA damage and S phase checkpoint activation and required ATR or ATM ki

62 Therefore, Trp53 is required for the S phase checkpoint activation observed in Fancd2 mutant

63 R-induced foci (IRIF) formation of R/M/N and S phase checkpoint activation, but only the BRCT domain

64 nd intermediate levels of UV sensitivity and S phase checkpoint activation, but similar levels of Mre

65 d breaks repair and DNA damage-induced intra-S phase checkpoint activation.

66 Intriguingly, an ATM inhibitor suppressed S-phase checkpoint activation after exposure to replicat

67 involved in replication fork stabilization, S-phase checkpoint activation and establishment of siste

68 E-822, to prevent chemotherapy-induced intra-S-phase checkpoint activation and evaluated the antitumo

69 processing is not necessary for ATR-mediated S-phase checkpoint activation and that the lesion recogn

70 oduces replication-dependent DNA lesions and S-phase checkpoint activation following DPC formation.

71 BS cells are radiosensitive and defective in S-phase checkpoint activation following irradiation.

72 DR), promotes cellular survival and prevents S-phase checkpoint activation in budding yeast undergoin

73 Each of these agents also triggered S-phase checkpoint activation in parental ES cells, as i

74 Following ionizing radiation-induced S-phase checkpoint activation, Tax-expressing cells prog

75 cell cycle re-entry after DNA damage-induced S-phase checkpoint activation.

76 duced p21(Waf1/Cip1) and MDM2, demonstrating S-phase checkpoint activation.

77 k1 phosphorylation, and abolished UV-induced S-phase checkpoint activation.

78 sphorylation of Chk2 and Smc1, necessary for S-phase checkpoint activation.

79 This intra-S-phase checkpoint actively regulates DNA synthesis by i

80 ia RPA and directly control the amplitude of S phase checkpoint activity and the subsequent deactivat

81 Ino80, function to attenuate and deactivate S phase checkpoint activity.

82 Both S-phase checkpoint activity and H3K4me are crucial for f

83 langiectasia and Rad3 related (ATR)-mediated S phase checkpoint acts as a surveillance mechanism to p

84 akage syndrome protein, known to mediate the S phase checkpoint after DNA damage.

85 cells from interphase arrest and loss of the S-phase checkpoint after DNA damage, accompanied by high

86 Furthermore, the S-phase checkpoint after UV irradiation was defective in

87 rosine phosphorylation mediated by the intra-S-phase checkpoint, allowing cells to continue replicati

88 UV exposure, a defective UV responsive intra-S phase checkpoint and a specific pattern of genomic ins

89 and SMC3 acetylation are required for intra-S phase checkpoint and cellular survival after IR.

90 nase is necessary for both activation of the S phase checkpoint and for efficient DNA damage repair r

91 Tipin complex plays an important role in the S phase checkpoint and replication fork stability in met

92 Both S phase checkpoint and SCC defects are phenocopied by H3

93 prevent mitotic catastrophe, function in the S-phase checkpoint and also cooperate with atm-1 in the

94 re equally important for triggering of intra-S-phase checkpoint and ATM signaling promoted recovery o

95 n important role for the p21-dependent intra-S-phase checkpoint and extensive rereplication, whereas

96 log of the human ATR/ATM genes, controls the S-phase checkpoint and prevents replication fork collaps

97 sion of MDC1 expression results in defective S-phase checkpoint and reduced apoptosis in response to

98 /Tim1 complex plays an important role in the S-phase checkpoint and replication fork stability.

99 st cancer cells is preceded by activation of S-phase checkpoint and selective induction of E2F1, a re

100 e to degrade cyclin D1 compromises the intra-S-phase checkpoint and suggest that cyclin D1 degradatio

101 requires the coordinated action of the intra-S-phase checkpoint and the Fanconi anaemia pathway, whic

102 ication fork arrest, activation of the intra-S phase checkpoint, and global defects in chromatin stru

103 eplication stress and activation of an intra-S phase checkpoint, and suppressed the growth of VHL-/-

104 ologous recombination, telomere maintenance, S-phase checkpoint, and genome stability during replicat

105 Neither the DNA damage nor the intra-S phase checkpoints are activated in the first cell cycl

106 ment, as well as DNA damage-induced G2/M and S phase checkpoint arrest and radiation survival are dep

107 lution triggers anaphase, is dispensable for S phase checkpoint arrest.

108 esulfonate, inducers of DNA damage and intra-S-phase checkpoint arrest in all examined eukaryotes.

109 S-phase checkpoint arrest was incomplete, however, allow

110 f Chk1 was associated with inefficient inter-S phase checkpoint, as Hsp72 depleted cells failed to ha

111 be explained by co-dependence on a single G1/S-phase checkpoint, as S phase and zygotic polarization

112 on--with zygotes having to pass through a G1/S-phase checkpoint before the polarization axis can be f

113 We propose that S phase arrest activates the S phase checkpoint blocking mitosis onset and inhibiting

114 d independently of the replication-dependent S phase checkpoint but by similar conditions involving t

115 Esc4p is not required for the intra-S-phase checkpoint but is essential for resumption of ch

116 the ataxia telangiectasia mutated-dependent S-phase checkpoint, but rather closely resembled a previ

117 of NBN is required for the activation of the S-phase checkpoint, but the mechanism whereby these phos

118 ally induce and activate p53 and activate an S phase checkpoint by modifying the Nijmegen breakage sy

119 tive phosphorylation by CK2 may affect intra-S phase checkpoint by modulating SMC3 phosphorylation by

120 Bypass of the intra-S-phase checkpoint by caffeine activates many new origin

121 Induction of the intra-S-phase checkpoint by hydroxyurea (HU) inhibits Rad52 fo

122 phase and that activating the Rad3 dependent S-phase checkpoint by inhibiting DNA replication had lit

123 g a high threshold for the ATR-Chk1-mediated S-phase checkpoint by promptly repairing DNA breaks that

124 eveal a novel pathway, defended by the intra-S-phase checkpoint, by which MDM2 induces unscheduled or

125 in response to cytarabine (ara-C) induced an S-phase checkpoint characterized by the inhibition of Cd

126 lizing or restarting replication forks under S phase checkpoint conditions.

127 n the absence and presence of DNA damage and S-phase checkpoint conditions.

128 The intra-S-phase checkpoint contributed to the high-level of fork

129 as a missing link between p53 activation and S phase checkpoint control designed to eliminate replica

130 lication machinery plays additional roles in S phase checkpoint control, although the identities of t

131 We propose that Ddk modulates the S-phase checkpoint control by attenuating checkpoint sig

132 ion of Nbs1-S343A mutant disrupted the intra-S-phase checkpoint, decreased homologous recombinational

133 proteins after IR, they exhibit a defective S-phase checkpoint, decreased survival, and increased ch

134 phosphorylation of Ser-1067 as well as intra-S phase checkpoint defect.

135 int competent, but set1Delta displays a mild S phase checkpoint defect.

136 53BP1(-/-) cells show a slight S-phase checkpoint defect and prolonged G(2)/M arrest af

137 horylation of ATM on Ser 1981, and caused an S-phase checkpoint defect in DNA-damaged cells.

138 e ATM kinase inhibitor KU 55933 results in a S-phase checkpoint defect similar to that observed in WR

139 pts checkpoint signaling and causes an intra-S-phase checkpoint defect.

140 eletion mutants (dot1Delta) are G1 and intra-S phase checkpoint defective after ionizing radiation bu

141 Nbs1(DeltaC/DeltaC) cells exhibit intra-S-phase checkpoint defects, but are otherwise indistingu

142 not S516A or DeltaSET mutant MLL rescues the S-phase checkpoint defects.

143 ent causes a persistent Mec1-dependent intra-S-phase checkpoint delay characterized by slow DNA repai

144 -R696W, we discovered that pol3-R696W causes S-phase checkpoint-dependent elevation of dNTP pools.

145 xia causes replication arrest independent of S-phase checkpoint, DNA damage response, or transformati

146 Multiple pathways, such as S-phase checkpoints, DNA replication, recombination, chr

147 at BID plays an unexpected role in the intra-S phase checkpoint downstream of DNA damage distinct fro

148 id-type genomic abnormalities, indicative of S-phase checkpoint dysfunction.

149 (MRN) complex is required for mediating the S-phase checkpoint following UV treatment, but the under

150 n of RPA2, a critical event in mediating the S-phase checkpoint following UV treatment.

151 We find that the S-phase checkpoint function of Sgs1p is dispensable for

152 of mismatch repair function restored normal S-phase checkpoint function.

153 gradation, thereby preventing attenuation of S-phase checkpoint functions and a compromised capacity

154 These data indicate that the intra-S-phase checkpoint functions to block late origin firing

155 F1 has also been implicated in regulating an S phase checkpoint, however its role in this checkpoint

156 w MRN affects DNA replication to control the S-phase checkpoint, however, remains unclear.

157 at Snm1B-deficient cells exhibit a defective S phase checkpoint in response to MMC, but not to IR, an

158 wo mechanisms are involved in regulating the S-phase checkpoint in an MRN-dependent manner following

159 involved in ATM pathway activation and in a S-phase checkpoint in cells exposed to DNA interstrand c

160 netic studies indicate the role of an intact S-phase checkpoint in maintaining genome integrity.

161 owed that DDK is an important target for the S-phase checkpoint in mammalian cells to suppress replic

162 an important mechanism underlying the intra-S-phase checkpoint in mammalian cells.

163 ubstrate of ATM and ATR to mediate the intra-S-phase checkpoint in mammalian cells.

164 Although the basic framework of the S-phase checkpoint in multicellular organisms has been o

165 as to how MDC1 regulates NBS1 and the intra-S-phase checkpoint in response to DNA damage.

166 ation, G2-M checkpoint arrest, and the intra-S-phase checkpoint in response to ionizing radiation.

167 air system is required for activation of the S-phase checkpoint in response to ionizing radiation.

168 r, DDK-null cells fail to activate the intra-S-phase checkpoint in the presence of hydroxyurea-induce

169 overexpress Cks1 or Cks2 override the intra-S-phase checkpoint in the presence of replication stress

170 ilon (Pol epsilon) was shown to activate the S-phase checkpoint in yeast in response to replicative s

171 failed to recover from the UV light-induced S-phase checkpoint), in sharp contrast to Polk(-/-) MEFs

172 Recovery from the S-phase checkpoint includes inactivation of checkpoint s

173 s(checkpoint kinase 1) (Grp(Chk1))-dependent S-phase checkpoint, increased levels of CycB drives cyto

174 se pathway and show that deregulation of the S-phase checkpoint incurred by MLL translocations probab

175 ever, dun1Delta cells are proficient for the S-phase-checkpoint-induced anaphase block.

176 e Dun1p, yeast Chk1p is not required for the S-phase-checkpoint-induced anaphase block.

177 During replication stress, the S-phase checkpoint inhibits the DDK- and CDK-dependent a

178 bromodeoxyuridine incorporation to evaluate S phase checkpoint integrity, monoubiquitination of Fanc

179 Furthermore, the intra-S-phase checkpoint is activated in Orc2-S188A-expressing

180 uce early mitotic entry, but reversal of the S-phase checkpoint is compromised by pairwise cyclin kno

181 Interestingly, the intra-S-phase checkpoint is crucial for the cellular response

182 ether, our study demonstrates that the intra-S-phase checkpoint is exerted by Chk1 not only upon repl

183 ssion yeast, the signal activating the intra-S-phase checkpoint is generated only when replication fo

184 ec1, a key regulatory ATR-like kinase in the S-phase checkpoint, is required for both normal chromati

185 t treated with hydroxyurea (HU) activate the S phase checkpoint kinase Rad53, which prevents DNA repl

186 mitant phosphorylation and activation of the S phase checkpoint kinase, Rad53.

187 The S-phase checkpoint kinase and telomere maintenance facto

188 The intra-S-phase checkpoint kinase Chk1 phosphorylates Cdc25A to

189 phorylation of S331 is mediated by CHK1, the S-phase checkpoint kinase implicated in the Fanconi anem

190 ilon depend on damage uninducible (Dun)1, an S-phase checkpoint kinase that maintains dNTP levels dur

191 evidenced by autophosphorylation of ATR, the S-phase checkpoint kinase, and by recruitment of ATR and

192 The S-phase checkpoint kinases Mec1 and Rad53 in the budding

193 signals from active replication forks to the S-phase checkpoint machinery in human cells.

194 to be an essential target inactivated by the S-phase checkpoint machinery that inhibits DNA replicati

195 o present evidence suggesting that the intra-S-phase checkpoint makes a relatively minor contribution

196 ons argue that Drf1 is regulated by an intra-S-phase checkpoint mechanism that down-regulates the loa

197 se progression to G2 by modulating the intra-S phase checkpoint mediated by Chk1.

198 the loading onto chromatin of various intra-S-phase checkpoint mediators and found that NONO favours

199 mined the expression and activation of known S-phase checkpoint mediators in FdUrd-treated SW620 and

200 The DNA replication or S-phase checkpoint monitors the integrity of DNA synthes

201 S-phase checkpoint mutants fail to stabilize Dia2 in res

202 In contrast, most S-phase checkpoint mutants were synthetically lethal in

203 to better understand replication dynamics in S-phase checkpoint mutants, we developed a replication o

204 ign MLL as a novel effector in the mammalian S-phase checkpoint network and identify checkpoint dysfu

205 treatment with SN-38 and UCN-01 resulted in S-phase checkpoint override, an amplified DNA damage res

206 cdk2 have only been implicated in the intra-S phase checkpoint pathway after DNA damage.

207 The S phase checkpoint pathway preserves genome stability by

208 lecular mechanisms by which the ATR-mediated S phase checkpoint pathway prevents DNA rereplication an

209 urthermore, cells lacking H2A.Z required the S-phase checkpoint pathway for survival.

210 iated proteolysis and that activation of the S-phase checkpoint pathway inhibits Dia2 protein degrada

211 During DNA replication, the S-phase checkpoint pathway responds to replication stres

212 h many chemotherapy drugs activate the intra-S-phase checkpoint pathway to block S-phase progression,

213 signaling through the conserved Mec1/Rad53, S-phase checkpoint pathway to induce the expression and

214 rity of the Pol binding module and block the S-phase checkpoint pathway, downstream of the Mec1 kinas

215 quire NBS1, a component of the IR-responsive S-phase checkpoint pathway.

216 ons as an effector in the ATM/NBS1-dependent S-phase checkpoint pathway.

217 the absence of Rtt/genome caretakers trigger S-phase checkpoint pathways to stimulate Ty1 reverse tra

218 Here, we show that either or both of two S-phase checkpoint pathways, the replication stress path

219 The S-phase checkpoint phenotype was independent of Nbs1 sta

220 ombination), mec1Delta tel1Delta (DNA damage/S-phase checkpoints), pif1Delta (maintenance of mitochon

221 hases of replication and triggers the "intra-S phase checkpoint." Previous work with budding yeast ha

222 iency in HCT116 is associated with defective S-phase checkpoint, prolonged G2 arrest, and hypersensit

223 Such compromised intra-S phase checkpoints promoted gene amplification independ

224 The S phase checkpoint protects the genome from spontaneous

225 The intra-S phase checkpoint protein complex Tof1/Csm3 of Saccharo

226 evel of global control mediated by the intra-S-phase checkpoint protein complex of Tof1p and Csm3p th

227 e function of DNA polymerase epsilon and the S-phase checkpoint protein Mec1.

228 droxyurea (HU) treatment activates the intra-S phase checkpoint proteins Cds1 and Mrc1 to prevent rep

229 Third, deletions of the intra-S phase checkpoint proteins Tof1 and Csm3 abolished fork

230 F-box protein Dia2 as a novel player in the S-phase checkpoint recovery pathway.

231 ring DNA replication reinitiation during the S-phase checkpoint recovery.

232 Dia2 contributes to Mrc1 degradation during S-phase checkpoint recovery.

233 ased recruitment of Mre11 to IRIF, abrogated S phase checkpoint, reduced activation of ATM, Chk1, and

234 much is known about how and where the intra-S-phase checkpoint regulates origins of replication in h

235 1 (whose products regulate G(2) and G(1) or S phase checkpoints, respectively) after the cells have

236 The budding yeast S phase checkpoint responds to hydroxyurea-induced nucle

237 ndent pathway plays an important role in the S phase checkpoint response following ionizing irradiati

238 The S phase checkpoint response slows down replication in th

239 may be an additional step in regulating the S phase checkpoint response to DNA damage on the leading

240 n stabilizing stalled replication forks, the S phase checkpoint response, and suppressing genetic cro

241 tes, disruption of DNA replication causes an S phase checkpoint response, which regulates multiple pr

242 s essential for the DNA damage-induced intra-S phase checkpoint response.

243 ATR-dependent phosphorylation of Chk2 or the S-phase checkpoint response after ionising radiation.

244 DM2 transgenic mice enter S phase and induce S-phase checkpoint response earlier than lung cells from

245 not inhibited during the DNA-damage-induced S-phase checkpoint response in Xenopus egg extracts and

246 Wild-type Tetrahymena elicits an intra-S-phase checkpoint response that is induced by hydroxyur

247 V fibroblasts lacking poleta showed a normal S-phase checkpoint response to BPDE (but failed to recov

248 nduces replication stress eliciting an early S-phase checkpoint response to inhibit further firing of

249 s is required for establishment of the intra-S-phase checkpoint response.

250 on, PP5 is required to elicit an appropriate S-phase checkpoint response.

251 uring S phase activate the S-phase and intra-S-phase checkpoint responses, respectively, regulated by

252 ion (IR), Hus1-deficient cells showed intact S-phase checkpoint responses.

253 he nucleus and not the cytoplasm to modulate S-phase checkpoint responses: alpha-syn up-regulates his

254 Thus, the MRN S-phase checkpoint role is separate from its Ctp1- and r

255 ctedly, induction of the p21-dependent intra-S-phase checkpoint seemed to be independent of both Cdt1

256 replication, whereas the ATR-dependent intra-S-phase checkpoint seemed to play a less dominant role.

257 The Chk1 kinase is a major effector of S phase checkpoint signaling during the cellular respons

258 cks on the same RPA70N surface that recruits S phase checkpoint signaling proteins to chromatin.

259 Inhibition of RPA/ATR/Chk1-mediated S-phase checkpoint signaling partially inhibited BPDE-in

260 rk at a replication fork pause site restores S-phase checkpoint signaling to chk1Delta dun1Delta cell

261 unctions as an upstream regulator to monitor S-phase checkpoint signaling.

262 that Ddk plays an active role in regulating S-phase checkpoint signaling.

263 In the absence of a functional S-phase checkpoint, stalled replication forks collapse a

264 The intra-S-phase checkpoint suppresses origin firing after the lo

265 x6-dependent Chk1 degradation contributes to S phase checkpoint termination and that a defect in this

266 angiectasia and Rad3-related (ATR)-dependent S phase checkpoint that inhibits replication fork progre

267 e during DNA-replication arrest requires the S phase checkpoint that inhibits the S phase CDK.

268 DNA replication elongation trigger the intra-S phase checkpoint that leads to the activation of the C

269 yeast, DNA replication stress activates the S phase checkpoint that stabilizes replication forks and

270 essoria on the rice leaf surface requires an S-phase checkpoint that acts through the DNA damage resp

271 r cell types, leads to override of the intra-S-phase checkpoint that blocks DNA replication in respon

272 intaining the integrity of the genome is the S-phase checkpoint that functions to prevent DNA replica

273 n and suppresses the ATM/ATR-dependent intra-S-phase checkpoint that inhibits origin firing.

274 ent with MMC is part of a caffeine-sensitive S-phase checkpoint that is controlled by xATR.

275 s that are stalled by DNA damage activate an S-phase checkpoint that prevents irreversible fork arres

276 ely resistant to FdUrd, have an intact early S-phase checkpoint that protects against FdUrd-induced D

277 e for aberrant Gli1 in the regulation of the S-phase checkpoint that suppresses replication stress an

278 completion of both double-stranded break and S-phase checkpoints that should arrest all replication w

279 cy, consequently causes abnormalities in the S-phase checkpoint, the G(2)/M checkpoint, the spindle c

280 Based on synthetic phenotypes, the intra-S-phase checkpoint, the SRS2 inhibitor of recombination,

281 es by their sensitivity to activation by the S-phase checkpoint, thereby, providing an effective mech

282 uced DNA damage signaling and controls intra-S-phase checkpoint through CHK2 activation.

283 horylation of Dbf4 is critical for the intra-S-phase checkpoint to inhibit DNA replication.

284 wever, most dying neurons do not pass the G1/S-phase checkpoint to resume DNA synthesis.

285 Rad17 are required for the activation of the S-phase checkpoint to suppress DNA synthesis in response

286 larization involves a novel, DDR-independent S-phase checkpoint, triggered by appressorium turgor gen

287 ent of replication forks in coordinating the S-phase checkpoint using dun1Delta cells that have a def

288 ting for DNA synthesis when the BPDE-induced S-phase checkpoint was active.

289 4) The G(1) to S-phase checkpoint was intact in primary and spontaneous

290 y, the ability of cytarabine to activate the S-phase checkpoint was severely compromised in Rad9(-/-)

291 ation initiation and elongation to the intra-S-phase checkpoint, we examined cells treated with the s

292 o investigate other potential targets of the S-phase checkpoint, we tested the effects of BPDE on the

293 stream and downstream of ATR to regulate the S-phase checkpoint when replication forks are stalled.

294 in Pol1 renders yeast cells dependent on the S phase checkpoint, whereas truncation of Pol1 at amino

295 HU treatment triggers the S-phase checkpoint, which arrests cells at S-phase, inhi

296 damage and may also play a role in the intra-S-phase checkpoint, which delays the replication of dama

297 V-induced DNA damage by activating the intra-S-phase checkpoint, which prevents replication fork coll

298 otes activate a signaling pathway called the S-phase checkpoint, which produces a multifaceted respon

299 re not caused by defects in the ATM-mediated S-phase checkpoint, which was intact in primary Fancd2 m

300 atively involving the activation of an intra-S-phase checkpoint, would also inhibit tumor proliferati