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1                                              S. coelicolor A3(2), M600 and J1501 possess L-TIRs, wher
2                                              S. coelicolor membranes were also able to catalyse the t
3                                              S. coelicolor mutants globally deficient in antibiotic p
4                                              S. coelicolor PecS, which exists as a homodimer, binds t
5                                              S. coelicolor PNPase was more effective than its E. coli
6                                              S. coelicolor produces SapB, an amphipathic peptide that
7                                              S. coelicolor shows a bias toward one type of genetic in
8             Expression of mmyF and mmyO in a S. coelicolor M145 derivative engineered to express mmr,
9 her characterize the Amycolatopsis sp. AA4 - S. coelicolor interaction by examining expression of dev
10                                           An S. coelicolor msdA mutant, constructed by insertion of a
11 d near the RNase ES termini interact with an S. coelicolor homologue of polynucleotide phosphorylase
12 minal region of RbpA and sigma domain 2, and S. coelicolor RbpA mutants that are defective in binding
13               Data from B. subtilis 3610 and S. coelicolor A3(2) provided a means of validation for t
14 x range of -450 to +80 mV, P. aeruginosa and S. coelicolor SoxR are less sensitive to viologens, whic
15 the reduced sensitivity of P. aeruginosa and S. coelicolor SoxR.
16 of colony biofilms in both P. aeruginosa and S. coelicolor, which shows that "secondary metabolites"
17 s possible to predict operons in E. coli and S. coelicolor with 83% and 93% accuracy respectively, us
18 efficacy as operon predictors in E. coli and S. coelicolor.
19 hat the Streptomyces species S. lividans and S. coelicolor, morphologically complex gram-positive soi
20 enotypic distinction between S. lividans and S. coelicolor.
21 n both the S. coelicolor parental strain and S. coelicolor YL/sgFabH (a deltafabH mutant carrying a p
22 t, we screened FGEs from M. tuberculosis and S. coelicolor against synthetic peptide libraries and id
23         Mycobacterium tuberculosis whiB2 and S. coelicolor whiB complemented the defect in M. smegmat
24 surfactin acts antagonistically by arresting S. coelicolor aerial development and causing altered exp
25                        Whilst referred to as S. coelicolor A3(2), this strain is more closely related
26          Transduction of plasmid DNA between S. coelicolor and S. verticillus was observed at frequen
27       Constructed disruptions of rnc in both S. coelicolor 1501 and Streptomyces lividans 1326 caused
28 o-ACP was phosphopantetheinylated to 100% by S. coelicolor holo-acyl carrier protein synthase (ACPS),
29                        Hydrolysis of PNPP by S. coelicolor PtpA was competitively inhibited by dephos
30                        Hydrolysis of PNPP by S. coelicolor PtpA were 0.75 mM (pH 6.0, 37 degrees C) a
31 s to find that deferrioxamine E, produced by S. coelicolor, could be readily utilized by Amycolatopsi
32 ally similar to the SapB peptide produced by S. coelicolor.
33 esis of the multiple antibiotics produced by S. coelicolor.
34 e development of aerial hyphae and spores by S. coelicolor is inhibited by surfactin, a lipopeptide s
35            The presence of L-TIRs in certain S. coelicolor strains represents a major chromosomal alt
36 nd show that, in contrast to most other CIS, S. coelicolor CIS (CIS(Sc)) mediate cell death in respon
37 transposition of a plasmid library of cloned S. coelicolor DNAs.
38 removed or duplicated hundreds of contiguous S. coelicolor genes, altering up to 33% of the chromosom
39 C3 were shown to restore to a SapB-deficient S. coelicolor mutant the capacity to undergo complete mo
40 xtracellular signalling cascade proposed for S. coelicolor and is a member of the bldD extracellular
41 extracellular signaling cascade proposed for S. coelicolor bld mutants.
42   Our data suggests a comprehensive role for S. coelicolor AfsS as a master regulator of both antibio
43 yces venezuelae (SvWhiD), which differs from S. coelicolor WhiD (ScWhiD) only at the C terminus.
44                          The Ku homolog from S. coelicolor contains a distinct version of the HEH dom
45 gue of M. tuberculosis CmtR (CmtR(Mtb)) from S. coelicolor, denoted CmtR(Sc).
46 r structural zinc, the RbpA orthologues from S. coelicolor and M. tuberculosis share a common structu
47              Mycelial extracts prepared from S. coelicolor cultures incorporated radioactive ATP into
48               Using a sigma factor SigT from S. coelicolor as a model, we successfully expressed and
49                Like its numerous homologues, S. coelicolor RNase J can also cleave some RNA internall
50                                           In S. coelicolor, the van genes are induced by both vancomy
51 active precursor, modulates SoxR activity in S. coelicolor to stimulate the production of a membrane
52                    Overexpression of afsS in S. coelicolor and certain related species causes antibio
53  first time the presence of albaflavenone in S. coelicolor and clearly demonstrate that the biosynthe
54  While sco5745 is the only RNase J allele in S. coelicolor, the gene is not essential.
55 duce the production of the Mm antibiotics in S. coelicolor.
56 vious studies of prodiginine biosynthesis in S. coelicolor support a novel role for RedJ in facilitat
57 al activator of actinorhodin biosynthesis in S. coelicolor, is inhibited by the binding of heptaene,
58 tive regulator of antibiotic biosynthesis in S. coelicolor.
59 ted regulation of antibiotic biosynthesis in S. coelicolor.
60 SDH that is involved in valine catabolism in S. coelicolor.
61 he actinorhodin biosynthetic gene cluster in S. coelicolor.
62  agent 5'-aza-2'-deoxycytidine (5-aza-dC) in S. coelicolor cultures, demonstrating that m5C affects b
63  metabolism and morphological development in S. coelicolor and the identification of host-encoded lea
64 n production or morphological development in S. coelicolor, although their mutation could influence t
65  modulating morphological differentiation in S. coelicolor.
66 ailless protein, unlike the other two Dps in S. coelicolor, does not readily oligomerise.
67 onCI, encoding a flavin-linked epoxidase, in S. coelicolor was shown to significantly increase the ab
68 ted foci and other weaker, irregular foci in S. coelicolor vegetative hyphae.
69 ed were substrates, including those found in S. coelicolor extracts, and all yielded several products
70 idues are not essential for DnaE function in S. coelicolor.
71 li survival, rns is not an essential gene in S. coelicolor.
72 x reductase (FDR) proteins coded by genes in S. coelicolor were expressed in Escherichia coli, purifi
73 lly, coexpressing the rifG-N and -J genes in S. coelicolor YU105 under the control of the act promote
74                 SoxR regulates five genes in S. coelicolor, including those encoding a putative ABC t
75  the antibiotic-specific regulatory genes in S. coelicolor.
76 n M. tuberculosis and critical for growth in S. coelicolor, these data support a model in which RbpA
77  the sigma(E) target promoters identified in S. coelicolor across 19 Streptomyces species.
78 dence that many of the targets identified in S. coelicolor are also under the control of the sigmaR h
79 th 76% amino acid identity was identified in S. coelicolor, and insertional mutagenesis indicated tha
80  is the third ACP to have been identified in S. coelicolor; the two previously characterized ACPs are
81 are consistent with duplication of GCH II in S. coelicolor promoting evolution of a new function.
82 pt from rpsO-pnp is cleaved by RNase IIIS in S. coelicolor.
83 ferring rifampin-resistance, was isolated in S. coelicolor to provide a genetic marker to follow tran
84 egulated in an RNase III-dependent manner in S. coelicolor.
85 tibiotics and other secondary metabolites in S. coelicolor, suggest that revision of the currently pr
86 rated by the absence of RamS modification in S. coelicolor hyphae treated with the Bacillus subtilis
87 coelicolor, it normally is expressed only in S. coelicolor-generating the deep-blue colonies responsi
88 ly increase the database of known operons in S. coelicolor and provide valuable information for explo
89  biogenesis might be an essential pathway in S. coelicolor.
90 RNA increases during the stationary phase in S. coelicolor and that induction of a plasmid-borne copy
91 read-through transcript normally produced in S. coelicolor.
92 ctors that regulate antibiotic production in S. coelicolor.
93  under the control of its native promoter in S. coelicolor M512, a host lacking the SCP1 plasmid, and
94            PNPase is a cold shock protein in S. coelicolor and the activity of the rpsO-pnp promoters
95  damage and that deletion of this protein in S. coelicolor increases antibiotic production.
96 cance of the redundancy of these proteins in S. coelicolor is not known.
97 w that a representative of these proteins in S. coelicolor possesses a dodecameric quaternary structu
98                          Deletion of redJ in S. coelicolor leads to a 75% decrease in prodiginine pro
99 anK is required for vancomycin resistance in S. coelicolor.
100  factors associated with stress responses in S. coelicolor.
101 [3H]-adenosine were used to label the RNA in S. coelicolor cultures of different ages, and total RNA
102 r the initiation of sporulation septation in S. coelicolor.
103 re color, showing that disruption of sigF in S. coelicolor changes the nature of the spore pigment ra
104                    While the role of SoxR in S. coelicolor remains under investigation, these studies
105  control the response to disulfide stress in S. coelicolor.
106 nd is a novel regulator of rRNA synthesis in S. coelicolor.
107  are dispensable for growth and viability in S. coelicolor.
108 ed fatty acids were also detected in vivo in S. coelicolor.
109  appropriate intracellular levels of zinc in S. coelicolor.
110 tionally mutated library was introduced into S. coelicolor, and transposon insertions were recovered
111  and to test whether their introduction into S. coelicolor affected antibiotic production.
112         Complementation by only dptI, or its S. coelicolor homologue, glmT, restored the biosynthesis
113 d that a 4.9 Mb central region of the linear S. coelicolor chromosome encodes 'core' functions expres
114 t in the production of actinorhodin, a major S. coelicolor antibiotic.
115                                   This makes S. coelicolor an advantageous system for the study of ce
116 emperature-sensitive DNA replication mutant, S. coelicolor ts-38.
117 ore genes were downregulated when grown near S. coelicolor, leading us to find that deferrioxamine E,
118  report the genome sequence of PhiCAM, a new S. coelicolor generalized transducing bacteriophage, iso
119 own to significantly increase the ability of S. coelicolor to epoxidize linalool, a model substrate f
120 oarrays to measure globally the abundance of S. coelicolor transcripts in cells growing in liquid med
121 ift assays revealed an increased affinity of S. coelicolor PNPase for the substrate possessing a 3' s
122 chromatography/mass spectrometry analysis of S. coelicolor culture extracts established the presence
123               Here we report the analysis of S. coelicolor WhiD purified anaerobically from Escherich
124 as also capable of restoring the capacity of S. coelicolor and S. tendae bald mutants to erect aerial
125 ce the wild-type allele in the chromosome of S. coelicolor and S. lividans.
126  During stationary phase, the composition of S. coelicolor transcripts appears to shift from large qu
127 chain elongation intermediate to cultures of S. coelicolor CH999/pJRJ2 results in formation of a 16-m
128  is significantly elevated after exposure of S. coelicolor cultures to urate.
129  rbpA expression is induced upon exposure of S. coelicolor to rifampicin and that this, in part, invo
130                                Expression of S. coelicolor acpP in Escherichia coli yielded several d
131                          After expression of S. coelicolor ptpA in Escherichia coli with a pT7-7-base
132  homogeneity from crude mycelial extracts of S. coelicolor and shown to be BldD.
133  which encodes the principal sigma factor of S. coelicolor.
134 with our previous demonstration that ftsZ of S. coelicolor is not needed for viability, these finding
135                   We show that the genome of S. coelicolor encodes for three Dps proteins including a
136 omoters changed over the course of growth of S. coelicolor and studies in three sigma factor mutant s
137  genes expressed during vegetative growth of S. coelicolor cultures, we used DNA microarrays to measu
138 tively constant over the course of growth of S. coelicolor M145, but that on a molar basis, the level
139 alin A (ConA) inhibited phi C31 infection of S. coelicolor J1929, and this could be partially reverse
140 uction of amychelin and in the inhibition of S. coelicolor development.
141 osomal state of the original soil isolate of S. coelicolor A3(2).
142 CE87.05, isolated from the cosmid library of S. coelicolor A3(2).
143 study that reports the cytosine methylome of S. coelicolor M145, supporting the crucial role ascribed
144 tions, construction of a sigF null mutant of S. coelicolor M145 caused the same change in spore color
145 that all of the characterized bld mutants of S. coelicolor are defective in the regulation of galP1,
146                              afsB mutants of S. coelicolor are deficient in the production of both co
147 cedure for generating insertional mutants of S. coelicolor based on in vitro transposition of a plasm
148 de that restored to developmental mutants of S. coelicolor the ability to raise aerial hyphae.
149                              Bald mutants of S. coelicolor, which are blocked in aerial mycelium form
150 ubstrate derived from the rpsO-pnp operon of S. coelicolor.
151 bstrates derived from the rpsO-pnp operon of S. coelicolor.
152 prenol phosphate in membrane preparations of S. coelicolor.
153                           In the presence of S. coelicolor malonyl CoA:ACP transacylase (MCAT), the r
154 t Streptomyces lividans, a close relative of S. coelicolor and naturally Pgl-, does not contain homol
155  Addition of the gamma-butyrolactone SCB1 of S. coelicolor resulted in loss of the DNA-binding abilit
156 al and essential sigma factor (sigmaHrdB) of S. coelicolor restored Act and Red production in the afs
157 d between spa2 of S. ambofaciens and spaA of S. coelicolor.
158 -Seq, we have examined the transcriptomes of S. coelicolor M145 and an RNase III (rnc)-null mutant of
159 enotype on S. diastatochromogenes but not on S. coelicolor.
160 ing to the approximate mass of the predicted S. coelicolor msdA product (52.6 kDa), and specific MSDH
161  as a substrate in assays employing purified S. coelicolor RNase III.
162 ion of a pentapeptide (HCDLP) to recombinant S. coelicolor NiSOD lacking these N-terminal residues, N
163 he length of the 22 kb TIRs of the sequenced S. coelicolor strain M145.
164 049 than to the type strain for the species, S. coelicolor Muller.
165 two phylogenetically distant streptomycetes, S. coelicolor A3(2) and S. griseus: (1) gamma -butyrolac
166 perature and osmotic upshifts, we found that S. coelicolor transiently induces a set of several hundr
167                            We show here that S. coelicolor desA encodes a novel LDC and we hypothesiz
168                  These results indicate that S. coelicolor PecS responds to the ligand urate by atten
169                            We also show that S. coelicolor AtrA can bind in vitro to the promoter of
170 in vitro and in vivo experiments showed that S. coelicolor ParB protein interacts specifically with t
171                                          The S. coelicolor absA locus was defined by four UV-induced
172                                          The S. coelicolor chromosome contains more parS sequences th
173                                          The S. coelicolor genome encodes a subgroup of sensor kinase
174                Unlike in other bacteria, the S. coelicolor Dps proteins are not induced in response t
175  predominate (approximately 70%) in both the S. coelicolor parental strain and S. coelicolor YL/sgFab
176 tion of differentiation-related mRNAs by the S. coelicolor AbsB/RNase III enzyme occurs largely by ri
177 lated globally and differentially during the S. coelicolor growth cycle by the RNaseIII homologue Abs
178 mplementing DNA and show that it encodes the S. coelicolor homolog of RNase III (rnc).
179          In marker exchange experiments, the S. coelicolor rnc gene rescued absB mutants, restoring a
180 g the deep-blue colonies responsible for the S. coelicolor name.
181 rth protein was sought and purified from the S. coelicolor CH999 host on the basis of its ability to
182  isolated SigT-interactive proteins from the S. coelicolor lysate based on the tandem affinity purifi
183 st other members of this class, however, the S. coelicolor bkdR gene product serves to repress transc
184 ese results suggest the cells arising in the S. coelicolor division of labor are analogous to altruis
185        The acceptor subsites +1 to +4 in the S. coelicolor enzyme are well conserved in the M. tuberc
186 re 57 putative GntR family regulators in the S. coelicolor genome) that respond to nutritional and/or
187 for an uridylyltransferase) are found in the S. coelicolor genome, the regulation of the GSI activity
188 ntial operator sites to be identified in the S. coelicolor genome.
189 P450 105D5 are located close together in the S. coelicolor genome.
190 tify 22 likely sigmaU regulon members in the S. coelicolor genome.
191 iology of yet another cryptic protein in the S. coelicolor genome.
192 ed regulation of antibiotic synthesis in the S. coelicolor life cycle.
193 d to be glycosylated with a trihexose in the S. coelicolor parent strain, J1929, but not in the pmt(-
194  bldN, and other key downstream genes in the S. coelicolor transcriptional cascade.
195 Unlike the E. coli soxR deletion mutant, the S. coelicolor equivalent is not hypersensitive to oxidan
196  of the predicted amino acid sequence of the S. coelicolor beta' subunit to those characterized from
197 ted mutagenesis, the carboxy terminus of the S. coelicolor beta' subunit was modified to contain six
198                            Disruption of the S. coelicolor dpsA, dpsB and dpsC genes resulted in irre
199 kinetics, and protein crystallography of the S. coelicolor enzyme, we have now identified the +1 to +
200 the E. coli enzyme was ca. twice that of the S. coelicolor enzyme.
201  gene (fabD) encoding another subunit of the S. coelicolor FAS, malonyl coenzyme A:ACP acyl-transfera
202 tematic and comprehensive mutagenesis of the S. coelicolor genome.
203 rresponding to the 4.9 Mb core region of the S. coelicolor M145 chromosome were more highly expressed
204 cleoside diphosphates on the activity of the S. coelicolor PNPase but not the E. coli enzyme.
205 s species that also contain orthologs of the S. coelicolor SerRS.
206 beta' subunits, one of which consists of the S. coelicolor subunit and those from Mycobacterium lepra
207 f the cleavage sites in the stem-loop of the S. coelicolor transcript are more akin to those identifi
208 those obtained by microarray analysis of the S. coelicolor transcriptome and with studies describing
209 acin and ramoplanin were not inducers of the S. coelicolor VanRS system, in contrast to results obtai
210 s of genes immediately adjacent to it on the S. coelicolor chromosome that likely encode an ATP-bindi
211 We exploited this distinction to replace the S. coelicolor vanRS genes with the vanRS genes from S. t
212 ination, indicating the possibility that the S. coelicolor promoter/activator functions appropriately
213 lmL), which exhibits a low similarity to the S. coelicolor SerRS, is hypothesized to play a role in v
214                                     When the S. coelicolor msdA gene was overexpressed in Escherichia
215 . twofold higher than that observed with the S. coelicolor enzyme.
216 ted interchange of this residue in the three S. coelicolor intragenomic homologues is necessary and s
217         Transfer of the pIPP2 derivatives to S. coelicolor and catechol dioxygenase assays demonstrat
218 levels changed by >/= 2-fold between the two S. coelicolor strains and organized those transcripts in
219 ere analyzed during development of wild-type S. coelicolor on solid medium.
220 ed to sporulating aerial hyphae in wild-type S. coelicolor.
221 wapping experiments, support a model whereby S. coelicolor umbrella toxin diversification at the leve
222  triketide 6, compounds 18, 31, and 32, with S. coelicolor CH999/pJRJ2, resulting in the formation of
223 ble macrolactone product when incubated with S. coelicolor CH999/pJRJ2.
224          While mutations that interfere with S. coelicolor development late in its life cycle did not

 
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