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1 pathogenic potential of F. nucleatum than of S. gordonii.
2 f P. gingivalis in heterotypic biofilms with S. gordonii.
3  activity of another species, H2O2-producing S. gordonii.
4 optimal coadhesion between P. gingivalis and S. gordonii.
5 losely related Streptococcal species such as S. gordonii.
6 ve oxidative stress response (osr) operon in S. gordonii.
7  fructose phosphotransferase system (PTS) in S. gordonii.
8 tion of GAPDH may be a similar adaptation by S. gordonii.
9 d by over 60% in an SspA-deficient mutant of S. gordonii.
10 slundii grew when coaggregated pairwise with S. gordonii.
11  human saliva-supported biofilm formation by S. gordonii.
12 E. faecalis and L. lactis but not on that of S. gordonii.
13 dependently isolated strains, DL1 and M5, of S. gordonii.
14 t pathway for competence induction exists in S. gordonii.
15 reased in the cdhR mutant after contact with S. gordonii.
16 yed elevated accumulation on a substratum of S. gordonii.
17 ransfer of plasmid DNA from E. faecalis into S. gordonii.
18  low-pH-dependent expression of ADS genes in S. gordonii.
19  DNA from mixed cultures of S. sanguinis and S. gordonii.
20 hotransferases encoded by downstream wefC in S. gordonii 38 and wefH in S. oralis 34.
21 UDP-Gal and UDP-GalNAc for RPS production by S. gordonii 38 depends on the dual specificity of the ep
22 d to identify and partially characterize the S. gordonii 38 RPS gene cluster.
23 efC and wefD in the type 2Gn gene cluster of S. gordonii 38 with wefF and wefG from the type 2G clust
24 hat produced by the wefB-deficient mutant of S. gordonii 38.
25 potently inhibits P. gingivalis adherence to S. gordonii (50% inhibitory concentration = 1.3 microM)
26 ted region, when expressed on the surface of S. gordonii, a commensal organism, binds to soluble and
27 may play an important role in development of S. gordonii-A. naeslundii communities in early dental pl
28 tispecies plaque interactions, the effect of S. gordonii AbpB on S. mutans Gtf-B activity was also te
29                                          The S. gordonii adc operon, consisting of the four ORFs adcR
30 ordonii and that the transposon insertion in S. gordonii adcR::Tn917-lac had resulted in a polar muta
31  adhesin CshA is an important determinant of S. gordonii adherence, forming peritrichous fibrils on i
32                               Next, putative S. gordonii adhesins were analyzed for contributions to
33 s the structural and functional component of S. gordonii adhesive fibrils, and they provide a molecul
34 ependent manner by P. gingivalis, but not by S. gordonii, after a 15-min exposure.
35  that results in increased expression of the S. gordonii alpha-amylase-encoding gene amyB.
36  we performed comparative analyses on 14 new S. gordonii and 5 S. sanguinis strains using various bio
37                              Contact between S. gordonii and a CdhR mutant resulted in increased tran
38                             Importantly, the S. gordonii and B. subtilis enzymes have crystallised in
39 that the abpA gene appears to be specific to S. gordonii and differs from genes encoding amylase-bind
40  analyses described here showed that in both S. gordonii and Escherichia coli Rgg is a positive trans
41 ptional changes that accompany competence in S. gordonii and form a basis for future intra- and inter
42 e examined their subcellular localization in S. gordonii and in Escherichia coli expressing the strep
43  is required for disulfide bond formation in S. gordonii and indicate that this enzyme may represent
44     GspB is glycosylated in the cytoplasm of S. gordonii and is then transported to the cell surface
45 eron is involved in manganese acquisition in S. gordonii and manganese homeostasis and appears to mod
46 nderstanding of the regulation of the ADS in S. gordonii and related organisms is needed to develop w
47 elopment of anti-adhesive agents that target S. gordonii and related streptococci.
48 iximab, protected 45%-88% of animals against S. gordonii and S. aureus IE (P < .05).
49 arides were more common among the strains of S. gordonii and S. mitis examined.
50 hibited the interaction of gp340 with intact S. gordonii and S. mutans cells, respectively.
51                                   While both S. gordonii and S. mutans were abundant colonizers of ra
52 ever, P. gingivalis grew in combination with S. gordonii and S. oralis, demonstrating its ability to
53                                  We revealed S. gordonii and S. sanguinis harbor open pan-genomes and
54 sights into the genetic distinctions between S. gordonii and S. sanguinis, which yields understanding
55 cterize the related pheromone determinant in S. gordonii and show that the peptide it encodes, gordon
56  arginine metabolism is tightly regulated in S. gordonii and that arginine is critical for gene regul
57 to mediate the adherence of P. gingivalis to S. gordonii and that the species specificity of adherenc
58 at adcRCBA are cotranscribed as an operon in S. gordonii and that the transposon insertion in S. gord
59 he arginine-responsive regulatory network of S. gordonii and the basis for conditional arginine auxot
60  stress tolerance between the oral commensal S. gordonii and the oral pathogen Streptococcus mutans.
61                In a closed system containing S. gordonii and V. atypica, flow cytometric analysis sho
62 ned the binding forces between S. mutans (or S. gordonii) and C. albicans in the presence and absence
63 ition, we found that Streptococcus gordonii (S. gordonii) and Enterococcus faecalis (E. faecalis) wer
64 treptococci, GBS), E. faecalis, S. pyogenes, S. gordonii, and E. coli containing pDC123 displayed a b
65 nd to Streptococcus pyogenes, S. agalactiae, S. gordonii, and Escherichia coli.
66  strains within the Streptococcus anginosus, S. gordonii, and S. intermedius species.
67 , and fruI are cotranscribed as an operon in S. gordonii, and the transposon insertion in S. gordonii
68 ns), which vastly exceeds the forces between S. gordonii andC.
69 ycoprotein-binding proteins SspA and SspB of S. gordonii; another had 79% identity with the Lactococc
70                                              S. gordonii appeared to have an intracellular store of p
71 esponses of V. parvula to coaggregation with S. gordonii are dominated by oxidative stress-related pr
72 etion, indicating that arcB levels may limit S. gordonii arginine biosynthesis.
73 trials provide encouragement that the use of S. gordonii as a live mucosal vaccine vector is a feasib
74    The same RPS has now been identified from S. gordonii AT, a partially sequenced strain.
75                           The data show that S. gordonii binding force to the C. albicans surface is
76 mponent system regulated in association with S. gordonii biofilm formation in vitro.
77  response, some of which may be important in S. gordonii biofilm formation.
78 with altered microcolony architecture within S. gordonii biofilms formed in saliva during a time fram
79  causes release of DNA from S. sanguinis and S. gordonii but does not result in obvious lysis of cell
80 demonstrated that cell protein extracts from S. gordonii, but not from A. naeslundii, interfered with
81                  S. oralis coaggregated with S. gordonii by an RPS-dependent mechanism, and both stre
82 rst time, direct induction of sspA and -B in S. gordonii by human saliva.
83  during early biofilm initiation compared to S. gordonii-C. albicans biofilms.
84         Coadhesion between P. gingivalis and S. gordonii can be mediated by the SspB protein of S. go
85 livarius and those of the urease produced by S. gordonii carrying the plasmid-borne ure genes.
86                                              S. gordonii carrying the urease genes was then demonstra
87               Surprisingly, S. sanguinis and S. gordonii cell integrity appears unaffected by conditi
88                   Conversely, aggregation of S. gordonii cells by fluid-phase gp340 was not affected
89 0-fold decrease in the level of abpA mRNA in S. gordonii cells cultured in BHI was noted after the ad
90 spB polypeptides are involved in adhesion of S. gordonii cells to human and bacterial receptors.
91 he 98-kDa protease occurred during growth of S. gordonii CH1 in CDM containing 0.075% total amino aci
92                        Following invasion by S. gordonii CH1, HUVEC monolayers showed 63% cell lysis
93 rity of these cloned products to the abpA of S. gordonii Challis ranged from 91 to 96%.
94 ighly similar to Hsa, a protein expressed by S. gordonii Challis that has been characterized as a sia
95  Although Hsa is required for the binding of S. gordonii Challis to sialic acid, most of the Hsa expr
96                         Biofilm formation of S. gordonii Challis was characterized using an in vitro
97        Eighteen biofilm-defective mutants of S. gordonii Challis were identified based on Southern hy
98  containing V. atypica expressed GFP; nearby S. gordonii colonies that lacked V. atypica did not expr
99      Caries induction reflected S. mutans or S. gordonii colonization abundance: the former highly ca
100 ein interaction has been proposed to promote S. gordonii colonization at multiple sites within the ho
101                                              S. gordonii competed with S. sanguinis more effectively
102      Results supported published findings on S. gordonii competence, showing up-regulation of 12 of 1
103 typica, flow cytometric analysis showed that S. gordonii containing the PamyB-'gfp reporter plasmid e
104 plain this observation, we hypothesized that S. gordonii could compete with S. sanguinis to adhere to
105                      In both subunits of the S. gordonii crystal structure (1.5 A resolution) the C-t
106 e control protein A gene (ccpA) homolog from S. gordonii, designated regG, was cloned.
107  that were infected with either 10(9) CFU of S. gordonii DL-1 or 10(7) CFU of P. gingivalis 33277 did
108 ) was used together with an antibody against S. gordonii DL1 (anti-DL1).
109 14.5 nm long, which are present on wild-type S. gordonii DL1 (Challis) cells, bind CshA-specific anti
110                      Inactivation of scaR in S. gordonii DL1 (Challis) resulted in constitutive derep
111 I/II polypeptides and Hsa in interactions of S. gordonii DL1 (Challis) with host receptors.
112 that Hsa directs primary adhesion events for S. gordonii DL1 (Challis) with immobilized gp340, epithe
113 d on the nature of their coaggregations with S. gordonii DL1 and other oral streptococci.
114                                  Adhesion of S. gordonii DL1 cells to gp340 was sialidase sensitive,
115  then it was linearized and transformed into S. gordonii DL1 for allelic replacement.
116  similarly to sHA, yet 10- to 50-fold excess S. gordonii DL1 reduced binding of S. sanguinis SK36 by
117 Insertional inactivation of the sspA gene in S. gordonii DL1 resulted in reduced binding of cells to
118 Hsa and AgI/II proteins mediated adhesion of S. gordonii DL1 to human HEp-2 epithelial cells.
119 sion and initial biofilm formation on teeth, S. gordonii DL1 was incubated with saliva-coated hydroxy
120 e the sialic acid-binding lectin activity of S. gordonii DL1 with a specific fibrillar antigen, which
121 ion properties of an isogenic sspB mutant of S. gordonii DL1, an sspAB double mutant, and a previousl
122                      Five strains, including S. gordonii DL1, caused severe disease, while the other
123 ater biofilm formation on sHA than wild-type S. gordonii DL1.
124 fy the homologous DNA in a fosmid library of S. gordonii DL1.
125  much greater recovery of rifampin-resistant S. gordonii DLl than of streptomycin-resistant S. gordon
126                                              S. gordonii does not appear to be a good candidate for r
127                                 In contrast, S. gordonii early CSP-responsive genes were not preceded
128       The arginine deiminase system (ADS) of S. gordonii enables cells to produce, ornithine, ammonia
129           We also identified determinants in S. gordonii encoding a signal peptidase and an Eep-like
130  preparation for clinical trials to evaluate S. gordonii engineered to express group A streptococcal
131 ssory Sec system in E. coli matched those in S. gordonii, establishing the validity of this approach.
132                              The srtA mutant S. gordonii exhibited a marked reduction in quantity of
133               Thus, A. naeslundii stabilizes S. gordonii expression of arginine biosynthesis genes in
134  isolated from the same intraoral sites, yet S. gordonii fails to be excluded and survives as a speci
135 d to participate in metabolic communication; S. gordonii ferments carbohydrates to form lactic acid,
136         However, infection with 10(9) CFU of S. gordonii followed by 10(7) CFU of P. gingivalis induc
137 ntration of approximately 12 +/- 5 muM above S. gordonii, followed by a gradual decrease in H2O2 conc
138 S. gordonii, and the transposon insertion in S. gordonii fruK::Tn917-lac resulted in a nonpolar mutat
139 ar GAPDH was the major secreted protein from S. gordonii FSS2, an endocarditis strain.
140 together, these results suggest that AbpA of S. gordonii functions as an adhesin to amylase-coated hy
141              Cell fractionation studies with S. gordonii further corroborated these microscopy result
142  biochemical properties and gene sequence of S. gordonii GAPDH are almost identical to those of other
143 at results in increased transcription of the S. gordonii gene amyB, encoding an alpha-amylase.
144                              The majority of S. gordonii genes examined were observed to be downregul
145 as used to quantify changes in expression of S. gordonii genes known or thought to be involved in bio
146 y screening a plasmid integration library of S. gordonii, genes were identified that are crucial for
147                                              S. gordonii glucosyltransferase (GtfG) and amylase-bindi
148                     The results suggest that S. gordonii governs the development of heterotypic oral
149 s cultures containing coaggregates, however, S. gordonii grew to high cell density at low arginine co
150  planktonic culture or as a biofilm, whereas S. gordonii grew under both conditions.
151 del, low concentrations of arginine promoted S. gordonii growth, whereas high concentrations (> 5 mM
152 ing the predicted catalytic triad of Asp2 of S. gordonii had no effect upon GspB transport but did re
153           In mixed cultures of S. mutans and S. gordonii harbouring a shuttle plasmid, plasmid DNA tr
154                      However, strain FSS2 of S. gordonii has been found to produce several extracellu
155 gulatory network that controls P. gingivalis-S. gordonii heterotypic communities.
156 ssary for platelet aggregation, and modulate S. gordonii-host engagements into biologically productiv
157 n of cdhR is elevated following contact with S. gordonii; however, regulation of cdhR did not occur i
158 donii can be mediated by the SspB protein of S. gordonii; however, the P. gingivalis cognate receptor
159 ibited the binding between P. gingivalis and S. gordonii in a dose-dependent manner up to 86%.
160                       S. mutans out-competed S. gordonii in in vivo plaque biofilm.
161 tain normal adhesion and biofilm function of S. gordonii in response to exogenous oxidants therefore
162  with beta-glucoside metabolism may regulate S. gordonii in vitro adhesion, biofilm formation, growth
163                                              S. gordonii, in contrast, neither was hindered by nor be
164 s significantly impacted by F. nucleatum and S. gordonii included the mitogen-activated protein kinas
165                                              S. gordonii-infected mice that were subsequently challen
166 duced production of these cytokines, whereas S. gordonii inhibited secretion from the epithelial cell
167 l a multidimensional aspect to P. gingivalis-S. gordonii interactions and establish pABA as a critica
168                                    In vitro, S. gordonii is conditionally auxotrophic for arginine in
169  Our findings illustrate that H2O2-producing S. gordonii is dominant while the buffering capacity of
170 tion of fructose transport and metabolism in S. gordonii is intricately tied to carbon catabolite con
171             Interaction of Mfa fimbriae with S. gordonii is necessary to initiate signalling through
172 CylA and CylB system by the alpha-haemolytic S. gordonii is presented.
173                               Like wild-type S. gordonii, isogenic mutants with mutations in antigen
174                                   Mutants of S. gordonii lacking components of the CiaRH, ComDE, or V
175 ompetence sigma factor, were found preceding S. gordonii late responsive genes.
176                   Nested PCR cloning from an S. gordonii library enabled the isolation and sequence a
177 eus (P < .005) but failed to protect against S. gordonii (&lt;30% protection).
178  and primer extension analyses revealed that S. gordonii luxS is monocistronic.
179                                           An S. gordonii luxS mutant that did not produce AI-2 was co
180 s strongly (10- to 100-fold) up-regulated in S. gordonii monocultures after 3 h of growth when exogen
181 ound to be coupled with the induction of the S. gordonii natural competence system.
182 ulated singly, S. mutans always out-competed S. gordonii on the teeth, independent of diet, strain of
183  the local microenvironment in biofilms when S. gordonii or V. parvula immigrate into the system.
184 g(2+) supplementation significantly improves S. gordonii oral colonization in mice.
185 ain the crucial role AbpB appears to play in S. gordonii oral colonization.
186   Thus, Hsa confers a selective advantage to S. gordonii over S. sanguinis in competitive binding to
187 of the high degree of similarity between the S. gordonii paralogues, analysis of SecA-SecA2 chimeras
188                                          The S. gordonii PepV gene is homologous to the PepV gene fam
189                    Overall, F. nucleatum and S. gordonii perturbed the gingival epithelial cell trans
190                                   Thus, only S. gordonii possessed all traits advantageous for growth
191                     These data indicate that S. gordonii produces an extracellular gelatinase/type IV
192                       Others have identified S. gordonii promoters that are up-regulated by a pH shif
193                                 Contact with S. gordonii propagates a tyrosine phosphorylation-depend
194 ral coimmunization of germfree rats with two S. gordonii recombinants expressing N (residues 55 to 14
195                We have investigated genes of S. gordonii required to support a heterotypic biofilm co
196  oxidative stress-related processes, whereas S. gordonii responses are more focussed on carbohydrate
197              Comparison of isogenic pairs of S. gordonii revealed a requirement for several surface p
198            Zymographic analysis of wild-type S. gordonii revealed peptidoglycan hydrolase activities
199 ulation, or presence/absence of mutations of S. gordonii's abpA and gtfG genes known to negatively or
200           Probe SSA-3 hybridized to DNA from S. gordonii, S. mitis, S. oralis, S. parasanguinis, and
201 the hlpA genes were cloned from S. pyogenes, S. gordonii, S. mutans, and S. sobrinus, using PCR ampli
202 e HUVEC was exhibited by selected strains of S. gordonii, S. sanguis, S. mutans, S. mitis, and S. ora
203 varius (two strains); and one strain each of S. gordonii, S. sanguis, S. sobrinus, and S. vestibulari
204 o a much lower maximum cell density than did S. gordonii; S. oralis did not grow reproducibly as a bi
205                            Comparison of the S. gordonii SecA and SecA2 proteins in vitro revealed th
206 nd biochemical methods to assess whether the S. gordonii SecA2 functions similarly to SecA.
207                         To test this theory, S. gordonii secY2, asp4, and asp5 were co-expressed in E
208                                 In biofilms, S. gordonii selectively expresses the msrA gene.
209      By contrast, an hsa-deficient mutant of S. gordonii showed significantly reduced binding and com
210  gordonii DLl than of streptomycin-resistant S. gordonii SK12 from the hearts of animals coinfected w
211 ease, while the other two strains, including S. gordonii SK12, caused minimal or no disease.
212                                  Both of the S. gordonii Ssp proteins bound labeled target cells, whe
213                                          The S. gordonii SspA and SspB polypeptides mediated higher b
214         Thus, the P. gingivalis receptor for S. gordonii SspB is a 100-kDa protein that structurally
215    These results indicate that expression of S. gordonii sspB is positively regulated by the sspA gen
216                                         Each S. gordonii strain aggregated with human platelets and b
217 roximately 1.5 x 10(9) CFU of SP204(1-1), an S. gordonii strain not bearing vaccine antigens.
218             Adhesin-mediated binding of each S. gordonii strain to PMNs also triggered phagocytosis.
219 rm(AM)] was inserted within the abpA gene of S. gordonii strains Challis and FAS4 by allelic exchange
220          On the contrary, genomic islands of S. gordonii strains contain additional copies of comCDE
221                             In contrast, two S. gordonii strains that lacked hemagglutinating activit
222                                              S. gordonii strains with specific mutations in the regio
223 ied, one of which was exclusively present in S. gordonii strains.
224 utinating activities of several heterologous S. gordonii strains; however, these bacteria were agglut
225  but also glucosyltransferase G (Gtf-G) from S. gordonii supernatants.
226                                          The S. gordonii surface proteins SspA and SspB are known to
227  restriction fragment from all 13 strains of S. gordonii tested.
228 ently on the sgc protease knockout mutant of S. gordonii than on the parent biofilms.
229  genes developed more abundant biofilms with S. gordonii than the parental strain developed.
230 ory cascade dominantly control phenotypes of S. gordonii that are critical to colonization, persisten
231  fluorescence levels 20-fold higher than did S. gordonii that had not been incubated with V. atypica.
232                                           In S. gordonii, there was a high degree of inter-sample var
233                                  An isolated S. gordonii::Tn917-lac biofilm-defective mutant containe
234                          Investigation of an S. gordonii::Tn917-lac biofilm-defective mutant isolated
235                                           An S. gordonii::Tn917-lac biofilm-defective mutant was isol
236 contrast, did not significantly compete with S. gordonii to adhere.
237 owed that attachment of A. naeslundii and of S. gordonii to glass flowcells was enhanced by a salivar
238 d Asp5 are necessary for optimal adhesion of S. gordonii to glycoproteins gp340 and fibronectin, know
239  sole nutrient showed that V. atypica caused S. gordonii to increase expression of a PamyB-'gfp trans
240 al constraint against S. sanguinis, enabling S. gordonii to persist within the oral cavity, despite t
241 a shuttle plasmid, plasmid DNA transfer from S. gordonii to S. mutans was observed in a CSP and mutac
242 Asp3 also resulted in an impaired ability of S. gordonii to secrete GspB.
243 ribution of GspB and Hsa to the adherence of S. gordonii to selected glycoproteins.
244                         Thus, the ability of S. gordonii to survive in PMNs following adhesin-mediate
245                              The capacity of S. gordonii to synthesize arginine was assessed using a
246 indicated by transformation frequencies, the S. gordonii transcriptome was analyzed at various time p
247                    Comparison of CSP-induced S. gordonii transcriptomes to results published for Stre
248 s demonstrated an increased DNA release from S. gordonii upon addition of the partially purified muta
249                             S. sanguinis and S. gordonii used oxygen availability and the differentia
250   To simulate pioneer colonization of teeth, S. gordonii V288 was incubated with sHA for 4 h in THB w
251  formation, a plasmid integration library of S. gordonii V288 was used.
252 ults support the potential usefulness of the S. gordonii vectors expressing P. gingivalis fimbrillin
253  delivery of P. gingivalis FimA epitopes via S. gordonii vectors resulted in the induction of FimA-sp
254 analysis, the entire accessory Sec system of S. gordonii was expressed in Escherichia coli.
255 and maximum AI-2 induction was detected when S. gordonii was grown in the presence of serum and carbo
256                         Biofilm formation by S. gordonii was observed to be influenced by the presenc
257 the expression of argC, argG, and pyrA(b) in S. gordonii was partially up-regulated although arginine
258                                              S. gordonii was recently shown to express a second Ssp p
259 ted in a dose-dependent manner while that of S. gordonii was unaffected.
260           In coaggregation assays, SspB from S. gordonii was unique in mediating coaggregation with o
261 To study saliva-regulated gene expression in S. gordonii, we used random arbitrarily primed PCR (RAP-
262 alysis, the 20-kDa AbpA protein is unique to S. gordonii, whereas the 82-kDa AbpB protein appears to
263 ontrast, type 1 fimbriated A. naeslundii and S. gordonii, which bound purified proline-rich proteins
264  of both species and well-defined mutants of S. gordonii with interrupted abpA and gtfG genes were st
265                  Furthermore, communities of S. gordonii with P. gingivalis or with A. actinomycetemc
266 x-prolyl dipeptidyl-peptidase (Sg-xPDPP, for S. gordonii x-prolyl dipeptidyl-peptidase), produced in

 
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