ライフサイエンスコーパス: SAF

1 SAF also significantly lowered fasting glucose (P = 0.03

2 SAF emerges when a fluorescing molecule is located very

3 SAF is a potentially valuable clinical screening tool fo

4 SAF partially mediated the association between T2DM and

5 SAF was classified into two types: type 1, which was fil

6 SAF was measured 5 y (median value) later using an AGE R

7 SAF was measured in participants with CKD stage 3 at bas

8 SAF, as well as the undercritical angle fluorescence (UA

9 SAF-1 activity was detected in the chondrocytes of OA ca

10 SAF-1 contains several negative and positively functioni

11 SAF-1 DNA-binding activity is increased in both cytokine

12 SAF-1 is a 477-amino acid protein with six zinc fingers.

13 SAF-1, a zinc finger transcription factor, is activated

14 SAF-1-overexpressing mice spontaneously developed AA amy

15 SAF-A oligomerization decompacts large-scale chromatin s

16 SAF-A/hnRNPU is an abundant nuclear protein with RNA-to-

17 SAFs are uploaded, together with their associated statis

18 SAFs computed from the different Monte Carlo codes were

19 SAFs for photons were generated for mildly and severely

20 SAFs of W-CIN cells were remarkably similar to those ind

21 SAFs studied between the obese phantoms and the 50th per

22 role of serum amyloid A-activating factor 1 (SAF-1) in MMP-1 expression was assessed by transient tra

23 factor, serum amyloid A-activating factor 1 (SAF-1), has been shown to regulate several genes, includ

24 factor serum amyloid A-activating factor-1 (SAF-1) has been identified as a regulator of a number of

25 Serum amyloid A (SAA) activating factor-1 (SAF-1) is an inducible transcription factor that plays a

26 amyloid A-activating transcription factor-1 (SAF-1) plays a major role in regulating transcription of

27 factor, serum amyloid A activating factor-1 (SAF-1), leading to markedly higher levels of angiogenesi

28 A SAF microscope can retrieve this near-field information

29 nesis of AA amyloidosis, we have developed a SAF-1 transgenic mouse model.

30 ly higher DNA binding activity than either a SAF-1 homodimer or a c-Fos/c-Jun heterodimer.

31 Scaffold attachment factor A (SAF-A), also called heterogenous nuclear ribonuclear pro

32 we report that scaffold attachment factor A (SAF-A), originally identified as a structural nuclear pr

33 oantigens, and scaffold attachment factor A (SAF-A).

34 hosphorylation sites created a highly active SAF-1 protein with high DNA-binding ability.

35 that reentry is important to maintain acute SAF.

36 important in maintaining stretch-induced AF (SAF).

37 pical South America (TSA), and South Africa (SAF).

38 Although SAF-1 transgenic mice do not spontaneously develop arthr

39 To develop an SAF teledermatology workflow within the Epic system, the

40 her levels of matrix metalloproteinase-1 and SAF-1 in the inflamed joints of SAF-1 transgenic mice co

41 on responsive transcription factors AP-1 and SAF-1 synergistically regulate transcriptional induction

42 same slides by using the FLIP algorithm and SAF score, blinded to their first evaluation.

43 tains the tumor suppressors SAFB1, BRG1, and SAF-A.

44 MP-dependent protein kinase (PKA-Calpha) and SAF-1.

45 ctural component of articular cartilage, and SAF-1 in both SAF-1 transgenic and nontransgenic mice.

46 Supplementation with CLA and SAF exerted different effects on BMI, total and trunk ad

47 r when the time difference between dAGEs and SAF measurements was shorter.

48 benefits of beam spinning EW excitation and SAF detection and provides the conditions for quantitati

49 P-1 family of proteins, c-Fos and c-Jun, and SAF-1 form a ternary protein complex, which has markedly

50 The combination of SP-PCR and SAF microlens array allows for on-chip highly sensitive

51 own to regulate microtubule organization and SAFs known to promote microtubule assembly such as Maski

52 ntaining either a functional or an antisense SAF-1 complementary DNA.

53 ce of endogenous SAF-1 activity by antisense SAF-1 messenger RNA inhibited interleukin-1-mediated MMP

54 ng the function of spindle matrix-associated SAFs.

55 Skin AGEs measured as skin autofluorescence (SAF) are a noninvasive reflection of long-term AGE accum

56 Non-invasive skin autofluorescence (SAF) measurement serves as a proxy for tissue accumulati

57 ely by measurement of skin autofluorescence (SAF).

58 ests, and noninvasive skin autofluorescence (SAF; a measure of tissue AGE levels) on people aged >55

59 Epic-based SAF teledermatology can improve access to dermatologic c

60 Higher baseline SAF was an independent risk factor for CVEs (hazard rati

61 The physical interaction between SAF-1 and AP-1 was demonstrated both in vitro by Far-Wes

62 ealed colocalization and interaction between SAF-1 and PKA-Calpha.

63 efficiently promotes transcription from both SAF-1 and AP-1 sites of human MMP-1 promoter.

64 nt of articular cartilage, and SAF-1 in both SAF-1 transgenic and nontransgenic mice.

65 omised the transactivation potential of both SAF-1 and AP-1.

66 es additional layers of regulation, and both SAFs are only degraded after being released from their i

67 or protein p21 was significantly affected by SAF-1; its expression level was highly induced by cellul

68 ic NAS score, 48% were classified as NASH by SAF score.

69 CMV-SAF-1 transgenic mice, upon B. burgdorferi infection, sh

70 Conceivably, SAF-1 could be a potential therapeutic target to control

71 In contrast, SAF had no effect on BMI or total adipose mass but reduc

72 health care organizations wanting to create SAF teledermatology workflows within the Epic EHR system

73 ion of SAF-1 protein from either end creates SAF-1 isoforms that are highly transcriptionally active.

74 The dAGE-SAF associations were also modified by the time differen

75 he most influential variables in determining SAF values in men, whilst in female participants, SR was

76 NUSAP1 contains a conserved SAP domain (SAF-A/B, Acinus, and PIAS).

77 whose expression levels were altered during SAF-1 overexpression.

78 Photon and electron SAFs were then calculated for relevant organs in all mod

79 sentative plots were made of photon electron SAFs, evaluating the traditional assumption that all ele

80 MP1 promoter, and interference of endogenous SAF-1 activity by antisense SAF-1 messenger RNA inhibite

81 Phosphorylation of endogenous SAF-1 in response to IL-1 and IL-6 was markedly inhibite

82 promoter as well as knockdown of endogenous SAF-1 markedly inhibited IL-1beta- and TGF-beta-mediated

83 Moreover, cells expressing SAF-A in which serine 59 is mutated to alanine have mult

84 n that the inflammatory transcription factor SAF-1 is, at least in part, responsible for the marked i

85 inflammation-responsive transcription factor SAF-1 was found to interact with it.

86 show that serum amyloid A-activating factor (SAF)-1, a novel transcription factor, and the AP-1 famil

87 nflammation-responsive transcription factor, SAF (for SAA activating factor), has been implicated in

88 le matrix contains spindle assembly factors (SAFs) such as Eg5 and dynein which are known to regulate

89 of importin-bound spindle assembly factors (SAFs), which stimulate microtubule (MT) nucleation and o

90 id cells and senescence-associated features (SAFs).

91 We use a self-assembling fiber (SAF) system to form structures tens of micrometers long.

92 rization of a self-assembling peptide fiber (SAF) system based on alpha-helical coiled-coil building

93 m fillets and the Sparus aurata fibroblasts (SAF-1) cell-line during an 8day storage period at +4 deg

94 (NAS) and steatosis, activity and fibrosis (SAF) score.

95 oring system (steatosis, activity, fibrosis [SAF]) allowing the use of an algorithm (fatty liver inhi

96 ient and Outpatient Standard Analytic Files (SAFs) from years 2012 to 2016.

97 ation with supercritical-angle fluorescence (SAF) detection efficiently rejects the fluorescence orig

98 ormed on a supercritical angle fluorescence (SAF) microlens array embedded in a microchip enabled qui

99 -PCR with super critical angle fluorescence (SAF) microlens array embedded in a microchip.

100 quivalent, supercritical angle fluorescence (SAF), is comparably less established, although it achiev

101 To identify possible activation partners for SAF-1, we used a yeast two-hybrid system that detected i

102 where most of the cells stained positive for SAF-1.

103 sis suggests that L(pro) contains a SAP (for SAF-A/B, Acinus, and PIAS) domain, a protein structure a

104 which one serves as the DNA-binding site for SAF-1 transcription factor.

105 External store-and-forward (SAF) teledermatology systems operate separately from the

106 e of obesity on specific absorbed fractions (SAFs) and dose factors in adults.

107 puted tables of specific absorbed fractions (SAFs) or S values based on dosimetric models.

108 ed to study how specific absorbed fractions (SAFs) vary with changes in adult body size, for persons

109 es to calculate specific absorbed fractions (SAFs) with internal photon and electron sources.

110 ta by first computing site allele frequency (SAF) likelihood for each site (i.e. the likelihood a sit

111 ents associated with the Subantarctic Front (SAF) jet since the earliest Oligocene (~34 Ma) based on

112 the task's speed-accuracy tradeoff function (SAF), which prevented us from falsely interpreting varia

113 Furthermore, SAF-1 transgenic mice rapidly developed severe AA amyloi

114 iotropic role of SAF-1 in vivo, we generated SAF-1 transgenic mice, in which CMV immediate-early prom

115 Greater SAF, T2DM, and cognitive impairment were each associated

116 T2DM was associated with greater SAF.

117 12 male patients; mean age, 20.1 years) had SAF type 1 (mean width, 5.2 x 4.5 mm).

118 46 male patients; mean age, 37.8 years) had SAF type 2 (mean width, 5.1 x 4.7 mm).

119 In persons on haemodialysis, SAF is an independent risk factor for cardiovascular eve

120 (95% CI: 0.009, 0.05) arbitrary units higher SAF.

121 ietary CML intake was associated with higher SAF only among participants with neither diabetes nor CK

122 We have identified SAF as an independent risk factor for CVE and ACM in per

123 sent in the atherosclerotic plaque implicate SAF-1 as a key regulator of MMP-14 gene induction in mac

124 sly unreported and significant difference in SAF values between men and women, with median (range) va

125 Two distinct but adjacent domains in SAF-1 are involved in protein-protein contact with c-Fos

126 A similar enhancement in SAF RNA expression is also detected in the HIV-1-infecte

127 Additionally, increase in SAF over 1 year was independently associated with subseq

128 vidence that VEGF expression is increased in SAF-1-transgenic mice and that SAF-1 induces VEGF transc

129 Differences in SAFs for organs irradiating themselves were between 0.5%

130 Differences in SAFs for organs outside the trunk were not greater than

131 ther splicing regulatory proteins, including SAF-B, hnRNP G, YB-1, and p72.

132 Also, during inflammation SAF-1 transgenic mice exhibited a prolonged acute phase

133 Development of internal SAF workflows within existing electronic health records

134 We investigated SAF as a risk factor for CVEs and ACM in a prospective s

135 his study identifies targeting of the lncRNA SAF as a potential means to specifically induce cell dea

136 we have identified the impact of the lncRNA SAF in regulating apoptotic effector caspases in macroph

137 Although many SAFs are non-motile MT-associated proteins, such as NuMA

138 The mean SAF of the study cohort was 2.06 (SD = 0.57) arbitrary u

139 We fabricated miniaturized SAF microlens array as part of a microfluidic chamber in

140 alues are then calculated from monoenergetic SAFs on the basis of the radioisotope decay data present

141 MPN-SAF TSS results significantly differed among MPN disease

142 MPN-SAF TSS was calculable for 1,408 of 1,433 patients with

143 A total of 402 MPN-SAF surveys were administered (English [25%], Italian [4

144 Serial administration of the English MPN-SAF among 53 patients showed that most MPN-SAF items are

145 rative Neoplasm Symptom Assessment Form [MPN-SAF], coadministered with the Brief Fatigue Inventory) t

146 N-SAF among 53 patients showed that most MPN-SAF items are well correlated (r > 0.5, P < .001) and hi

147 tomatic elements represented on both the MPN-SAF and the European Organisation for Research and Treat

148 The MPN-SAF is a comprehensive and reliable instrument that is a

149 The MPN-SAF TSS had excellent internal consistency (Cronbach's a

150 The MPN-SAF TSS is a concise, valid, and accurate assessment of

151 nderlying construct, indicating that the MPN-SAF TSS is an appropriate, unified scoring method.

152 The MPN-SAF TSS strongly correlated with overall quality of life

153 h increase could be detected with the mutant SAF-1 proteins.

154 Our findings identify serine 59 of SAF-A as a new target of both PLK1 and PP2A in mitosis a

155 xecute this pathway leads to accumulation of SAF-A-RNA complexes on mitotic chromosomes, defects in m

156 ether, these results show that activation of SAF-1 in response to IL-1 and -6 is mediated via MAP kin

157 tribution of MAP kinase in the activation of SAF-1, we prepared two independent mutant proteins in wh

158 tion is involved in functional activation of SAF-1.

159 which PKA increases functional activities of SAF-1.

160 lation increases transcriptional activity of SAF-1 by unmasking the DNA-binding domain.

161 Increased binding of SAF-1 to the MMP-14 promoter correlated with the transcr

162 overexpression of SAF-1 and coexpression of SAF-1 and MMP-14 in the macrophages present in the ather

163 The data also demonstrate that control of SAF-1 activity can suppress induced expression of MMP-1.

164 Deletion of SAF-1 binding elements from the VEGF promoter as well as

165 thermore, we found that terminal deletion of SAF-1 protein from either end creates SAF-1 isoforms tha

166 oth phosphorylation and dephosphorylation of SAF-A serine 59 by PLK1 and PP2A, respectively, are requ

167 ed 293 patients with a lifetime diagnosis of SAF disorder, bipolar disorder and major depressive diso

168 n constructs, the core DNA-binding domain of SAF-1 is mapped between amino acids 282 and 361, which c

169 In vivo evidence of SAF-1 and PKA-Calpha interaction was further revealed by

170 Expression of SAF is significantly up-regulated in HIV-1-infected huma

171 Prolonged high level expression of SAF-1 in cultured cells failed to produce any stable cel

172 To test the fate of SAF-1-overexpressing cells, the cells were monitored for

173 The high frequency of SAF on MR arthrograms (10.5%), the absence of subchondra

174 PKA) and presented evidence for induction of SAF-1-regulated genes by a PKA signaling pathway.

175 Previously, we showed in vivo interaction of SAF-1 and protein kinase A (PKA) and presented evidence

176 einase-1 and SAF-1 in the inflamed joints of SAF-1 transgenic mice compared with their levels in nont

177 We present evidence that knockdown of SAF-1 by small interfering RNAs inhibits AP-1-mediated i

178 on assay, in vivo, markedly higher levels of SAF-1 interaction with the VEGF promoter was detected in

179 processing activity during overexpression of SAF-1 and coexpression of SAF-1 and MMP-14 in the macrop

180 Although overexpression of SAF-1 could increase expression of the MMP-9 promoter an

181 Overexpression of SAF-1 in OA chondrocytes increased the expression of the

182 Our study shows that overexpression of SAF-1 predisposes animals to arthritis.

183 ical conditions that favor overexpression of SAF-1, such as an acute inflammatory condition, can trig

184 on of MMP-9 gene concurrent participation of SAF-1 and AP-1 is required.

185 markedly induces in vivo phosphorylation of SAF-1 and transcription of SAF-regulated reporter genes.

186 ably lowers the transactivation potential of SAF-1.

187 ng activity and transactivation potential of SAF-1.

188 ptional repression and active recruitment of SAF-1-mediated transcriptional activation.

189 Down-regulation of SAF with siRNA treatment increases caspase-3/7 activity

190 es that Aurora-B-dependent relocalization of SAF-A during cell division contributes to the fidelity o

191 chanism of synergy and the essential role of SAF-1 and AP-1 in up-regulating human MMP-1 expression u

192 Together these results suggest a role of SAF-1 in the pathogenesis of inflammation-induced arthri

193 To assess the pleiotropic role of SAF-1 in vivo, we generated SAF-1 transgenic mice, in wh

194 t under native condition, N and C termini of SAF-1 are engaged in an inhibitory intramolecular intera

195 hosphorylation of SAF-1 and transcription of SAF-regulated reporter genes.

196 e, we describe the potential underpinning of SAF microscopy and spectroscopy, particularly in compari

197 ebsite allows the display and downloading of SAFs and the corresponding S values for 1,252 radionucli

198 gated linoleic acid (CLA) and safflower oil (SAF), on body weight and composition in obese postmenopa

199 g/d of ethyl esters of either safflower oil (SAF; control), eicosapentaenoic acid (EPA), or docosahex

200 Mechanistically, this is dependent on SAF-A's AAA(+) ATPase domain, which mediates cycles of p

201 bony fossa in the roof of the acetabulum, or SAF.

202 IR and steatosis, activity, and fibrosis (or SAF) scoring systems.

203 duce any stable cell line that overexpresses SAF-1.

204 he cells that were programmed to overproduce SAF-1 were found to undergo growth arrest and reduce DNA

205 dy we provide evidence that, similar to p53, SAF-1 is able to activate p21 gene expression by promoti

206 were made to the reference (50th) percentile SAF values.

207 were made to the reference (50th) percentile SAF values.

208 tions of radiation transport were performed; SAFs for photons were generated for 10th, 25th, 75th, an

209 ted that unphosphorylated and phosphorylated SAF-1 proteins are structurally distinct.

210 is, we asked whether DNA-PKcs phosphorylates SAF-A in mitosis.

211 alone or pHrodo complexed to E. coli, pHrodo-SAFs report pH in both the cytoplasm and phagosomes, as

212 Results: The OpenDose collaboration produced SAFs for all source region and target combinations of th

213 In the MMP-9 promoter, SAF-1 and AP-1 DNA-binding elements are present in close

214 In the human VEGF promoter, SAF-1- and KLF-4-binding elements are overlapping, where

215 ctor-1/c-Myc-associated zinc finger protein (SAF-1/MAZ), and mutation of the SAF-1RE had little effec

216 nopausal women with type 2 diabetes received SAF or CLA (8 g oil/d) during two 16-wk diet periods sep

217 We assessed reference SAF and skin reflectance (SR) values in a Saudi populati

218 microtubule assembly caused by the released SAFs would lead to excessive microtubule sliding that re

219 the heterogeneous nuclear ribonucleoprotein SAF-A previously associated with DNA damage repair.

220 Myocardin is a SAP (SAF-A/B, Acinus, PIAS) domain transcription factor that

221 c Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.

222 isorders (that is, bipolar, schizoaffective (SAF), major depression) based on contemporary diagnostic

223 or four known SR protein-binding motifs: SF2/SAF, SC35, SRp40, and SRp55.

224 e with Xist, three of these proteins--SHARP, SAF-A and LBR--are required for Xist-mediated transcript

225 MR arthrograms showing SAF were evaluated for subchondral reactions.

226 Since SAF-A, DNA-PK catalytic subunit (DNA-PKcs), and protein

227 ited States, and development of a successful SAF workflow within it is needed.

228 used to study the relationships among T2DM, SAF, and gray matter volume (GMV).

229 olishing reentry with chloroquine terminates SAF more effectively than traditional Na+-channel blocka

230 ore effective than flecainide in terminating SAF in isolated sheep hearts by significantly increasing

231 increased in SAF-1-transgenic mice and that SAF-1 induces VEGF transcription by directly binding to

232 We demonstrate that SAF improves the surface selectivity of TIRF, even at sh

233 , these results provide direct evidence that SAF-1 plays a key role in the development of AA amyloido

234 Together these data indicate that SAF-1 controls cell cycle progression via p21 induction,

235 The results indicate that SAF-1 is involved in the regulation of MMP1 gene express

236 review the challenges and opportunities that SAF presents from a biophysical perspective, and we disc

237 e kinase 1 (PLK1) rather than DNA-PKcs, that SAF-A interacts with PLK1 in nocodazole-treated cells, a

238 green fluorescent protein reporter show that SAF-1 contains two independent nuclear localization sign

239 We further show that SAF-1 is phosphorylated in vitro by PKA-Calpha and that

240 Here, we show that SAF-1-mediated induction of VEGF is repressed by KLF-4 t

241 Our results show that SAF-A and caRNAs form a dynamic, transcriptionally respo

242 We show that SAF-A is phosphorylated on serine 59 in mitosis, that ph

243 ivation of SRp20 by SRrp86, we now show that SAF-B, hnRNP G, and 9G8 all antagonize the activity of S

244 In this paper we have shown that SAF-1, a major member of the SAF family, is abundantly p

245 distinct DNA-binding elements suggests that SAF-1 and AP-1 function in a mutually beneficial manner

246 The SAF results were compared with values from similar studi

247 The SAF-1.c-Fos.c-Jun ternary complex efficiently promotes t

248 improved NASH resolution (p < 0.001) and the SAF scores (p < 0.05) while the NAS improvement approach

249 No subchondral changes were found around the SAF.

250 For each case, the SAF score was created including the semiquantitative sco

251 near in the number of genomes to compute the SAF likelihood.

252 thod produces an accurate SFS, computing the SAF likelihood is quadratic in the number of samples seq

253 ity score but to report it separately in the SAF score.

254 orylation analyses revealed two sites in the SAF-1 protein, serine 187 and threonine 386, as the targ

255 cartilage defect was seen at the site of the SAF at arthroscopy.

256 have shown that SAF-1, a major member of the SAF family, is abundantly present in human AA amyloidosi

257 algorithm, all non-negligible values of the SAF likelihood are concentrated on a few cells around th

258 gh fluorescence collection efficiency of the SAF microlens array, the SP-PCR assay on the LOC platfor

259 gh fluorescence collection efficiency of the SAF microlens array.

260 ed multiplexed SP-PCR directly on top of the SAF microlens array.

261 tudy was to determine whether the use of the SAF score and FLIP algorithm can decrease interobserver

262 m 42% to 75% in Group 2 after the use of the SAF score and FLIP algorithm.

263 t robust constraint of the initiation of the SAF to date.

264 The width of the SAF was measured on coronal and sagittal MR images.

265 romoter was used to direct expression of the SAF-1 transgene in multiple organs.

266 reduced ability to promote expression of the SAF-1-regulated promoter.

267 ger protein (SAF-1/MAZ), and mutation of the SAF-1RE had little effect on IL-6 induction of gammaFBG

268 gh Aurora-B-dependent phosphorylation of the SAF-A DNA-binding domain; failure to execute this pathwa

269 The FLIP algorithm based on the SAF score should decrease interobserver variations among

270 of the terminal negative modules renders the SAF-1 protein functionally very active.

271 age defects at arthroscopy indicate that the SAF of the acetabulum likely represents a variant.

272 Here we report that the SAF-A/B, Acinus, and PIAS (SAP) domain of MANF selective

273 With regard to the SAF score, concordance was substantial in Group 1 for st

274 Myocardin belongs to the SAF-A/B, Acinus, PIAS (SAP) domain family of transcripti

275 e suggest describing liver lesions using the SAF score.

276 Also, the SAFs were used with standardized decay data to develop d

277 With preceding designs, the SAFs are thickened, highly ordered structures in which m

278 f self-assembly and self-organization in the SAFs is unprecedented for a designed peptide-based mater

279 with C-terminal thioester moieties into the SAFs.

280 Here, we describe the structure of the SAFs determined to approximately 8 A resolution using cr

281 designed a self-assembling fiber system, the SAFs, in which two small alpha-helical peptides are prog

282 isk of underdiagnosing NASH in comparison to SAF score.

283 Relative to SAF, EPA and DHA supplementation resulted in higher MVs

284 While the DNA-binding activity of wild-type SAF-1 protein was markedly increased upon phosphorylatio

285 ng variations in position along an unchanged SAF as a change in skill.

286 We surmised that reentry underlies SAF, and that abolishing reentry with chloroquine termin

287 highly induced by cellular conditions where SAF-1 is abundant.

288 -4-binding elements are overlapping, whereas SAF-1 induces and KLF-4 suppresses VEGF expression.

289 To assess whether SAF-1 is directly linked to the pathogenesis of AA amylo

290 mpacts large-scale chromatin structure while SAF-A loss or monomerization promotes aberrant chromosom

291 four hip joints with SAF type 1 and 13 with SAF type 2.

292 analyses, CML was positively associated with SAF after excluding both individuals with diabetes and i

293 None of them was associated with SAF in the total study population.

294 ntake were not significantly associated with SAF.

295 d obesity all showed strong association with SAF, particularly when gender differences were taken int

296 icipants, SR was also highly correlated with SAF.

297 The association of dAGEs with SAF was analyzed in linear regression models and stratif

298 ose from arthroscopy in four hip joints with SAF type 1 and 13 with SAF type 2.

299 A total of 1,707 of 1,741 participants with SAF readings at baseline were included in this analysis:

300 AP kinase phosphorylation site, PPTP, within SAF-1 could be phosphorylated by MAP kinase in vitro.