ライフサイエンスコーパス: SAR

1 SAR analysis of the resulting analogs suggests that for

2 SAR analysis, using cell culture assays, led to the disc

3 SAR and hydroxyl radical probing identified aptamer stru

4 SAR around the C-3 substituents investigated effects on

5 SAR investigation of fragment 1, aided by X-ray structur

6 SAR investigations around the screening hits provided a

7 SAR relating to rings A and B was established.

8 SAR studies have enabled the discovery of a predictive 3

9 SAR studies highlighted the pyrazole moiety as an essent

10 SAR studies of 1 are reported herein with the objective

11 SAR studies on conserved residues (Leu25, His26, Val29,

12 SAR studies on the initial hit, compound 4 (IC(50) = 257

13 SAR studies pointed to the sites on the scaffold that ca

14 SAR study indicated that the allyl group could be replac

15 SAR, SED, accumulated SED, and acquisition time were ret

16 re acute respiratory syndrome coronavirus 2 (SARs-CoV-2) has resulted in a global pandemic.

17 We analyzed data from 237 SAR/anaphylaxis in 237 children.

18 ose a more restricted upper limit for HOU-3 (SAR approximately 3).

19 Thirteen out of 237 (5.5%) SAR/anaphylaxis patients were triggered by Ana o 3.

20 These differences define a SAR of Tg for SPCA1a distinct from that of SERCA1a, indi

21 Herein, we present a SAR of the sulfonylpyridine molecule by introducing subs

22 ily counseling sessions in households with a SARs-CoV-2-infected member.

23 ity of advanced peptide synthesis to achieve SAR tractability in a challenging synthetic modality.

24 In addition, SAR with substituted imidazoles on improvement of antivi

25 2-yl)methyl (CyHQ) chromophore to conduct an SAR study with the aim of enhancing its photochemical pr

26 ective of the present study is to develop an SAR (Structure-Activity Relationship) model that can be

27 The A analogue SARs also highlight the types of modifications tolerated

28 l evaluation in cell culture experiments and SAR revealed that the compounds' effectiveness depends o

29 th sequence analysis, homology modeling, and SAR, allows us to propose CPD4 as potential starting sca

30 ve oxygen species, and expression of SA- and SAR-related genes, including the SAR regulatory AZELAIC

31 dopsis thaliana, long-distance signaling and SAR activation in uninfected tissues occur without circu

32 E1 are required for eNAD(P)(+) signaling and SAR, and the kinase activities of LecR-VI.2 and BAK1 are

33 An X-ray cocrystal structure and SAR study revealed the ability of an alkynyl linker to s

34 The design, synthesis, and SAR of this series and confirmation of its in vivo activ

35 ompound preparation, biological testing, and SAR interpretation, robust and flexible synthetic routes

36 interferometry (InSAR) and multiple-aperture SAR interferometry (MAI) techniques were integrated to r

37 al information for hazard responses, such as SAR and oil spill containment, and hence have the potent

38 ression for a given target is referred to as SAR transfer, which is of interest in lead optimization.

39 In beta-arrestin assays, SARs were different, indicating biased agonism.

40 This study assesses SARs-CoV-2 transmission among community health workers i

41 AR-signal-producing mutant plants associated SAR with monoterpene emissions.

42 By developing cell-based SAR and using chemical proteomics, we identified pirin a

43 t vs proficient MMR had significantly better SAR (adjusted hazard ratio [AHR], 0.70; 95% CI, 0.52-0.9

44 Chukchi bacterial community is dominated by SAR clades, Flavobacterium, Paraglaciecola, and Polariba

45 Through careful SAR, the successful replacement of a polar pyrazole grou

46 re meaningful interpretation of the cellular SAR analysis.

47 Both results revealed cohesive SARs, demonstrating that the methylenedioxy functional g

48 In summary, comprehensive SAR analysis accompanied by data analysis successfully i

49 hat Atg11 self-interactions help concentrate SARs as a necessary precondition for cargo capture.

50 acid series of GPR120 agonists and conducted SAR studies to optimize GPR120 potency.

51 ack displacements produced with conventional SAR interferometry (InSAR) and multiple-aperture SAR int

52 nists, 18a and 25a, which further delineates SAR associated with allosterism at D3R and provides lead

53 tural elucidation to enable chemistry design/SAR development.

54 We described a detailed SAR in TLR2 agonistic scaffolds and also covered the des

55 ethoxy DABO series (12-14) present different SAR at the dihalo benzyl substitution, with the most pot

56 This cell-based driven SAR produced compounds with strong single agent in vivo

57 During SAR, systemic leaves become primed for the superinductio

58 es with open and accessible chromatin during SAR and identifies MLO3 and two previously unidentified

59 o understand the molecular regulation during SAR induction, we examined mRNA levels, microRNA (miRNA)

60 Critical analysis of synthetic efforts, SAR studies, and the way forward are provided hereunder.

61 Engineering SAR in crop plants would enable external control of a pl

62 Existing SAR studies of Pam(2)Cys with TLR2 indicate that the str

63 pproach gives new dimensions to the existing SAR and opens a new opportunity for the lead optimizatio

64 ed libraries targeting such domain to expand SAR studies and fully characterize their mode of interac

65 Herein, we developed an extended SAR study using sumanirole (1) as the primary pharmacoph

66 Herein, we report an extensive SAR study of this chemical series and identify the key p

67 st C. neoformans, and performed an extensive SAR study, which led to the identification of five promi

68 Here, we describe our extensive SAR studies exploring both von Hippel-Lindau (VHL) and c

69 So far, SAR transfer has been investigated at the level of compo

70 For SAR that could not be rationalized through the cocrystal

71 of benzenesulfonamide (BSA) derivatives for SAR analysis.

72 and KRAS (P = .02) by primary tumor site for SAR.

73 disparity provided the perfect templates for SAR investigation.

74 quence, the calculated whole-body values for SAR, dB/dt, and scan duration were collected.

75 parallel with SA The volatile emissions from SAR signal-emitting plants induced defense in neighborin

76 Further SAR optimization yielded the orally bioavailable LOX inh

77 Further SAR studies resulted in the discovery of the most potent

78 Here, we report the further SAR exploration of this chemical family through more tha

79 Achieving higher SAR is desirable for improved zeolite (hydro)thermal sta

80 d with the small set of available historical SAR data, they highlight both localized rates of high su

81 hodology across different targets identified SAR transfer events with high frequency.

82 stress "druglikeness", and rapidly identify SAR trends.

83 ed to next-generation sequencing to identify SAR regulators.

84 Improved SAR was observed for patients with deficient MMR tumors

85 BAK1 are indispensable to their function in SAR.

86 NA and miRNA regulation enhances AHO-induced SAR.

87 Informative SAR analogues were identified, which display potent affi

88 ng an RNA-dependent ATPase assay and initial SAR study identified two different Brr2 inhibitors, 3 an

89 Interestingly, SAR was divergent between the new 5,6-heterobicyclic sys

90 al subsidence as detected by interferometric SAR measurements.

91 tion of systematic surveillance in Hong Kong SAR, China, and new gene sequencing methods has been use

92 Local SAR was significantly reduced at the lead tip with both

93 ovides a robust approach to minimizing local SAR with respect to lead trajectory.

94 omparing 1.5- with 3.0-T MRI sequences, mean SAR (1.09 W/kg +/- 0.69 vs 1.14 W/kg +/- 0.61), mean SED

95 entified, enabling the detection of multiple SAR transfer events.

96 of synthesized compounds has highlighted new SAR, and low toxicity profiles of pyroglutamides herein

97 Nineteen SAR images are used to estimate the oil seepage rate fro

98 f SAR-related emissions of wild-type and non-SAR-signal-producing mutant plants associated SAR with m

99 We previously reported a novel SAR campaign that converted a metabolically unstable ser

100 h seasonal allergens was positive in 100% of SAR and group A cases, whereas the BAT with perennial al

101 phy coupled to mass spectrometry analyses of SAR-related emissions of wild-type and non-SAR-signal-pr

102 For a systematic assessment of SAR transfer, computational approaches are required.

103 l method for structure-guided exploration of SAR transfer.

104 mmation, supporting the idea of an impact of SAR on cognitive functions.

105 ys a central role in biological induction of SAR.

106 In this study, the influence of SAR on memory and multitasking performance, as two poten

107 ion of plant defense genes and initiation of SAR.

108 ilevel response with cardinal involvement of SAR, redox homeostasis and reconfiguration of primary me

109 ch should be considered in the management of SAR symptoms.

110 reviously unidentified positive regulator of SAR.

111 The most common triggers of SAR/anaphylaxis were seeds (50.6%), among them, the stor

112 dinone scaffold through our understanding of SAR and use of structure-based design.

113 ooling algorithms based on available data on SAR-CoV-2 viral dynamics.

114 Our SAR study revealed that the thiol ligand is also very im

115 Finally, based on our SAR analysis we propose avenues for the further developm

116 Thus, our SAR study has resulted in an improved GPR68 PAM for inve

117 s whether MAR confers long-term benefit over SAR in patients with renal dysfunction who require CABG.

118 consistent between independent, overlapping SAR tracks covering a region 100 km in extent.

119 the cocrystal complex, we sought to predict SAR through a QSAR model developed in house.

120 ation while maintaining the overall profile, SAR was developed at the C2' position for a series of cl

121 monoterpenes, particularly pinenes, promote SAR, acting through ROS and AZI1, and likely function as

122 accuracy and predictivity of the obtained (Q)SAR models.

123 hole-body averaged specific absorption rate (SAR) and change in magnetic field per unit time (dB/dt),

124 ose To compare the specific absorption rate (SAR) and specific energy dose (SED) of fetal MRI at 1.5

125 he system-provided specific absorption rate (SAR) models.

126 to minimize local specific absorption rate (SAR) surrounding the implant tip while maintaining spati

127 y, which leads to specific absorption rates (SARs) 2-3 orders of magnitude lower than the safety regu

128 pitalized due to systemic allergic reaction (SAR) and food anaphylaxis were recruited.

129 hing them on the propensity to have received SAR versus MAR, within groups with preoperative glomerul

130 ing number of selective autophagy receptors (SARs) (e.g., Atg19 in yeasts, p62/SQSTM1 in mammals), wh

131 A number of selective autophagy receptors (SARs) have been characterized that interact both with th

132 Selective autophagy receptors (SARs) mark the cargo for degradation and, in yeast, recr

133 kers with patient survival after recurrence (SAR) of cancer is poorly understood but may guide manage

134 thesis and other downstream factors regulate SAR in jmj14 plants.

135 s and their structure-activity relationship (SAR) against methicillin-resistant Staphylococcus aureus

136 The structure-activity relationship (SAR) analysis revealed that the aromatic isoxazole subst

137 lution, and structure-activity relationship (SAR) analysis, a compound of furanonaphthoquinone-based

138 Through structure-activity relationship (SAR) analysis, we obtained an optimized lead compound (3

139 via a rapid structure-activity relationship (SAR) analysis.

140 hesized for structure-activity relationship (SAR) analysis.

141 focused on structure-activity relationship (SAR) and structure-affinity relationship (SAfiR) studies

142 As such, a structure-activity relationship (SAR) campaign was pursued to improve their metabolic sta

143 as based on structure-activity relationship (SAR) data generated in vitro.

144 ET-specific structure-activity relationship (SAR) effort, and specific binding assessment using a LC-

145 Additional structure-activity relationship (SAR) efforts aimed both at increasing potency and improv

146 systematic structure-activity relationship (SAR) efforts driven by structural biology studies led to

147 a reliable structure-activity relationship (SAR) model.

148 escribe the structure-activity relationship (SAR) of a library of pyrimidine-4-carboxamides as inhibi

149 nthesis and structure-activity relationship (SAR) of a novel series of 2,4,5-trisubstituted-7H-pyrrol

150 the initial structure-activity relationship (SAR) of antischistosomal ozonide carboxylic acids OZ418

151 ormation on structure-activity relationship (SAR) of ELA.

152 escribe the structure-activity relationship (SAR) of the antimalarial ozonide artefenomel (OZ439).

153 he existing structure-activity relationship (SAR) of the nitroimidazopyrazinone scaffold against a pa

154 mation, the structure-activity relationship (SAR) of the quinolinol-5-sulfonamide scaffold was explor

155 o probe the structure-activity relationship (SAR) of the scaffold 1, we synthesized 14 analogs of com

156 xplored the structure-activity relationship (SAR) of this compound series to improve otoprotective po

157 hniques and structure-activity relationship (SAR) optimization studies led to the discovery of a seri

158 rresponding structure-activity relationship (SAR) progression for a given target is referred to as SA

159 systematic structure-activity relationship (SAR) studies carried out to identify novel sulfonamide d

160 emistry and structure-activity relationship (SAR) studies identified a lead clinical candidate, MDI-2

161 Structure-activity relationship (SAR) studies indicated a crucial role for both meta-nitr

162 Structure-activity relationship (SAR) studies led to the discovery of AMT inhibitors with

163 Structure-activity relationship (SAR) studies led to the identification of compound 12b w

164 Further structure-activity relationship (SAR) studies of heterocyclic core modifications to repla

165 d extensive structure-activity relationship (SAR) studies of small-molecule ERalpha degraders based o

166 the lack of structure-activity relationship (SAR) studies of these compounds.

167 systematic structure-activity relationship (SAR) studies on the two phenyl rings and amide nitrogen

168 Structure-activity relationship (SAR) studies resulted in a series of compounds with impr

169 l extensive structure-activity relationship (SAR) studies with 70 analogues, unveiling several that e

170 mprehensive structure-activity relationship (SAR) study of a thienopyrimidine series previously ident

171 e present a structure-activity relationship (SAR) study of quinazoline compounds that serve as inhibi

172 we report a structure-activity relationship (SAR) study of this compound, which resulted in the poten

173 mprehensive structure-activity relationship (SAR) study on the scaffold of 1.

174 this work a structure-activity relationship (SAR) study that involves a broader range of derivatives

175 dimensional structure-activity relationship (SAR) study that led to compound 23a.

176 conducted a structure-activity relationship (SAR) study to probe ligand recognition features importan

177 e present a structure-activity relationship (SAR) study using analogues of A to probe the basis for O

178 n extensive structure-activity relationship (SAR) study was carried out with 32 such benzenesulfonami

179 Retro-1, a structure-activity relationship (SAR) study was undertaken and yielded an analogue with a

180 uantitative structure-activity relationship (SAR) study, 25 disulfide bond-containing analogues were

181 From this structure-activity relationship (SAR) study, novel irreversible inhibitors were identifie

182 s well as a structure-activity relationship (SAR) study.

183 The structure-activity relationship (SAR) trends identified were substantiated by a molecular

184 some of the structure-activity relationship (SAR) trends observed.

185 lot in vivo structure-activity relationship (SAR) was explored, evaluating the efficacy of its analog

186 modynamics, structure-activity relationship (SAR), NMR, and molecular dynamics (MD) studies.

187 mprehensive structure-activity relationship (SAR).

188 mprehensive structure-activity relationship (SAR).

189 nd detailed structure-activity relationship (SAR).

190 ation method, the species-area relationship (SAR).

191 a revealed structure-activity relationships (SAR) and identification of potent new monobactam antibio

192 lly driven structure-activity relationships (SAR) from literature data, including kinase, protein-pro

193 ry limited structure-activity relationships (SAR) have been reported.

194 Structure-activity relationships (SAR) in the aurone pharmacophore identified heterocyclic

195 thesis and structure-activity relationships (SAR) of a dipeptide library bearing Arg alpha-ketobenozo

196 report the structure-activity relationships (SAR) of a previously reported small molecule ATX inhibit

197 thesis and structure-activity relationships (SAR) of colchicine alkaloids and their analogues with mo

198 ishment of structure-activity relationships (SAR) responsible for translation inhibition.

199 ed through structure-activity relationships (SAR) studies.

200 xplore the structure-activity relationships (SAR) through the design, synthesis, and biological evalu

201 eport the structural activity relationships (SARs) and analysis of the physicochemical properties of

202 oration of structure-activity relationships (SARs) and optimization of ADME properties resulted in th

203 lores both structure-activity relationships (SARs) and the biology of PBDs, and the strategies for th

204 ication of structure-activity relationships (SARs) and to optimize ADME profiles.

205 prehensive structure-activity relationships (SARs) for NNMT inhibitors.

206 delineate structure-activity relationships (SARs) for PPARdelta-selective targeting and structural m

207 tablishing structure-activity relationships (SARs) for prospective therapeutic agents.

208 Yet, no structure-activity relationships (SARs) have been identified to predict lipid self-assembl

209 expand the structure-activity relationships (SARs) in this family.

210 extensive structure-activity relationships (SARs) investigations were carried out on both its aromat

211 Structure-activity relationships (SARs) were steep.

212 the first structure-activity relationships (SARs) within this class of compounds.

213 studies of structure-activity relationships (SARs), machine learning (ML) models are trained to recog

214 ogation of structure-activity relationships (SARs), structure-based drug design, and optimization of

215 by linker structure-activity relationships (SARs).

216 ion of the structure-activity-relationships (SARs) of the phenylthiazoles revealed two important stru

217 ltered the structure-activity-relationships (SARs) of the unwanted CYP3A4 induction and the desired H

218 ese fatalities is to make Search and Rescue (SAR) algorithms more efficient.

219 (AHO) induces systemic acquired resistance (SAR) in Nicotiana.

220 Systemic acquired resistance (SAR) is a long-lasting broad-spectrum plant immunity ind

221 Systemic acquired resistance (SAR) is a powerful immune response that triggers broad-s

222 c compounds in systemic acquired resistance (SAR), a salicylic acid (SA)-associated, broad-spectrum i

223 e regulator of systemic acquired resistance (SAR), which provides broad spectrum systemic immunity in

224 esponse called systemic acquired resistance (SAR).

225 tablishment of systemic acquired resistance (SAR).

226 Exogenous Pip partially restored SAR in jmj14 plants, suggesting that JMJ14 regulated Pip

227 of subjects with seasonal allergic rhinitis (SAR) and subjects without allergy and tested for cross-s

228 Seasonal allergic rhinitis (SAR) caused by intermittent exposure to seasonal pollen

229 h, patients with seasonal allergic rhinitis (SAR) showed poorer school and work performance during pe

230 group and in six seasonal allergic rhinitis (SAR), eight perennial local allergic rhinitis (LAR), six

231 pollen allergy (seasonal allergic rhinitis [SAR] group, n = 16), sublingual immunotherapy (SLIT)-tre

232 c patients (with seasonal allergic rhinitis [SAR]), and 12 nonatopic control subjects.

233 ximately 10% of CF recovery while sarcosine (SAR) showed insignificant effects.

234 Subsequent SAR study of AS4583 gave compound RJ-LC-07-48 which exhi

235 de guided by sharply defined and synergistic SAR.

236 entral core, identified through a systematic SAR study carried out on biphenyl moiety.

237 A systematic SAR study further revealed that replacement of the key o

238 to "druglike" compounds guided by systematic SAR studies.

239 Our findings suggest that SAR has a differentiated and complex impact on cognitive

240 The SAR analysis revealed cooperative potency effects of the

241 The SAR data and analysis of crystal structures provide insi

242 The SAR data formed the basis for a three-dimensional pharma

243 The SAR findings and the enhanced allosteric activity in thi

244 The SAR group had increased proportions of ILC2s (P = .002)

245 The SAR outcome has confirmed the requirement of near planar

246 The SAR studies aided the design of more potent compounds, o

247 neutrally stochastic null models such as the SAR and rarefaction are likely to underestimate extincti

248 Herein, we expanded the SAR of that campaign and determined that the incorporati

249 We also explore the SAR and the prospective clinical application of thiazole

250 the rings in this scaffold and exploring the SAR of this new core, two promising analogues were disco

251 ed in the SCIT group compared to that in the SAR (both, P < .01).

252 d in the SCIT group compared to those in the SAR group (P < .001) during the pollen season compared t

253 of SA- and SAR-related genes, including the SAR regulatory AZELAIC ACID INDUCED1 (AZI1) gene and thr

254 ibacter ubique and most other members of the SAR 11 clade of the Alphaproteobacteria, can evade filtr

255 ly evolved in amoebozoans and members of the SAR and haptophyte clades.

256 The remarkable potency and depth of the SAR, as well as the relatively low molecular weight of t

257 we examined the effect of cationicity on the SAR of these analogues.

258 tered during multiproperty optimization, the SAR transfer concept can be applied attempting to replac

259 drug discovery campaign involves probing the SAR around one or more fragment hits.

260 e absence of a pathogen, suggesting that the SAR trait can be engineered to enhance a plant's endogen

261 putational modelling was used to explain the SARs of certain key compounds and set the stage for the

262 the selective autophagy and discuss how the SARs may be involved in the pathogenesis of NDDs.

263 ew, we critically discuss the biology of the SARs with special emphasis on their interactions with UB

264 The NOP partial agonists and their SAR reported here may be useful to develop nondopaminerg

265 These SARs may help predict the formation and survival of prot

266 zed into potent tankyrase inhibitors through SAR exploration around the quinazolinone core and the 4'

267 natural products, including contributions to SAR development, mode of action studies, and eventually

268 This synthetic route, well-suited to SAR, represents a generalizable route toward all manner

269 dence for the mechanisms involved in tobacco SAR, which are likely to be present in other plants.

270 on of these genes in tomato leaves triggered SAR in distal tissues in the absence of a pathogen, sugg

271 is a putative mobile signal, which triggers SAR through its receptor complex LecRK-VI.2/BAK1 in Arab

272 putational modeling, revealed the unexpected SAR of these carbasugar SGLT2 inhibitors, and enabled th

273 was instrumental in the generation of useful SAR during a RORgammat inverse agonist program.

274 Using SAR data, we show that peptide class A GPCRs can be divi

275 August 2014 M6.0 South Napa earthquake using SAR data from the Italian Space Agency's COSMO-SkyMed an

276 MAR versus SAR does not correlate with a difference in MACE amongst

277 atients with GFR >=60, the use of MAR versus SAR was associated with a lower rate of MACE [hazard rat

278 i-protein and permitted in vitro and in vivo SAR exploration of this modality.

279 Interestingly, we find that in vivo SARs differ from those collected in vitro, and most impo

280 s with reduced monoterpene biosynthesis were SAR-defective but mounted normal local resistance and me

281 Associations of biomarkers with SAR were analyzed using Cox proportional hazards models

282 tumor on the association of biomarkers with SAR.

283 odynamically feasible to synthesize FAU with SAR=2-7, though kinetic factors seemingly impose a more

284 Non-medicated patients with SAR (n = 41) and healthy non-allergic controls (n = 42)

285 ushings were collected from 29 patients with SAR and 31 control subjects during and after the pollen

286 l barrier function, were DA in patients with SAR and control subjects, irrespective of season.

287 fferentially regulated between patients with SAR and control subjects, with inverse abundance dynamic

288 c IgE levels were increased in patients with SAR compared to nonatopic control subjects (all, P < .00

289 (all, P < .001) compared with patients with SAR.

290 nctioning, was investigated in patients with SAR.

291 (MCP-1) levels were higher in subjects with SAR, whereas IL-8 levels were higher in subjects without

292 borne pollen concentrations in subjects with SAR, with a time lag between 0 and 13 days depending on

293 ithout allergy were lower than in those with SAR but followed the pollen exposure with similar kineti

294 to-oncogene (KRAS) in the primary tumor with SAR in patients with stage III colon carcinomas treated

295 Clinical MRI protocols without SAR restriction were used.

296 icantly associated with worse SAR, and worse SAR for BRAFV600E or KRAS mutant tumors was more strongl

297 .57; 95% CI, 0.40-0.83; P = .003), and worse SAR was observed for tumors of the distal colon with mut

298 1.21; 95% CI, 1.00-1.47; P = .052) had worse SAR compared with those whose tumors had wild-type copie

299 00E were significantly associated with worse SAR, and worse SAR for BRAFV600E or KRAS mutant tumors w

300 The mitochondrial protein Atg32 is the yeast SAR that mediates mitophagy, the selective autophagic ca