ライフサイエンスコーパス: SCF

1 SCF (Skp1-Cullin-F-box) ubiquitin ligases comprise sever

2 SCF complexes have a variable F-box protein subunit that

3 SCF E3 ligases are activated in many cancers and inhibit

4 SCF enzymes share a common catalytic core containing Cul

5 SCF prevented loss of clonogenic potential under differe

6 SCF(FBXW7) E3 ligase then promotes polyubiquitylation of

7 SCF(FBXW7)-mediated degradation of p53 promotes cell rec

8 SCF(Skp2/Cks1) ubiquitinates Thr187-phosphorylated p27 f

9 SCF(Slmb) interacts with a phosphor degron embedded with

10 SCF-FBXL17 therefore probes both shape and complementari

11 SCF-Fbxl8 poly-ubiquitylates p-Thr-283 cyclin D3 targeti

12 SCF-FBXO24 polyubiquitinates NDPK-A at K85, and two NH(2

13 SCF-type complexes can engage variant ubiquitination sub

14 The -CF(2)SCF(3) moiety has interesting properties due to the elec

15 thylthio-alpha,alpha-difluoroketone (-COCF(2)SCF(3)) functionality.

16 xes with IrCp*Cl(2), RuCl(2), AuCl, or CuO(3)SCF(3).

17 anolysis reactions in the presence of Cu(O(3)SCF(3))(2) determined.

18 or the construction of the benzylic C(sp(3))-SCF(3) bond to synthesize trifluoromethylthio-diarylmeth

19 substrate of FBW7, a tumor suppressor, and a SCF (SKP1/CUL1/F-box)-type ubiquitin ligase.

20 iquitinated proteins, including TDP-43 and a SCF(Cyclin F) substrate.

21 Our results indicate that abnormal SCF activity with subsequent impairment of the autophagi

22 reduced degree of apoptosis 1 week after Ad.SCF injection.

23 recombinant adenovirus encoding for SCF (Ad.SCF, n=9) or beta-gal (Ad.beta-gal, n=6) into the infarc

24 antly higher in pigs after SCF treatment (Ad.SCF, 55.5+/-11.6 mm Hg versus Ad.beta-gal, 31.6+/-12.6 m

25 work was significantly higher in pigs after SCF treatment (Ad.SCF, 55.5+/-11.6 mm Hg versus Ad.beta-

26 kp1 and Cul1 are invariant components of all SCF complexes, the 69 different human F-box proteins are

27 Complex dissociation allows SCF-FBXL17 to wrap around a single BTB domain, resulting

28 (ARI-1) coordinate with CDC34 (UBC-3) and an SCF E3 complex to ubiquitinate a common substrate, a SKP

29 owth and pigmentation, partly by creating an SCF-dependent niche for follicular melanocytes.

30 K, but instead forms via its F-box domain an SCF (Skp1-Cul1-F-box)-type E3 ubiquitin ligase module.

31 related FBP, reduces its ability to form an SCF, resulting in an increase in AFB1 levels.

32 ed ubiquitination events and that EXO1 is an SCF-Cyclin F substrate in the response to UV radiation.

33 lin F, a substrate recognition subunit of an SCF (Skp1-Cul1-F-box protein) complex, as the G2 ubiquit

34 W7 is the substrate-recruiting subunit of an SCF ubiquitin ligase and a major tumor-suppressor protei

35 t complex with COI1, the F-box subunit of an SCF-type ubiquitin E3 ligase.

36 regulation of RAD51 protein stability via an SCF ubiquitin ligase dependent on EMI1.

37 he divergent behaviors between the CF(3) and SCF(3) reagents.

38 n explain the rapid association of Cdc34 and SCF.

39 on, and the ubiquitin ligases CRL4(Cdt2) and SCF(Skp2) couple to degrade p21 prior to the G1/S transi

40 Both G-CSF and SCF had pronounced effects on frataxin levels (the prima

41 but only in mice producing IL-3, GM-CSF, and SCF transgenically or in regular mice in which the cells

42 icle delivery, next generation gammaPNAs and SCF treatment may offer a minimally invasive treatment f

43 Interweaving MALDI and SCF facilitates a comparison between the experimentally

44 arin, which binds ligands including PDGF and SCF, and imatininib which blocks downstream tyrosine kin

45 ticipants consuming fibers (polydextrose and SCF combined) in comparison with NFC.

46 2 +/- 2% and 13 +/- 2% with polydextrose and SCF, respectively, compared with NFC.

47 h activities depend on the F-box protein and SCF (Skp, Cullin, F-box) complex component MORE AXILLARY

48 Here we describe an insulin-signaling and SCF(LIN-23)-regulated pathway that controls mitochondria

49 h synergistic interactions between SMAP1 and SCF(TIR)(1) ubiquitin proteasome components.

50 e were resistant to TRAIL-induced apoptosis, SCF-stimulated MCs underwent apoptosis in response to TR

51 fically with Cullin-RING E3 ligases, such as SCF (Skp1-Cullin-F-box).

52 We engineered a mechanism-based SCF partial agonist that impaired c-Kit dimerization, tr

53 nd a site flanking Myc Box I that also binds SCF(FbxW7) We determined the crystal structure of the co

54 Both SCF complexes targeted the cyclin-dependent kinase inhib

55 The Skp-Cul-F box (SCF) ubiquitin E3 ligase machinery recognizes predominan

56 box protein PhMAX2A of the Skp-Cullin-F-box (SCF) complex and/or a repressor of SL signaling, PhD53A.

57 lants, the multi-subunit Skp1-Cullin1-F-box (SCF) complexes compose the largest group of E3 ligases w

58 Skp1-Cul1-F-box (SCF) E3 ligases play key roles in multiple cellular proc

59 sary for recognition by Skp1/Cullin-1/F-box (SCF) E3 ubiquitin ligases leading to subsequent proteaso

60 essential components of the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligases.

61 nated by a member of the Skp1-Cullin1-F-box (SCF) family of ubiquitin ligases in a phosphorylation-de

62 -box protein, part of the Skp1-cullin-F-box (SCF) ubiquitin ligase complex, involved in ubiquitinatio

63 e combined activity of two Skp-cullin-F-box (SCF) ubiquitin ligase complexes that included as substra

64 ecognition subunit of the Skp1-cullin-F-box (SCF) ubiquitin ligase that targets oncoproteins for ubiq

65 d for degradation by the SKP1-CULLIN1-F-BOX (SCF) ubiquitin-protein ligases containing TRANSPORT INHI

66 ress ribosomal RNA (rRNA) transcription, but SCF loading and repression mechanisms are unclear.

67 oteins stimulates robust EIN3 degradation by SCF(EBF1/EBF2) E3 ligases.

68 re cytosolic XLF is subsequently degraded by SCF(beta-TRCP) in a CKI-dependent manner.

69 by GSK3 kinase and consequently degraded by SCF(FBW)(7alpha) Failure to degrade SOX9 promotes migrat

70 structural insight into target selection by SCF-FBXL17, a dimerization-quality-control E3 ligase tha

71 regulates the levels of proteins targeted by SCF-E3 ligases, such as C-MYC, beta-catenin, and steroid

72 ontexts that depend on p27 ubiquitination by SCF(Skp2-Cks1) ubiquitin ligase and therefore help forec

73 as a context in which p27 ubiquitination by SCF(Skp2/Cks1) is required for p27 downregulation.

74 ase 3 at serine 33 and then ubiquitylated by SCF(FBXW7) and degraded.

75 The prototypic CRLs in yeast, called SCF enzymes, employ a single E2 enzyme, Cdc34, to build

76 I1, through which EMI1 assembles a canonical SCF ubiquitin ligase complex that constitutively targets

77 However, the structural aspects of the Cdc34-SCF interaction and how they permit rapid complex format

78 tein-mediated viral latency through cellular SCF E3 ligase targeting of viral replication proteins is

79 ociated protein1/Cullin1/F-box protein COI1 (SCF(COI1)) E3 ubiquitin ligase complex, and their degrad

80 ciation with the E3 ubiquitin ligase complex SCF(MAX2) and downstream targets SUPPRESSOR OF MAX2 1 (S

81 bunit of E3 ubiquitin protein ligase complex SCF, and the latter was functionally involved in NICD1 u

82 t of an E3 ubiquitin-protein ligase complex (SCF(Cyclin F)).

83 Consequently, SCF(Met30) substrate ubiquitylation is blocked and trigg

84 erfering RNAs (siRNAs) against the conserved SCF subunit Skp1 protected PKR from NSs-mediated degrada

85 tability is regulated by the SKP2-containing SCF (SKP1-cullin1-F-box protein) E3 ubiquitin ligase in

86 and activation of the beta-TrCP1-containing SCF ubiquitin ligase complex.

87 unit of the CUL1-RING ubiquitin ligase (CRL1/SCF(KDM2B)) complex.

88 r Fbw7, betaTrCP, and Skp2 Skp-F-box-cullin (SCF) E3 ubiquitin ligases, which degrade and suppress st

89 7(+) cells expressed CXCL12 and the cytokine SCF, were mesenchymal progenitors capable of differentia

90 strigolactone signalling mediated by the D14-SCF(MAX) (2) -SMXL7 complex is only one of a number of c

91 Daily SCF consumption significantly increased bone calcium ret

92 results show that the skin microbiome drives SCF production in keratinocytes, which triggers the diff

93 highlighting the deep crosstalk between E2F, SCF-Cyclin F, and APC/C in regulating the oscillator und

94 n intact UBX domain is crucial for effective SCF(Met30) disassembly, and a concentration threshold of

95 ultured in the presence of stem cell factor (SCF) and FMS-like tyrosine kinase 3 ligand (FLT3L) give

96 nerally assumed to require stem cell factor (SCF) and KIT signaling during differentiation for the fo

97 Surprisingly, stem cell factor (SCF) as the MC-supportive mediator par excellence potent

98 Expression of stem cell factor (SCF) by these cells is necessary for the maintenance of

99 nic protein 4 (BMP-4), and stem cell factor (SCF) constituted a common cytokine signature in the vitr

100 ulating factor (G-CSF) and stem cell factor (SCF) in a humanized murine model of Friedreich's ataxia.

101 Stem cell factor (SCF) is a growth factor that acts through the c-Kit rece

102 ating factor (GM-CSF), and stem cell factor (SCF) on the experimental genesis of a human AML in xenog

103 ersed by neutralization of stem cell factor (SCF) or cell adhesion molecule 1 (CADM1).

104 s membrane-bound FLT3L and stem cell factor (SCF) together with CXCL12 induce the specification of hu

105 Stem cell factor (SCF) was secreted by differentiated tumor cells and supp

106 elated with skin levels of stem cell factor (SCF), a critical MC differentiation factor, and lipoteic

107 Although stem cell factor (SCF), a cytokine, is known to be important for wound rep

108 human MCs, which depend on stem cell factor (SCF)-induced or constitutive KIT activation.

109 HSC maintenance, including stem cell factor (SCF).

110 on plus stimulation of the stem cell factor (SCF)/c-Kit pathway yielded high levels of gene editing i

111 terleukin-7 [IL-7], Flt3L, stem cell factor [SCF], ThPO, and IL-6) from bone marrow mesenchymal strom

112 erichia coli, the secondary channel factors (SCFs) GreB and DksA both repress ribosomal RNA (rRNA) tr

113 with the E3 ligase complex SKP-CULLIN-FBXL3 (SCF(FBXL3)) to reduce E2F steady state protein levels.

114 e examined how the E3 ubiquitin ligase FBXO7-SCF (SKP1, Cul1, F-box protein) expressed in myelinating

115 Dietary soluble corn fiber (SCF) significantly improves calcium absorption in adoles

116 lydextrose (21 g/d), and soluble corn fiber (SCF; 21 g/d) for 21 d each.

117 well as serum concentrations of IL-7, Flt3L, SCF, and ThPO to the levels displayed by specific pathog

118 or Shp1/p47 is an additional key element for SCF(Met30) disassembly during heavy metal stress.

119 either a recombinant adenovirus encoding for SCF (Ad.SCF, n=9) or beta-gal (Ad.beta-gal, n=6) into th

120 he idea that CRYs function as co-factors for SCF(FBXL3), provide a resource of potential substrates,

121 CULLIN1-neddylation is required for SCF(TIR1/AFB) functionality, as exemplified by mutants d

122 P complexes do not allow sufficient time for SCFs to dissociate.

123 , 17-19] or as "small carbonaceous fossils" (SCFs) [20, 21].

124 , was detected between 0 and 20 g fiber from SCF/d (8%; P = 0.035).

125 compare doses of 0, 10, and 20 g fiber from SCF/d for 50 d.

126 effect was shown with 10 and 20 g fiber from SCF/d, whereby bone calcium retention was improved by 4.

127 ized that FBXL16 might not form a functional SCF-E3 ligase complex.

128 XL2 (the receptor subunit of one of 69 human SCF (SKP1, CUL1, F-box protein) ubiquitin ligase complex

129 n F, the substrate receptor of 1 of 69 human SCF ubiquitin ligase complexes.

130 hether gene transfer of membrane-bound human SCF improves cardiac function in a large animal model of

131 The results demonstrate the human SCF enzyme system is diversified by association with mul

132 rrangements from the hypervalent (I-CF(3), I-SCF(3)) to the corresponding ether-type form (O-CF(3), O

133 form (O-SCF(3)), and the hypervalent form (I-SCF(3)) has been elusive.

134 library based on western blot and identified SCF-FBXO32 to be a new E3 ligase, which is responsible f

135 s scarce due to the low number of identified SCF substrates.

136 rotein linking cullin-1 to F-box proteins in SCF (Skp1/Cullin-1/F-box protein) E3 ubiquitin ligases,

137 ity to a range of cellular factors including SCF E3 ubiquitin ligases and the kinetochore in eukaryot

138 Fs (SLF4 and SLF13) that were assembled into SCF(SLF) complexes.

139 find evidence that SMAX1 is degraded by KAI2-SCF(MAX2) but is also subject to MAX2-independent turnov

140 hat produce growth factor c-Kit ligand (Kitl/SCF) and chemokine CXCL12, and were thought to be static

141 tating their ubiquitination by the E3 ligase SCF(beta-TrCP).

142 its the ubiquitination of c-Jun by E3 ligase SCF(FBW) (7) (FBW7), increases c-Jun-dependent transcrip

143 and degradation through the ubiquitin ligase SCF(beta-TrCP2).

144 n that is recognized by the ubiquitin ligase SCF(Cdc4).

145 components that bind to the ubiquitin ligase SCF(Dia2).

146 nd ubiquitination by the E3 ubiquitin ligase SCF(FbxW7) However, N-Myc protein (the product of the MY

147 as the degron that mediates ubiquitin ligase SCF(Grr1)-dependent destruction of Med13 following oxida

148 or, beta-Catenin, and its cognate E3 ligase, SCF(beta-TrCP).

149 he kinase module depends upon the E3 ligase, SCF(FBW7) In addition, genetically insulin-resistant and

150 scade consisting of the E3 ubiquitin ligases SCF(Mdm30) and Rsp5, and the Cdc48 cofactor Doa1.

151 elf) and four families of ubiquitin ligases (SCF(EBF1/2), CUL3(LRB), CUL3(BOP), and CUL4(COP1-SPA)) t

152 Two distinct E3 ligases, SCF(FBXL19) and HECW1, degrade thyroid transcription fac

153 ne kinase (RTK)-dependent signaling event, m-SCF/c-Kit and VEGF-A/vascular endothelial growth factor

154 uired membrane-localized stem cell factor (m-SCF) in megakaryocytes, which was regulated, in turn, by

155 broad-spectrum inhibitors that targeted many SCF ligases, or conversely, a highly specific inhibitor

156 thologs UBE2R1 and UBE2R2, appear to mediate SCF-catalyzed substrate polyubiquitylation in vitro.

157 The data reveal that a model SCF functions by a 'delayed inhibition' mechanism and su

158 ere, we identified components of the modular SCF (Skp1, Cul1, F-box protein)-type E3 ubiquitin ligase

159 ocultured, and was inhibited by neutralizing SCF or CADM1.

160 13, IL-17F, leptin, G-CSF, GM-CSF, LIF, NGF, SCF, and TGF-alpha.

161 ls cellular specialization within the niche: SCF from LepR(+) cells is broadly required by HSCs and r

162 Together, our work reveals a novel SCF(Cyclin F)-mediated mechanism required for precise on

163 is model is based on the NOD-scid IL2rg(null)SCF/GM-CSF/IL3 (NSG-SGM3) strain of mice engrafted with

164 he corresponding ether-type form (O-CF(3), O-SCF(3)).

165 hermodynamically stable thioperoxide form (O-SCF(3)), and the hypervalent form (I-SCF(3)) has been el

166 Furthermore, the absence of SCF or imatinib treatment prevents progenitors from deve

167 p28 deficiency corrected the accumulation of SCF(Fbw7) substrate proteins, including NICD1, c-Jun, an

168 4 binds to RBX1 and inhibits the activity of SCF(TIR)(1), an E3 ligase responsible for degradation of

169 at GF mice express abnormally low amounts of SCF, a critical MC differentiation factor, and contain M

170 ods that preserve the in vivo assemblages of SCF complexes and apply quantitative mass spectrometry t

171 aimed to determine the skeletal benefits of SCF in postmenopausal women.

172 To enable the quantitative comparisons of SCF-dependent ubiquitylation reactions with physiologica

173 Skp2 is a crucial component of SCF(Skp2) E3 ubiquitin ligase and is often overexpressed

174 dipocyte biology that encodes a component of SCF-type E3 ubiquitin ligase complexes.

175 We describe the identification of SCF-Fbxl8 as the E3 ligase for Thr-283 phosphorylated cy

176 Despite the broad cellular impact of SCF enzymes, important questions remain about the archit

177 ir, the cellular and molecular mechanisms of SCF in wound closure remain poorly understood.

178 Mouse models of SCF-mediated anaphylaxis, radioprotection, and hematopoi

179 oid cultures on OP9-DLL4, in the presence of SCF, FLT3L, and IL7, UM171 selectively expanded CD34(+)C

180 that keratinocytes' autocrine production of SCF activates a transient c-kit receptor in keratinocyte

181 Here we show purification of SCF(Fbxo4) complexes results in the identification of fr

182 s the antiviral kinase PKR by recruitment of SCF-type E3 ubiquitin ligases containing FBXW11 and beta

183 ce the Src tyrosine kinase as a regulator of SCF(beta-TrCP).

184 er, these factors enable rapid remodeling of SCF complexes to promote biased assembly of SR modules b

185 When the role of SCF(Skp2/Cks1)-mediated p27 ubiquitination in cancer was

186 3 months and suggests an angiogenic role of SCF.

187 al evidence showing the polymorphic roles of SCF complexes.

188 allowed us to uncover a comprehensive set of SCF functions.

189 F-box genes well support a broad spectrum of SCF functions, experimental evidence is scarce due to th

190 alysis of ask1 uncovered a large spectrum of SCF functions, which is greater than a 10-fold increase

191 f UBE2R1/2 had no effect on the stability of SCF substrates in cells.

192 es reveal that Fxr1 is a direct substrate of SCF(Fbxo4).

193 s well as the DELLA repressors, substrate of SCF(SLY)(1) We propose that the alf4 phenotype is partly

194 ore than one hundred potential substrates of SCF(FBXL3+CRY1/2), including the cell cycle regulated To

195 unctions as the substrate-binding subunit of SCF(cyclin F) E3 ubiquitin ligase.

196 Suppression of SCF or KIT signaling greatly reduced the expression of g

197 Instead, the tethering of SCF(Dia2) to the replisome progression complex increases

198 raises questions about genetic buffering of SCFs in human cells and challenges the dogma that E3s al

199 ic C-terminal tail of Cdc34 and a feature on SCF called the basic canyon.

200 on following ubiquitination by APC/C-CDH1 or SCF(FBXW7).

201 ; this was prevented by inhibition of KIT or SCF.

202 Unlike the phosphorylation of other SCF (SKP1-CUL1-F-box)/CRL1 substrates that promotes subs

203 iling of migrating cells revealed a possible SCF/c-Kit paracrine mechanism contributing to migration

204 sults demonstrate that keratinocyte-produced SCF is essential to wound closure due to the increased r

205 depends exclusively on keratinocyte-produced SCF.

206 the E2 UBE2D3 and the E3 ARIH1 both promoted SCF-mediated polyubiquitylation in a substrate-specific

207 domain-containing protein, SAMD14, promotes SCF/proto-oncogene c-Kit (c-Kit) signaling, erythroid pr

208 F3-EBFs to the core SKP1-CUL1-F box protein (SCF) scaffold is facilitated by light signals or PIF3 ph

209 Skp1-Cul1-F-box protein (SCF) ubiquitin ligases direct cell survival decisions by

210 the role of the SKP1-Cullin-1-F-box protein (SCF)-[F-box and tryptophan-aspartic acid (WD) repeat dom

211 subunit of the Skp1/Cullin-1/F-box protein (SCF)-class of E3-ubiquitin ligases, is a natural substra

212 studies placed the Skp1-Cul1-F-box-protein (SCF) family of E3 ubiquitin ligases with the F-box prote

213 ial amoeba Dictyostelium, where it regulates SCF assembly and O2-dependent development.

214 Orsten) or recalcitrant fragmentary remains (SCFs) restricting their phylogenetic precision [5, 12, 1

215 not mean that mast cell progenitors require SCF and KIT signaling throughout differentiation.

216 ease of important bone marrow niche signals (SCF, IL-1beta, G-CSF, TGFbeta and CXCL4) and activation

217 showed that mH2A1 is a new substrate of Skp2 SCF complex whose degradation by Skp2 promotes CDK8 gene

218 lation and recruits E3 ligase TRAF6 and Skp2-SCF to the Akt complex, independently of its demethylase

219 field (NEO-DeltaSCF), complete active space SCF (NEO-CASSCF), and nonorthogonal configuration intera

220 ed13 itself is modified by Slt2 to stimulate SCF(Grr1)-mediated destruction.

221 ation in its inhibitory sites and subsequent SCF-dependent degradation of the PHLPP phosphatase respo

222 In summary, SCF(FBXW7) targets HsSAS-6 for degradation and thereby c

223 Targeting SCF and CADM1 may enhance beta2-AR efficacy, particularl

224 We conclude that SCF can have selective MC-dampening functions.

225 ical and functional studies demonstrate that SCF(FBXO31) is capable of recruiting and ubiquitinating

226 We find that SCF-cyclin F controls E2F1 ubiquitylation and degradatio

227 We find that SCF-FBXL17 disrupts aberrant BTB dimers that fail to sta

228 Here, we found that SCF expression in the epidermis is decreased in mouse mo

229 In focused studies, we found that SCF(FBXW11) bound, polyubiquitylated, and destabilized R

230 We also found that SCF(FBXW7) interacts with HsSAS-6 and targets it for ubi

231 Specifically, we found that SCF(FBXW7)-specific targeting of p53 is crucial for the

232 Here, we report that SCF(beta-TRCP) earmarks Set8 for ubiquitination and degr

233 prevailing consensus, our results show that SCF and KIT signaling are dispensable for early mast cel

234 Here, we show that SCF from LepR(+) cells is also necessary to maintain man

235 It has been shown that SCF expression increases after myocardial infarction (MI

236 These results suggest that SCF(SLF) complexes have evolved specifically to function

237 Both genetic and molecular data support that SCF(EBF1/2) function as photomorphogenic E3s during seed

238 The SCF(FBXO31) (Skp1-Cul1-Rbx1-FBXO31) ubiquitin ligase com

239 Instead, we found that Src attenuates the SCF(beta-TrCP) E3-ligase activity in blunting Taz protea

240 n the absence of JA, but de-repressed by the SCF(COI)(1) complex on perception of JA.

241 ion of JA signal, degradation of JAZ3 by the SCF(COI1) complex releases YABs to activate a subset of

242 player in HR, RAD51, is ubiquitylated by the SCF(FBH1) complex.

243 ion-dependent cyclin E ubiquitylation by the SCF(Fbw7) ubiquitin ligase.

244 quitin-dependent degradation mediated by the SCF(Fbw7) ubiquitin ligase.

245 idue which generates a phosphodegron for the SCF (Skp-Cul-Fbox) ubiquitin E3-ligase receptor protein

246 em and label-free proteomics to identify the SCF(Slmb) ubiquitin E3 ligase complex as a novel SMN bin

247 kpoint kinase Chk1 at the MBT results in the SCF(beta-TRCP)-dependent degradation of a limiting repli

248 mponent CRY2 is an essential cofactor in the SCF(FBXL3)-mediated ubiquitination of c-MYC.

249 FBXW7 and disables its recruitment into the SCF complex.

250 equires E3 ubiquitin ligase complexes of the SCF (Skp1, Cul1, F-box protein) type to destroy PKR.

251 Skp1 is a subunit of the SCF (Skp1/Cullin 1/F-box protein) class of E3 ubiquitin

252 sm may involve regulation of assembly of the SCF complex.

253 2 is a novel interactor and substrate of the SCF E3 ubiquitin ligase beta-TrCP (FBXW1).

254 utation destabilizes the CUL1 subunit of the SCF Reduced CUL1 levels are associated with increased le

255 about the architecture and regulation of the SCF repertoire, including whether SRs compete for Cul1 a

256 ng UBE2R1/2 resulted in stabilization of the SCF substrates p27 and CYCLIN E as well as the CUL2-RING

257 omain-containing 7 (FBXW7), a subunit of the SCF ubiquitin ligase, down-regulates spindle assembly 6

258 drawing, albeit lipophilic, character of the SCF(3) group, which can be combined with the high electr

259 aTrCP, the substrate-receptor subunit of the SCF(betaTrCP) ubiquitin ligase, and promotes betaTrCP de

260 showed that Vif is a novel substrate of the SCF(cyclin F) E3 ligase, where cyclin F mediates the ubi

261 , the substrate-recognition component of the SCF(FBW7) multiprotein E3 ligase complex, targets both W

262 1 (a conventional Rbx1) as components of the SCF(S) (2-) (SLF) (1) complex.

263 gulatory subunit 1 (Cks1), a cofactor of the SCF(Skp2) ubiquitin ligase complex and a downstream targ

264 As part of the SCF(Skp2) ubiquitin ligase, Skp2 drives the cell cycle b

265 Skp2, a substrate-recruiting subunit of the SCF(Skp2) ubiquitin ligase.

266 Skp2, a substrate recruiting subunit of the SCF-Skp2 E3 ubiquitin ligase, as an early repression tar

267 Here we report that the SCF(Cyclin F) ubiquitin ligase complex prevents DNA re-r

268 Thus, the SCF(FBXO17) E3 ubiquitin ligase complex negatively regul

269 , interacts with TCP14 and targets it to the SCF(COI1) degradation complex by connecting it to the JA

270 te stability by targeting the protein to the SCF(Fbw1a) E3 ubiquitin ligase.

271 sphorylates beta-cat and transfers it to the SCF-TrCP E3-ubiquitin ligase for ubiquitination and dest

272 residence in the BM and interaction with the SCF(+) stromal niche, which is disrupted during HSC mobi

273 This SCF variant elicited biased activation of hematopoietic

274 d hematopoietic expansion revealed that this SCF partial agonist retained therapeutic efficacy while

275 In turn, this SCF(FBXO3) (SKP1-CUL1-F box) complex ubiquitylates AIRE,

276 maturation of MCs within the dermis through SCF production by LTA-stimulated keratinocytes.

277 environment, such as nutrient loss, through SCF E3 ligase activities, and responds by initiating act

278 d is predicted to severely impair binding to SCF proteins.

279 dc48 and Shp1 are recruited independently to SCF(Met30) during cadmium stress.

280 otein Met30 from the core ligase, leading to SCF(Met30) inactivation.

281 of Thr-187-phosphorylated p27 (p27T187p) to SCF(Skp2/Cks1) ubiquitin ligase.

282 concentration threshold of Shp1 recruited to SCF(Met30) needs to be exceeded to initiate Met30 dissoc

283 t CRY2 recruits phosphorylated substrates to SCF(FBXL3) was unexpected, we investigated the scope of

284 Both CRY1 and CRY2 recruit TLK2 to SCF(FBXL3), and TLK2 kinase activity is required for thi

285 C expansion conditions (SFEM with added TPO, SCF, FLT3L, IL3 and IL6) in the presence of UM171 predom

286 -mediated interaction with a Slimb/beta-TrCP SCF E3 ligase complex.

287 s a nucleophilic trifluoromethylthiolating (-SCF(3)) reagent.

288 (MIG, IL22, TRAIL, APRIL, VEGF, IL3, TWEAK, SCF, IL21), identified patients who developed de novo HC

289 By using SCF conditionally knocked out mice, we demonstrated that

290 These results provide a rationale for using SCF(FBXW7) inhibitors in the treatment of this subset of

291 iggered in an ubiquitin-dependent manner via SCF(betaTrCP1) complex; however, structural characteriza

292 red by HSCs and restricted progenitors while SCF from endothelial cells is required mainly by HSCs.

293 obust in vitro chain extension activity with SCF, and UBE2G1 knockdown in cells lacking UBE2R1/2 resu

294 ubiquitylation alone or in combination with SCF(Skp2)-mediated ubiquitylation.

295 and showed intermittent close contacts with SCF-expressing perivascular stromal cells.

296 to Aurora-A alters how N-Myc interacts with SCF(FbxW7) to disfavor the generation of Lys48-linked po

297 f a conserved serine (S270A) interferes with SCF(Slmb) binding and stabilizes SMNDelta7.

298 Injection of thalassemic mice with SCF plus nanoparticles containing gammaPNAs and donor DN

299 ood survive, mature, and proliferate without SCF and KIT signaling in vitro.

300 The budding yeast SCF(Met30) complex is an essential cullin-RING ubiquitin