ライフサイエンスコーパス: SCN

1 SCN neurons are exposed to glutamate from multiple sourc

2 SCN neurons exhibit 24 h oscillations in spontaneous fir

3 SCN-enriched transcripts identified in this study provid

4 SCNs of the pancreas are invariably benign entities.

5 l-autonomous circadian timing by the ~20,000 SCN cells is welded into a tight circuit-wide ensemble o

6 oisy circadian rhythms in the isolated E14.5 SCN and most show reliable, self-sustained, synchronized

7 sustained, synchronized rhythms in the E15.5 SCN.

8 not disrupt circadian synchrony in the E15.5 SCN.

9 in the C=N stretch region originates from a SCN-H-O-Al complex, suggesting the surface site specific

10 sults, we transformed five WRKY genes into a SCN-susceptible soybean cultivar and generated transgeni

11 The kinetic measurements showed that (a) SCN(-) did not affect the affinity of MPO for H(2)O(2),

12 tral phase wave of PER2 typical of the adult SCN appears approximately P2, indicating that multiple s

13 opeptide critical for synchrony in the adult SCN, and its receptor, VPAC2R, reached detectable levels

14 n clock gene expression typical of the adult SCN.

15 r how alterations in CRY1/2 stability affect SCN neurophysiology.

16 s are governed by dynamic interactions among SCN neurons, with neuroadaptations in network function d

17 emporally reorganize circadian phasing among SCN neurons, which in turn changes the period length of

18 Here, we identified a convergence to an SCN state that is widespread across epithelial cancers a

19 Transdifferentiation toward an SCN phenotype has been reported as a resistance route in

20 First, we analyse SCN timekeeping at the cell-autonomous and the circuit-b

21 Measuring circadian behavioral and SCN rhythmicity in these temporally chimeric male mice t

22 te because a sufficient amount of Gnd(+) and SCN(-) partitioned to the polymer surface to prevent cro

23 data modeling discriminated between IPMN and SCN with 100% accuracy and distinguished IPMN LGD or IPM

24 -Cas9 system in the SCN-resistant Peking and SCN-susceptible Essex soybean lines.

25 an important role in vesicle trafficking and SCN resistance, the protein's binding partners and the m

26 functionally characterized prototypical ANO/SCN/TRPM ion channel-expressing pacemaker cells in the b

27 2, circadian behavior is compromised because SCN cells cannot synchronize.

28 roles of proteins acting in the SCN because SCN dysfunction underlies jet lag in humans and influenc

29 functional, di-synaptic connectivity between SCN(VIP) neurons and dorsomedial hypothalamic neurons, p

30 The transition between SCN states is critical for maintaining behavioral respon

31 isms are known to be capable of biodegrading SCN(-); however, little is known regarding the potential

32 naling was activated in Arabidopsis early by SCN infection.

33 Specific mutations in SEC61A1 cause SCN through dysregulation of the UPR.

34 ying our model are: an ELANE mutation causes SCN; CSF3R mutations occur spontaneously at a low rate;

35 ocus is the most used and best characterized SCN resistance locus, and contains three genes including

36 Stability of BeB11 (X)12(3-) (X=CN, SCN, BO) trianions is demonstrated in the gas phase, wit

37 In contrast, SCN astrocytes are active during circadian nighttime, wh

38 mised TTFL time-keeping in the corresponding SCN slices.

39 nover, and elevated Drd1-signaling decreases SCN neuronal activity, which we posit disinhibits downst

40 , and cellular desynchrony in Lhx1-deficient SCN largely results from Vip loss [17, 18].

41 For degus SCN c-Fos activation by light was stronger with RGB-ligh

42 diated disease to include autosomal dominant SCN.

43 idnight triggered c-Fos expression in dorsal SCN.

44 The transcription factor LHX1 drives SCN Vip expression, and cellular desynchrony in Lhx1-def

45 lapping, but some divergent responses during SCN infection.

46 Pd-catalyzed reaction using an electrophilic SCN source offered an efficient tool to access a panel o

47 st screened soybean WRKY genes for enhancing SCN resistance when over-expressed in transgenic soybean

48 sterone secretion, collectively establishing SCN VIP cells as influential regulators of physiological

49 vasoactive intestinal polypeptide-expressing SCN (SCN(VIP)) neurons, including their molecular clock,

50 s in Fbxl3(Afh/Afh) compared with Fbxl3(+/+) SCN slices.

51 tored by observation of a deeply colored Fe[(SCN)(H(2)O)(5)](2+) complex that formed in situ exclusiv

52 olypeptide (VIP) signalling is essential for SCN function and whole animal circadian rhythmicity, the

53 nsity, spectra, and timing are important for SCN synchronisation.

54 Here we reveal a key role for SCN VIP cells in central clock output.

55 two-phase model of disease development from SCN to sMDS.

56 luid can improve discrimination of IPMN from SCN and within PMNs predict the grade of dysplasia.

57 myeloid leukemia (AML), and progression from SCN to AML is accompanied by mutations in CSF3R encoding

58 tion and perform patch-clamp recordings from SCN brain slices across the projected day/night cycle.

59 od CK1epsilon tau mutation specifically from SCN astrocytes resulted in lengthened rhythms in the SCN

60 -activated K channels (Slo2), voltage-gated (SCN) Na(+) and Na(+) leak channels, nonselective (NALCN)

61 ies (Cl(-) >= Br(-) > NO(3)(-) > ClO(4)(-) > SCN(-)).

62 to soybean breeders aiming to develop highly SCN-resistant soybean varieties.

63 omous clockwork can be used to determine how SCN cells interact to generate an ensemble circadian sig

64 nah exon 12, all consistent with a change in SCN RBFOX activity.

65 racellular molecular clock drives changes in SCN neuronal excitability, but it is unclear how mutatio

66 e also demonstrated functional correlates in SCN gene transcripts; inclusion of Cacna1c exon 7, and a

67 produces rhythmic action potential firing in SCN.

68 uired for normal daytime firing frequency in SCN neurons and circuit rhythms.

69 Cs are the primary regulators of [Cl(-)]i in SCN neurons.

70 CN(-) reactor expressed proteins involved in SCN(-) degradation, sulfur oxidation, carbon fixation, a

71 Of eleven isoforms in SCN and cerebral cortex that exhibit exon variation acro

72 ean, to understand its regulatory network in SCN defense.

73 ata reveals TRESK plays an essential part in SCN regulatory mechanisms and light induced adaptive beh

74 are rare in de novo AML, are so prevalent in SCN/AML.

75 NKCC1 contributes to [Cl(-)]i regulation in SCN neurons, but that the KCCs are the primary regulator

76 ian period of bioluminescent TTFL rhythms in SCN slices recorded ex vivo Abrogation of circadian comp

77 e GmSNAP18 is performing a different role in SCN resistance than PI 88788-type GmSNAP18.

78 ctions aside from its main enzymatic role in SCN resistance.

79 dentifying genes which may play key roles in SCN physiology or provide SCN-specific drivers.

80 e essential clock gene Bmal1 specifically in SCN astrocytes lengthened the circadian period of clock

81 ype current among the major VGCC subtypes in SCN neurons, but also reveal that diurnal modulation is

82 Access to rewarding food increases SCN dopamine turnover, and elevated Drd1-signaling decre

83 amus, it is unclear how firing of individual SCN neurons gates individual features of daily activity.

84 ed in this study provide novel insights into SCN function, including identifying genes which may play

85 buted to the early degeneration of the ipRGC-SCN pathway and disrupted circadian regulation during HD

86 buted to the early degeneration of the ipRGC-SCN pathway and the circadian abnormality during HD prog

87 To tune behavior according to day length, SCN neurons display unified rhythms with synchronous pha

88 ies (Cl(-) < Br(-) < NO(3)(-) <= ClO(4)(-) < SCN(-)).

89 the "wrong" time of day-nighttime-when most SCN neurons are silent.

90 ure MPO by using the pseudohalogenation (MPO/SCN(-)/H(2)O(2)) and catalase-like (MPO/H(2)O(2)) cycles

91 colour, and turbidity in sour cherry nectar (SCN), sweetened with sucrose (SCNS), maltose syrup (SCNM

92 Soybean cyst nematode (SCN) is the most damaging pest of soybean worldwide.

93 agricultural pathogen soybean cyst nematode (SCN) relies on the use of SCN-resistant soybean cultivar

94 s that contributes to soybean cyst nematode (SCN) resistance in the Peking-type resistance of soybean

95 mediate resistance to soybean cyst nematode (SCN).

96 mediate resistance to soybean cyst nematode (SCN).

97 e widely used against soybean cyst nematode (SCN, Heterodera glycines Ichinohe).

98 Soybean cyst nematode (SCN; Heterodera glycines) is the largest pathogenic caus

99 ant interactions with soybean cyst nematode (SCN; Heterodera glycines).

100 plasma from IPMN and serous cystic neoplasm (SCN) patients in a pancreas resection cohort (n = 35).

101 eal-life picture of serous cystic neoplasms (SCNs) management once a presumptive diagnosis is made.

102 ific cell type, the Shepherd's crook neuron (SCN), extends dendrites in both input regions.

103 Severe congenital neutropenia (SCN) evolves to secondary myelodysplastic syndrome (sMDS

104 Severe congenital neutropenia (SCN) is characterized by a near absence of neutrophils,

105 ular cause of severe congenital neutropenia (SCN) is unknown in 30% to 50% of patients.

106 dels of human severe congenital neutropenia (SCN) using patient-derived mutations in the GFI1 transcr

107 namics also occur in plant stem cell niches (SCN), remain elusive.

108 e) currents were recorded from day and night SCN slices.

109 membrane depolarisation, increased nocturnal SCN firing, inverted basal calcium levels and impaired s

110 More broadly, non-SCN metastases have higher expression of SCN-associated

111 CN-associated transcription factors than non-SCN primary tumors.

112 he early postnatal period tunes the IGL(NPY)-SCN circuit to allow entrainment to time-restricted feed

113 uiding the assembly of a functional IGL(NPY)-SCN circuit.

114 rcadian clock in the suprachiasmatic nuclei (SCN) and the SCN in turn synchronizing peripheral tissue

115 The hypothalamic suprachiasmatic nuclei (SCN) are the principal mammalian circadian timekeeper, c

116 tion of rod/cone and suprachiasmatic nuclei (SCN) by light was paradoxically greatly reduced, while t

117 ck is located in the suprachiasmatic nuclei (SCN) of the hypothalamus and it regulates circadian osci

118 ls is located in the suprachiasmatic nuclei (SCN) which regulate physiology and behaviour, as well as

119 cular defects in the suprachiasmatic nuclei (SCN), the cause of circadian disruption in HD remains to

120 etworking within the suprachiasmatic nuclei (SCN), the circadian "master clock," which is DNA methyla

121 -down of Cdk5 in the suprachiasmatic nuclei (SCN), the main coordinator site of the mammalian circadi

122 tinal peptide in the suprachiasmatic nuclei (SCN), which may explain the impaired circadian photoentr

123 adian pacemaker, the suprachiasmatic nuclei (SCN).

124 master clock in the suprachiasmatic nuclei (SCNs) and/or reduce the synchronizing effects of light i

125 circadian pacemaker (Suprachiasmatic Nuclei, SCN) maintains the phase relationship with the external

126 The suprachiasmatic nucleus (SCN) acts as a master pacemaker driving circadian behavi

127 master clock in the suprachiasmatic nucleus (SCN) appears to be intact, we hypothesize that Kiss1(ARH

128 The suprachiasmatic nucleus (SCN) circadian clock is critical for optimising daily cy

129 The suprachiasmatic nucleus (SCN) co-ordinates circadian behaviour and physiology in

130 an pacemaker in the suprachiasmatic nucleus (SCN) in the brain.

131 The suprachiasmatic nucleus (SCN) is a complex structure dependent upon multiple mech

132 al pacemaker in the suprachiasmatic nucleus (SCN) is considered hierarchically dominant over peripher

133 The suprachiasmatic nucleus (SCN) is the fulcrum of this pathway from gene to cell to

134 neurons within the suprachiasmatic nucleus (SCN) master circadian clock have the ability of encoding

135 rangely depleted in suprachiasmatic nucleus (SCN) neurons, and may be compensated by a change in Rbfo

136 ly in the liver and suprachiasmatic nucleus (SCN) of mice, disturb the rhythmic redox control of CLOC

137 The suprachiasmatic nucleus (SCN) of the hypothalamus is the principal circadian time

138 nal activity in the suprachiasmatic nucleus (SCN) of the hypothalamus of mice that displayed contagio

139 The suprachiasmatic nucleus (SCN) of the hypothalamus orchestrates daily rhythms of p

140 hese project to the suprachiasmatic nucleus (SCN) of the hypothalamus to entrain circadian rhythms th

141 ly expressed in the suprachiasmatic nucleus (SCN) of the hypothalamus, a region critical for coordina

142 aster clock" in the suprachiasmatic nucleus (SCN) of the hypothalamus, it is unclear how firing of in

143 ial activity in the suprachiasmatic nucleus (SCN) of the hypothalamus, which governs daily rhythms in

144 mic hamsters in the suprachiasmatic nucleus (SCN) that paralleled changes in the medial septum and hi

145 ntial firing in the suprachiasmatic nucleus (SCN) translate time-of-day throughout the mammalian brai

146 dian pacemaker, the suprachiasmatic nucleus (SCN), determine the period of wheel-running activity.

147 entral clock in the suprachiasmatic nucleus (SCN), modifying timing signals to contributing periphera

148 ignaling within the suprachiasmatic nucleus (SCN), the central circadian pacemaker, disrupts the timi

149 The suprachiasmatic nucleus (SCN)-often referred to as the master circadian clock-is

150 n is relayed to the suprachiasmatic nucleus (SCN)-the central circadian pacemaker-and the intergenicu

151 nal encoding by the suprachiasmatic nucleus (SCN).

152 dian pacemaker, the suprachiasmatic nucleus (SCN).

153 area (VTA) and the suprachiasmatic nucleus (SCN).

154 r, the hypothalamic suprachiasmatic nucleus (SCN).

155 tribution of VPAC2-expressing cells (~35% of SCN cells) to SCN time-keeping.

156 Activation of SCN GRP/GRPR neurons evoked scratching behavior.

157 ighttime, when they suppress the activity of SCN neurons by regulating extracellular glutamate levels

158 (-) reactor, Thiobacillus strains capable of SCN(-) degradation were highly abundant, whereas the amm

159 To determine the effects of SCN mutations, we generated single-cell references for g

160 roteins influence the temporal expression of SCN neuronal state or intercellular communication within

161 non-SCN metastases have higher expression of SCN-associated transcription factors than non-SCN primar

162 ck gene expression and circadian function of SCN neurons via glutamatergic signals.

163 illators in human adipocytes, independent of SCN signaling.

164 The majority of SCN cases are due to a germline ELANE mutation.

165 The majority of SCN cases arise because of germline mutations in the gen

166 The molecular mechanism of SCN resistance remains largely unknown.

167 ver a key step in the molecular mechanism of SCN resistance, and will be invaluable to soybean breede

168 ltogether, our work establishes necessity of SCN(VIP) neurons for the LMA circadian rhythm, elucidate

169 nnels that regulate the circadian pattern of SCN firing have not been comprehensively identified.

170 onium sulfate to mimic breakdown products of SCN(-).

171 cadian changes in the membrane properties of SCN neurons, but it is unclear how alterations in CRY1/2

172 simultaneously measure the vSFG response of SCN(-) ions experiencing charged and neutral surface sit

173 Seepage of SCN(-)-contaminated waters into aquifers can occur from

174 y-molecular dynamics (DFT-MD) simulations of SCN(-) near the neutral alpha-Al(2)O(3)(0001)/H(2)O inte

175 These findings extend our understanding of SCN circuit topology.

176 ean cyst nematode (SCN) relies on the use of SCN-resistant soybean cultivars, a strategy that has bee

177 (-/-) mice may be the result of an effect on SCN output, rather than an effect on timekeeping within

178 ategy is reported, in which a high dose of p-SCN-Bn-deferoxamine-porphyrin-PEG nanocomplex (Df-PPN) i

179 alphaCD11b was conjugated with p-SCN-Bn-DOTA followed by labeling with (64)Cu.

180 By postnatal day 2 (P2), SCN oscillators displayed the daily, dorsal-ventral phas

181 idually and in complexes: whether particular SCN neuronal populations act as pacemakers, and if so, b

182 RFRP-3 fibers are found in the POA, SCN, PVN, DMH, VMH, and ARC.

183 various hypothalamic areas, notably the POA, SCN, PVN, DMH, VMH, supraoptic nucleus, and the ventral

184 Presumed SCNs evaluated from 1990 to 2018 were included.

185 A total of 672 presumed SCNs were included.

186 How ELANE mutations produce SCN remains unknown.

187 play key roles in SCN physiology or provide SCN-specific drivers.

188 with higher current magnitudes, and reduced SCN circuit rhythmicity recorded by multi-electrode arra

189 currents have been identified that regulate SCN firing, including voltage-gated Ca(2+) currents, but

190 ming that t-SNAREs are critical to resisting SCN infection.

191 Approximately 75% of light-responsive SCN units modulate their firing according to simple spat

192 l cues for cell fate transitions in the root SCN.

193 ment with theoretical expectations of saliva SCN(-) concentrations compared to colorimetry.

194 In the real-life scenario, SCNs still represent an indication for surgery particula

195 ctive intestinal polypeptide-expressing SCN (SCN(VIP)) neurons, including their molecular clock, in g

196 ironmentally realistic assessment of in situ SCN(-) biodegradation potential.

197 the potential of native microbes for in situ SCN(-) biodegradation, a remediation option that is less

198 hat suggests distinct functions for specific SCN(VIP) subtypes.

199 The hypothalamic suprachiasmatic (SCN) clock contains several neurochemically defined cell

200 in the preoptic area (POA), suprachiasmatic (SCN), and arcuate (ARC) nuclei, and that RFRP-3 neurons

201 hallenge the currently prevailing model that SCN results from mutant ELANE, which triggers endoplasmi

202 Single-nuclei RNA-sequencing revealed that SCN(VIP) neurons comprise two transcriptionally distinct

203 genetics and real-time imaging, we show that SCN cells expressing vasoactive intestinal polypeptide (

204 We show that SCN slices in organotypic culture demonstrate rapid and

205 riate homeostatic responses, suggesting that SCN neurons can integrate internal circadian time and ac

206 The SCN also receives input from other retinorecipient brain

207 The SCN convergent phenotype and common sensitivity profiles

208 Although the SCN is small, it is composed of many cell types, making

209 in the suprachiasmatic nuclei (SCN) and the SCN in turn synchronizing peripheral tissues via endocri

210 l major tissues across the organism, and the SCN is their central co-ordinator.

211 SCN-susceptible cultivar (cv.) Essex and the SCN-resistant cv. Forrest (whose resistance is derived f

212 in GHT output, indicating modulation at the SCN level.

213 etic activation of the ipRGCs that avoid the SCN, we show that these cells are sufficient for acute c

214 of the 1884-residue SHMT8 tetramers from the SCN-susceptible cultivar (cv.) Essex and the SCN-resista

215 ocytes resulted in lengthened rhythms in the SCN and behavior.

216 lone can drive molecular oscillations in the SCN and circadian behavior in mice.

217 adian period of clock gene expression in the SCN and in locomotor behavior.

218 ed, possibly by coordinating activity in the SCN and septohippocampal pathway.

219 insight into VIP signal transduction in the SCN at the level of genes, cells and neural circuit.

220 nding of the roles of proteins acting in the SCN because SCN dysfunction underlies jet lag in humans

221 cute inhibition of IGL(NPY) terminals in the SCN decreased food-anticipatory activity.

222 ical for maintaining state plasticity in the SCN network.

223 Key organisms in the SCN(-) reactor expressed proteins involved in SCN(-) deg

224 In the SCN(-) reactor, Thiobacillus strains capable of SCN(-) d

225 well as the immediate-early gene Fos in the SCN, dorsal hippocampus, and olfactory bulb.

226 used to probe cell-autonomous timing in the SCN, identifying the integral components of the clock.

227 ination, using the CRISPR-Cas9 system in the SCN-resistant Peking and SCN-susceptible Essex soybean l

228 od of the master circadian oscillator in the SCN.

229 -40') C-terminal domain (CTD)-variant in the SCN.

230 major classes of peptidergic neurons in the SCN: AVP (arginine vasopressin) and VIP (vasoactive inte

231 cking excitatory GABA(A) signaling locks the SCN into its long day state.

232 tinct TTFLs in neurons and astrocytes of the SCN and show that, in the absence of other cellular cloc

233 tial for autonomous network synchrony of the SCN and stability of circadian rhythmicity.

234 istinct, functionally powerful subset of the SCN circuit, contributing to computation of ensemble per

235 The cells of the SCN harvested at E15.5 expressed sustained, synchronous

236 Investigating the function of the SCN has often focused on the identification of rhythmica

237 The time-averaged firing rate of the SCN is modestly increased under these conditions, but in

238 The cells of the SCN must synchronize to each other to drive these circad

239 at determines the emergent properties of the SCN timekeeper.

240 e master clock to modulate the output of the SCN.

241 rcadian synchrony during the ontogeny of the SCN.

242 ide (VIP) mediate retinal entrainment of the SCN; and in the absence of VIP, or its cognate receptor

243 etwork-level interactions that confer on the SCN its emergent properties of robustness, light-entrain

244 Here, we report that it also renders the SCN responsive to visual images.

245 evel mechanisms whereby VIP synchronises the SCN are poorly understood.

246 mbient light (irradiance) to synchronize the SCN's endogenous circadian clock with local time and dri

247 ationic guanidinium (GA(+) ) rather than the SCN(-) , maintaining the intact cubic structure and faci

248 Our data indicate that the SCN contains information about irradiance and spatial pa

249 Our results challenge the idea that the SCN is a major relay for the acute effects of light on n

250 Thus, the SCN is not simply a 24-h metronome: specific populations

251 activity can help gate retinal input to the SCN according to time of day.

252 ght input and glutamatergic signaling to the SCN were concomitantly assessed through behavioral assay

253 at ipRGCs, by integrating light input to the SCN, participate in the circadian regulation in HD mice.

254 except a subpopulation that projects to the SCN.

255 ical mimic of the light input pathway to the SCN.

256 ed in many retinal cells that project to the SCN.

257 anslational feedback loop (TTFL), whilst the SCN circuit as a whole is synchronised to solar time by

258 her than an effect on timekeeping within the SCN itself.

259 te or intercellular communication within the SCN network.

260 tly discovered role of astrocytes within the SCN network.

261 genetic rescue of Drd1 expression within the SCN restores diet-induced overconsumption, weight gain,

262 cadian rhythms that are generated within the SCN.

263 Without the SCN, these peripheral clocks rapidly become desynchroniz

264 cotransporters to setting [Cl(-)]i in these SCN neurons and found that the chloride uptake transport

265 s showed only a 36% decrease in thiocyanate (SCN(-)) concentration, but a sharp Raman peak at 2068 cm

266 suggests, and experiments confirm, that this SCN reorganization depends upon GABAergic signaling.

267 Thus, SCN circuit-level timekeeping arises from interdependent

268 sponse mutant ctr1-1, was less attractive to SCN.

269 aling pathway reduces root attractiveness to SCN in a way similar to that reported for root-knot nema

270 rize the principal biogeochemical barrier to SCN(-) biodegradation for an autotrophic microbial conso

271 PAC2-expressing cells (~35% of SCN cells) to SCN time-keeping.

272 ficant lipid pathway alterations compared to SCN.

273 rcadian outflow from and modulatory input to SCN(VIP) cells, and demonstrates a subpopulation-level m

274 ed EMS mutants that lose their resistance to SCN carry missense and nonsense mutations at the GmSHMT0

275 xhibited significantly reduced resistance to SCN, confirming that t-SNAREs are critical to resisting

276 RKY genes that promote soybean resistance to SCN, we first screened soybean WRKY genes for enhancing

277 ce of functional redundancy in resistance to SCN.

278 P11 contributes to an additive resistance to SCN.

279 th genes associated with soybean response to SCN infection were identified and validated using transg

280 In response to SCN infection, the susceptible line exhibited reduced gl

281 pression that may prime the NIL responses to SCN infection.

282 Raman peak at 2068 cm(-1), attributable to (SCN(-)) vibrations, normalized to C-H peak, was on avera

283 vulnerabilities are found across unannotated SCN-like epithelial cases, small-round-blue cell tumors,

284 st proposed systemic mechanism for uncoupled SCN cell division and differentiation.

285 rs and the molecular mechanisms underpinning SCN resistance remain unclear.

286 The roles of the various SCN cell types in communicating timing information to do

287 ht and enhances hyperpolarization of ventral SCN neurons at this time.

288 ythm in membrane excitability in the ventral SCN (vSCN) was enhanced in amplitude and delayed in timi

289 of hypoexcited neuronal state in the ventral SCN at night and enhances hyperpolarization of ventral S

290 omically identified population of mouse VIP+ SCN neurons is active at the "wrong" time of day-nightti

291 ombating the widespread increase in virulent SCN.

292 eding can improve cognitive performance when SCN timing has been compromised, possibly by coordinatin

293 rons, providing a circuit substrate by which SCN(VIP) neurons may regulate LMA rhythms.

294 In vivo photometry revealed that while SCN(VIP) neurons are acutely responsive to light, their

295 ented SNP clusters that were associated with SCN resistance, supporting our mutational analysis.

296 SF3R occur in >70% sMDS/sAML associated with SCN.

297 Thus, the truncated G-CSFRs associated with SCN/AML may protect myeloid precursor cells from apoptos

298 es encoding these syntaxins co-localize with SCN resistance quantitative trait loci.

299 n SEC61A1 (c.A275G;p.Q92R) in a patient with SCN who was born to nonconsanguineous Belgian parents.

300 Patients with SCN are predisposed to acute myeloid leukemia (AML), and

301 e was identified in HSPCs from patients with SCN compared with 3.9 +/- 0.4 for healthy controls (P =