ライフサイエンスコーパス: SDB

1 SDB appears to be just as prevalent, if not more, than o

2 SDB is associated with an increased risk of atrial fibri

3 SDB is associated with systolic/diastolic hypertension i

4 SDB is common in chronic disorders and has significant i

5 SDB measures accounted for 4-6% of the variance in NP co

6 SDB of moderate level was significantly associated with

7 SDB severity during REM and non-REM sleep was quantified

8 SDB was assessed at baseline with full polysomnography.

9 SDB was assessed with home overnight multichannel monito

10 SDB was associated with an increased adjusted odds of im

11 SDB was categorized using the apnea-hypopnea index (AHI)

12 SDB was characterized by apnea-hypopnea index >/=15 even

13 SDB was characterized with the respiratory disturbance i

14 SDB was identified on the basis of either sleep apnea or

15 SDB was quantified with the apnea hypopnea index (AHI) a

16 ) affinity and potency, whereas a benzyl (5F-SDB-006) head group did not.

17 inantly white children 6 to 10 years of age, SDB amplified the adverse cognitive and weight outcomes

18 AMI-SDB and AMI-only patients were matched by age, body mass

19 e formation were significantly higher in AMI-SDB compared with AMI-only patients.

20 n monocytes were significantly higher in AMI-SDB patients, whereas plasma stromal cell-derived factor

21 tive function, as well as the presence of an SDB cutoff, have not been fully explored.

22 etween l-DLPFC GABA levels, but not Glx, and SDB severity by AHI (r = -0.68, P < 0.0001), and a posit

23 Patients with HF and SDB have more severe muscle vasoconstriction during hypo

24 d be more pronounced in patients with HF and SDB than in patients with HF without SDB (NoSBD).

25 s varied with increasing body mass index and SDB.

26 h home overnight multichannel monitoring and SDB was defined based on an apneahypopnea index >/= 10 (

27 health-related problems, such as obesity and SDB.

28 B), we describe the distributions of SDB and SDB risk factors in African-Americans and Caucasians.

29 ons increased the risk of adverse weight and SDB outcomes by 2.9- and 7.9-fold, respectively.

30 enrolled: NoSDB (n=13, 46 [39-53] years) and SDB (n=28, 57 [54-61] years).

31 ossibly owing to different methods to assess SDB or cognitive domains, making it difficult to draw co

32 Our study suggests that baseline SDB is associated with increased cancer mortality in a c

33 cted of the longitudinal association between SDB and change in weight.

34 017 that reported on the association between SDB and cognitive function.

35 inding of an independent association between SDB and frailty indicator variables among older women co

36 It is possible that the association between SDB and glucose metabolism is distinct for non-REM versu

37 types reveals a stronger association between SDB and hypertension for those aged <60 years than previ

38 y have underestimated an association between SDB and systolic/diastolic hypertension in the elderly b

39 Associations between SDB and incident HTN and MS were evaluated with adjusted

40 We examined associations between SDB and LV diastolic and systolic function using data fr

41 However, potential associations between SDB severity and neurocognitive function, as well as the

42 No association was found between SDB and systolic/diastolic hypertension in those aged >

43 trast, no association was identified between SDB severity and subclinical markers of LV systolic func

44 sults support a direct temporal link between SDB events and the development of these arrhythmias.

45 that interactions may be operational between SDB and obesity to adversely affect neurocognitive outco

46 sion in those aged > or =60 years or between SDB and ISH in either age category.

47 6, the authors explored the relation between SDB and components of frailty among 1,042 participants o

48 s to assess the independent relation between SDB and impaired glucose metabolism.

49 on-based studies on the relationship between SDB and risk of cognitive impairment.

50 ildren with mild sleep-disordered breathing (SDB) (i.e., habitual snoring but not frequent obstructiv

51 ociation between sleep-disordered breathing (SDB) and cognitive decline in elderly persons.

52 olymorphism with sleep-disordered breathing (SDB) and hypertension in 1,100 subjects of the Wisconsin

53 reported between sleep-disordered breathing (SDB) and insulin resistance, but no prospective studies

54 g recognition of sleep-disordered breathing (SDB) and its morbidity have prompted reevaluation of tec

55 Sleep-disordered breathing (SDB) and sleep apnea have been linked to hypertension in

56 Sleep-disordered breathing (SDB) during pregnancy has been linked to adverse fetal o

57 Sleep-disordered breathing (SDB) has been associated with neuropsychological (NP) de

58 Sleep-disordered breathing (SDB) has been noted commonly in hemodialysis (HD) patien

59 tophan can treat sleep-disordered breathing (SDB) in an animal model of OSAHS; the effectiveness of t

60 risk factors for sleep-disordered breathing (SDB) in children and adolescents; specifically, quantify

61 Sleep-disordered breathing (SDB) in children is associated with cognitive challenges

62 risk factors for sleep-disordered breathing (SDB) in children.

63 Sleep-disordered breathing (SDB) is a common disorder in aging that is associated wi

64 Whether sleep-disordered breathing (SDB) is a risk factor for left ventricular (LV) hypertro

65 ng evidence that sleep-disordered breathing (SDB) is an independent risk factor for cardiovascular di

66 Sleep-disordered breathing (SDB) is associated with daytime sleepiness and impaired

67 ies suggest that sleep-disordered breathing (SDB) is associated with glucose intolerance and insulin

68 Sleep-disordered breathing (SDB) is associated with hypertension in the middle-aged.

69 Rationale: Sleep-disordered breathing (SDB) is associated with increased vascular resistance in

70 Sleep-disordered breathing (SDB) is associated with pathophysiology that may influen

71 Sleep-disordered breathing (SDB) is both prevalent and associated with serious chron

72 have found that sleep-disordered breathing (SDB) is common among those with left ventricular (LV) dy

73 Sleep-disordered breathing (SDB) is common in patients with heart failure (HF), and

74 in children with sleep-disordered breathing (SDB) is different from healthy children and, if so, whet

75 Sleep-disordered breathing (SDB) is frequently associated with atrial arrhythmias.

76 Yet, sleep-disordered breathing (SDB) is highly prevalent in patients with AMI.

77 in patients with sleep-disordered breathing (SDB) is not well defined.

78 Prevalence of sleep-disordered breathing (SDB) is reported to increase in menopausal women.

79 erformed because sleep-disordered breathing (SDB) is suspected, but periodic leg movements during sle

80 extent to which sleep-disordered breathing (SDB) may explain associations between obesity and wheezi

81 The effect of sleep-disordered breathing (SDB) on right heart structure and function is controvers

82 sing to familial sleep-disordered breathing (SDB) was assessed in 31 subjects 28 +/- 10 yr of age (me

83 determinants of sleep-disordered breathing (SDB), a common set of disorders that contribute to signi

84 associated with sleep-disordered breathing (SDB), a prevalent condition in the US general population

85 eep consistency, sleep-disordered breathing (SDB), and sleep architecture.

86 in children with sleep-disordered breathing (SDB), but during wakefulness, active neural processes pr

87 H), as occurs in sleep disordered breathing (SDB), induces spatial learning deficits associated with

88 isorders such as sleep-disordered breathing (SDB), sleep-related movement disorders, circadian rhythm

89 family study of sleep-disordered breathing (SDB), we describe the distributions of SDB and SDB risk

90 eepiness to mild sleep-disordered breathing (SDB), which affects as much as half the adult population

91 Obstructive sleep-disordered breathing (SDB), which includes primary snoring through to obstruct

92 ildren with mild sleep-disordered breathing (SDB), who may not be recommended for adenotonsillectomy,

93 associated with sleep-disordered breathing (SDB).

94 in patients with sleep-disordered breathing (SDB).

95 y presented with sleep-disordered breathing (SDB).

96 the severity of sleep-disordered breathing (SDB).

97 bjects with mild sleep-disordered breathing (SDB).

98 in children with sleep-disordered breathing (SDB).

99 ull polysomnography was used to characterize SDB.

100 s to the episodic hypoxia that characterizes SDB, thereby enhancing neurocognitive susceptibility in

101 In a community-based cohort, SDB is associated with echocardiographic evidence of inc

102 4 adult patients with suspected or confirmed SDB, we tested for an association between the rate of pe

103 studies used surrogate information to define SDB (eg, snoring) and were based on small clinic populat

104 rwent overnight polysomnography to determine SDB severity (obstructive apnea-hypopnea index).

105 gation in children with clinically diagnosed SDB warranting adenotonsillectomy and healthy control su

106 f cortical oxy-Hb and systemic SpO(2) during SDB may reflect a loss of compensatory mechanisms agains

107 rial diameter was not associated with either SDB measure.

108 nimum CSA is a useful measure for evaluating SDB risk factors in preadolescent children.

109 These data suggest that familial SDB may be based partly on a familial abnormality in ven

110 Further adjustment for SDB attenuated the association between obesity and wheez

111 ory problems and obesity as risk factors for SDB in children and adolescents.

112 amplified the risk by 0.39- to 0.40-fold for SDB and cognitive outcomes, respectively.

113 These findings have implications for SDB screening and treatment.

114 were evaluated twice at 4-year intervals for SDB.

115 els were 0.50, 0.43, 0.97, and 1.66 mg/L for SDB severity levels of AHI <1, 1 to 4.9, 5 to 14.9, and

116 rom clinical trials that supports a role for SDB intervention on rhythm control is not available.

117 regarding whether to continue treatment for SDB with positive airway pressure given concern for aero

118 They were offered surgical treatment for SDB.

119 Greater SDB severity was associated with LV hypertrophy and subc

120 ercent were overweight or obese, and 12% had SDB (AHI > or =5).

121 Nineteen had SDB (oxygen desaturation index > 5 events/h).

122 ol subjects.Methods: Thirty children who had SDB warranting intervention clinically diagnosed by expe

123 e information on medical and family history, SDB symptoms; measurement of height, weight, blood press

124 ests that intranasal corticosteroids improve SDB as measured by polysomnography; however, the effect

125 or prevention or treatment of arrhythmias in SDB.

126 had higher mortality than mussel embryos in SDB sediments, with higher survivability associated with

127 dependent determinants of hypersomnolence in SDB.

128 information on quality of life impairment in SDB.

129 and bed partner-assessed quality of life in SDB.

130 Diabetes is more prevalent in SDB and this relationship is independent of other risk f

131 and glutamate, respectively, play a role in SDB.

132 y enhancing neurocognitive susceptibility in SDB patients.

133 s management; and sleep deficiency including SDB often corresponds to several disease morbidities (ne

134 sion increased significantly with increasing SDB measures, although some of this association was expl

135 Interestingly, SDB and the insertion/deletion polymorphism interacted s

136 nized under the leadership of Judith Kimble (SDB President, U. Wisconsin-Madison), the meeting attrac

137 ntrol are likely to be effective in managing SDB and reducing new occurrence of SDB.

138 nitive measures in a severity-graded manner, SDB could adversely impact children's capacity to attain

139 evaluated the interactions between maternal SDB and offspring growth and adiposity measurements afte

140 e explored the interactions between maternal SDB and offspring growth and adiposity patterns during i

141 Our findings suggest that maternal SDB during pregnancy affects head circumference growth a

142 confidence interval [CI], 0.5-2.7) for mild SDB (AHI, 5-14.9), 2.0 (95% CI, 0.7-5.5) for moderate SD

143 assessing the clinical significance of mild SDB, we estimate that an AHI of 15 is equivalent to the

144 (the reference category), subjects with mild SDB (5.0-14.9 events/hour) and moderate to severe SDB (>

145 ls had an age-adjusted prevalence of minimal SDB (AHI >/= 5), moderate SDB (AHI >/= 15), and severe S

146 Moderate SDB was associated with being male (adjusted odds ratio,

147 valence of minimal SDB (AHI >/= 5), moderate SDB (AHI >/= 15), and severe SDB (AHI >/= 30) of 25.8, 9

148 5-14.9), 2.0 (95% CI, 0.7-5.5) for moderate SDB (AHI, 15-29.9), and 4.8 (95% CI, 1.7-13.2) for sever

149 +/- 8.5 kg/m2) and had evidence of moderate SDB (AHI: 47.6 +/- 29.3 events/h).

150 40 children with primarily mild to moderate SDB before and after adenotonsillectomy and in 40 matche

151 Coexistent mild to moderate SDB in patients with AMI increased the mobilization, pro

152 nsity score-weighted logistic regression, no SDB measures were associated with SARS-CoV-2 positivity.

153 tolaryngological examination for obstructive SDB at 1 of 3 outpatient clinical sites in Maryland from

154 We hypothesize that in the absence of SDB the effect of the deletion allele alone may not be s

155 ohort studies support strong associations of SDB and cardiac arrhythmia, with evidence that discrete

156 ndependent and dose-response associations of SDB with CRP were addressed through linear mixed-effects

157 is study was to quantify the associations of SDB, sleep duration, and CRP in adolescents to better un

158 support the need for increased awareness of SDB, with particular emphasis on children with more seve

159 ay-night patterning and circadian biology of SDB-induced pathophysiological sequelae collectively inf

160 study of the cardiovascular consequences of SDB.

161 facial morphology in midlife development of SDB in women.

162 Diagnosis of SDB was based on the results of overnight polysomnograph

163 hing (SDB), we describe the distributions of SDB and SDB risk factors in African-Americans and Caucas

164 lation-based study of the natural history of SDB.

165 elded conflicting results, and the impact of SDB on the right heart has not been investigated in the

166 lights the significant deleterious impact of SDB, particularly in children with moderate to severe ob

167 groups, indicating a dose-response impact of SDB.

168 The incidence of SDB and the effect of risk factors on this incidence are

169 Incidence of SDB is influenced independently by age, sex, BMI, waist-

170 ly relevant and easily measured indicator of SDB severity but its genetic contribution has never been

171 sex, ethnicity, prematurity, and indices of SDB.

172 e-aged snorers with relatively low levels of SDB (RDI < 30) may benefit more from nasal CPAP than fro

173 hazards of cancer mortality across levels of SDB severity were compared using crude and multivariate

174 ESS score was seen across all four levels of SDB, from 7.2 (4.3) in subjects with RDI < 5 to 9.3 (4.9

175 At severe levels of SDB, the effect of sleep apnea on blood pressure overwhe

176 abetes in subjects with increasing levels of SDB.

177 tial mechanisms for the higher likelihood of SDB in the HD population must be identified to provide s

178 asure the apnea-hypopnea index, a measure of SDB severity.

179 tions of hypertension with either measure of SDB were seen in both sexes, older and younger ages, all

180 ypercapnia to a greater extent in members of SDB families than in controls (0.169 +/- 0.054 cm H2O/L/

181 o evaluate the utility of various metrics of SDB and to identify the optimal respiratory metric that

182 ed in terms of a pathophysiological model of SDB in which hypoxia-mediated inhibitory neurotransmissi

183 fluence body mass index or the occurrence of SDB, but was dose-dependently associated with blood pres

184 managing SDB and reducing new occurrence of SDB.

185 The presence of SDB (defined as apnea-hypopnea index >=15/h) was assesse

186 ifty-seven participants with a wide range of SDB contributed 62 arrhythmias (76% NSVT).

187 on biases, or are manifest across a range of SDB is unclear.

188 36% black; 50% female) with a wide range of SDB severity underwent polysomnography and measurement o

189 We assessed the relation of SDB to LV morphology and systolic function in a communit

190 The relationship of SDB with a broad range of NP functions was examined in 1

191 ly lower among the first-degree relatives of SDB families than among controls (-0.76 +/- 0.47 L/min/%

192 anic/Latinos, who may be at elevated risk of SDB and heart failure.

193 adolescents to better understand the role of SDB in CVD risk.

194 rtality was less with increasing severity of SDB (P value for interaction between AHI and FEV1, 0.004

195 tronger in those with increasing severity of SDB in a community-based cohort of middle-aged and older

196 ality diminishes with increasing severity of SDB.

197 xamined in 100 volunteers with a spectrum of SDB and without underlying comorbidity.

198 o be associated with SDB, but few studies of SDB and hypertension distinguish systolic/diastolic hype

199 icipants in a genetic-epidemiologic study of SDB and included 399 children and adolescents 2 to 18 yr

200 nclude that in this community-based study of SDB and right heart echocardiographic features, RV wall

201 d hypoxic chemoreflex is a cardinal trait of SDB in obesity.

202 ific anatomical and non-anatomical traits of SDB in males and females while considering the impacts o

203 e common conditions and whether treatment of SDB might reduce risk of cognitive impairment.

204 Successful treatment of SDB, which is frequently associated with chronic sleepwa

205 An understanding of SDB among these populations is needed given evidence tha

206 related to degree of baseline sleepiness or SDB.

207 ing levels of CRP, suggesting that pediatric SDB may confer additional CVD risk beyond that of obesit

208 a index >=15/h) was assessed with a portable SDB monitor the night before surgery.

209 each independently (of the other) predicted SDB.

210 d Cross and Red Crescent Societies, provided SDB services.

211 obin saturation < 90%) were used to quantify SDB severity.

212 /= 5), moderate SDB (AHI >/= 15), and severe SDB (AHI >/= 30) of 25.8, 9.8, and 3.9%, respectively.

213 lts of overnight polysomnography, and severe SDB was defined as an apnea-hypopnea index of >30 per ho

214 greater than the 97th percentile, and severe SDB.

215 e was independent association between severe SDB and 1 or more frailty indicator variables (adjusted

216 29.9), and 4.8 (95% CI, 1.7-13.2) for severe SDB (AHI >/= 30) (P-trend = 0.0052).

217 HD patients were more likely to have severe SDB (>30 respiratory events per hour) compared with the

218 ncidence is about 7.5% for moderately severe SDB and 16% (or less) for mild to moderately severe SDB.

219 16% (or less) for mild to moderately severe SDB.

220 5.0-14.9 events/hour) and moderate to severe SDB (> or =15 events/hour) had adjusted odds ratios of 1

221 66.1 +/- 1.9 years) with moderate to severe SDB, defined as having an Apnea-Hypopnea Index (AHI) gre

222 in the odds of developing moderate-to-severe SDB.

223 e was a strong association of HD with severe SDB and nocturnal hypoxemia independent of age, BMI, and

224 ere referred to a specialist for significant SDB symptoms were included; exclusions were previous ade

225 for age, sex, body mass index, and smoking, SDB was associated with total and cancer mortality in a

226 a homolog binned within the 'Smithella' sp. SDB genome scaffold, were detected via RT-PCR, implying

227 These findings suggest SDB in Hispanic/Latino men and women may contribute to t

228 hildren referred for evaluation of suspected SDB and control subjects, before and after application o

229 However, it is not clear that SDB is causal in the development of diabetes.

230 We conclude that SDB and obesity each are associated with asthma and whee

231 We conclude that SDB is associated with excess sleepiness in community-dw

232 se populations is needed given evidence that SDB increases cardiovascular risk.

233 cross-sectional study to date indicate that SDB is associated with systemic hypertension in middle-a

234 The results of this study suggest that SDB is independently associated with glucose intolerance

235 conductance) were significantly lower in the SDB group compared with the NoSDB group (P<0.001 to all

236 conductance) were significantly lower in the SDB group compared with the NoSDB group (P<0.01 to all c

237 MSNA was higher in the SDB group.

238 to be higher to hypercapnia (P=0.066) in the SDB group.

239 l these patients were treated only for their SDB, using nasal continuous positive airway pressure (CP

240 ws have described findings related mainly to SDB but have not examined the relationship between other

241 en of disease may be attributed to untreated SDB, supporting the development and evaluation of cultur

242 ies have been performed to determine whether SDB is causal in the development of diabetes.

243 ctive of this study was to determine whether SDB was associated with glucose intolerance and insulin

244 of the present study was to examine whether SDB is associated with cancer mortality in a community-b

245 Of 1,001 polysomnography subjects, 90 with SDB defined as a respiratory disturbance index (RDI) sco

246 cardiovascular changes noted in adults with SDB may also occur in children with SDB.

247 African-Americans with SDB were younger than Caucasians with SDB (37.2 +/- 19.5

248 for covariates, ISH was not associated with SDB in either age category.

249 pertension is expected to be associated with SDB, but few studies of SDB and hypertension distinguish

250 e partly mediated by factors associated with SDB.

251 Five metabolite associations with SDB PCs are discovered and replicated.

252 s with SDB were younger than Caucasians with SDB (37.2 +/- 19.5 versus 45.6 +/- 18.7 yr, p < 0.01).

253 receptor-activating peptide) (children with SDB = 114.8 aggregation units [AU] vs. control subjects

254 Twenty-four children with SDB completed an open-label intervention study for 16 we

255 Children with SDB displayed reduced HEP amplitude during sleep, which

256 EP were significantly lower in children with SDB during non-REM sleep (stage 2: P = 0.03; slow-wave s

257 Measurements and Main Results: Children with SDB exhibited increased platelet aggregation to TRAP (th

258 surgically naive nonsyndromic children with SDB or obstructive sleep apnea [OSA] at risk for residua

259 hildren, habitual snorers, and children with SDB relative to unaffected children.

260 as therapeutic alternatives in children with SDB too mild to justify referral for adenotonsillectomy.

261 ances, which were absent in 16 children with SDB who did not receive treatment.

262 lts with SDB may also occur in children with SDB.

263 curate identification of those children with SDB.

264 66.2%] male), 91 (59.1%) were diagnosed with SDB.

265 ecruited from families having no member with SDB.

266 13 families having two or more members with SDB.

267 The offspring of mothers with SDB had a significantly smaller head circumference at bi

268 increased by only 6.0% in participants with SDB (hazard ratio, 1.06; 95% confidence interval, 1.04-1

269 with 56 patients without SDB, patients with SDB (57) showed a significantly increased level of activ

270 assess quality of life in 122 patients with SDB (apnea-hypopnea index > or = 5 events/hour), this st

271 gree of hypersomnolence in 741 patients with SDB (apnea-hypopnea index [AHI] >/= 10 events/h).

272 t in both control subjects and patients with SDB (p < 0.005).

273 tivation in atrial myocytes of patients with SDB consistent with significantly increased CaMKII-depen

274 s/hour), this study found that patients with SDB generally rate their quality of life higher than the

275 In atrial myocardium of patients with SDB, increased CaMKII-dependent phosphorylation of Na(V)

276 ctions in atrial trabeculae of patients with SDB, which could be blocked by either AIP or KN93 (N-[2-

277 rial proarrhythmic activity in patients with SDB.

278 the RV hypertrophy observed in persons with SDB is associated with increased morbidity and mortality

279 A dose-response relationship with SDB successfulness was apparent for both transmission ou

280 CRP levels demonstrated a dose response with SDB above a threshold AHI of 5.

281 icantly greater (p = 0.005) in subjects with SDB (0.78 +/- 0.02 cm) than in the low-RDI subjects (0.6

282 ignificantly different between subjects with SDB and the low-RDI subjects.

283 cidence of type II diabetes in subjects with SDB and whether an independent relationship exists betwe

284 echocardiographic features of subjects with SDB at the Framingham Heart Study site of the Sleep Hear

285 In subjects with SDB, levels of l-DLPFC GABA, but not Glx, were significa

286 all thickness was increased in subjects with SDB.

287 as 26.9 per 1,000 person-years in those with SDB (AHI >/=5 events/h) and 18.2 per 1,000 person-years

288 -sectional studies suggested that those with SDB had slightly worse executive function (standard mean

289 rospective studies indicated that those with SDB were 26% (risk ratio, 1.26; 95% CI, 1.05-1.50) more

290 duce the risk of comorbidities in those with SDB, warranting early treatment interventions.

291 The 14 (24.1%) women with SDB had a higher body mass index (BMI) (P = 0.003), elev

292 of life in normal subjects (n = 15) without SDB (apnea-hypopnea index < 5 events/hour) recruited fro

293 ytes compared with patients with AMI without SDB.

294 Subjects with (n = 10) and without SDB (n = 12) were recruited from 13 families having two

295 HF and SDB than in patients with HF without SDB (NoSBD).

296 Compared with 56 patients without SDB, patients with SDB (57) showed a significantly incre

297 xia and hypercapnia than HF patients without SDB, which seems to be associated with endothelial dysfu

298 ortality increased by 11.0% in those without SDB (hazard ratio, 1.11; 95% confidence interval, 1.08-1

299 ol levels (P = 0.009) than the women without SDB.

300 lts (age +/- SD: 62.3 +/- 1.3 years) without SDB (AHI < 5).