ライフサイエンスコーパス: SECM

1 SECM allows positioning of the probe without touching th

2 SECM data treatment based on scanning probe microscopy i

3 SECM imaging allowed the determination of different morp

4 SECM is demonstrated to be a powerful technique for eluc

5 SECM is important in the development of miniaturized bio

6 SECM measurements of the patterned cells, performed with

7 SECM-based CV is obtained under high mass-transport cond

8 SECM-based nanogap voltammetry in approximately 1 ppb-TO

9 adical ions in the microgap formed between a SECM probe and a transparent microsubstrate provides a d

10 rent scanning electrochemical microscopy (AC-SECM) for simultaneous measurements of impedance and far

11 Additionally, SECM results of tape-stripped different human melanoma c

12 e - scanning electrochemical microscopy (AFM-SECM) imaging of topography and redox species diffusion

13 rce-scanning electrochemical microscopy (AFM-SECM) probes with electrochemically deposited PDA result

14 e of a positively polarized PDA-modified AFM-SECM probe was 6.2 +/- 2.2 nN, and it was about 50% less

15 ppropriate potential to the PDA-modified AFM-SECM probe, thereby enabling adhesion measurements under

16 Overall, we demonstrate that Mt/AFM-SECM enables high throughput reading of dense nanoarrays

17 We show that the high resolution of Mt/AFM-SECM enables the electrochemical interrogation of severa

18 , operated in molecule touching mode (Mt/AFM-SECM), and of dense nanodot arrays, for designing an ele

19 ographical data under force control (QNM-AFM-SECM).

20 The versatility of such switchable AFM-SECM probes is demonstrated for electrochemical force sp

21 solvents, probes, and mediators) used in all SECM publications since 1989, irrespective of the applic

22 oducing two novel features into amperometric SECM tips based on the micropipet-supported interface be

23 An SECM approach curve of (ferrocenylmethyl)trimethylammoni

24 We used this new type of Ca(2+)-ISME as an SECM probe to quantitatively map the chemical microenvir

25 experiments, and (4) the construction of an SECM stage to avoid artifacts in SECM images.

26 xpansion and contraction of components of an SECM stage upon a temperature change and can be dramatic

27 w to moderate scan voltammetry) and analyzes SECM data assuming simple ET kinetics at the substrate a

28 XRD, contact angle, SEM, AFM and SECM studies revealed that the surface of the metal was

29 RP1 were determined using flow cytometry and SECM, and our findings show that these parameters do not

30 implementation of HIC-SECM is described, and SECM feedback measurements in three-dimensional (3D) spa

31 Optical microscopy and SECM revealed that cells adapt to the underlying surface

32 CV at scan rates to 100 V/s and SECM indicated the reaction pathway involves ligand-coup

33 Both voltammetric and SECM responses of the prepared nanoelectrodes are consis

34 ive feedback as well as other modes, such as SECM approach curves performed at substrates displaying

35 tween SECM tip and substrate or collected at SECM substrate (e.g., an Au UME).

36 The highly selective GOD-based SECM tip showed a high current density of 94.44 (+/-18.5

37 precise and accurate positioning of Hg-based SECM probes over any sample and enable the deployment of

38 l equations to optimize the coupling between SECM imaging and mass spectrometry detection.

39 e to form oxalate within the nanogap between SECM tip and substrate or collected at SECM substrate (e

40 The recessed geometry is noticeable also by SECM but is not obvious from a cyclic voltammogram.

41 observed both by fluorometric as well as by SECM measurements.

42 ntermediate Sn(III) species was confirmed by SECM(3-), where the Sn(III) generated at the Au tip was

43 of GTC on cancer cells could be confirmed by SECM, and the presented study shows an alternative appro

44 The DMA(*+) intermediate is detected by SECM, where the DMA(*+) generated at the ca. 500 nm radi

45 ver, extracting intracellular information by SECM is challenging, since it requires redox species to

46 he aqueous phosphate buffer/SLG interface by SECM, in both generation/collection (G/C) and feedback m

47 lity of the NPCs is successfully measured by SECM and theoretically analyzed.

48 and the roof permeability can be obtained by SECM using a small probe molecule, ferrocenemethanol (Fc

49 tive tool for visualizing cell properties by SECM.

50 rgest determined for a substrate reaction by SECM.

51 ogen peroxide production was also studied by SECM.

52 g of an open SICM barrel, and a solid carbon SECM electrode enabled correlation of surface activity w

53 In each case, SECM images, obtained at increasing times, show a gradua

54 rication of scanning probe tips that combine SECM with atomic force microscopy (AFM) to perform measu

55 al devices supplementing existing commercial SECM instruments.

56 proof-of-concept is demonstrated by coupling SECM with matrix-assisted laser desorption/ionization ma

57 k is placed in the emission path of our dual SECM/optical microscope, generating a double helix point

58 In addition, a solid-state dual SECM pH probe was used to correlate the release of calci

59 t to avoid electrochemical tip damage during SECM experiments, and (4) the construction of an SECM st

60 nism for measuring the tip-sample gap during SECM experiments, it also enables facile tip alignment a

61 rmats and analytical parameters of enzymatic SECM sensors and immunosensors are reviewed.

62 es under the conditions of positive feedback SECM.

63 ly shaped carbon paste UMEs, appropriate for SECM measurements and micrometer to nanometer gap experi

64 In this Article, the theory is developed for SECM current vs distance curves obtained with a disk-sha

65 on microscopy (TEM) of quartz nanopipets for SECM imaging of single solid-state nanopores by using na

66 The suitability of the probes for SECM-SICM imaging is demonstrated by both feedback-mode

67 dopamine is a well-adapted redox system for SECM in feedback mode and in unbiased conditions.

68 The isothermal chamber is useful for SECM and, potentially, for other scanning probe microsco

69 confirmed and kinetically characterized from SECM toward an insulating substrate, with promising pote

70 fouled electrode surface was determined from SECM approach curves, allowing a comparison of insulatin

71 and experimental high speed constant height SECM imaging.

72 establish a kinetic "map" of constant-height SECM scans, free of topography contributions.

73 HIC-SECM combines a hopping imaging mode, in which data are

74 itous in chemistry and allied areas, and HIC-SECM opens up the possibility of detailed flux visualiza

75 Moreover, because HIC-SECM utilizes an oscillating probe, alternating current

76 act-scanning electrochemical microscopy (HIC-SECM) is introduced as a powerful new technique for the

77 The implementation of HIC-SECM is described, and SECM feedback measurements in thr

78 used to predict the faradaic response in HT-SECM experiments.

79 -tip scanning electrochemical microscopy (HT-SECM) is a novel surface characterization technique util

80 A good understanding of HT-SECM was achieved, both experimentally and theoretically

81 In this paper, HT-SECM was studied in positive and negative feedback modes

82 diffusion layer was studied by hydrodynamic SECM in the substrate generation/tip collection (SG/TC)

83 ionally, preliminary studies of hydrodynamic SECM imaging of a 2 mm Pt disk electrode surface in the

84 in quiescent solution show that hydrodynamic SECM offers attractive complementary information.

85 The hydrodynamic SECM system integrates a high-precision stirring device

86 ction of an SECM stage to avoid artifacts in SECM images.

87 The interest of catechol in SECM as a sensitive redox mediator is exemplified by mon

88 In contrast to previous efforts in SECM towards this goal, our method uses a finite element

89 chniques, reveals hidden details embedded in SECM images, and allows individual features to be separa

90 encapsulate ultramicroelectrodes employed in SECM, is also found to be important and affects the volt

91 the approach curve and probe scan methods in SECM.

92 Time-lapse SECM imaging revealed a suitable window of 30 min to com

93 often lose a current response or give a low SECM feedback in current-distance curves.

94 Here, we employed the T-UME to measure SECM approach curves and showed remarkable approach capa

95 m S. epidermidis conditioned culture medium (SECM), but not similar preparations from other bacteria,

96 chemical-scanning ion conductance microcopy (SECM-SICM) has been used to map the electroactivity of s

97 sensing scanning electrochemical microcopy (SECM) probe by covalently immobilizing the glucose oxida

98 of the scanning electrochemical microscope (SECM) can be used to sensitively probe and alter the mix

99 The scanning electrochemical microscope (SECM) equipped with a nanometer-sized tip was recently u

100 in the scanning electrochemical microscope (SECM) for surface patterning with the spatial resolution

101 into a scanning electrochemical microscope (SECM) is presented.

102 ip of a scanning electrochemical microscope (SECM) perpendicular to the substrate in a sinusoidal fas

103 used as scanning electrochemical microscope (SECM) probes because of their inherent fast response tim

104 e-built Scanning Electrochemical Microscope (SECM) setup in which an AC potential is applied to the s

105 A scanning electrochemical microscope (SECM) was used to arrange two microelectrodes face-to-fa

106 in the scanning electrochemical microscope (SECM), it can be precisely positioned at the sampling lo

107 in the scanning electrochemical microscope (SECM).

108 in the scanning electrochemical microscope (SECM).

109 mode of scanning electrochemical microscopy (SECM) allows for spatially resolved detection of a nanog

110 Scanning electrochemical microscopy (SECM) allows imaging and analysis of a variety of biolog

111 d using scanning electrochemical microscopy (SECM) and fluorescence microscopy.

112 ed from scanning electrochemical microscopy (SECM) and generator-collector experiments, as well as an

113 noscale scanning electrochemical microscopy (SECM) and neurochemical analysis inside single cells.

114 ty with Scanning Electrochemical Microscopy (SECM) and obtain conductivity maps of heterogeneous subs

115 tion of scanning electrochemical microscopy (SECM) and scanning electrochemical cell microscopy (SECC

116 aces by scanning electrochemical microscopy (SECM) and to probe molecules present or generated at the

117 mode of scanning electrochemical microscopy (SECM) and voltammetric methods.

118 CV) and scanning electrochemical microscopy (SECM) approach curves and imaging.

119 We used scanning electrochemical microscopy (SECM) as a screening tool to characterize TPEs.

120 Scanning electrochemical microscopy (SECM) can map surface characteristics, record catalyst a

121 te that scanning electrochemical microscopy (SECM) can quantitatively and noninvasively track multidr

122 se as a scanning electrochemical microscopy (SECM) chemical probe to quantitatively map the microbial

123 de on a scanning electrochemical microscopy (SECM) configuration and was used to record approach curv

124 ed in a scanning electrochemical microscopy (SECM) configuration, and their use for both approach cur

125 typical scanning electrochemical microscopy (SECM) configuration.

126 Scanning electrochemical microscopy (SECM) enables high-resolution imaging by examining the a

127 odes by scanning electrochemical microscopy (SECM) enables voltammetric measurement of ultrafast elec

128 SV) and scanning electrochemical microscopy (SECM) experiments.

129 ed with scanning electrochemical microscopy (SECM) for in situ spectroscopic detection of electrochem

130 gulated scanning electrochemical microscopy (SECM) has been associated with Raman microspectrometry i

131 Scanning electrochemical microscopy (SECM) has been widely used for the electrochemical imagi

132 Scanning electrochemical microscopy (SECM) has previously been employed in probing photoelect

133 des and scanning electrochemical microscopy (SECM) have recently been used to measure kinetics of sev

134 ted for scanning electrochemical microscopy (SECM) imaging of molecular microarrays.

135 use of scanning electrochemical microscopy (SECM) in determining the heterogeneous electron transfer

136 obe for scanning electrochemical microscopy (SECM) in order to map pH over a platinum ultramicroelect

137 ed with scanning electrochemical microscopy (SECM) in order to provide both spectroscopic and electro

138 FM with scanning electrochemical microscopy (SECM) in PFT mode, thereby offering spatially correlated

139 llowing scanning electrochemical microscopy (SECM) in positive feedback mode at a close distance, whi

140 We used scanning electrochemical microscopy (SECM) in the feedback and H(2)O(2) collection modes to i

141 ME) for scanning electrochemical microscopy (SECM) investigations of any substrate.

142 tor for scanning electrochemical microscopy (SECM) investigations was evaluated in the challenging si

143 noscale scanning electrochemical microscopy (SECM) is a powerful scanning probe technique that enable

144 olution scanning electrochemical microscopy (SECM) is a powerful technique for mapping surface topogr

145 Scanning electrochemical microscopy (SECM) is a powerful tool that enables quantitative measu

146 Scanning electrochemical microscopy (SECM) is a rising technique for the study of energy stor

147 ips for scanning electrochemical microscopy (SECM) is a slow and cumbersome task that often results i

148 Scanning electrochemical microscopy (SECM) is an electroanalytical scanning probe technique c

149 mode of scanning electrochemical microscopy (SECM) is extended to the in situ quantification of adsor

150 Scanning electrochemical microscopy (SECM) is increasingly applied to study and image live ce

151 Scanning electrochemical microscopy (SECM) is very useful, non-invasive tool for the analysis

152 CM) and scanning electrochemical microscopy (SECM) measurements is demonstrated to have powerful new

153 died by scanning electrochemical microscopy (SECM) on single-layer graphene (SLG).

154 y using scanning electrochemical microscopy (SECM) permits measurement of heterogeneous standard elec

155 Scanning electrochemical microscopy (SECM) provided near-surface pH and oxidant formation mea

156 IS) and scanning electrochemical microscopy (SECM) techniques were employed in the characterization o

157 thod of scanning electrochemical microscopy (SECM) that can be used to separate multireactional elect

158 A new scanning electrochemical microscopy (SECM) tip positioning method that allows surface topogra

159 Scanning electrochemical microscopy (SECM) tips with rounded glass insulation around the meta

160 e apply scanning electrochemical microscopy (SECM) to demonstrate quantitatively that the electroacti

161 ent for scanning electrochemical microscopy (SECM) to enable quasi-steady-state voltammetry of rapid

162 tion of scanning electrochemical microscopy (SECM) to enable the in situ, real-time, and quantitative

163 mployed scanning electrochemical microscopy (SECM) to in situ characterize the redox state of a singl

164 ing and scanning electrochemical microscopy (SECM) to probe quorum sensing (QS)-mediated communicatio

165 e apply scanning electrochemical microscopy (SECM) to quantitatively study the permeability of the NP

166 tion of scanning electrochemical microscopy (SECM) to the measurement of the ion-selective permeabili

167 use of scanning electrochemical microscopy (SECM) together with electrochemical and spectroscopic te

168 d using scanning electrochemical microscopy (SECM) toward different insulating surfaces such as glass

169 Scanning electrochemical microscopy (SECM) using Hg/Pt UMEs showed that the steady-state amal

170 noscale scanning electrochemical microscopy (SECM) using three-dimensional super-resolution fluoresce

171 robe in scanning electrochemical microscopy (SECM) was evaluated for the determination of the absolut

172 Scanning electrochemical microscopy (SECM) was used for the study of electrogenerated chemilu

173 CV) and scanning electrochemical microscopy (SECM) were used to investigate the reduction of Sn(IV) a

174 perform scanning electrochemical microscopy (SECM) with nanometer-scale resolution.

175 tion of scanning electrochemical microscopy (SECM) with single-bounce attenuated total reflection Fou

176 tate by scanning electrochemical microscopy (SECM) with ultramicroelectrodes using the tip generation

177 In scanning electrochemical microscopy (SECM), an approach curve performed in feedback mode invo

178 , e.g., scanning electrochemical microscopy (SECM), cannot be used as a robust alternative yet becaus

179 olution scanning electrochemical microscopy (SECM), we must overcome the theoretical limitation assoc

180 eport a scanning electrochemical microscopy (SECM)-based analytic technique to design and optimize me

181 ally by scanning electrochemical microscopy (SECM).

182 ry, and scanning electrochemical microscopy (SECM).

183 ing and scanning electrochemical microscopy (SECM).

184 se with scanning electrochemical microscopy (SECM).

185 time by scanning electrochemical microscopy (SECM).

186 back in scanning electrochemical microscopy (SECM).

187 d using scanning electrochemical microscopy (SECM).

188 such as scanning electrochemical microscopy (SECM).

189 time by scanning electrochemical microscopy (SECM).

190 ores by scanning electrochemical microscopy (SECM).

191 ions of scanning electrochemical microscopy (SECM).

192 ing and scanning electrochemical microscopy (SECM).

193 tips in scanning electrochemical microscopy (SECM).

194 time by scanning electrochemical microscopy (SECM).

195 ICM and scanning electrochemical microscopy (SECM).

196 died by scanning electrochemical microscopy (SECM).

197 s using scanning electrochemical microscopy (SECM).

198 mode of scanning electrochemical microscopy (SECM).

199 on with scanning electrochemical microscopy (SECM).

200 FM) and scanning electrochemical microscopy (SECM).

201 chemical microscopy-atomic force microscopy (SECM-AFM) have been batch-fabricated, and their applicat

202 rming a scanning electrochemical microscopy-(SECM) like approach of a Pt microelectrode (ME), which w

203 during Ru(bpy)(3)(2+) mediated feedback mode SECM experiments.

204 olymer depositions induced via feedback mode SECM using a 25 mum Pt disk ultramicroelectrode (UME).

205 de tips is critical for the progress in nano-SECM.

206 mparable to those obtained in recent nanogap/SECM experiments.

207 enabled us to successfully build a nanoscale SECM, which can be utilized to map the electrocatalytic

208 turized more readily to facilitate nanoscale SECM imaging.

209 e and hardware instrumentation for nanoscale SECM are explicitly explained including (1) the LabVIEW

210 se studies has not yet matched the nanoscale SECM resolution attained without substrate illumination.

211 task to quantitatively understand nanoscale SECM images, which requires accurate characterization of

212 Besides, it also provides a new SECM method to in situ investigate the redox mechanism o

213 The obtained SECM results show that the cardiomyocytes cultured on th

214 ct was relevant in vivo as administration of SECM to mice decreased susceptibility to infection by GA

215 Herein, we demonstrate the advantage of SECM-based nanogap voltammetry to assess the cleanness o

216 Technical challenges and advantages of SECM, experimental parameters, used enzymes and redox me

217 This review focuses on the application of SECM technique for the analysis of surfaces pre-modified

218 The powerful combination of SECM with cyclic voltammetry (CV) at a gold substrate re

219 ntracellular content through the coupling of SECM with immunoassay strategies for the detection of sp

220 Hg-based probes allow the extension of SECM investigations to ionic processes, but the risk of

221 Interpretation of SECM data using a reactive transport model allowed for a

222 e electrochemically investigated by means of SECM.

223 ve was recorded in negative feedback mode of SECM and revealed the contact point of the ME and WE on

224 Herein, we propose a new imaging mode of SECM based on real-time analysis of the approach curve t

225 ith the tip currents in the feedback mode of SECM.

226 the substrate in the proposed MD-SC mode of SECM.

227 he working principles and operating modes of SECM are outlined.

228 on-collection and redox competition modes of SECM on surfaces modified by enzymes or labelled with an

229 ed to attain sub-10 nm spatial resolution of SECM imaging and kinetic studies.

230 This finding demonstrates the usefulness of SECM in quantitative studies of MRP1 inhibitors and sugg

231 0 peer-reviewed publications have focused on SECM, including several topical reviews.

232 ons demonstrate the unique capability of our SECM chemical probes for studying real-time metabolic in

233 y sample and enable the deployment of CV-PAS SECM as an analytical tool for traditionally challenging

234 Herein, we introduce nanoscale photo-SECM with a glass-sealed, polished tip simultaneously se

235 al focus with a single, precisely positioned SECM nanostructure.

236 y confirming the reliability of quantitative SECM imaging at the nanoscale level.

237 The quantitative SECM image of single nanopores allows for the determinat

238 rk demonstrates the value of high-resolution SECM-SICM for low-current amperometric imaging of nanosy

239 One-directional lateral scan SECM was used as a rapid and reproducible tool for simul

240 One-directional y-scan SECM measurements showed the unique spatial mapping of h

241 e ions is enabled by using the ion-selective SECM tips based on the micropipet- or nanopipet-supporte

242 vel photoelectrocatalytic materials, several SECM-based techniques have been developed, aiming on the

243 By SI-SECM, independent titrations of surface Co(III) and Co(I

244 tion scanning electrochemical microscopy (SI-SECM) of two electrodeposited manganese-based electrocat

245 tion scanning electrochemical microscopy (SI-SECM), fine and accurate control of the delay time betwe

246 tion scanning electrochemical microscopy (SI-SECM).

247 The rapid switching SI-SECM has been implemented in a substrate generation-tip

248 has been measured by the rapid switching SI-SECM.

249 ay control up to ca. 1 mus, enhancing the SI-SECM to be competitive in the time domain with the decay

250 In previous applications of the SI-SECM, the resolution in the control of tdelay has been l

251 Significantly, SECM-based CV will be useful for the in situ characteriz

252 quipment was found to be adequate for simple SECM measurements under hindered diffusion conditions.

253 Comparison of experimental and simulated SECM approach curves, images, and tip voltammograms enab

254 remarkable approach capability for a nm-size SECM probe.

255 based on forced convection during high speed SECM imaging.

256 This probe geometry enables successful SECM-SICM imaging on features as small as 180 nm in size

257 of the structure-property relationships that SECM provides.

258 The SECM configuration makes it possible to observe in the s

259 The SECM methodology also demonstrates how dissolved oxygen

260 For quantitative analysis, the SECM approach curves using dopamine could simply be char

261 itive feedback between the substrate and the SECM microelectrode tip.

262 a Hg/Au film UME, which were utilized as the SECM tips.

263 positive feedback signal was observed at the SECM electrode, and the topographical channel compared w

264 The extracellular ROS level detected at the SECM tip was found to be similar to the intracellular RO

265 dation of a Fe(II) species, generated at the SECM tip, under conditions in which SLG shows slow inter

266 its subsequent volume, as determined by the SECM imaging technique, was (0.59 +/- 0.38) x 10(7) um(3

267 r environment, thiodione was detected by the SECM tip at levels of 140, 70, and 35 microM upon exposu

268 = d/a and d is the distance traveled by the SECM tip, was observed in both systems (e.g., I(T)(L) =

269 Therefore, this strategy can be used for the SECM investigation of cell topography or the passive tra

270 eflection is qualitatively detected from the SECM tip current measurement and a quantitative estimate

271 NI) was deposited electrochemically from the SECM tip side until it bridged the two electrodes.

272 his aim, adherent cells were analyzed in the SECM feedback mode in three different conditions: (i) al

273 The well-defined stirring of the SECM electrolyte results in steady state diffusion layer

274 A finite element simulation of the SECM image was performed to assess quantitatively the sp

275 ent particle to the insulating sheath of the SECM tip extends this technique to nonfluorogenic electr

276 k generation-collection configuration of the SECM.

277 cts of reversible reactant adsorption on the SECM response.

278 structured Pd hydride films deposited on the SECM tip.

279 Overall, the SECM results correlate well with the fluorescence result

280 g (1) the LabVIEW code that synchronizes the SECM tip movement with the electrochemical response, (2)

281 current responses and also reveals that the SECM images of 100 nm diameter Si3N4 nanopores are enlar

282 rt the amounts of this adsorbate through the SECM feedback response.

283 ioning control without risking damage to the SECM probe, we implement cyclic voltammetry probe approa

284 e positioning of target cells underneath the SECM sensor.

285 ifferent cancer progression stages using the SECM substrate generation-tip collection mode.

286 th spatial and temporal resolution using the SECM tip.

287 system by carrying out experiments with the SECM and light-detecting apparatus inside an inert atmos

288 divided by the electrode radius), and their SECM feedback approach curves were studied in solutions

289 Thus, SECM kinetic measurements, particularly in a nanogap con

290 probes for bulk measurements extends also to SECM studies, where the disc geometry facilitates small

291 In other words, it is a practical guide to SECM.

292 The extension of the model to SECM-induced transfer is considered and it is shown that

293 eatment, as evidenced by the analysis of TPM-SECM approach curves (current-distance characteristics).

294 Using SECM and a solid-state H(+) and Ca(2+) ion-selective mic

295 thiophene) (PEDOT) film were evaluated using SECM imaging in the presence of NADH, demonstrating the

296 chamber to be detected and quantified using SECM.

297 - and microelectrodes to soft surfaces using SECM for a rapid and more convenient characterization an

298 Using various SECM redox probes, it is possible to select a specific g

299 he rate of thionine leaching, determined via SECM imaging.

300 uantification of the conductivity of GO with SECM.