ライフサイエンスコーパス: SFB

1 SFB adhere tightly to the surface of epithelial cells in

2 SFB cause an increase in serum amyloid A (SAA), suggesti

3 SFB cytotoxicity was evaluated by multiple assays in the

4 SFB induce autoantibodies in lung during the pre-arthrit

5 SFB induced histone modifications in IECs at sites enric

6 SFB induced PP Tfh cell differentiation by limiting the

7 SFB primed and induced Th17 cells locally in the LP and

8 SFB produces the quorum-sensing AI-2 and promotes the pr

9 SFB(+) microbiota enabled PTH to expand intestinal TNF(+

10 SFB-induced gut Th17 cells are preferentially recruited

11 SFB-positive, but not SFB-negative, females had a substa

12 SFBs, standardized by using toxic Pfiesteria (coupled wi

13 d the California Walnuts Commission 09933838 SFB 105 (to I Shai).

14 e German Research Foundation (DFG, 158989968/SFB 900), the Deutsche Kinderkrebsstiftung, Wilhelm-Sand

15 ith N-succinimidyl-4-18F-fluorobenzoate (18F-SFB) under slightly basic condition (pH 8.5).

16 ing N-succinimidyl-4-18F-fluorobenzoate (18F-SFB) with glycine at 90 degrees C (pH 8) for 20 min.

17 ing N-succinimidyl 4-18F-fluorobenzoate (18F-SFB) with N-(2-aminoethyl)maleimide.

18 ith N-succinimidyl-4-18F-fluorobenzoate (18F-SFB).

19 35 +/- 5 (mean +/- SD) min starting from 18F-SFB, and the tracer 18F-FB-T84.66 diabody was synthesize

20 [18F]SFB remains an optimal reagent for labeling proteins and

21 f N-succinimidyl 4-[18F]fluorobenzoate ([18F]SFB), an agent widely used for labeling proteins and pep

22 Using this method, [18F]SFB can be synthesized in decay-corrected radiochemical

23 For the [18F]SFB synthesis, the quaternary salt is first converted to

24 uorobenzoic acid, which is converted to [18F]SFB by treatment with N,N-disuccinimidyl carbonate.

25 arch Foundation - project number 209933838 - SFB 1052; B11, Israel Ministry of Health grant 87472511

26 he Forschungsgemeinschaft, grant 394046635 - SFB 1365 from the Deutsche Forschungsgemeinschaft, and E

27 toward aerobic glycolysis and, accordingly, SFB cytotoxicity was dramatically increased by glucose w

28 nduced in mesenteric lymph nodes early after SFB colonization and distributed across different segmen

29 small-intestinal Th17 cells and ameliorates SFB-promoted inflammation in the central nervous system.

30 R)-expressing Th17 cells recognizing both an SFB epitope and self-antigen, thus augmenting autoimmuni

31 We identified an SFB-dependent role of type 3 innate lymphoid cells (ILC3

32 ), a neuropeptide that modulates M cells and SFB levels to protect against Salmonella infection.

33 tion, S(13m) -RNase has a 23 bp deletion and SFB(13)' has a 1 bp substitution that lead to premature

34 -mapping mice revealed a c-Maf-dependent and SFB-induced T(H)17-to-T(FH) cell reprogramming that domi

35 nalyzed for total immunoglobulin A (IgA) and SFB-specific IgA production.

36 in lung during the pre-arthritic phase, and SFB-dependent lung pathology requires the T helper 17 (T

37 ree alleles, S(6m2)-RNase, S(13m)-RNase, and SFB(13)', however, these transcripts presumably result i

38 ed increased fecal interleukin 17A, SAA, and SFB levels.

39 t, while commensal epithelial cell-attaching SFB overgrew in a c-Maf-deficient environment, highlight

40 ween those of P. tenella SFB(8) and P. avium SFB(1).

41 entiating in response to commensal bacteria (SFB) to those differentiating in response to a pathogen

42 l numbers of Segmented filamentous bacteria (SFB) and Akkermansia muciniphila in the small intestine.

43 obes such as segmented filamentous bacteria (SFB) and certain extracellular pathogens.

44 vergrowth of segmented filamentous bacteria (SFB) and increased microbial loads in deep tissues.

45 e identified segmented filamentous bacteria (SFB) antigens targeted by serum and intestinal antibodie

46 Segmented filamentous bacteria (SFB) are autochthonous bacteria inhabiting the intestina

47 Segmented filamentous bacteria (SFB) are found in multiple species and play an important

48 Segmented filamentous bacteria (SFB) are sufficient to induce TH17 cells and to promote

49 Segmented filamentous bacteria (SFB) are Th17-inducing commensals that potentiate autoim

50 roteins from segmented filamentous bacteria (SFB) are transferred into intestinal epithelial cells (I

51 microbiota, segmented filamentous bacteria (SFB) colonize the guts of a variety of vertebrates and i

52 Segmented filamentous bacteria (SFB) contribute to immune-system maturation.

53 In rodents, segmented filamentous bacteria (SFB) induce intestinal Th17 cells, but analogously funct

54 ization with segmented filamentous bacteria (SFB) is known to promote IL-17 production in the gut; he

55 e with mouse-segmented filamentous bacteria (SFB) partially restored T cell numbers, suggesting that

56 presence of segmented filamentous bacteria (SFB) promotes Th17 differentiation and the development o

57 Intestinal segmented filamentous bacteria (SFB) protect from ameba infection, and protection is tra

58 deficient in segmented filamentous bacteria (SFB) were resilient to the induction of depressive-like

59 evealed that segmented filamentous bacteria (SFB) were sufficient to protect mice against RV infectio

60 of mice with segmented filamentous bacteria (SFB), a commensal that induces IL-17A production, exacer

61 n levels of segmentous filamentous bacteria (SFB), a gut microbe residing on ileum villi and PP FAE t

62 rial strain, segmented filamentous bacteria (SFB), a gut microbe that induces intestinal Th17 cell ex

63 ducing taxon segmented filamentous bacteria (SFB), activation of gammadelta T cells was followed by e

64 , especially segmented filamentous bacteria (SFB), are a crucial factor that drives T helper 17 (Th17

65 ies, such as segmented filamentous bacteria (SFB), are sufficient to induce the expansion of Th17 cel

66 cillales and segmented filamentous bacteria (SFB), as well as an increase of interleukin 17 (IL-17) p

67 microbiota, segmented filamentous bacteria (SFB), distantly provoke lung pathology.

68 ial species, segmented filamentous bacteria (SFB), in inducing a robust T-helper cell type 17 (Th17)

69 of commensal segmented filamentous bacteria (SFB), known to promote Th17 cells.

70 ttachment by segmented filamentous bacteria (SFB), members of the mouse intestinal microbiota.

71 ermined that segmented filamentous bacteria (SFB), naturally acquired or exogenously administered, pr

72 lonized with segmented filamentous bacteria (SFB), pentanoate inhibits the generation of small-intest

73 microbiota, segmented filamentous bacteria (SFB), promote autoimmune arthritis by inducing Tfh cells

74 al bacteria, segmented filamentous bacteria (SFB), promote early protection against the pathogen Citr

75 ota, such as segmented filamentous bacteria (SFB), promote their differentiation.

76 ut commensal segmented filamentous bacteria (SFB)-induced systemic arthritis despite the production o

77 gress of gut segmented filamentous bacteria (SFB)-induced T(FH) cells from Peyer's patches (PP) to sy

78 dysbiosis by segmented filamentous bacteria (SFB)-positive fecal transfer significantly suppressed th

79 nducing taxa segmented filamentous bacteria (SFB).

80 vergrowth of segmented filamentous bacteria (SFB).

81 bes, such as segmented filamentous bacteria (SFB).

82 10 mice with Segmented Filamentous Bacteria (SFB).

83 by commensal segmented filamentous bacteria (SFB).

84 Spore-forming bacteria (SFB) survive various environmental stress conditions by

85 pecific for segmented filamentous bacterium (SFB) after cecal ligation and puncture (CLP)-induced sep

86 al microbe, segmented filamentous bacterium (SFB), is sufficient to induce the appearance of CD4(+) T

87 it on demand by using solar flow batteries (SFBs) is a promising way to address the challenge of sol

88 us lithium-iodine (Li-I) solar flow battery (SFB) by incorporation of a built-in dye-sensitized TiO2

89 ollected in a transect of San Francisco Bay (SFB) and their temporal variations within the Bay over t

90 en flow bead (SAFB) and screening flow bead (SFB) assays.

91 logic evidence of direct interaction between SFB and intraepithelial mononuclear cells.

92 omenon resulted from the interaction between SFB and the passively acquired maternal mucosal immunity

93 Two assays, standardized fish bioassays (SFBs) with juvenile fish and fish microassays (FMAs) wit

94 se beads into a novel swirl flow bioreactor (SFB), of low capital and running costs and of simple con

95 other T cells, recognize antigens encoded by SFB.

96 tence of colonization of the neonatal gut by SFB depends on the immune status of both mothers and pup

97 Colonization of the ileum by SFB induced changes in host gene expression and accelera

98 Previous stimulation of mucosal immunity by SFB did not prevent the translocation of M. morganii in

99 led to disruption of endocytosis induced by SFB and decreased epithelial antigen acquisition, with c

100 other CD4+ T cell-based responses induced by SFB.

101 ondrial damage and ROS drive cell killing by SFB, while glycolytic cell reprogramming may represent a

102 Thus, independent of immune cells, SFB confer protection against certain enteric viral infe

103 nschaft (DFG) Collaborative Research Centre (SFB) KIDGEM 1140 (project 246781735, to CB), and Federal

104 After the climax, SFB quickly declined to very low levels in the small int

105 Collectively, SFB gut colonization in the NZM2410 mouse exacerbates ki

106 Consequently, SFB can promote IL-17-dependent immune and autoimmune re

107 findings suggest that microbiota containing SFB create an intestinal milieu that may induce Ag-speci

108 7 cells in response to microbiota containing SFB occurred in the absence of lymphotoxin-dependent lym

109 tiation as well as how microbiota containing SFB regulate Ag-specific intestinal Th17 cells remain po

110 lls in the presence of microbiota containing SFB was dependent on MHC class II expression by CD11c+ c

111 ence of cognate Ag and microbiota containing SFB.

112 In contrast, SFB depletion protected from obesity-induced hepatocellu

113 y, we demonstrate that Th17 cells controlled SFB burden.

114 e way for developing practical and efficient SFBs.

115 r, protein sequences of the pollen-expressed SFB alleles were not identical, harbouring 12 amino-acid

116 Conjugation of (18)F-SFB to IL2 yielded (18)F-FB-IL2 as the major product.

117 (18)F-SFB was efficiently prepared using a 3-step radiochemica

118 Purified (18)F-SFB was incubated with IL2 in borate buffer (pH 8.5) and

119 (18)F-SFB was produced with a 34%-38% radiochemical yield.

120 N-succinimidyl 4-(18)F-fluorobenzoate ((18)F-SFB) for the synthesis of N-(4-(18)F-fluorobenzoyl)inter

121 N-succinimidyl-4-(18)F-fluorobenzoate ((18)F-SFB) prosthetic group.

122 N-succinimidyl-4-(18)F-fluorobenzoate ((18)F-SFB) prosthetic group.

123 N-succinimidyl-4-(18)F-fluorobenzoate ((18)F-SFB) under a slightly basic condition.

124 N-succinimidyl-4-(18)F-fluorobenzoate ((18)F-SFB) was conjugated to S-2-((2-(S-4-amino-4-carboxybutan

125 N-succinimidyl-4-(18)F-fluorobenzoate ((18)F-SFB), and its biodistribution, tumor-targeting potential

126 N-succinimidyl-4-(18)F-fluorobenzoate ((18)F-SFB).

127 N-succinimidyl-4-(18)F-fluorobenzoate ((18)F-SFB).

128 N-succinimidyl 3-(18)F-fluorobenzoate ((18)F-SFB).

129 gnificantly higher (P < 0.05) than for (18)F-SFB-5F7 (25.4 +/- 10.3); however, kidney uptake was 28-3

130 ted (125)I-SGMIB-5F7, whereas that for (18)F-SFB-5F7 was lower than coincubated (125)I-SGMIB-5F7 and

131 26%-28% higher (P < 0.05) than that of (18)F-SFB-5F7.

132 aphy purification was 25%-35% based on (18)F-SFB.

133 The binding affinity of (19)F-SFB-conjugated NAPamide, (19)F-FB-NAPamide, was determin

134 RMSH-1 and RMSH-2 and their respective (19)F-SFB-conjugated peptides ((19)F-FB-RMSH-1 and (19)F-FB-RM

135 s about 25-30% ( n = 5) starting from [(18)F]SFB ( n = 5) with an effective specific activity about 4

136 uccinimidyl 4-[ (18)F]fluorobenzoate ([(18)F]SFB) with Boc-Dmt-Tic--Lys(Z)-OH under slightly basic co

137 gent N-succinimidyl-4-[(18)F]fluorobenzoate (SFB) to the anti-VEGFR2 antibodies.

138 the intestinal epithelium is dispensable for SFB-induced Th17 response, we explored other CD4+ T cell

139 T cells with antigen receptors specific for SFB-encoded peptides differentiated into RORgammat-expre

140 1c(+) cells was necessary and sufficient for SFB-induced Th17 cell differentiation.

141 tion of the radiolabeled antibodies and free SFB differed from the distribution of the targeted MBs.

142 adiolabeled antibodies alone (n = 3) or free SFB (n = 3).

143 In contrast, AMs from SFB-colonized mice were intrinsically altered to resist

144 Yet, AMs from SFB-colonized mice were not quiescent.

145 perating condition optimization of this GaAs SFB lead to a record SOEE of 15.4% among single-junction

146 Remarkably, germ-free animals harboring SFBs alone developed EAE, showing that gut bacteria can

147 cuyer et al. (2014) provide evidence for how SFB induce antigen-specific T helper 17 cells and promot

148 The Li-I SFB can be charged at a voltage of 2.90 V under 1 sun AM

149 nto RORgammat-expressing TH17 cells, even if SFB-colonized mice also harboured a strong TH1 cell indu

150 In SFB-negative mice, AMs were quickly depleted as RVI prog

151 led a temporal increase in the Gd anomaly in SFB from the early 1990s to the present.

152 (TCR) repertoire of intestinal TH17 cells in SFB-colonized mice has minimal overlap with that of othe

153 The dynamic changes in SFB colonization of the small intestines of the differen

154 crease in anthropogenic Gd concentrations in SFB, from 8.27 to 112 pmol kg(-1) over the past two deca

155 eability or "leakiness" was also detected in SFB colonized mice.

156 P-1 and CXCL1 were significantly elevated in SFB colonized mice.

157 Intestinal RA levels were elevated in SFB mice, despite the inhibition of mammalian RA product

158 hoid cells (ILCs) resulted in an increase in SFB-independent Th17 cell differentiation.

159 further explored the role of bone marrow in SFB-mediated protection.

160 liferation in CLP-treated SFB(+), but not in SFB(-), mice.

161 We revealed a compartmentalized response in SFB-specific B cell activation, with a gradient of immun

162 naling in the enteric epithelium resulted in SFB dysbiosis due to reduced expression of alpha-defensi

163 ony-stimulating factor (GM-CSF) signaling in SFB-colonized mice prevented GMP expansion, decreased gu

164 es (SOEE) have been recently demonstrated in SFBs, the complex multi-junction photoelectrodes used ar

165 opsoids caused no juvenile fish mortality in SFBs even at high densities, and low larval fish mortali

166 ce of a small group of commensals, including SFB, and results in an impaired mucosal barrier.

167 prone to spontaneous colitis with increased SFB and Th17 cells.

168 we report an efficient and stable integrated SFB built with back-illuminated single-junction GaAs pho

169 Interestingly, SFB-specific CD4 T cells underwent Ag-driven proliferati

170 dingly, transfer of SFB-transformed AMs into SFB-free hosts recapitulated SFB-mediated protection aga

171 a record SOEE of 15.4% among single-junction SFB devices.

172 s using mice that either contained or lacked SFB as a normal gut-resident microbe.

173 ature transcripts dominated the very limited SFB-induced molecular changes detected in SI-LP CD4(+) T

174 mice or rats with SFB indigenous to mice (M-SFB) or rats (R-SFB), M-SFB and R-SFB showed host-specif

175 ndigenous to mice (M-SFB) or rats (R-SFB), M-SFB and R-SFB showed host-specific adhesion to small int

176 d A (SAA), suggesting that SAA might mediate SFB's effects on BMDCs.

177 Most SFB-induced Th17 cells recognized SFB in an MHCII-depend

178 SFB-positive, but not SFB-negative, females had a substantial population of Th

179 thway dynamically regulates the abundance of SFB as well as mucosal barrier function in the adult ani

180 by reciprocal crossings and backcrossings of SFB-monoassociated, formerly germ-free, immunocompetent

181 onses, and immunoglobulin A (IgA) coating of SFB in the gut.

182 There was a strong cosegregation of SFB positivity and diabetes protection in females, but n

183 We studied the effect of SFB on the mucosal immune system by monoassociating form

184 nflammation compared to NZM2410 mice free of SFB.

185 A second group of SFB-monoassociated mice was colonized with a gram-negati

186 ated to the dynamic changes in the levels of SFB coated with secretory IgA (sIgA), which resulted fro

187 Finally, the intestinal microbiome of SFB colonized mice at 15 and 30 weeks of age exhibited d

188 found that low concentrations (2.5-5 muM) of SFB had a relatively modest effect on LCSC-2 or 293 T ce

189 We monitored the number of SFB on the mucosa of the small intestine in the four dif

190 ere, we exploit the incomplete penetrance of SFB colonization of NOD mice in our animal facility to e

191 We assessed the performance of SFB for detecting changes in SAFB profiles with 35 serum

192 that MHCII-dependent antigen presentation of SFB antigens by intestinal dendritic cells (DCs) is cruc

193 Gene expression profiling of SFB-treated cells was consistent with a shift toward aer

194 alies were observed in the southern reach of SFB, which is surrounded by several hospitals and resear

195 In this study, we isolated 243 strains of SFB from the roots and rhizosphere soils of crops.

196 tional program clearly distinct from that of SFB, suggesting an alternative mechanism of promoting Th

197 Moreover, the transfer of SFB-like microbes capable of triggering the expansion of

198 Accordingly, transfer of SFB-transformed AMs into SFB-free hosts recapitulated SF

199 In contrast, insulitis did not depend on SFB colonization.

200 but lower photovoltages for high performance SFBs and pave the way for developing practical and effic

201 omponent S-haplotype-specific F-box protein (SFB).

202 to mice (M-SFB) or rats (R-SFB), M-SFB and R-SFB showed host-specific adhesion to small intestinal EC

203 th SFB indigenous to mice (M-SFB) or rats (R-SFB), M-SFB and R-SFB showed host-specific adhesion to s

204 formed AMs into SFB-free hosts recapitulated SFB-mediated protection against IAV.

205 Most SFB-induced Th17 cells recognized SFB in an MHCII-dependent manner.

206 secondary lethal infection with recombinant SFB Ag-expressing virulent Listeria (but not wild-type v

207 kin 23 (IL-23) and IL-22, which can regulate SFB.

208 Rhythmic SFB attachment was driven by the circadian clock through

209 Mechanistically, rhythmic SFB attachment activated an immunological circuit involv

210 wever, the corresponding introns and S-RNase-SFB intergenic regions showed considerable differences.

211 f whether the pups were scid/scid or scid/+, SFB could be found earlier on the mucosa of the small in

212 Since SFB targets mitochondria, cell metabolic reprogramming m

213 cinoma, the multikinase inhibitor Sorafenib (SFB) usually fails to eradicate liver cancer.

214 ith this, inhibiting RA signaling suppressed SFB-induced protection.

215 cid replacements between those of P. tenella SFB(8) and P. avium SFB(1).

216 h cells, and autoantibody responses and that SFB can mitigate this repression.

217 that of conventionally reared mice, and that SFB-specific IgA was produced but accounted for less tha

218 e arthritic K/BxN mice, we demonstrated that SFB-induced arthritis is linked to the reduction of Tfr

219 We determined that SFB, by driving differentiation and egress of PP Tfh cel

220 R signaling strength, and we discovered that SFB-reduced CTLA-4 is associated with a reduction of Nur

221 We found that SFB drive the conversion of cognate CD4+ T cells to gran

222 We found that SFB stimulated GCRs in PP from day 6 after monoassociati

223 Our findings generally indicate that SFB are one of the single most potent microbial stimuli

224 of mammalian RA production, indicating that SFB directly modulate RA.

225 of mice and rats, it has been observed that SFB are absent during the suckling period and appear in

226 lly restored T cell numbers, suggesting that SFB and other MMb organisms are required for full immune

227 tinoic acid receptor motifs, suggesting that SFB may enhance defense through retinoic acid (RA).

228 17 production in the gut; here, we show that SFBs also induced IL-17A-producing CD4(+) T cells (Th17)

229 The SFB did not accurately detect the variations of SAFB pro

230 psis primed for a protective response by the SFB-specific CD4 T cells.

231 couples in neutral pH electrolyte enable the SFB to achieve stable cycling over 408 h (150 cycles).

232 that this mechanism is indispensable for the SFB-driven increase in the turnover of epithelial cells

233 ed relatively disease-free regardless of the SFB status.

234 This SFB-mediated CTLA-4 reduction is associated with increas

235 onally, we found that in peripheral tissues, SFB selectively expand dual T cell receptor (TCR)-expres

236 hypermutation driven affinity maturation to SFB antigens under homeostatic conditions.

237 aracterize cancer cell metabolic response to SFB, we measured oxygen consumption, generation of react

238 reviously uncharacterized immune response to SFB, which is dependent on the epithelial MHCII function

239 on the intestinal epithelium in response to SFB.

240 estinal intraepithelial space in response to SFB.

241 Similar to SFB, B. adolescentis was closely associated with the gut

242 dies and generated B cell tetramers to track SFB-specific B cells in gut-associated lymphoid tissues.

243 Moreover, CLP-treated SFB(+) mice showed resistance to secondary lethal infect

244 rwent Ag-driven proliferation in CLP-treated SFB(+), but not in SFB(-), mice.

245 The protocols for the synthesis of unlabeled SFB and the quaternary salt precursor 4-formyl-N,N,N-tri

246 In this study, using SFB in autoimmune arthritic K/BxN mice, we demonstrated

247 ve-like behavior, and were resensitized when SFB was reintroduced in the gut.

248 roduction was restricted to the ileum, where SFB makes direct contact with the epithelium and induces

249 With SFB colonization mice experienced an increase in small i

250 aluate the effect of prior colonization with SFB on the ability of M. morganii to translocate to the

251 Transient gut colonization with SFB or SAA administration alone transiently increased th

252 Gut colonization with SFB was associated with worsening glomerulonephritis, gl

253 Colonization with SFB was correlated with increased expression of genes as

254 aboratory mice, which are not colonized with SFB.

255 ociating formerly germfree C3H/HeN mice with SFB.

256 ocolonization of germ-free mice or rats with SFB indigenous to mice (M-SFB) or rats (R-SFB), M-SFB an

257 thelial cell turnover. Incubation of RV with SFB-containing feces reduced infectivity in vitro, sugge