ライフサイエンスコーパス: SHBG

1 SHBG and TE are independent risk factors for the develop

2 SHBG concentration was positively associated and DHT con

3 SHBG concentrations were 23% lower in women with a high

4 SHBG concentrations were measured in all participants, V

5 SHBG decreased slightly until ~ 4 years postmenopause an

6 SHBG increased 22.4% (P < .001) with diet and 25.8% (P <

7 SHBG increased total androgen and estrogen concentration

8 SHBG levels were positively associated with isoflavones

9 SHBG may also affect IHD independent of testosterone, wh

10 SHBG may be an important diagnostic measure of risk for

11 SHBG might lower the risk of IHD in men, with a role ind

12 SHBG produced in the brain may be released endogenously

13 SHBG was inversely associated with the risk of T2D, wher

14 SHBG was negatively associated only with bone density in

15 SHBG, SHBG plus estradiol (SHBG-E), and SHBG-E plus oxyt

16 .80, p = 0.003), SELE (r = 0.59, p = 0.026), SHBG (r = 0.99, p < 0.001), TNFRSF10C (r = 0.78, p = 0.0

17 east cancer risk (odds ratio doubling, 0.82 [SHBG] to 1.37 [estrone sulfate]).

18 CV at baseline had higher TT (P < .0001) and SHBG (P < .0001) compared with participants who had achi

19 [2.69] vs 5.66 [1.93] mIU/mL; P < .001) and SHBG (35.07 [11.11] vs 46.41 [14.03] nmol/L; P < .001).

20 ound between plasma TNF-alpha receptor 1 and SHBG levels in obese patients.

21 y higher concentrations of insulin (16%) and SHBG (19%) and lower concentrations of leptin (18%) (all

22 plore the relationship between TNF-alpha and SHBG in obese patients and an interventional study to ex

23 l 1.02-1.24); other endogenous androgens and SHBG were not associated with overall risk.

24 integration of DHEA-S, androstenedione, and SHBG as widely available and cost-effective novel blood

25 SHBG, SHBG plus estradiol (SHBG-E), and SHBG-E plus oxytocin all significantly increased female

26 ssing the prospective association of ESH and SHBG with T2D in women.

27 is limited, while the role of estradiol and SHBG on these muscle characteristics are unclear.

28 s produced stronger effects on estrogens and SHBG.

29 ed on the Pritikin Program, insulin fell and SHBG rose and it was suggested that prostate cancer migh

30 e was no relation between D327N genotype and SHBG levels.

31 COS and suggests including BMI, glucose, and SHBG-circulating levels in the risk stratification.

32 y of different substrates, such as GLUT1 and SHBG, demonstrating that the posttranslational glycosyla

33 Seven sex steroid hormones and SHBG were quantitated using gas chromatography-tandem ma

34 Seven sex steroid hormones and SHBG were quantitated using gas chromatography/tandem ma

35 s (kd) for testosterone with soluble HSA and SHBG.

36 homocysteine levels and elevate Apo A-I and SHBG concentrations.

37 e presence of SHBG (immunocytochemistry) and SHBG mRNA (in situ hybridization).

38 of 4-dione may be associated with lower, and SHBG with higher, LC risk in women.

39 stenedione may be associated with lower, and SHBG with higher, liver cancer risk in women.

40 weeks, average levels of nAPCsr, nTMsr, and SHBG decreased from 4.11 (standard deviation [SD], 2.06)

41 testosterone or between any of the PFAAs and SHBG.

42 strone sulfate, testosterone, prolactin, and SHBG; change in AUC, 8.8 [P < .001] for Gail score and 5

43 was associated with muscle radiodensity and SHBG was inversely associated with muscle radiodensity.C

44 the relation between breast cancer risk and SHBG rs6259 was found to vary by body mass index (weight

45 rs1003623, ESR1 rs2234693, GSTP1 rs1695, and SHBG rs6259) showed generally consistent results in SBCS

46 Total testosterone and SHBG concentrations were measured in serum obtained from

47 authors found higher total testosterone and SHBG to be inversely related to carotid atherosclerosis,

48 Testosterone and SHBG were assayed, and free testosterone was calculated.

49 er levels of total and free testosterone and SHBG were significantly associated with increased develo

50 associated with lower serum testosterone and SHBG, and greater E2.

51 gle baseline measurement of testosterone and SHBG.

52 nts with longitudinal determinations, TT and SHBG decreased significantly (P < .0001) while FT remain

53 The serum concentrations of TT and SHBG were also included in the validation analyses.

54 Serum concentrations of TT and SHBG were dichotomized into high TT levels (>46 ng/dL [t

55 n men, even after adjustments for weight and SHBG.

56 directions corresponding to their associated SHBG.

57 explain heterogeneity in studies associating SHBG gene variants and soy consumption with breast cance

58 G levels versus type 2 diabetes association (SHBG levels are 0.23 standard deviations lower in type 2

59 the SHBG-SNP versus SHBG levels association (SHBG levels are 0.2 standard deviations higher per copy

60 genes, including SERPINF2, PRPF8, BAIAP2L1, SHBG, PRMT6, and PPIF, related to liver function.

61 monstrated a significant association between SHBG and insulin, testosterone, triacylglycerols, body m

62 ificant gene-environment interaction between SHBG D356N polymorphism and dietary isoflavone exposure

63 extracts and used as a nutraceutical, binds SHBG with relatively low affinity.

64 The clinical usefulness of both SHBG genotypes and plasma levels in stratification and i

65 d for IPI-bound SHBG, but not with DVT-bound SHBG.

66 l-1-ylmethyl)-2phenyl-1H-indole (IPI), bound SHBG with an affinity similar to that of testosterone an

67 s with SHBG similarly occurred for IPI-bound SHBG, but not with DVT-bound SHBG.

68 AI), the amount of testosterone not bound by SHBG.

69 prostate tissue, whose RSHBG was occupied by SHBG, reproduced the results seen with dihydrotestostero

70 K Biobank, suggested that higher circulating SHBG affects the body impedance, bone density and choles

71 s associated with differences in circulating SHBG and sex steroid hormones.

72 ecially since mice and rats lack circulating SHBG post-natally.

73 n why obese individuals have low circulating SHBG has been attributed to hyperinsulinemia, but no mec

74 he in vivo physiological role of circulating SHBG remains unclear, especially since mice and rats lac

75 ect of insulin administration on circulating SHBG in type 2 diabetic patients were performed.

76 d dietary isoflavone exposure on circulating SHBG levels in 1,988 postmenopausal women.

77 D327N) have been associated with circulating SHBG concentrations in women.

78 uivalent AR binding affinity-but contrasting SHBG binding-and therefore can be used as agents for eva

79 results and HOMA-IR), hormone levels (DHEAS, SHBG, total and free testosterone and FAI), lipid profil

80 alpha plays an important role downregulating SHBG in chronic low-grade inflammatory diseases such as

81 notypes associated with genetically elevated SHBG after Bonferroni correction for multiple testing.

82 one deficiency may be masked due to elevated SHBG.

83 SHBG, SHBG plus estradiol (SHBG-E), and SHBG-E plus oxytocin all significantly incr

84 of protein kinase A prevented the estradiol.SHBG-induced increase in prostate-specific antigen but n

85 The estradiol.SHBG-induced increase in prostate-specific antigen was n

86 re aged 20-34 years at the time of the first SHBG measurement.

87 rgely attenuated after further adjusting for SHBG (OR 0.71 [95% CI 0.31-1.61]; P for trend = 0.47).

88 r, 7alpha-18F-FM-DHT has a high affinity for SHBG, whereas 7alpha-18F-FM-norT has a relatively low af

89 t 7alpha-FM-norT has much lower affinity for SHBG.

90 boon may be related to its high affinity for SHBG.

91 The corresponding constants for SHBG were 0.053-0.058 s(-1) and 0.7-1.2 x 10(9) M(-1).

92 ile an inverse relationship was observed for SHBG with abdominal muscle radiodensity (0.3, 0.0-0.6, a

93 y competitively displacing testosterone from SHBG.

94 ogical age contribute to changes in LH, FSH, SHBG and AMH across mid-life in women, and BMI, smoking

95 ed changes in reproductive hormones-LH, FSH, SHBG and AMH-by chronological age and time around the me

96 clinico-endocrinological profiles (LH, FSH, SHBG, DHEAS, and testosterone levels) of men with early

97 otein (9%) and sex-hormone binding globulin (SHBG) (21%), and lower concentrations of leptin (28%), t

98 adiol bound to sex hormone-binding globulin (SHBG) and total estradiol in the statistical model, the

99 (nTMsr), with sex hormone-binding globulin (SHBG) as a secondary end point.

100 umin (HSA) and sex hormone binding globulin (SHBG) as models.

101 androgens and sex hormone-binding globulin (SHBG) as potential mediators of increasing cardiovascula

102 hat unliganded sex hormone-binding globulin (SHBG) binds to a receptor (RSHBG) on prostate membranes.

103 inding protein sex hormone binding globulin (SHBG) by attempting to block E-BSA-stimulated release of

104 tenedione, and sex hormone-binding globulin (SHBG) concentrations (secondary).

105 stosterone and sex hormone-binding globulin (SHBG) concentrations at age 15 years with prenatal expos

106 , estrone, and sex hormone-binding globulin (SHBG) concentrations were measured by a chemiluminescent

107 estradiol, and sex hormone binding globulin (SHBG) concentrations were not related to baseline period

108 Sex hormone-binding globulin (SHBG) determines the equilibrium between free and protei

109 estradiol, and sex hormone-binding globulin (SHBG) for 3,043 cases and 3,478 controls in the Breast a

110 In the sex hormone binding globulin (SHBG) gene, a pentanucleotide-repeat polymorphism [(TAAA

111 prolactin, and sex hormone-binding globulin (SHBG) improved risk prediction for postmenopausal invasi

112 androgens, and sex hormone-binding globulin (SHBG) in a population-based sample of postmenopausal wom

113 tosterone, and sex hormone-binding globulin (SHBG) in the etiology of lung and colorectal cancers in

114 Sex hormone-binding globulin (SHBG) is a circulating glycoprotein and a regulator of s

115 Sex hormone-binding globulin (SHBG) is a plasma protein synthesized and secreted by th

116 Sex hormone-binding globulin (SHBG) is an important regulator of plasma sex steroids a

117 Sex hormone-binding globulin (SHBG) is believed to play a key role in steroidal radiop

118 Sex hormone binding globulin (SHBG) is found in the brain and acts directly on plasma

119 Sex hormone-binding globulin (SHBG) is the high-affinity binding protein for androgens

120 estradiol, and sex hormone binding globulin (SHBG) levels and calculated free androgen index (FAI), f

121 Low plasma sex hormone-binding globulin (SHBG) levels are associated with obesity and predict the

122 at circulating sex hormone binding globulin (SHBG) levels are lower in type 2 diabetes patients than

123 y decreased as sex hormone-binding globulin (SHBG) levels at follow-up increased.

124 ng hormone and sex hormone binding globulin (SHBG) levels were associated with LC risk, overall and b

125 ng hormone and sex hormone binding globulin (SHBG) levels were associated with liver cancer risk, ove

126 mone (FSH) and sex hormone-binding globulin (SHBG) levels were measured in the three matrices.

127 rmone (LH) and sex hormone binding globulin (SHBG) levels with relatively low BMI and insulin levels,

128 (AMH) levels, sex hormone-binding globulin (SHBG) levels, menopause age, adiposity, insulin resistan

129 ng circulating sex hormone-binding globulin (SHBG) levels.

130 x hormones and sex hormone-binding globulin (SHBG) may account for the inverse association between co

131 hat binding to sex hormone binding globulin (SHBG) might enhance tumor uptake.

132 oestradiol to sex hormone binding globulin (SHBG) ratio (oestradiol-SHBG ratio) on the development o

133 Sex-hormone binding globulin (SHBG) was associated inversely with ABSI but positively

134 androgens, and sex hormone-binding globulin (SHBG) was investigated in 2172 postmenopausal control wo

135 hether ESH and sex hormone-binding globulin (SHBG) were associated with the risk of incident T2D.

136 rrespondingly, sex hormone binding globulin (SHBG) which lowers circulating testosterone might protec

137 s needed since sex hormone binding globulin (SHBG), a glycoprotein which binds androgens with high af

138 with levels of sex hormone binding globulin (SHBG), a key regulator of testosterone bioavailability.

139 fate (DHEAS)], sex hormone binding globulin (SHBG), and EOC risk by tumor characteristics (i.e., hist

140 testosterone, sex hormone-binding globulin (SHBG), dehydroepiandrosterone sulfate (DHEAS), luteinizi

141 testosterone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), dihydrotestosterone (DH

142 testosterone, sex hormone-binding globulin (SHBG), luteinizing hormone (LH), dihydrotestosterone, an

143 association of sex hormone-binding globulin (SHBG), testosterone, and the risk of developing diabetes

144 st quartile of sex hormone-binding globulin (SHBG), those in the highest quartile had a significantly

145 ciations among sex hormone-binding globulin (SHBG), visceral adipose tissue (VAT), liver fat content,

146 tosterone, and sex hormone-binding globulin (SHBG), were performed in 682 women (ages 35 to 49 years)

147 ther the whole sex hormone-binding globulin (SHBG)-like domain (Val243-Ser635; chimera III) or the SH

148 one (BAT), and sex hormone binding globulin (SHBG).

149 d hormones and sex hormone-binding globulin (SHBG).

150 um insulin and sex hormone-binding globulin (SHBG).

151 d moieties and sex hormone binding globulin (SHBG).

152 ex steroids or sex hormone binding globulin (SHBG).

153 gher levels of sex hormone binding globulin (SHBG).

154 d FT) and high sex hormone-binding globulin (SHBG).

155 s of total and sex-hormone-binding-globulin (SHBG)-bound testosterone were 13% and 15% higher, respec

156 gene encoding sex hormone-binding globulin, SHBG, that were robustly associated with the protein lev

157 s in 511 Black men and 698 White men who had SHBG measured in multiple serum samples collected over a

158 ; 2) the aMED was associated with 19% higher SHBG and 16% lower triglycerides (P-trend = 0.02 and 0.0

159 In contrast, higher SHBG was associated with higher BNP and NT-proBNP, while

160 95% CI, 0.12 to 0.30), while men with higher SHBG levels (>28.3 vs < or =28.3 nmol/L) had a 52% lower

161 ve studies indicating that women with higher SHBG levels (>60 vs < or =60 nmol/L) had an 80% lower ri

162 Compared with the highest SHBG quartile, liver fat was 2.9-fold (95% CI 2.4, 3.4)

163 on target organs in mice expressing a human SHBG transgene.

164 vo studies using human HepG2 cells and human SHBG transgenic mice.

165 how two nonsteroidal compounds bind to human SHBG, and how they influence androgen activity in cell c

166 infused into the medial basal hypothalamus, SHBG-E plus oxytocin resulted in significantly increased

167 According to the free hormone hypothesis, SHBG modulates the bioactivity of sex steroids by limiti

168 tional studies to estimate the difference in SHBG levels between type 2 diabetes patients and control

169 Despite improvements in SHBG following SVR, low FT was common and persisted afte

170 as significant reduction FT4 and increase in SHBG and sex steroids with Resmetirom compared to placeb

171 -I), and free testosterone with increases in SHBG and IGF binding protein-1.

172 rs1799941 in SHBG is highly significantly associated with circulating

173 known loci with serum T levels (rs727428 in SHBG: P = 1.26 x 10(-12); rs5934505 in FAM9B: P = 1.61 x

174 Moreover, two additional variants in SHBG [rs72829446, in strong linkage equilibrium with the

175 loring intervention strategies that increase SHBG is important for targeting IHD treatments.

176 Infusing SHBG into the medial preoptic area or medial basal hypot

177 These three loci (JMJD1C, SHBG and FAM9B) were estimated to account for ~5.3 and 4

178 terminus sex hormone-binding globulin-like (SHBG) domain of PS is critical for neuronal protection i

179 iation study (GWAS) has identified two loci, SHBG at 17p13 and FAM9B at Xp22, for serum testosterone

180 ed the associations of increased natural log SHBG with higher impedance of the arms and whole body, l

181 Low SHBG and high FAI are strongly associated with CV risk f

182 Low SHBG and high FAI were strongly and consistently related

183 Low SHBG and testosterone may constitute part of the prediab

184 rs and >32 ng/dL for age >=50 years) and low SHBG levels (<2.85 mug/mL [to convert to nanomoles per l

185 with overweight, the association between low SHBG and increased risk of T2D was, for a large part, me

186 could be the main factor accounting for low SHBG levels in obesity.

187 .8%) had high TT levels, 210 (10.4%) had low SHBG levels, 825 (39.8%) had obesity, and 965 (45.5%) ha

188 95% CI, 1.21-2.54]) were associated with low SHBG levels but not with high TT levels.

189 ate metabolites could be associated with low SHBG levels, obesity, and metabolic syndrome depending o

190 Lower SHBG concentration was associated with lower all-cause m

191 Lower SHBG concentrations were associated with higher incidenc

192 drogen profiles (higher median FAI and lower SHBG levels) than controls.

193 Among HT nonusers, lower SHBG and higher FAI levels were noted among postmenopaus

194 BMI, glucose, and insulin levels with lower SHBG and LH levels.

195 Men with lower SHBG concentrations have higher risk for MI but lower ri

196 nd physical activity, nonusers in the lowest SHBG quartile had an OR of 2.25 (95% CI, 1.03 to 4.91) f

197 tatistically significant differences in mean SHBG concentrations for White men with genotypes of (TAA

198 years, mean BMI was 30 (SD 4) kg/m2, median SHBG was 47 (interquartile range [IQR] 34-65) nmol/L in

199 Neither estradiol alone nor SHBG alone duplicated these effects.

200 reast cancer risk with increasing oestradiol-SHBG ratio was found in the placebo group (trend per qua

201 artile 4 (0.56 [0.23 to 0.76]) of oestradiol-SHBG ratio, but not in quartile 1 (0.18 [-0.60 to 0.59])

202 ne binding globulin (SHBG) ratio (oestradiol-SHBG ratio) on the development of all breast cancers, in

203 To better understand the action of SHBG, we have synthesized and tested in vivo 2 novel 18F

204 Addition of SHBG or any measure of free testosterone to the multivar

205 le and noncarriers of rs6257 minor allele of SHBG gene consuming >/=2 cups/day of caffeinated coffee

206 release of oxytocin with two antagonists of SHBG receptor actions: the 5alpha-reduced androgens dihy

207 ower risk in men; the inverse association of SHBG with risk was stronger in women than in men.

208 The association of SHBG with T2D did not change by menopause status, wherea

209 Study, the authors assessed associations of SHBG polymorphisms with serum SHBG levels in 511 Black m

210 riables and diet to plasma concentrations of SHBG.

211 n randomization suggested a causal effect of SHBG on LOY but there was no evidence for an effect of L

212 We searched for potential causal effects of SHBG in UK Biobank (N = 334 977) and followed-up our top

213 ing to investigate the biological effects of SHBG or develop targets for therapeutic intervention.

214 atically appraise the potential functions of SHBG while reducing potential biases such as confounding

215 These two disparate functions of SHBG, regulation of the concentration of free steroids i

216 xamined in relation to circulating levels of SHBG (N = 4720), testosterone (N = 4678), 3 alpha-andros

217 cantly associated with circulating levels of SHBG (P = 4.52 x 10(-21)), consistent with previous stud

218 than 1,912 incident T2D cases, low levels of SHBG and high levels of TE were associated with increase

219 vels of FAI, and Chinese had lower levels of SHBG and higher levels of FAI.

220 red with whites, blacks had higher levels of SHBG and lower levels of FAI, and Chinese had lower leve

221 tivariable-adjusted geometric mean levels of SHBG were 26.6 nmol/l among women consuming >/=4 cups/da

222 indings indicate how nonsteroidal ligands of SHBG maybe designed to modulate the bioavailability of s

223 the design of other nonsteroidal ligands of SHBG.

224 The molecular nature of SHBG makes it a feasible target for preventative or ther

225 Our systematic MR-pheWAS of SHBG, which was comprehensive to the range of phenotypes

226 ained a significant independent predictor of SHBG.

227 ter adjustments, the strongest predictors of SHBG concentrations were the dietary intake of rice (bet

228 man prostate, we demonstrate the presence of SHBG (immunocytochemistry) and SHBG mRNA (in situ hybrid

229 TNF-alpha-induced reduction of SHBG expression was mediated by downregulating HNF4A.

230 be used as agents for evaluating the role of SHBG binding in the target tissue uptake of AR PET imagi

231 To assess the sex-specific role of SHBG in IHD, in univariable Mendelian randomization (MR)

232 To probe the role of SHBG in prostate tumor uptake of PET imaging agents, we

233 ls to evaluate more definitively the role of SHBG in radiotracer delivery of steroidal systems to tar

234 Crystal structures of SHBG in complex with DVT or IPI at 1.71-1.80 angstrom re

235 here was no evidence for an effect of LOY on SHBG.

236 t was not associated with week 12 estrone or SHBG concentrations.

237 T, no significant differences in hormones or SHBG were observed among women who developed CVD and con

238 free estradiol to release oxytocin, perhaps SHBG receptors.

239 Plasma SHBG was significantly increased rather than decreased a

240 wide significant genetic variants to predict SHBG, and examined their association with IHD in the UK

241 Genetically predicted SHBG was associated with liver fat content (women: SD -0

242 Genetically predicted SHBG was associated with lower IHD risk in men [odds rat

243 affinity to a specific membrane receptor (R(SHBG)) in prostate stromal and epithelial cells, wherein

244 mal and epithelial cells, wherein the SHBG.R(SHBG) complex forms.

245 and the N variant is associated with reduced SHBG clearance compared with the D variant.

246 The RSHBG.SHBG complex is rapidly activated by estradiol to stimul

247 The importance of the protein S SHBG-like domain (and its laminin G-type 1 subunit) for

248 e show that binding of TFPI to the protein S SHBG-like domain enables TFPI to interact optimally with

249 to the interindividual variability in serum SHBG levels.

250 ssociations of SHBG polymorphisms with serum SHBG levels in 511 Black men and 698 White men who had S

251 SHBG, SHBG plus estradiol (SHBG-E), and SHBG-E plus oxytocin a

252 In addition, SUV(SHBG) could potentially be used as an even simpler metho

253 When calculating SUV(SHBG), correlation to K (i) improved (R (2) = 0.88).

254 for sex hormone-binding globulin levels (SUV(SHBG)).

255 model including the covariates testosterone, SHBG, age, etiology, and MELD, total testosterone remain

256 rations of estrone, estradiol, testosterone, SHBG, dehydroepiandrosterone sulfate, free estradiol, an

257 is of total testosterone, free testosterone, SHBG, and hypogonadism in men within the Million Veteran

258 ociated with variation in male testosterone, SHBG, and LH concentrations.

259 Pretransplantation serum testosterone, SHBG, and other variables were collected on 190 consecut

260 ated the effect of the baseline testosterone-SHBG ratio on breast cancer development.

261 weaker effect was seen for the testosterone-SHBG ratio in the placebo group (trend 1.21 [1.05 to 1.4

262 In this paper we demonstrate that SHBG is produced in human prostate cancer cell lines (LN

263 cent genetic study, strengthen evidence that SHBG and sex hormones are involved in the aetiology of t

264 onal and prospective studies both found that SHBG was more protective in women than in men (P< or =.0

265 ions are consistent with the hypothesis that SHBG, destined to participate in signaling at the cell m

266 Our findings suggest that SHBG may account for the inverse association between cof

267 The SHBG gene contains a D356N polymorphism and the N varian

268 The SHBG SNP rs1799941 was associated with type 2 diabetes [

269 ons higher per copy of the A allele) and the SHBG levels versus type 2 diabetes association (SHBG lev

270 fat, high-fiber diet was significant for the SHBG-bound fraction (P = 0.04).

271 ted (OR 0.92, 95% CI: 0.88, 0.96), given the SHBG-SNP versus SHBG levels association (SHBG levels are

272 s/liter with placebo) and an increase in the SHBG concentration (4.3 versus -1.3 mmoles/liter with pl

273 est that the (TAAAA)(n) repeat length in the SHBG gene, but not the D327N variant, might contribute t

274 ns revealed their unique orientations in the SHBG ligand-binding pocket and suggested opportunities f

275 ingle nucleotide polymorphism (SNP) near the SHBG gene, rs1799941, that is strongly associated with S

276 allele, carriers of a variant allele of the SHBG single-nucleotide polymorphism (SNP) rs6259 had 10%

277 er mediated 43% (women) and 60% (men) of the SHBG-T2D association.

278 e domain (Val243-Ser635; chimera III) or the SHBG laminin G-type 1 subunit (Ser283-Val459; chimera I)

279 We also observed that the SHBG locus was associated with serum DHT levels (rs72742

280 te stromal and epithelial cells, wherein the SHBG.R(SHBG) complex forms.

281 5% CI: 0.91, 0.97; P = 2 x 10(-5)], with the SHBG raising allele associated with reduced risk of type

282 tradiol but not testosterone, IPI binding to SHBG was reduced by ~20-fold in the presence of zinc, wh

283 atively associated with % estradiol bound to SHBG (OR for the highest quartile = 0.05, 95% CI 0.01-0.

284 l) that prevents the binding of estradiol to SHBG.

285 % CI: 0.88, 0.96), given the SHBG-SNP versus SHBG levels association (SHBG levels are 0.2 standard de

286 isk (OR = 0.50; 95% CI = 0.30-0.82), whereas SHBG was associated with a 31% increased risk (OR = 1.31

287 but not insulin, is the main factor by which SHBG is reduced in obesity.

288 cancer risk (OR=0.50,95%CI=0.30-0.82), while SHBG was associated with a 31% increased risk (OR=1.31,9

289 and estradiol (E2) were evaluated along with SHBG and the free androgen index (FAI), the amount of te

290 inated coffee was positively associated with SHBG but not with sex hormones.

291 tic driver mutations was not associated with SHBG but was associated with LOY at clonal fractions abo

292 rs1799941, that is strongly associated with SHBG levels.

293 ffeinated coffee nor tea was associated with SHBG or sex hormones.

294 strongest reduction in risk associated with SHBG rs6259 was found for lean (body mass index <23) pos

295 ted cholesterol eliminated associations with SHBG and FAI.

296 bles was modestly positively correlated with SHBG and negatively with insulin values.

297 radiol-dependent fibulin-2 interactions with SHBG similarly occurred for IPI-bound SHBG, but not with

298 s of (TAAAA)(n) and D327N polymorphisms with SHBG concentrations.

299 cted P = 0.006); and 11q13.2-rs10896449 with SHBG (uncorrected P = 0.005)).

300 In women, SHBG is also implicated in diverse pathologies such as c