ライフサイエンスコーパス: SHRSP

1 SHRSP offspring fostered on WKY dams had systolic blood

2 SHRSP showed significant elevations in SBP, as compared

3 ol x min(-1) x [20 microl packed cells](-1), SHRSP vs. WKY, respectively, P = 0.01) and inhibition of

4 All SHRSP received dexamethasone (12 micro g/kg per d, subcu

5 Although SHRSP is a genetic model for CSVD, environmental factors

6 derived from SHRSP(HD)/WKY-0(HD) (n=115) and SHRSP(HD)/WKY-1(HD) (n=139) crosses (WKY-0(HD) and WKY-1

7 was significantly different between WKY and SHRSP as early as 4 weeks of age, and remained different

8 n the development of HT by comparing WKY and SHRSP microbiota during the pre-hypertensive state and l

9 apoptosis in neural tissues of both WKY and SHRSP rats.

10 To test this hypothesis, newly born SHRSP pups were placed with foster dams of the SHRSP str

11 patic lipidosis, and hyperleptinemia in both SHRSP and WKY rats, the SHRSP rats weighed less but had

12 WKY rats, which supports the use of HFD-fed SHRSP rats as a unique model for studying the metabolica

13 were also evident in myoblast cultures from SHRSP compared with WKY cultures.

14 is were performed on F2 hybrids derived from SHRSP(HD)/WKY-0(HD) (n=115) and SHRSP(HD)/WKY-1(HD) (n=1

15 ions of insulin) in adipocytes isolated from SHRSP.

16 We show that skeletal muscle from SHRSP animals exhibits a marked decrease in insulin-stim

17 e markedly elevated in skeletal muscles from SHRSP compared with WKY animals.

18 m was significantly impaired in vessels from SHRSP males + PVAT relative to females (maximum relaxati

19 ota, and Proteobacteria, in pre-hypertensive SHRSP, as compared to WKY.

20 The stroke-prone spontaneously hypertensive (SHRSP) rat is a model of human insulin resistance and is

21 In SHRSP rats, SEH inhibition reduced wall-to-lumen ratio a

22 ease in response to insulin: 1.4 +/- 0.15 in SHRSP, 2.29 +/- 0.22 in WKY; n = 4, P = 0.02), but the s

23 ive abundance was significantly different in SHRSP versus WKY at the pre-hypertensive ages of 4 or 6

24 We measured BP and HR in SHRSP(HD) and normotensive Wistar-Kyoto rats (WKY), as w

25 tributes directly to the regulation of HR in SHRSP(HD) but exhibits no effect on BP.

26 HR in SHRSP(HD) was significantly higher than in WKY-0(HD) bot

27 pathway and increased indole metabolites in SHRSP versus WKY plasma.

28 ence and expression are apparently normal in SHRSP, it is likely that the molecular mechanism for def

29 cerebral ischemia via vascular protection in SHRSP rats and neural protection in both the SHRSP and W

30 ues and skeletal muscle were up-regulated in SHRSP than WKY rats.

31 ase and plasma levels of NEFA are similar in SHRSP and WKY.

32 map was constructed in two F2 intercrosses (SHRSP x BN and FHH x ACI), containing a total of 4736 si

33 eased approximately 2-fold in PVAT from male SHRSP vessels.

34 ts for defects in insulin action in the male SHRSP rat model compared with the normotensive, insulin-

35 ide screen in an F2 cross obtained by mating SHRSP and SHR, in which latency to stroke on Japanese ra

36 pathogenesis of thrombotic microangiopathy, SHRSP were adrenalectomized and infused with vehicle, An

37 ive effect against stroke in the presence of SHRSP alleles and STR-2 co-localized with the genes enco

38 Similarly WKY offspring fostered on SHRSP dams had significantly increased SBP compared to W

39 At ~20 weeks of age, rats fostered on SHRSP dams showed enhanced inflammation in distal ileum

40 when compared to the SHRSP rats fostered on SHRSP dams.

41 eks, compared to SHRSP offspring fostered on SHRSP dams.

42 diet modulate gut microbiota and predispose SHRSP rats to develop metabolic syndrome.

43 in spontaneously hypertensive stroke-prone (SHRSP) and Wistar-Kyoto (WKY) rats.

44 in spontaneously hypertensive stroke-prone (SHRSP) rats protects against cerebral ischemia induced b

45 stroke-prone spontaneously hypertensive rat (SHRSP(HD)), is a primary, genetically determined trait a

46 stroke-prone spontaneously hypertensive rat (SHRSP) as a model organism, mated it with the stroke-res

47 stroke-prone spontaneously hypertensive rat (SHRSP) is a genetically determined model of "salt-sensit

48 spontaneously hypertensive stroke-prone rat (SHRSP) is an experimental model of stroke characterized

49 roke-prone, spontaneously hypertensive rats (SHRSP) without controlling hypertension.

50 troke prone spontaneously hypertensive rats (SHRSP).

51 pontaneously hypertensive stroke prone rats (SHRSP), an animal model for hypertensive cerebral small

52 pontaneously hypertensive stroke prone rats (SHRSP).

53 were also observed in the insulin-resistant SHRSP strain.

54 tty acid metabolism in the stroke-prone SHR (SHRSP).

55 SHRSP rats and neural protection in both the SHRSP and WKY rats, indicating that SEH inhibition has b

56 The goal of this study was to examine the SHRSP gut microbiota before, during, and after the onset

57 chromosome 3: in animals homozygous for the SHRSP(HD) allele, HR was 414+/-49 compared with 383+/-44

58 genome scan in an F2 cross derived from the SHRSP and the normotensive reference strain, WKY rat.

59 In the SHRSP fed a normal NaCl diet, supplementing dietary K+ w

60 responsible for large infarct volumes in the SHRSP in response to a focal ischaemic insult by perform

61 that the insulin resistance observed in the SHRSP is manifest at the level of skeletal muscle, that

62 ividual species that contribute to HT in the SHRSP model have not been identified.

63 dysbiosis contributes to hypertension in the SHRSP model, and suggest for the first time the potentia

64 The observations suggest that in the SHRSP selectively supplemented with Cl- the likelihood o

65 al reason, is that nearly all studies of the SHRSP gut microbiota have analyzed samples from rats wit

66 y of stroke the phenotypic expression of the SHRSP is (i) either increased or decreased, depending on

67 RSP pups were placed with foster dams of the SHRSP strain or dams of the WKY strain, the control stra

68 determines the phenotypic expression of the SHRSP.

69 erleptinemia in both SHRSP and WKY rats, the SHRSP rats weighed less but had comparable percent adipo

70 We found that the SHRSP rats were hypertensive, hyperphagic, less sensitiv

71 rial candidates that might contribute to the SHRSP phenotype, we compared the functional capacity of

72 re fostered on WKY dams when compared to the SHRSP rats fostered on SHRSP dams.

73 mHg (P < .001) from 16-20 weeks, compared to SHRSP offspring fostered on SHRSP dams.

74 sulin action on 2-deoxy-D-glucose transport (SHRSP 3.3 +/- 1.5 vs. 21.0 +/- 7.4 pmol x min(-1) x [20

75 mpared the functional capacity of WKY versus SHRSP microbial communities.

76 g 120 F(2) rats generated from an SR/JrHsd x SHRSP intercross.