ライフサイエンスコーパス: SRF

1 SRF is an essential regulator of skeletal muscle differe

2 SRF Ser(103) phosphorylation is bidirectionally regulate

3 SRF Ser(103) phosphorylation is significantly decreased

4 SRF subsequently funded animal research to evaluate sucr

5 SRF terminated Project 259 without publishing the result

6 SRF thickness >118.25 mum at baseline predicted requirin

7 SRF-VP16iHep mHCC reveal convergent Ras/MAPK and Rho/act

8 Consistently, 35 SRF/IGF2BP1-dependent genes showing conserved associatio

9 n activator of cell contractility and MRTF-A/SRF (myocardin-related transcription factor A/serum resp

10 n is lost and correlates with reduced MRTF-A/SRF activity leading to cell adhesion defects.

11 of cell adhesion, contractility, and MRTF-A/SRF activity.

12 reviously unknown link of RASSF1A and MRTF-A/SRF in tumour suppression.

13 d for regulation of cell spreading or MRTF-A/SRF transcriptional activity.

14 ion resulting in reduced myogenically active SRF, but enhanced SRF activity on target genes involved

15 associated with stronger F-actin alignment, SRF and TEAD are up-regulated.

16 achieved when treatment aimed to resolve all SRF completely.

17 e expression but did not significantly alter SRF target gene or proliferative gene expression.

18 activated smooth muscle gene promoters in an SRF-dependent manner.

19 n proposed that coating the inner wall of an SRF cavity with superconducting thin films increases Hvp

20 ning, funding, and internal evaluation of an SRF-funded research project titled "Project 259: Dietary

21 vity-regulated transcription factors AP1 and SRF.

22 cerebellum, NR3C1 in the cerebral cortex and SRF in the basal forebrain.

23 lower volumes of NSR, RPE, sPED, fvPED, and SRF.

24 d similar efficacy in visual improvement and SRF resolution.

25 differentiate, and quantify intraretinal and SRF using area under the receiver operating characterist

26 All individual IRC and SRF lesions were manually delineated on each of the 128

27 rrelations were computed between the IRC and SRF parameters and the baseline BCVA, final BCVA, and BC

28 s of fit of correlations between the IRC and SRF parameters and the baseline BCVA, final BCVA, and BC

29 underwent complete quantification of IRC and SRF.

30 -treated eyes, the majority had both IRF and SRF (54.7%).

31 acuity, new haemorrhage, presence of IRF and SRF on an optical coherence tomography (OCT) scan.

32 e" treatment (complete resolution of IRF and SRF) or ranibizumab "relaxed" treatment (resolution of I

33 ting the ability of Pfn to influence MKL and SRF expression.

34 sive transcription factors such as MRTFA and SRF contribute to both upregulation of morphological gen

35 rovided evidence that TCF21 blocks MYOCD and SRF association by direct TCF21-MYOCD interaction.

36 l as key SMC transcription factors MYOCD and SRF, at the RNA and protein level.

37 was complete resolution of his symptoms and SRF.

38 and intraretinal fluid (IRF; intensive arm: SRF intolerant) or resolution of all IRF only (relaxed a

39 or resolution of all IRF only (relaxed arm: SRF tolerant except for SRF >200 mum at the foveal cente

40 rrative case study method was used to assess SRF Project 259 from 1967 to 1971 based on sugar industr

41 t; however, no meaningful impact of baseline SRF status on treatment outcomes with IAI was demonstrat

42 ts of IAI over laser, regardless of baseline SRF status.

43 rs for BCVA change at month 12 were baseline SRF (P = 0.05), PVD (P = 0.03), IRC (P = 0.05), treatmen

44 f 100 was greater for patients with baseline SRF versus those without (nominal P < 0.001, for interac

45 f IAI was observed in patients with baseline SRF versus those without; however, no meaningful impact

46 letters, respectively, (those with baseline SRF) and +10.3, +10.6, and +2.5 letters, respectively, (

47 +10.9, and -2.3 letters (those with baseline SRF) and +10.6, +10.0, and +2.7 letters (those without).

48 and 8.9%, respectively, (those with baseline SRF) and 30.9%, 29.1%, and 8.2%, respectively, (those wi

49 nd 12.9%, respectively, (those with baseline SRF) and 33.3%, 30.5%, and 12.5%, respectively, (those w

50 No robust associations were found between SRF and baseline BCVA (R2 = 0.06; P = .14) or BCVA chang

51 resolution of all retinal fluid (i.e., both SRF and intra-retinal fluid [IRF]) in patients with nAMD

52 The presence of both SRF and PVD at baseline was associated with similar BCVA

53 In patients with both SRF and PVD at baseline, similar BCVA outcomes were obse

54 Stimulation also enhanced the long bound SRF fraction at specific timepoints (20 and 60 min) in b

55 atest and most rapid resolution, followed by SRF and PED the least.

56 cardiac myocyte hypertrophy is modulated by SRF (serum response factor) phosphorylation, constitutin

57 duced by TGF-beta1 and MYOCD, and reduced by SRF deficiency in VSMCs.

58 nce to BRAF inhibitors, which is reversed by SRF/MRTF inhibitors.

59 the binding to its transcriptional cofactor SRF.

60 follow-up; all recurrent cases had complete SRF resolution after another PDT treatment.

61 ific role of the transcription factors CREB, SRF, and MEF2 in the depression and potentiation compone

62 In this study, we tested the role of CREB, SRF, and MEF2 in ocular dominance plasticity (ODP), a pa

63 to block the transcription function of CREB, SRF, and MEF2 in the visual cortex, and measured visuall

64 We found that CREB, SRF, and MEF2 are all required for ODP, but have differe

65 novel MRTF/SRF inhibitor, markedly decreased SRF reporter gene activity and showed a greater inhibito

66 logous mouse SRF enhancer revealed decreased SRF expression in aorta and heart tissues.

67 gether, these results suggest that decreased SRF expression induces replicative stress and chromosoma

68 act as general antagonists of MRTF-dependent SRF target gene expression, competing directly with the

69 C data, we identified over 700 TCF-dependent SRF direct target genes involved in signaling, transcrip

70 Forty-six (90%) study participants developed SRF during the study period, with 9 (20%) experiencing s

71 kness of 39 study participants who developed SRF at the first visit increased from 280 (26) microm at

72 e, we demonstrate that the single Drosophila SRF ortholog, termed Blistered (Bs), is expressed in all

73 tiple cancer-related pathways including Elk1/SRF, AP1, NFkappaB and STAT, and reduces EGFR expression

74 educed myogenically active SRF, but enhanced SRF activity on target genes involved in proliferation.

75 This results in enhanced SRF-dependent transcriptional activity and promotes tumo

76 On examination, SRF appeared as elevated, yellow-orange pockets in the f

77 genes controlled by the transcription factor SRF, and overexpression of SRF rescues impaired chromoso

78 s through their partner transcription factor SRF.

79 ial role of myocardin/serum response factor (SRF) and Notch signaling in the transcriptional regulati

80 transcription factor serum response factor (SRF) and set the chromatin state of SRF-targeted genes e

81 factor A (MRTF-A) and serum response factor (SRF) and the other using the transcriptional coactivator

82 al remodelling on the serum response factor (SRF) co-factors Megakaryoblastic Leukemia-1 and -2 (MKL1

83 Serum response factor (SRF) has an established role in controlling actin homeos

84 Serum response factor (SRF) mediates immediate early gene (IEG) and cytoskeleta

85 tion of Rho-dependent serum-response factor (SRF) signaling.

86 lators and to promote serum response factor (SRF) signalling has raised the question of whether MRL p

87 transcription factor serum response factor (SRF) to activate mitogen-induced transcription.

88 dering the binding of serum response factor (SRF) to the proximal CArG box.

89 teraction between the serum response factor (SRF) transcription factor and one of its principal co-ac

90 Serum response factor (SRF) was predicted as a transcriptional regulator drivin

91 s where they activate serum response factor (SRF), a regulator of actin and other cytoskeletal protei

92 cific co-activator of serum response factor (SRF), is increased in DCM porcine and patient cardiac ti

93 )-A, a coactivator of serum-response factor (SRF), known to promote fibroblast-like behaviors in many

94 gen-responsiveness to serum response factor (SRF), which controls aggressive CaP behavior and is main

95 gnificantly inhibited serum response factor (SRF)-dependent reporter gene (SRE-LUC) activity and mRNA

96 ) are coactivators of serum response factor (SRF)-mediated gene expression.

97 lastic leukemia (MKL)/serum-response factor (SRF)-mediated gene transcription is a highly conserved m

98 ription factor (MRTF)/serum response factor (SRF)-mediated gene transcription with good potency (IC(5

99 merization results in serum response factor (SRF)-mediated transcription through nuclear retention of

100 r TGF-beta1 and MYOCD/serum response factor (SRF)-regulated TSPANs in VSMC by using RNA-seq analyses

101 transcription factor serum response factor (SRF).

102 lates the activity of serum response factor (SRF).

103 binding sites of the serum-response factor (SRF).

104 transcription factor, serum response factor (SRF); however, the mechanisms dynamically regulating SMC

105 CREB (cAMP response element binding factor), SRF (serum response factor), and MEF2 (myocyte enhancer

106 So far, SRF transcriptional dynamics have not been investigated

107 incomplete resolution of sub-retinal fluid (SRF) </=200 mum at the foveal centre relative to a T&E p

108 as intra-retinal (IRF) or sub-retinal fluid (SRF) were evident on SD-OCT, followed by a gradual exten

109 CRT), height of subfoveal sub-retinal fluid (SRF), central choroid thickness (CCT), mean number of PD

110 ion showed the presence of subretinal fluid (SRF) and pachychoroid supporting the diagnosis of CSCR.

111 ch as the baseline area of subretinal fluid (SRF) as measured on ultrasound images in the third cohor

112 uity (BCVA), resolution of subretinal fluid (SRF) demonstrated by optical coherence tomography (OCT),

113 cs, presence of persistent subretinal fluid (SRF) or intraretinal fluid (IRF), and on-study events (a

114 On OCT, subretinal fluid (SRF) was detected in 77% of CM patients and 60% of UM pa

115 al cystoid fluid (IRC) and subretinal fluid (SRF) was developed.

116 was present in 86.4%, and subretinal fluid (SRF) was present in 76.3%.

117 tinal fluid (IRF), 38% had subretinal fluid (SRF), 36% had subretinal pigment epithelium (RPE) fluid,

118 intraretinal fluid (IRF), subretinal fluid (SRF), and pigment epithelial detachment (PED) were deter

119 intraretinal cysts (IRCs), subretinal fluid (SRF), and pigment epithelial detachment (PED), presentin

120 tinal cystoid fluid (IRC), subretinal fluid (SRF), and pigment epithelial detachment (PED).

121 id material and persistent subretinal fluid (SRF), but also a RPE-independent visual cycle for cone p

122 tinal cystoid fluid (IRC), subretinal fluid (SRF), pigment epithelial detachment, and vitreomacular i

123 intraretinal fluid (IRF), subretinal fluid (SRF), sub-retinal pigment epithelium (RPE) fluid, and su

124 intraretinal fluid (IRF), subretinal fluid (SRF), subretinal hyperreflective material (SHRM), retina

125 t of intraretinal fluid or subretinal fluid (SRF); (4) presence, location, and amount of hyperreflect

126 literature, respectively): subretinal fluid (SRF; 30,9), chorioretinal folds (30,68), macular exudate

127 traretinal fluid [IRF], or subretinal fluid [SRF]) versus aflibercept (q8-week).

128 was 148 mum (99) for retina, 5 mum (21) for SRF, 125 mum (107) for subretinal tissue complex, 11 mum

129 coefficient of 0.90 for IRC and of 0.96 for SRF.

130 F only (relaxed arm: SRF tolerant except for SRF >200 mum at the foveal center) before extending trea

131 Thus, competition between TCFs and MRTFs for SRF determines the balance between antagonistic prolifer

132 ubiquitin proteasome system responsible for SRF stabilization and KLF4 repression and is required fo

133 s uncover an evolutionarily ancient role for SRF in regulating muscle actin expression, and provide a

134 the most accurate CT volumetry technique for SRF and the prediction of postdonation kidney function (

135 t of the enhanced secondary radiation force (SRF).

136 l contours using a structured random forest (SRF) contour detector with fast parallel prediction and

137 In 1965, the Sugar Research Foundation (SRF) secretly funded a review in the New England Journal

138 h MYOCD to competitively displace MYOCD from SRF.

139 ters commonly evaluate split renal function (SRF) with Tc-99m-mercapto-acetyltriglycin (MAG3) scintig

140 of analytical Spontaneous Release Functions (SRF) whose parameters may be randomly sampled from appro

141 Furthermore, SRF delivered by CAGE exhibited significantly different

142 Furthermore, SRF downregulation in diploid hPSCs induces replication

143 Only 2 participants (4%) were found to have SRF at the last study visit after discontinuation of tre

144 transcription factor depletion in the heart (SRF(HKO)) or of cardiac hypertrophy triggered by transve

145 Eyes from Black individuals had higher SRF, RPE, and serous PED volumes compared with other eth

146 ctin expression, and provide a model for how SRF might function to sustain muscle fate downstream of

147 However, SRF alone is not sufficient for regulating smooth muscle

148 These results identify SRF and its MRTF cofactors as major transcriptional regu

149 tor of therapy resistance, while identifying SRF/MRTF as a potential therapeutic target.

150 inding supports previous reports implicating SRF and MEF2 in long-term depression (required for Dc-OD

151 ds achieving higher acceleration gradient in SRF cavity accelerator beyond the theoretical limit of b

152 pression of a wide range of genes, including SRF itself and many important structural and regulatory

153 anchoring protein beta), such that increased SRF phosphorylation activates AP-1 (activator protein-1)

154 binding, indicating a cell type-independent SRF property.

155 Androgen treatment induced SRF-PKN1 interaction, and PKN1 knockdown or overexpressi

156 Using integrated SRF ChIP-seq and Hi-C data, we identified over 700 TCF-d

157 utilized Nb ellipsoid to simulate an inverse SRF cavity and investigate the effect of coating it with

158 baseline, the proportions of eyes with IRC, SRF, and PED were balanced between the aflibercept and r

159 the action of MKL that is independent of its SRF-related activity.

160 agreement between CT volumetry SRF and MAG3-SRF (bias, 95% limits of agreement: ROI vs MAG3 0.4%, -7

161 at day 3 was r = 0.85 to 0.88, between MAG3-SRF and PDKF (r = 0.84).

162 ic SRF was determined and compared with MAG3-SRF, postoperation donor kidney function, and graft func

163 the notion that modulation of the mAKAPbeta-SRF signalosome could be a new therapeutic approach for

164 to function in a similar manner to mammalian SRF in muscle maturation.

165 omatin immunoprecipitation-sequencing to map SRF-binding sites in human coronary artery SMC, showing

166 Our findings show that mDia2-SRF-beta2 integrin signaling is critical for HSPC lodgme

167 ations associated with IIH include CNVM, ME, SRF, VSR, chorioretinal folds, choroidal infarction, and

168 Mechanistically, PI3K/Akt-mediated SRF activation promotes nuclear translocation and bindin

169 ey cardiac TFs (GATA4, NKX2-5, MEF2A, MEF2C, SRF, TBX5, TEAD1) to sensitively and reproducibly map th

170 in a possible feedback loop of the actin/MKL/SRF signaling circuit.

171 study, we examined the possible role of MKL/SRF in the context of regulation of profilin (Pfn), a ma

172 his conserved motif in the orthologous mouse SRF enhancer revealed decreased SRF expression in aorta

173 Thus, the MRF-SRF and YAP-TEAD pathways interact indirectly through th

174 yocardin-related transcription factor (MRTF) SRF cofactor family.

175 We compared MRTF-SRF and YAP-TEAD target gene sets and identified genes d

176 lore the impact of the actin-controlled MRTF-SRF (myocardin-related transcription factor-serum respon

177 In CAFs, expression of direct MRTF-SRF genomic targets is also dependent on YAP-TEAD activi

178 We used vav-iCre to inactivate MRTF-SRF signaling early during hematopoietic development.

179 et gene expression is also dependent on MRTF-SRF signaling.

180 Both the MRTF-SRF and the YAP-TEAD transcriptional regulatory networks

181 We show that the MRTF-SRF pathway is activated in cancer-associated fibroblast

182 that YAP-TEAD activity is sensitive to MRTF-SRF-induced contractility, while MRTF-SRF signaling resp

183 o MRTF-SRF-induced contractility, while MRTF-SRF signaling responds to YAP-TEAD-dependent TGFbeta sig

184 y different WH2 domains correlates with MRTF-SRF activation.

185 scription factor/Serum response factor (MRTF/SRF) pathway plays a key role in fibroblast activation a

186 scription factor/serum response factor (MRTF/SRF) pathway represents a promising therapeutic target t

187 CCG-222740, a novel MRTF/SRF inhibitor, markedly decreased SRF reporter gene acti

188 ts of new pharmacological inhibitors of MRTF/SRF signalling in a preclinical model of fibrosis.

189 We conclude that inhibitors of MRTF/SRF-regulated gene transcription such as CCG-222740, pot

190 d showed a greater inhibitory effect on MRTF/SRF target genes than the previously described MRTF-A in

191 ed" treatment (resolution of IRF or >200 mum SRF only at foveal centre).

192 ls of HRT2 concomitantly disrupted myocardin/SRF and Notch transcription complex formation at respect

193 agged1 ligand- and Notch1-enhanced myocardin/SRF complex formation at the promoter CArG element.

194 ta indicate that TCF21 antagonizes the MYOCD-SRF pathway through multiple mechanisms, further establi

195 identified the first VSMC-enriched and MYOCD/SRF and TGF-beta1/SMAD-dependent TSPAN family member, wh

196 2 is regulated by 2 parallel pathways, MYOCD/SRF and TGF-beta1/SMAD, via distinct binding elements wi

197 cription by binding to SRF to form the MYOCD/SRF/CArG box triad (known as the ternary complex).

198 on OCT had better mean VA than eyes with no SRF (72.8 vs. 66.6 letters; P = 0.006).

199 o DeltaNT in a distinct assay (activation of SRF luciferase).

200 es observed in transcriptional activation of SRF or TEAD.

201 ndingly, TRIM32 attenuated the activation of SRF signaling and hypertrophy due to dysbindin, whereas

202 Patients with a larger area of SRF on ultrasound showed more RD progression from baseli

203 nce, and the presence and characteristics of SRF noted on optical coherence tomography.

204 A combination of SRF, GATA6 and CRP2 required CSRP2BP for robust smooth m

205 ption factor/coactivator complex composed of SRF/Mkl1.

206 CAGE increased peak blood concentrations of SRF by 2.2-fold.

207 The determination of SRF is conducted at a reading centre while the assessmen

208 PTEN interacts with the N-terminal domain of SRF and PTEN-SRF interaction promotes SRF binding to ess

209 ision and weak positive prognostic effect of SRF.

210 oth cell types, individual binding events of SRF molecules segregated into three chromatin residence

211 rate that IGF2BP1 promotes the expression of SRF in a conserved and N6-methyladenosine (m6A)-dependen

212 CaP patient-derived xenograft, expression of SRF target genes was maintained while AR target gene exp

213 K-regulated ternary complex factor family of SRF partner proteins.

214 A constitutively active form of SRF/Mkl1 was not sufficient to induce focal adhesion ass

215 icates cell shape is a stronger indicator of SRF and TEAD mechanosignaling pathways than coactivators

216 The elimination half-life of SRF was also increased by 2-fold and the mean absorption

217 s in the nuclear subcellular localization of SRF and MAL.

218 37 of 46 (80%) individuals; the location of SRF accumulation varied.

219 The detection and measurement of SRF were also highly accurate with an AUC of 0.92 (range

220 ays and cofactors demonstrated modulation of SRF chromatin occupancy by actin signaling, MAP kinases,

221 Overexpression of SRF or beta2 integrins rescues HSPC engraftment defects

222 nscription factor SRF, and overexpression of SRF rescues impaired chromosome condensation and segrega

223 The presence of SRF did not lead to permanent ocular sequelae.

224 The presence of SRF was common in study participants undergoing treatmen

225 ting the therapy, there was no recurrence of SRF.

226 eferentially affected androgen regulation of SRF over direct AR target genes.

227 ulated, respectively, androgen regulation of SRF target genes.

228 monthly until either complete resolution of SRF and intraretinal fluid (IRF; intensive arm: SRF into

229 isted on OCT in patients after resolution of SRF and papilledema.

230 half-time PDT showed complete resolution of SRF within 6 months after PDT, but 3 eyes that received

231 in the PDT group had complete resolution of SRF, while none of the HSML-treated patients had complet

232 , respectively, had a complete resolution of SRF.

233 -treated patients had complete resolution of SRF.

234 GE provided excellent apparent solubility of SRF tosylate (> 500 mg/mL).

235 factor (SRF) and set the chromatin state of SRF-targeted genes early growth response 1 (egr1) and c-

236 ta2 integrins are transcriptional targets of SRF.

237 y to ECM stiffness, and compare with that of SRF/MAL, which is another important regulator of differe

238 A protocol to adjudicate on SRF has been established by the central reading centre a

239 PKN1's effects on SRF relied on its kinase domain.

240 A via their respective DNA-binding partners (SRF and TEAD) and is therefore indirect, arising as a co

241 t Q8wks), and 52% (ranibizumab) of patients; SRF resolved in 75% (both aflibercept Q4wks/Q8wks) and 6

242 found in patient characteristics, persistent SRF or IRF, or on-study events to account for the observ

243 s that received half-dose PDT had persistent SRF before loss to follow-up at months 5, 7, and 8 (P =

244 cCSC patients with persistent SRF at the final visit of the PLACE trial were included.

245 We highlight PGC1alpha, SRF and the MEF2 family as transcription factors that ma

246 technique for the evaluation of predonation SRF and allows a reliable prediction of donor's PDKF.

247 The difference of predonation SRF between preserved and donated kidney was the lowest

248 ain of SRF and PTEN-SRF interaction promotes SRF binding to essential promoter elements in SM-specifi

249 s with the N-terminal domain of SRF and PTEN-SRF interaction promotes SRF binding to essential promot

250 itch, namely mAKAPbeta signalosome-regulated SRF phosphorylation, that controls a transcriptional pro

251 Finally, we demonstrate that regulated SRF expression, in turn, is critical for the effects of

252 in IGF2BP1 and the transcriptional regulator SRF modulate gene expression in cancer.

253 tical coherence tomographic imaging revealed SRF beneath the interdigitation zone.

254 e was associated with lower volumes for RPE, SRF, NSR, and sPED; in second-treated eyes, older age wa

255 ranibizumab T&E protocol who tolerated some SRF achieved VA that is comparable, with fewer injection

256 l delivery of a hydrophobic drug, sorafenib (SRF).

257 Time to first sustained SRF clearance seemed to be shorter in the IAI arms versu

258 We provide a study of single Halo-tagged SRF molecules in fibroblasts and primary neurons.

259 Analysis of direct TCF-SRF target genes and chromatin modifiers confirmed this

260 Mechanistic studies revealed that SRF-CAGE solution spontaneously formed a self-assembled

261 driving immediate response, suggesting that SRF activity mirrors the build-up and release of sleep p

262 The SRF accurately reproduced the dynamics of SCRE and its d

263 The SRF pathway registers changes in G-actin levels, leading

264 The correlation coefficient between the SRF area at baseline and worst relative RD progression f

265 d a gene expression program initiated by the SRF/MRTF transcriptional pathway, which results in a mel

266 In conclusion, these findings identify the SRF/IGF2BP1-, miRNome- and m6A-dependent control of gene

267 TCF21, including at a novel enhancer in the SRF gene, and at the MYOCD gene promoter.

268 ro and in vivo induces the expression of the SRF (serum response factor), myocardin, and MRTFA (myoca

269 hese peaks correlated with activation of the SRF cofactors MRTF-A and MRTF-B (myocardin-related trans

270 ncer CArG box regulates transcription of the SRF gene, and mutation of this conserved motif in the or

271 by impairing the miRNA-directed decay of the SRF mRNA.

272 These data support a central role of the SRF/MRTF pathway in the pathobiology of lung fibrosis an

273 led to MRTF nuclear shuttling to promote the SRF transcriptional activity required for entosis.

274 In vitro genome editing indicated that the SRF enhancer CArG box regulates transcription of the SRF

275 The majority of these SRF/IGF2BP1-enhanced genes, including PDLIM7 and FOXK1,

276 ated with ERM presence (P = 0.0045), thicker SRF (P = 0.0006), larger intraretinal cysts (P = 0.0015)

277 peting directly with the MRTFs for access to SRF.

278 MC-specific gene transcription by binding to SRF to form the MYOCD/SRF/CArG box triad (known as the t

279 (PKN1) transduces androgen-responsiveness to SRF.

280 The results suggested to SRF that gut microbiota have a causal role in carbohydra

281 Furthermore, PM blebbing triggered SRF-mediated up-regulation of the metastasis-associated

282 In turn, SRF cooperated with MEF2 to sustain the expression of LM

283 , IGF2BP1 sustains the expression of various SRF-target genes.

284 orrelation between predonation CT volumetric SRF of the preserved kidney and PDKF at day 3 was r = 0.

285 Preoperation CT volumetric SRF was determined and compared with MAG3-SRF, postopera

286 alysis showed agreement between CT volumetry SRF and MAG3-SRF (bias, 95% limits of agreement: ROI vs

287 nt with MEK inhibitors is not indicated when SRF is present.

288 bleb dynamics for cell-in-cell invasion when SRF is suppressed.

289 ecessary for both Dc-ODP and Pc-ODP, whereas SRF and MEF2 are only needed for Dc-ODP.

290 required for 2 patients (1 with VSR, 1 with SRF); others were treated with weight loss and acetazola

291 Among clinical patients, 2 (1 with SRF, 1 with CNVM) had distinctive retina-related VF defe

292 ent genes showing conserved association with SRF and IGF2BP1 expression indicate a poor overall survi

293 Eyes with SRF in the foveal center on OCT had better mean VA than

294 CSRP2BP directly interacted with SRF, CRP2 and myocardin.

295 transient, occurring in 9 participants with SRF (20%; 95% CI, 10%-33%).

296 In the 26 patients with SRF, the fovea was affected in 85%.

297 nctioning as an indispensible regulator with SRF to maintain the differentiated SM phenotype.

298 tor for CRP2 that works synergistically with SRF and myocardin to regulate smooth muscle gene express

299 and FOXK1, show conserved upregulation with SRF and IGF2BP1 synthesis in cancer.

300 nt treatments compared with patients without SRF, without PVD, or without either who may require more