ライフサイエンスコーパス: SRM

1 SRM 1950 is the first reference material developed speci

2 SRM 1950 Metabolites in Human Plasma is intended to have

3 SRM 612 (Trace Elements in Glass) was also analyzed desp

4 SRM 972a was developed in collaboration with the Nationa

5 SRM detection provides the relative quantitation of each

6 SRM domains are then polarized by the microtubule-depend

7 SRM is organized into three substrate-binding lobes pois

8 SRM or MRM modes were employed to avoid artifacts that a

9 SRM polarization requires F-actin but not the F-actin or

10 SRM signals are integrated to produce an array of peak a

11 SRM techniques allow the visualization of subcellular or

12 al certified reference materials (SRM 1568a, SRM 1570a, CRM 7503-a, BC211 and IPE-120) were analysed

13 thod was also applied to Tomato Leaves 1573a SRM to check the accuracy.

14 The ABHD5/SRM/spermidine axis in TAMs might represent a potential

15 ns below 1500 Hz, are critical for achieving SRM in NH listeners.

16 th in mice can be prevented by an additional SRM transgene in macrophages.

17 hese methods, biologists have begun adopting SRM to address a wide range of questions in many types o

18 ation outcome was best predicted by advanced SRM stage (hazard ratio, 4.89; P<0.0001) and diabetes me

19 thione are also moderately selective against SRM.

20 promises that must be made when designing an SRM experiment.

21 ing risks of mortality, all patients with an SRM should be considered for a biopsy when the results m

22 igated using CRM BCR679, NIST SRM 1573a, and SRM 1640a, as well as spiked recovery experiments.

23 electrophoresis than nephelometric data and SRM is unaffected by antigen excess.

24 groundwater, NIST SRM 1568b Rice Flour, and SRM 1632 bituminous coal.

25 Hg and Pb in NIST SRM 1547 peach leaves and SRM 1573a tomato leaves reference materials and three he

26 eference materials SRM 1547 Peach Leaves and SRM 1573a Tomato Leaves.

27 dard reference materials (BCR-482 Licken and SRM 1573a Tomato Leaves) and spiked real food and herb s

28 ultiple evolving G20 cultures and in another SRM, D. vulgaris Hildenborough.

29 We approach SRM from another direction: we focus on the current prac

30 Atrial SRM is identified on LGE-MRI, and extensive LGE (>/=30%

31 not readily detectable via antibody-based-, SRM- or conventional PRM assays.

32 accessory olfactory bulb stimulation before SRM acquisition blocked long-term SRM, supporting the in

33 Patients were categorized by SRM stage (I-IV) based on the percentage of LA wall enha

34 quential analysis of fractionated eluates by SRM (SAFE-SRM), to plasma from cancer patients and disco

35 ent of these proteins in nuclear extracts by SRM permitted the reproducible quantification of 42% of

36 amples were digested by trypsin, followed by SRM detection.

37 with up to three charges, can be targeted by SRM on a triple quadrupole instrument.

38 s Proteotypic Predictor, to select candidate SRM transitions when no previous mass spectrometry evide

39 proteome and its use in selecting candidate SRM peptides to establish assays for use in determining

40 enges are addressed to effectively correlate SRM with other microscopy techniques, including light mi

41 also discuss the application of correlative SRM to materials characterization and single-molecule re

42 Application of DD-SRM to human serum and tissue provides precise quantific

43 ed an antibody-independent deep-dive SRM (DD-SRM) approach that capitalizes on multidimensional high-

44 Thus, DD-SRM holds great promise for precisely measuring extremel

45 tein level were observed when comparing DDA, SRM and LA-ICP-MS results.

46 developed an antibody-independent deep-dive SRM (DD-SRM) approach that capitalizes on multidimension

47 asurements of diagnostic product ions during SRM transitions by ratiometric comparisons with stable i

48 m was employed and cross-validated by LC-ESI-SRM-MS/MS.

49 We also evaluated SRM inhibition by tungstate in advective upflow oil-sand

50 to selected reaction monitoring experiments (SRM) as it may result in a gain in selectivity in detect

51 fort highlights the development of the first SRM for reduced nicotine and reduced tobacco-specific ni

52 ertified reference material (CRM) Rice Flour SRM 1568b (NIST) was used for the validation of both pro

53 For SRM inhibition, MFP is synergistic with nitrite and chlo

54 tions, composting may be a viable method for SRM disposal.

55 e that experimental conditions optimized for SRM 955c (caprine blood) are not valid for human blood s

56 of establishing precursor-product pairs for SRM.

57 Selecting the best peptides for SRM analysis to ensure that protein- or gene-specific in

58 s in Frozen Human Serum as a replacement for SRM 972, which is no longer available.

59 ple is more than 3 times lower than that for SRM 955c.

60 Radical nephrectomy for SRMs should only be reserved for patients who possess a

61 Partial nephrectomy (PN) for SRMs is the standard treatment that should be offered to

62 This novel 3D fluorescence-free SRM technique was successfully applied to resolve the po

63 presents the first of its kind for a gaseous SRM developed by NIST.

64 ncertainties specified to date for a gaseous SRM produced by NIST.

65 thmias (failed ablations) occurred at higher SRM stages with 28 of 133 (21.0%) in stage I, 40 of 140

66 The linear range of HILIC-SRM was slightly less ( approximately 3 orders of magnit

67 The performance was compared with two IA SRM methods which were recently validated for individual

68 ndard selected reaction monitoring assay (ID-SRM).

69 ved to be equivalent to the gold-standard ID-SRM in terms of sensitivity (1-10 ppm), accuracy, and pr

70 ate within a factor of 2 when compared to ID-SRM.

71 Despite its importance, SRM is still relatively little studied.

72 actions of interest, significantly improving SRM sensitivity by approximately 5 orders of magnitude w

73 As in SRM, quantification using DIA data is based on the area

74 ed in an Acquity BEH HILIC silica column, in SRM mode.

75 Averaged measurements of FA and 5-MTHF in SRM-1849a were within the certified value range.

76 ologists navigate through common pitfalls in SRM specimen preparation and optimization of image acqui

77 ecently we have made significant progress in SRM sensitivity for enabling quantification of low nanog

78 ithout precipitation, and completely inhibit SRM activity.

79 he applicability of the novel ambient LARESI SRM/MRM MSI method to both investigating and discovering

80 and conventional liquid chromatography (LC)-SRM (45 min gradient) showed that the long-gradient sepa

81 r multiplexing capacity than conventional LC-SRM due to an increase in average peak widths (~3-fold)

82 f magnitude when compared to conventional LC-SRM.

83 The immuno-LC-SRM assay has a limit of detection of 2 x 10(4) CFU/mL i

84 omatography selected reaction monitoring (LC-SRM) analyses of low-abundance peptides spiked into a hi

85 omatography-selected reaction monitoring (LC-SRM) approach that we demonstrate is capable of quantita

86 oupled with selected reaction monitoring (LG-SRM) for targeted protein quantification.

87 Direct comparison of LG-SRM (5 h gradient) and conventional liquid chromatograph

88 of >0.99 was observed for the results of LG-SRM and enzyme-linked immunosorbent assay (ELISA) measur

89 Further enhancement of LG-SRM sensitivity was achieved by applying front-end IgY14

90 Besides improved sensitivity, LG-SRM potentially offers much higher multiplexing capacity

91 The LG-SRM detection of seven out of eight endogenous plasma pr

92 Therefore, LG-SRM holds great potential for bridging the gap between g

93 st that the proposed oxygen and LLL12 loaded SRMs provide a promising drug delivery strategy for more

94 which hurdles still need to be taken to make SRM a robust and more accurate method for sFLC measureme

95 vide a basis for solar radiation management (SRM) geoengineering.

96 Spatial release from masking (SRM) occurs when spatial separation between a signal and

97 ffect known as spatial release from masking (SRM).

98 ptions for patients with small renal masses (SRMs).

99 y analysing the standard reference material (SRM 1577 b).

100 y analyzing the standard reference material (SRM 1640a) and spiked real samples.

101 ST) new protein standard reference material (SRM 8671) is becoming the benchmark molecule against whi

102 a bovine blood standard reference material (SRM 966, Level 2).

103 Standard Reference Material (SRM) 1649b Urban Dust was characterized; 34 organic acid

104 constitute NIST Standard Reference Material (SRM) 1720 Northern Continental Air, were certified by NI

105 and Technology Standard Reference Material (SRM) 1950, "Metabolites in Frozen Human Plasma", against

106 total sulfur in Standard Reference Material (SRM) 2682c Subbituminous Coal (nominal mass fraction 0.5

107 ) has developed Standard Reference Material (SRM) 972a Vitamin D Metabolites in Frozen Human Serum as

108 tobacco filler Standard Reference Material (SRM) has been issued by the National Institute of Standa

109 has developed a Standard Reference Material (SRM) to support technology development in metabolomics r

110 s in house dust standard reference material (SRM).

111 in a house dust standard reference material, SRM 2585, demonstrating their environmental relevance.

112 and Pb in NIST standard reference materials SRM 1547 Peach Leaves and SRM 1573a Tomato Leaves.

113 alidated using certified reference materials SRM 1570A (spinach leaves) with satisfactory and compati

114 Several certified reference materials (SRM 1568a, SRM 1570a, CRM 7503-a, BC211 and IPE-120) wer

115 NIST Standard Reference Materials (SRM) 3257 Catechin Calibration Solutions and 3255 Camell

116 ns of disposing of specified risk materials (SRM) or animal mortalities potentially infected with pri

117 dry whole air standard reference materials (SRMs 1720 and 1721) and the NIST Traceable Reference Mat

118 l materials or Standard Reference Materials (SRMs) from the National Institute of Standards and Techn

119 four powdered standard reference materials (SRMs) fused in lithium borate glasses: two sediments as

120 pheres as NIST standard reference materials (SRMs).

121 , randomly distributed sterol-rich membrane (SRM) domains form at the plasma membrane, independent of

122 bute to long-term social recognition memory (SRM) formation.

123 Social recognition memory (SRM) is crucial for reproduction, forming social groups,

124 hought to mediate social recognition memory (SRM).

125 d LLL12 in stimuli responsive microdroplets (SRMs) by a gas-driven coaxial flow focusing (CFF) proces

126 activity of sulfate-reducing microorganisms (SRM) is of grave concern because of the associated healt

127 produced by sulfate-reducing microorganisms (SRM) poses significant health and economic risks, partic

128 reservoirs, sulfate reducing microorganisms (SRM) produce hydrogen sulfide which is toxic, explosive,

129 respiratory sulfate reducing microorganisms (SRM), and no study has systematically and quantitatively

130 cal Raman spectroscopy (SRS) and microscopy (SRM).

131 of super-resolution fluorescence microscopy (SRM) opened an unprecedented vista into nanoscopic lengt

132 Super-resolution microscopy (SRM) bypasses the diffraction limit, a physical barrier

133 Final, 3D super-resolution microscopy (SRM) images were obtained by resolving 3D coordinates an

134 The rise of super-resolution microscopy (SRM) over the past decade has drastically improved the r

135 he field of superresolution (SR) microscopy (SRM).

136 s approach "Scientific Regret Minimization" (SRM), as it focuses on minimizing errors for cases that

137 Selected reaction monitoring mode (SRM) of tandem mass spectrometry was developed for analy

138 for the sulfate reduction pathway in a model SRM, we screened a panel of inorganic oxyanions.

139 used the fugacity-based small-region model (SRM) to calculate predicted environmental concentrations

140 This novel spectral resonance modulator (SRM) shows great potential in an ultrafast compressive s

141 odule, and the substrate recruitment module (SRM).

142 s method using selected reaction monitoring (SRM) aimed at quantitative profiling of the stoichiometr

143 MS assay using selected reaction monitoring (SRM) allows simultaneous quantitation of five molecular

144 SI MS/MS) with selected reaction monitoring (SRM) and quantitation by high mass accuracy analysis of

145 oduce a set of selected reaction monitoring (SRM) assays for the systematic measurement of 464 protei

146 ion (HRMS) and selected reaction monitoring (SRM) based mass spectrometric detection to quantify a po

147 rsor ions for selective reaction monitoring (SRM) detection.

148 time-triggered selected reaction monitoring (SRM) in positive electrospray ionization (ESI) mode.

149 methylation by selected reaction monitoring (SRM) is one of the current quantitative methods.

150 5, and PLF4 by selected reaction monitoring (SRM) liquid chromatography (LC)-MS/MS.

151 that utilizing selected reaction monitoring (SRM) mass spectrometry allows researchers to confirm pro

152 f principle, a selected reaction monitoring (SRM) mass spectrometry-based methodology was applied to

153 AC approach to selected reaction monitoring (SRM) mass spectrometry.

154 ometry (MS) in Selected Reaction Monitoring (SRM) mode is proposed for in-depth characterisation of m

155 re detected in selected reaction monitoring (SRM) mode, and transition m/z 874.3 --> 778.3 was used f

156 roid esters in selected reaction monitoring (SRM) mode, for the first time in ASAP.

157 d MS using the selected reaction monitoring (SRM) mode.

158 (SIM) mode and selected reaction monitoring (SRM) mode.

159 n SPROX using selective reaction monitoring (SRM) on a triple quadrupole mass spectrometer (QQQ-MS).

160 S) operated in selected reaction monitoring (SRM) or multiple reaction monitoring (MRM) modes was dev

161 erences in the selected reaction monitoring (SRM) transition of the signature peptide due to the incr

162 tform utilizes selected reaction monitoring (SRM) with polarity switching and amide hydrophilic inter

163 Similarly to selected reaction monitoring (SRM), peptides can be quantified from DIA data using tar

164 is the use of selected reaction monitoring (SRM), where the areas under the curve (AUCs) of peptides

165 performed by selective reaction monitoring (SRM), while the presence of a product ion at m/z 355, sp

166 ere describe a selected reaction monitoring (SRM)-based approach for the discovery and validation of

167 We applied selected reaction monitoring (SRM)-based proteomics, profiling 43 proteins in serum pr

168 rt an extended selected reaction monitoring (SRM)-based strategy to reproducibly and quantitatively m

169 tion (DDA) and selected reaction monitoring (SRM).

170 uantitation by selected reaction monitoring (SRM).

171 as achieved by selected reaction monitoring (SRM).

172 termination by selected reaction monitoring (SRM).

173 ed on selected/multiple reaction monitoring (SRM/MRM) mass spectrometry into the clinical laboratory

174 selective (or parallel) reaction monitoring (SRM/PRM) is challenging because of the high variability

175 teomics (e.g., selected reaction monitoring, SRM) is emerging as an attractive alternative to immunoa

176 ometric method selected reaction monitoring, SRM.

177 on state within its Slimb-recognition motif (SRM).

178 hat the adjacent stimulation response motif (SRM) stabilizes SANT1 and transiently samples its active

179 A novel LC/MS/MS SRM-based method has been developed to detect and quanti

180 NIST SRM 1515 Apple leaves and GBW-07605 Tea certified refere

181 NIST SRM 987 Sr was used as an internal standard, and the rep

182 ce materials (SLRS-4 Riverine water and NIST SRM 1515 Apple leaves).

183 sis of LGC 6010 Hard drinking water and NIST SRM 1573a Tomato leaves standard reference materials.

184 rformance using pooled human plasma and NIST SRM 1950 samples.

185 onors, mouse and rat plasma, as well as NIST SRM 1950 reference plasma.

186 thod was investigated using CRM BCR679, NIST SRM 1573a, and SRM 1640a, as well as spiked recovery exp

187 Comparing to consensus values for NIST SRM-1950, nearly 80% of comparable analytes demonstrated

188 and improving extraction of Cr(VI) from NIST SRM 2701, a standard COPR-contaminated soil.

189 -611) low level bromide in groundwater, NIST SRM 1568b Rice Flour, and SRM 1632 bituminous coal.

190 e determination of As, Cd, Hg and Pb in NIST SRM 1547 peach leaves and SRM 1573a tomato leaves refere

191 curate determination of all analytes in NIST SRM 1568b (rice flour).

192 his study is used to quantify lipids in NIST SRM 1950 human plasma annotated using LipidMatch and MZm

193 s of the APC and the reference material NIST SRM 1632d were compared to data in the literature.

194 ternational standard reference material NIST SRM 977 (delta(81)BrSMOB = -0.65 +/- 1.1 per thousand, 1

195 rice flour standard reference material (NIST SRM 1568a).

196 d using a certified reference material (NIST SRM 1643e) and groundwater sample analysis, indicating t

197 Technology Standard Reference Material (NIST SRM) 2779 Gulf of Mexico crude oil by GC coupled to vacu

198 lyses of certified reference materials (NIST SRM 1515 Apple leaves, IAEA 336 Lichen, GBW 07605 Tea).

199 nalysing certified reference materials; NIST SRM 1515 Apple leaves, IAEA-336 Lichen and GBW-07605 Tea

200 salt, Pb acetate, or in a soil matrix (NIST SRM 2710a).

201 oposed method was verified by measuring NIST SRM 3149 standard over different days (nine independent

202 o that of the bone mineral component of NIST SRM 1486 (bone meal), as determined by powder X-ray diff

203 h a QTA, as demonstrated by analysis of NIST SRM 1643e (trace elements in water).

204 the certified values in the analysis of NIST SRM 955c (Caprine Blood) Level 3 and the certified human

205 either dietary Pb source (Pb acetate or NIST SRM 2710a), low dietary P level markedly increased accum

206 he assay for standard reference plasma (NIST SRM 1950) were 107% and 6.7%, respectively.

207 ully applied to different food samples (NIST SRM 2976 mussel tissue, pepper, ginger, wheat flour, red

208 ne Premium Coal (APC) series and in the NIST SRM 1632d is presented.

209 5)Tl/(203)Tl ratio of a sample from the NIST SRM 997 Tl isotope standard in parts per 10(4)) versus 1

210 Interlaboratory variance for the NIST SRM-1950 has a median of 10% for amino acids, 24% for bi

211 identical within experimental errors to NIST SRM 2779, demonstrating that Marlin crude is an appropri

212 n a certified reference material, viz., NIST SRM 1640a natural water, which was found to be in good a

213 ed using certified reference materials (NIST-SRM-1946).

214 species concentrations for levels 2 and 4 of SRM 955c are reported here for the first time.

215 roposed method was evaluated by analysing of SRM Apple Leaves 1515 certified reference material.

216 Accuracy was assessed by analysis of SRM (Standard Reference Material) and recovery experimen

217 ccuracy of method, tested by the analysis of SRM 1566b and DORM-4 was in good agreement with the cert

218 y of the method was evaluated by analysis of SRM 1573a with good agreement compared to the certified

219 e method was investigated by the analysis of SRM and the recovery of analytes from various spiked foo

220 er, play major roles in the consolidation of SRM, but these roles are different in each structure vis

221 s in both structures in the consolidation of SRM.

222 To test the effectiveness of SRM mass spectrometry in determining protein abundance i

223 w opportunities in the fast-growing field of SRM.

224 MFP remains a potent inhibitor of SRM growing by fermentation, and MFP is tolerated by nit

225 ified perchlorate as a specific inhibitor of SRM.

226 state as a selective and potent inhibitor of SRM.

227 identify potent and selective inhibitors of SRM, quantitatively ranked the selectivity and potency o

228 erence material, three of the four levels of SRM 972a are composed of unmodified human serum.

229 experiments were conducted with a number of SRM isolates and enrichments at 30-80 degrees C and an i

230 ely evaluated the selectivity and potency of SRM inhibitors.

231 The plasma used in the preparation of SRM 1950 was collected from both male and female donors,

232 of reviews on the fundamental principles of SRM and the remarkable achievements made with these meth

233 s that may compromise the reproducibility of SRM data.

234 irectional hearing, but the possible role of SRM, or whether such specializations exhibit limitations

235 Here we expand the scope of SRM to photoactivated localization microscopy (PALM) ima

236 These results demonstrate the utility of SRM-based targeted proteomics to guide the identificatio

237 Histological validation of SRM was performed comparing LGE-MRI with surgical biopsy

238 e the effectiveness of tungstate as a potent SRM inhibitor, particularly at higher temperatures, and

239 odified from those utilized for the previous SRM, and all three approaches now incorporate chromatogr

240 The PRISM-SRM quantification of protein phosphorylation illustrate

241 rate that the CFF process is able to produce SRMs with uniform size distribution, large oxygen loadin

242 omized on the basis of known unlabeled Q1/Q3 SRM transitions and adjusted to account for the correspo

243 left atrial (LA) wall structural remodeling (SRM) and stratify patients who are likely or not to bene

244 nalysis of fractionated eluates by SRM (SAFE-SRM), to plasma from cancer patients and discovered two

245 rtified Reference Materials (marine sediment SRM 1944, fish tissue 1947, and loamy soil CRM 962-50) a

246 MFP) was not known previously as a selective SRM inhibitor, but has promising characteristics includi

247 caused by the digestion and a less selective SRM transition of the signature peptide as compared to u

248 s) in the standard reference material serum (SRM 1958, NIST).

249 We identified several SRM selective inhibitors including selenate, selenite, t

250 In samples with high levels of sFLC, SRM data was more consistent with serum protein electrop

251 use with UV and/or tandem mass spectrometry (SRM) detection.

252 ctive reaction monitoring-mass spectrometry (SRM-MS) is sufficiently sensitive to detect latent HIV r

253 ptimized and finally a sensitive streamlined SRM based analytical method for allergens detection in i

254 Potential implications for studying SRM in hearing-impaired listeners are discussed.

255 w that the lipolytic factor ABHD5 suppresses SRM-dependent spermidine production in TAMs and potentia

256 cally, ABHD5 suppresses spermidine synthase (SRM)-dependent spermidine production in macrophages by i

257 we present can be readily adapted to target SRM in diverse environments and similar strategies could

258 lly detected and quantified using a targeted SRM workflow.

259 e mice impaired the persistence of long-term SRM but had no effect on sociability and preference for

260 on test to evaluate short-term and long-term SRM in adult Sprague-Dawley male rats (n = 38).

261 Our results indicate that long-term SRM in rats involves protein synthesis and oxytocin-depe

262 ion before SRM acquisition blocked long-term SRM, supporting the involvement of LTD in the MeA in for

263 ated rats, which are known to lack long-term SRM.

264 of LTD in the MeA in formation of long-term SRM.

265 the MeA prevented the formation of long-term SRM.

266 is crucial for the persistence of long-term SRM.SIGNIFICANCE STATEMENT Oxytocin receptors (OXTRs) ar

267 We demonstrate that SRM can be extended toward reproducible detection and qu

268 Together, these results indicate that SRM-MS is a viable method for measuring latent HIV-1 res

269 We show that SRM protein analysis is a sensitive and rapid approach t

270 We conclude that SRMs are key to cell polarization.

271 The SRM method only measured a signature peptide generated f

272 The EZH2 TAD comprises the SRM (Stimulation-Responsive Motif) and SANT1 (SWI3, ADA2

273 on to this trend was the loss of PsbO in the SRM analysis, which highlights the necessity of validati

274 Within 60-80 minutes, the SRM method performs microbial identification (I), antibi

275 The relative orientations of the SRM and the motor on the nucleosome explain the directio

276 ditions suggests that the performance of the SRM increases when worst-case conditions are replaced by

277 he approach by demonstrating that two of the SRM-identified factors, Mot3 and Azf1, are required for

278 ntermediate precision analyses show that the SRM 1950 profiling is reproducible enough to consider th

279 ng, the results presented here show that the SRM strategy developed for multibiomarker measurement pa

280 The methodology was validated using the SRM NIST 1568a Rice Flour and recovery tests, with agree

281 tion of a single residue (Ser293) within the SRM is critical for Slimb binding and ubiquitination.

282 This SRM application is illustrated by the analysis of the hu

283 This SRM has certified and reference values for the following

284 This SRM was designed to apply broadly to the field, not towa

285 holds or improve localization accuracy, thus SRM does not operate in this range of spatial separation

286 The specific contribution of the MeA to SRM formation and the specific actions of oxytocin in th

287 (ENV) and temporal fine structure (TFS), to SRM in normal-hearing (NH) human listeners.

288 y of PRM assays were compared to traditional SRM workflows on triple quadrupole instruments.

289 The measurement accuracy in two SRMs was 71-113%.

290 Unlike SRM, data acquisition is not constrained to a predetermi

291 ounds and identified previously unrecognized SRM selective inhibitors and synergistic interactions be

292 We further use SRM to visualize nm-thin yet mum-long dynamic, supramole

293 Here, we provide guidance on how to use SRM techniques advantageously for investigating cellular

294 Using SRM, we find that incorporating a set of deontological p

295 /z 404-->m/z 386) in positive ESI mode using SRM scanning.

296 cialization has lowered the barrier to using SRM and the awarding of the Nobel Prize has drawn attent

297 ion of stable isotope labeling combined with SRM can overcome many of the current potential analytica

298 om surgical biopsy specimens correlated with SRM on LGE-MRI.

299 tion, we used 2D chromatography coupled with SRM of candidate peptides.

300 sFLC concentrations measured with SRM were comparable to those obtained by nephelometry an