1 SUDEP also mainly occurs during nighttime sleep.
2 SUDEP excludes other forms of seizure-related sudden dea
3 SUDEP typically occurs at night.
4 SUDEP typically occurs during the night following a seiz
5 SUDEP typically occurs during the night, although the re
6 SUDEP usually occurs when the seizures are not witnessed
7 SUDEP-prone Kcna1-/- mice with partial genetic ablation
8 Demographic and clinical information of
61 SUDEP cases were collected.
9 The
61 SUDEP cases were categorized as definite SUDEP (n = 54),
10 .1 channel subunits and are widely used as
a SUDEP model that mirrors key features in humans. To asse
11 pontaneous epileptic seizures resulting in
a SUDEP-like event are not preceded by cardiac arrhythmia.
12 s of BECTS are present in the North
American SUDEP Registry (NASR).
13 ocampus, culminating in seizure activity
and SUDEP.
14 duced the incidence of ictal bradycardia
and SUDEP in DS mice.
15 ot cardiac, KO of Scn1a produced cardiac
and SUDEP phenotypes similar to those found in DS mice.
16 profound postictal cerebral dysfunction,
and SUDEP.
17 to mechanisms and prevention of epilepsy
and SUDEP.
18 us Scn8a(N1768D/+) mice exhibit seizures
and SUDEP, confirming the causality of the de novo mutation
19 pyramidal neurons could lead to seizures
and SUDEP.
20 disorder, including spontaneous seizures
and SUDEP.
21 hough the exact relationship between sex
and SUDEP remains unclear.
22 Circumstances surrounding SIDS
and SUDEP deaths often facilitate CO(2) elevation, and fault
23 iorespiratory findings related to SUDEP,
and SUDEP animal models.
24 the present work we show, in freely
behaving SUDEP-prone transgenic mice, that apnea is induced when
25 the ryanodine receptor-2 (RyR2) gene in
both SUDEP and sudden cardiac death cases linked to catechola
26 grammed electrical stimulation. Two
captured SUDEP events, one per sex, displayed similar patterns of
27 = 54), probable SUDEP (n = 5), and
definite SUDEP plus (n = 2).
28 61 SUDEP cases were categorized as
definite SUDEP (n = 54), probable SUDEP (n = 5), and definite SUD
29 Two deaths were
definite SUDEP, and 1 was probable SUDEP.
30 iac injury at autopsy in a postmortem
DEPDC5 SUDEP case.
31 and brain-heart communication in
determining SUDEP susceptibility.
32 In this review, we
discuss SUDEP population studies, case-control studies, witnesse
33 Sudden unexpected death in
epilepsy (
SUDEP) accounts for approximately 1 in 5 deaths in patie
34 ed with sudden unexpected death in
epilepsy (
SUDEP) and behavioral alterations including hyperactivit
35 Sudden unexpected death in
epilepsy (
SUDEP) can affect individuals of any age, but is most co
36 Sudden unexpected death in
epilepsy (
SUDEP) has been linked to respiratory dysfunction, but t
37 taneous sudden unexpected death in
epilepsy (
SUDEP) in two of our strain combinations.
38 Sudden unexpected death in
epilepsy (
SUDEP) is a devastating complication of epilepsy with po
39 Sudden unexpected death in
epilepsy (
SUDEP) is a leading cause of epilepsy-related mortality
40 Sudden unexpected death in
epilepsy (
SUDEP) is increasingly recognized as a common and devast
41 Sudden unexpected death in
epilepsy (
SUDEP) is the leading cause of death in patients with re
42 STRACT: Sudden unexpected death in
epilepsy (
SUDEP) is the leading cause of epilepsy-related death.
43 Sudden unexpected death in
epilepsy (
SUDEP) is the leading cause of epilepsy-related mortalit
44 Sudden unexpected death in
epilepsy (
SUDEP) is the leading cause of premature death in patien
45 Sudden unexpected death in
epilepsy (
SUDEP) is the most common category of epilepsy-related m
46 Sudden unexpected death in
epilepsy (
SUDEP) is the most common cause of death in intractable
47 Sudden unexpected death in
epilepsy (
SUDEP) is the most common cause of death in patients wit
48 Sudden unexpected death in
epilepsy (
SUDEP) is the most common cause of death in patients wit
49 Sudden unexplained death in
epilepsy (
SUDEP) is the most common cause of premature mortality i
50 Sudden unexpected death in
epilepsy (
SUDEP) is the most extreme consequence of epilepsy.
51 risk of Sudden Unexpected Death in
Epilepsy (
SUDEP) of all epilepsy syndromes.
52 g lower sudden unexpected death in
epilepsy (
SUDEP) rates.
53 Sudden unexpected death in
epilepsy (
SUDEP) refers to the sudden death of a seemingly healthy
54 dels of sudden unexpected death in
epilepsy (
SUDEP) that exhibit audiogenic generalized convulsive se
55 d with sudden unexplained death in
epilepsy (
SUDEP), we propose that dysfunctions of KCNQ channels ma
56 ice to sudden unexplained death in
epilepsy (
SUDEP), which we recorded fortuitously in one animal.
57 bute to sudden unexpected death in
epilepsy (
SUDEP).
58 risk of sudden unexpected death in
epilepsy (
SUDEP).
59 nderlie sudden unexpected death in
epilepsy (
SUDEP).
60 ence of sudden unexpected death in
epilepsy (
SUDEP).
61 isk for sudden unexpected death in
epilepsy (
SUDEP).
62 ated in sudden unexpected death in
epilepsy (
SUDEP).
63 logy of sudden unexpected death in
epilepsy (
SUDEP).
64 due to sudden unexpected death in
epilepsy (
SUDEP).
65 risk of sudden unexpected death in
epilepsy (
SUDEP).
66 ial for sudden unexpected death in
epilepsy (
SUDEP).
67 isk for sudden unexpected death in
epilepsy (
SUDEP).
68 isk for sudden unexpected death in
epilepsy (
SUDEP).
69 isk of sudden unexplained death in
epilepsy (
SUDEP).
70 lity is sudden unexpected death in
epilepsy (
SUDEP).
71 isms of Sudden Unexpected Death in
Epilepsy (
SUDEP).
72 use of sudden unexplained death in
epilepsy (
SUDEP).
73 isk for sudden unexpected death in
epilepsy (
SUDEP).
74 ia, and sudden unexpected death in
epilepsy (
SUDEP).
75 ause of sudden unexpected death in
epilepsy (
SUDEP).
76 nation, sudden unexpected death in
epilepsy (
SUDEP, 18% of all deaths) did not fully explain the earl
77 redictor of early death even after
excluding SUDEP (e.g. reduction in years of life for those who had
78 epresent a promising class of biomarkers
for SUDEP risk stratification.
79 ltiple seizures was a strong risk factor
for SUDEP.
80 ic seizures are the greatest risk factor
for SUDEP; most often, SUDEP occurs after this type of seizu
81 No candidate genes
for SUDEP in Chinese people have been identified.
82 Little is known about candidate genes
for SUDEP in people of Chinese origin as most studies have a
83 s, to identify potential candidate genes
for SUDEP.
84 l apnea, may be a pathogenetic mechanism
for SUDEP.
85 ous system and establish an animal model
for SUDEP.
86 e that there is a time-of-day preference
for SUDEP, with more SUDEP occurring during the night.
87 ied from these cases as well as screened
for SUDEP, epilepsy, heart disease or respiratory disease-re
88 Four SUDEP cases (7%) had mutations in common genes responsib
89 38 (1.54%) of 2468 participants died
from SUDEP (12 definite, 18 probable, and eight possible SUDE
90 of SWA power compared with the other
groups (
SUDEP group mean 0.005 standardised error of the mean [S
91 dardised error of the mean [SEM] 0.003;
high-
SUDEP risk group -0.005, 0.002; low-SUDEP risk group -0.
92 SD 0.09; SD mean 0.54 s SD 0.35 s) and
high-
SUDEP risk groups (0.11, 0.03; 0.46 s, 0.19 s) compared
93 king Kcna1 a strong candidate gene for
human SUDEP.
94 This study aimed to
identify SUDEP risk markers using multimodality data with long-te
95 mice with bumetanide resulted in a delay
in SUDEP onset compared to controls in a subset of mice, wi
96 nerated to investigate the role of Depdc5
in SUDEP and cardiac activity during seizures.
97 To search for genetic risk factors
in SUDEP cases, we performed an exome-based analysis of rar
98 ppression (PGES) and apnea are implicated
in SUDEP.
99 es is common and suspected to play a role
in SUDEP.
100 Incident SUDEP mortality rate was 4.76 (95% CI 3.37-6.53) cases p
101 en premortem peri-ictal apnoea and
increased SUDEP risk.
102 4]) were significant predictors of
increased SUDEP risk.
103 euptake inhibitor (SSRI), blocks GCS-
induced SUDEP in both DBA/2 and DBA/1 mice.
104 luding epilepsy, sudden death syndromes
like SUDEP and SIDS, and cardiac arrhythmia.
105 03; high-SUDEP risk group -0.005, 0.002;
low-
SUDEP risk group -0.003, 0.002; non-epilepsy controls -0
106 .11, 0.03; 0.46 s, 0.19 s) compared with
low-
SUDEP risk group (0.08, 0.03; 0.30 s, 0.14 s) and non-ep
107 onger lifespans than males, suggesting
lower SUDEP rates.
108 es. This finding may contribute to the
lower SUDEP risk in females and underscores the complex interp
109 ffectively postictally, potentially
lowering SUDEP risk.
110 ible sleep interventions that could
mitigate SUDEP risk.
111 time-of-day preference for SUDEP, with
more SUDEP occurring during the night.
112 ies were found in the Utilization,
Mortality/
SUDEP, and Economic categories.
113 In cases with an LQTS gene
mutation,
SUDEP may occur as a result of a predictable and prevent
114 ve seizures and often associated with (
near)
SUDEP.
115 In a subanalysis excluding possible and
near-
SUDEP cases, longer ictal central apnoea was not signifi
116 eight possible SUDEP cases) and two had
near-
SUDEP events.
117 The aetiology
of SUDEP is unclear.
118 Understanding the genetic basis
of SUDEP may inform cascade testing of at-risk family membe
119 of SUDEP, while searching for biomarkers
of SUDEP risk embedded in electroencephalography (EEG) and
120 lity during sleep as potential biomarkers
of SUDEP risk.
121 and sleep-related respiratory biomarkers
of SUDEP risk.
122 Cases
of SUDEP among children who received a diagnosis of BECTS a
123 amples collected from five incident cases
of SUDEP identified in a large epilepsy cohort in rural Chi
124 tonic-clonic seizures precede most cases
of SUDEP, patients must be better educated about prevention
125 to lead to death in the majority of cases
of SUDEP.
126 The cause
of SUDEP remains unknown.
127 Respiratory failure is a leading cause
of SUDEP, and DS patients' frequently exhibit disordered br
128 from people with epilepsy who later died
of SUDEP (the SUDEP group) with data from age and sex-match
129 15, 2022, 41 participants who later died
of SUDEP and 123 matched controls (41 people living with ep
130 ep in people with epilepsy who later died
of SUDEP and in people with epilepsy at high risk of SUDEP.
131 ht in people with epilepsy who later died
of SUDEP, and an increase in respiratory variability during
132 ng video-EEG recording and who later died
of SUDEP.
133 underlying heart disorder may be a driver
of SUDEP risk.
134 A crucial element
of SUDEP is brainstem dysfunction, for which postictal gene
135 The frequency
of SUDEP varies depending on the severity of the epilepsy,
136 clinical data emphasize the heterogeneity
of SUDEP and its infrequent overlap with sudden cardiac dea
137 umbed to SUDEP and 6 had a family history
of SUDEP.
138 in-heart association as potential indices
of SUDEP susceptibility.
139 the Kcna1 knockout mouse (Kcna1-/-) model
of SUDEP, while searching for biomarkers of SUDEP risk embe
140 In two mouse models
of SUDEP we found that generalized convulsive seizures impa
141 D/+) (D/+) mice of both sexes, two models
of SUDEP, and found that convulsive seizures caused a posti
142 etion acts as protective genetic modifier
of SUDEP and suggest measures of brain-heart association as
143 nd increase in duration of PGES, the odds
of SUDEP increased by a factor of 1.7%(p < 0.005).
144 res indicated significantly elevated odds
of SUDEP with PGES durations of >50 seconds (p < 0.05).
145 rtant contributors to the pathophysiology
of SUDEP, and serotonin (5-HT) system dysfunction may be in
146 ons may contribute to the pathophysiology
of SUDEP.
147 greater importance to the pathophysiology
of SUDEP.
148 nterval had the greatest predictive power
of SUDEP risk (between-group point estimate difference 0.30
149 e for the increased night-time prevalence
of SUDEP ABSTRACT: Sudden unexpected death in epilepsy (SUD
150 e for the increased night-time prevalence
of SUDEP and that the underlying mechanism is phase conserv
151 ave important implications for prevention
of SUDEP in DS patients.
152 A sizeable proportion
of SUDEP cases have clinically relevant mutations in cardia
153 clonic seizure [GTCS] per year), low risk
of SUDEP (no history of GTCS), and non-epilepsy controls.
154 le with epilepsy, classified as high risk
of SUDEP (with >=1 generalised tonic-clonic seizure [GTCS]
155 The substantial lifetime risk
of SUDEP and the lack of a clear pathophysiological connect
156 gher the risk of SUDEP; furthermore, risk
of SUDEP is also elevated in male patients, patients with l
157 entifying which patients are most at risk
of SUDEP is hindered by a complex genetic etiology, incompl
158 Risk
of SUDEP may be increased in direct proportion to duration
159 Nighttime seizures may increase risk
of SUDEP via multiple mechanisms, as evident by peak sponta
160 people living with epilepsy at hight risk
of SUDEP, 41 people living with epilepsy at low-risk of SUD
161 1 people living with epilepsy at low-risk
of SUDEP, and 41 non-epilepsy controls) were enrolled.
162 o clinicians on ways to minimise the risk
of SUDEP, information to pass on to patients, and medicoleg
163 ractory epilepsy patients who are at risk
of SUDEP.
164 ery might contribute to reducing the risk
of SUDEP.
165 nical management of patients at high risk
of SUDEP.
166 and in people with epilepsy at high risk
of SUDEP.
167 respiratory features to predict the risk
of SUDEP.
168 IEE13 (OMIM 614558), which has a 10% risk
of SUDEP.
169 onic-clonic seizures, the higher the risk
of SUDEP; furthermore, risk of SUDEP is also elevated in ma
170 were found dead in circumstances typical
of SUDEP.
171 greatest risk factor for SUDEP; most
often,
SUDEP occurs after this type of seizure in bed during sl
172 Sudden unexpected death in epilepsy,
or SUDEP, is a devastating outcome of intractable epilepsy.
173 n of sudden unexpected death in epilepsy,
or SUDEP.
174 udden unexpected death in epilepsy
patients (
SUDEP).
175 12 definite, 18 probable, and eight
possible SUDEP cases) and two had near-SUDEP events.
176 tropine-sensitive ictal bradycardia
preceded SUDEP.
177 isk of seizure-induced death, and to
prevent SUDEP by enhancing postictal 5-HT tone.SIGNIFICANCE STAT
178 s how wearable devices might help to
prevent SUDEP.
179 ath, which may lead to novel ways to
prevent SUDEP.
180 could be a promising strategy for
preventing SUDEP.
181 gorized as definite SUDEP (n = 54),
probable SUDEP (n = 5), and definite SUDEP plus (n = 2).
182 aths were definite SUDEP, and 1 was
probable SUDEP.
183 en repository established in 2011 to
promote SUDEP research.
184 an effective therapeutic strategy to
reduce SUDEP risk in DS.
185 , exposure to toxic substances, or
suicide);
SUDEP classification was determined by the consensus of
186 Video monitoring demonstrated
that SUDEP occurred immediately following generalized tonic-c
187 Given
that SUDEP often occurs in association with generalised seizu
188 These findings suggest
that SUDEP is caused by apparent parasympathetic hyperactivit
189 It has been suggested
that SUDEP may kill over 20 000 people with epilepsy in China
190 The SUDEP group showed an abnormal lack of overnight decline
191 ath interval was significantly higher in
the SUDEP (coefficient of variation mean 0.15, SD 0.09; SD m
192 ger in the generalized motor seizures of
the SUDEP group (p < 0.001).
193 e with epilepsy who later died of SUDEP (
the SUDEP group) with data from age and sex-matched living p
194 t tested that blocks RA selectively in
these SUDEP models, which may be clinically relevant.
195 effects of the 5-HT(2B/2C) agonist in
these SUDEP models.
196 esentations that are likely to contribute
to SUDEP and discuss how wearable devices might help to pre
197 ary cardiac defects that could contribute
to SUDEP and therefore impact the clinical management of pa
198 sfunction in these systems may contribute
to SUDEP associated with mutations of Scn8a.
199 hypoxemia and hypercapnia may contribute
to SUDEP.
200 are, and thus has potential to contribute
to SUDEP.
201 hat might underlie a primary contribution
to SUDEP in the spectrum of DEPDC5-related epilepsies.
202 s, but physiological mechanisms that lead
to SUDEP are unknown.
203 model might be shared with those leading
to SUDEP.
204 t all autonomic manifestations are linked
to SUDEP.
205 eizure cardiorespiratory findings related
to SUDEP, and SUDEP animal models.
206 hort, of whom 3 DEPDC5 patients succumbed
to SUDEP and 6 had a family history of SUDEP.
207 The primary endpoint was time
to SUDEP.
208 Understanding the mechanisms
underlying SUDEP is paramount to developing preventative strategies
209 gest the most probable mechanisms
underlying SUDEP.
210 ould inform the development of a
validatable SUDEP risk index.
211 Understanding
why SUDEP occurs more frequently during the night may inform
212 psy and respiratory problems associated
with SUDEP.