ライフサイエンスコーパス: SV40 T antigen

1 the hepatitis C virus (NS3) and SV40 virus (SV40 T antigen).

2 y are stably transfected with both IRS-1 and SV40 T antigen.

3 ted by expression of wild-type (p53-binding) SV40 T antigen.

4 mechanisms regulating transformation by the SV40 T antigen.

5 tions of Pes1 with IRS-1 itself and with the SV40 T antigen.

6 uch as the papillomavirus E1 protein and the SV40 T antigen.

7 ependent DNA synthesis, totally dependent on SV40 T-antigen.

8 based on the nuclear localization signal of SV40 T-antigen.

9 r the nuclear localization signal motif from SV40 T-antigen.

10 emonstrated that Puralpha interacts with the SV40 T-antigen.

11 nd Rb tumor suppressors is a key activity of SV40 T-antigen.

12 tive helicases such as DnaB helicase and the SV40 T-antigen.

13 lial cells transformed with simian virus 40 (SV40) T antigen.

14 re driven to proliferate by simian virus 40 (SV40) T-antigen.

15 e insertion in the C-terminal portion of the SV40 T antigen, a region involved in the regulation of v

16 RB could be attenuated by the coinjection of SV40 T-antigen, adenovirus E1A, or a high level of E2F-1

17 SV40 T antigen also induces H3K18 hypoacetylation.

18 antly delayed in NHAs, and the expression of SV40 T antigen alters the cellular environment, which im

19 her DNA tumor virus origin-binding proteins, SV40 T antigen and Epstein-Barr virus nuclear antigen 1

20 o the FR, inhibits DNA unwinding in vitro by SV40 T antigen and Escherichia coli dnaB helicases in an

21 retroviral vector LoTPRRNLo which expresses SV40 T antigen and H-ras val12 oncogenes as a dicistroni

22 Both PC12 cells expressing SV40 T antigen and PC12 cells treated with p53 antisense

23 c alleles, specifically the simian virus 40 (SV40) T antigens and oncogenic Ras(12V), affect fatty ac

24 of cells) interacts with both IRS-1 and the SV40 T antigen, and markedly decreases the interaction o

25 use embryo fibroblasts can be transformed by SV40 T antigen, and that ErbB-3 may play a role in permi

26 ry complexes on the DnaB, T7 gene 4 protein, SV40 T-antigen, and UvrD DNA helicases.

27 ells was detected in direct association with SV40 T-antigen, and was therefore likely to be inactive.

28 mmortalized human fibroblasts expressing the SV40 T antigen (AR5 cells).

29 own that phosphorylation of simian virus 40 (SV40) T antigen at threonine 124 enhances the binding of

30 With sequence homology to the SV40 T antigen-binding domain of the retinoblastoma prot

31 ot analysis showed that 661W cells expressed SV40 T antigen, blue and green cone pigments, transducin

32 oding either MDM2 or a pRb-binding mutant of SV40 T antigen, both of which abrogate p53 function, sti

33 We show that the HPV16 E7 protein but not SV40 T antigen can complement mutations in the Ad5 E1A C

34 These results suggest that SV40 T antigen can regulate p53-mediated transcription e

35 rs and anthracyclines were studied in CEA424/SV40 T-antigen (CEA/Tag) transgenic mice, which develop

36 old derived from a scrambled sequence of the SV40 T-antigen consensus NLS (ScT).

37 e rats bearing the albumin promoter/enhancer SV40 T antigen construct as a transgene demonstrated a 2

38 ture, were transfected with simian virus 40 (SV40) T antigen-containing virus with a neomycin resista

39 These data suggest that SV40 T antigen contains a novel functional domain involv

40 Our results suggest that the SV40 T antigen could be a valuable tool to dissect cellu

41 The SV40 T antigen database is a listing of plasmids and/or

42 The SV40 T antigen database lists viruses and plasmids expre

43 e form, whereas DnaB, T7 gene 4 protein, and SV40 T-antigen did not.

44 We have shown that SV40 T-antigen diminished TGF-beta1 expression in glial

45 d a similar pattern of discrepancies between SV40 T-antigen DNA PCR results obtained with primers wit

46 with the isolated rolling circles, including SV40 T antigen, DNA polymerase alpha, replication protei

47 calvariae of transgenic mice containing the SV40 T-antigen driven by the mouse bone morphogenetic pr

48 protein, the adenovirus E4orf6 protein, and SV40 T antigen each can bind to p53 and inhibit p53 func

49 after attaining confluence, indicating that SV40 T antigen enhanced the intrinsic genomic instabilit

50 NS3 and SV40 T antigen enhanced the spontaneous rate of dissocia

51 proach to treating homozygous erythropoietin-SV40 T antigen (Epo-TAg(h)) mice with relative erythropo

52 cells, alphaB-crystallin-/- cells expressing SV40 T antigen exhibited a widespread cytocidal response

53 oncogenic transformation is elicited by the SV40 T antigens expressed under the control of the rat i

54 Gal I or ST8Sia I cDNAs are overexpressed in SV40 T antigen-expressing primate (COS) cells.

55 of the viral origin of replication (ori) by SV40 T antigen, followed by denaturation of ori in a rea

56 ndependent binding sites on simian virus 40 (SV40) T antigen for topoisomerase I (topo I) were identi

57 ns, we observed deletion of a portion of the SV40 T-antigen gene in 100% of replicated plasmid pZ189

58 h a selectable plasmid vector expressing the SV40 T-antigen gene resulted in high-frequency single-st

59 R was done with four sets of primers for the SV40 T-antigen gene.

60 carcinoma in situ of the bladder induced by SV40 T antigen had increased expression of cell cycle re

61 Like the Escherichia coli dnaB and SV40 T antigen helicases, therefore, the MCM complex is

62 amphotropic retroviral constructs containing SV40 T antigen, hTERT, and activated H-ras.

63 its complexes were detected in milk-derived, SV40 T-antigen-immortalized mammary luminal epithelial c

64 Co-expression of IRS-1 with the SV40 T antigen in 32D cells results in nuclear transloca

65 Although Pes1 can replace the SV40 T antigen in inducing colony formation in soft agar

66 ribe the results of their efforts to express SV40 T antigen in mature B cells of mice.

67 etastatogenesis in TRAMP mice, which express SV40 T antigen in the prostate epithelium.

68 m-specific expression of activated H-ras and SV40 T antigen in transgenic mice produced two distincti

69 Mice expressing SV40 T-Antigen in liver under control of the phosphoenol

70 e, we show that we could noninvasively image SV40 T antigen-induced prostate tumorigenesis in mice wi

71 SV40 T-antigen-induced apoptosis has generally been cons

72 We also found that SV40 T antigen inhibited the ability of RPA to increase

73 , chimeric-T-antigen constructs in which the SV40 T-antigen J domain was replaced with that from the

74 f normal human prostatic epithelial cells by SV40 T antigen led to a reduction in LRAT protein expres

75 by the temperature-sensitive tsA58 mutant of SV40 T antigen, MDP activity was not detectable, in cell

76 Here we found that SV40 T antigen-mediated transformation inhibits HCMV inf

77 of alphaT3 or DT (co-expressing IFNgamma and SV40-T-Antigen) mice and the transformed lens cells are

78 The transformed cells expressed the SV40 T antigen mRNA as assayed by reverse transcription

79 A simian virus 40 (SV40) T-antigen mutant containing only the N-terminal 13

80 transgenic expression of a simian virus 40 (SV40) T-antigen N-terminal fragment (N-termTag) is known

81 cortical cells with plasmids encoding hTERT, SV40 T antigen, neo, and green fluorescent protein.

82 lassical monopartite NLSs, such as c-myc and SV40 T-antigen NLSs.

83 an fibroblasts depleted of functional p53 by SV40 T antigen or HPV-16 E6, and primary embryo fibrobla

84 hibition of p53 function by the K1 mutant of SV40-T antigen or by m175 (Arg to His) dominant-negative

85 , mimicking a DNA structure found within the SV40 T antigen-ori complex.

86 that mimics a DNA structure found within the SV40 T antigen-origin (ori) complex.

87 grade 1 and minimal intrarenal expression of SV40-T antigen (P < 0.001).

88 cted the wild-type and R- cell lines with an SV40 T antigen plasmid and selected three clones from ea

89 umor suppressor p53 and pRb in urothelium by SV40 T antigen resulted in urothelial carcinoma, resembl

90 transform either W or R- cells; (3) Grb2 and SV40 T antigen, singly transfected, cannot transform R-

91 structures of the viral replicative helicase SV40 T antigen suggest that a novel concerted mode of nu

92 ll lines immortalized using simian virus 40 (SV40) T antigen, suggesting the possibility of transcomp

93 t of human telomerase (hTERT), together with SV40 T antigen (SV40T) and oncogenic N-ras.

94 ning the fetal globin promoter linked to the SV40 T antigen (T Ag) viral oncogene (Ggamma/T-15) resul

95 2dn or cdk3dn, is resistant to the action of SV40 T antigen (T).

96 formed between the origin-binding domain of SV40 T antigen (T-ag-obd), the initiator protein of the

97 ucture of a representative SF3 helicase, the SV40 T-antigen (T-ag).

98 The interaction of simian virus 40 (SV40) T antigen (T-ag) with the viral origin has served

99 he conditional expression of two transgenes, SV40 T antigen (TAg) and lacZ, can be tightly regulated

100 nt protein kinase (DNA-PK) which inactivates SV40 T antigen (TAg) by phosphorylation.

101 hat the MUC2 promoter could be used to drive SV40 T antigen (Tag) expression in the same cell type, d

102 ian virus 40 (SV40) pre-replication complex, SV40 T antigen (Tag) helicase actively loads replication

103 Transgenic mice expressing the oncogene SV40 T antigen (Tag) in the insulin-producing beta cells

104 ough seeding of tumorigenic hepatocytes from SV40 T antigen (Tag) transgenic MTD2 mice into the liver

105 derived from transgenic mice expressing the SV40 T antigen (Tag) under control of the tetracycline (

106 nse activity was determined by inhibition of SV40 T-antigen (TAg) expression in CV1 cells.

107 Interferon gamma (IFNgamma) induction of the SV40 T-antigen (TAg) was assayed by immunohistochemistry

108 ter also successfully directed expression of SV40 T-antigen (TAg), human E2F2, and dominant negative

109 tic islets of transgenic mice expressing the SV40 T-antigens (Tag) under transcriptional control of t

110 enic alleles, including the simian virus 40 (SV40) T antigen (TAg) and oncogenic H-Ras, inhibit HCMV

111 ementary assays to characterize functions of SV40 T antigen that are necessary for its ability to imm

112 N-terminus of human topoisomerase I and the SV40 T antigen that is detectable in vitro using both af

113 mortalization via genetic influences such as SV40 T-antigen, thus limiting our knowledge of the event

114 The ability of SV40 T antigen to block apoptosis was investigated in Ra

115 The inability of SV40 T antigen to complement suggests that RB binding on

116 FT cells derived from targeted expression of SV40 T antigen to mouse pituitary display characteristic

117 known about the ability of simian virus 40 (SV40) T antigen to bind single-stranded DNA.

118 iral vector encoding a temperature sensitive SV40 T antigen, to provide a snapshot of potential heter

119 We also find that SV40 T-Antigen tracks directionally while encircling dsD

120 ectopic CRBP expression in MTSV1-7 cells, a SV40 T antigen-transformed human breast epithelial cell

121 henomenon similar to postsenescent crisis of SV40 T-antigen-transformed human diploid fibroblasts in

122 ing ghrelinomas induced by a tissue-specific SV40 T-antigen transgene.

123 sed to target a temperature-sensitive mutant SV40 T antigen (tsA58) to smooth muscle in transgenic mi

124 f nuclear localization signals (NLSs) of the SV40 T-antigen type.

125 ng and producer cell lines developed express SV40 T antigen under the control of the reverse tetracyc

126 noma mouse prostate (TRAMP) mice express the SV40 T-antigen under the control of the probasin promote

127 s on a C57BL/6 (B6) background and expresses SV40 T-antigen under the probasin promoter.

128 line by directing expression of the oncogene SV40 T antigen using a gonadotrope-specific region of th

129 us cytopathic effects (CPE) were present and SV40 T antigen was detected in CV-1 cells cultured with

130 ficant, the original immortalizing oncogene, SV40 T antigen, was spontaneously lost.

131 effect of the receptor on transformation by SV40 T antigen, we established three independent fibrobl

132 mpetition assays using in vivo expression of SV40 T-antigen, we show here that the carboxyl-terminal

133 NS3 and SV40 T antigen were able to displace streptavidin from a

134 mine and a cationic decapeptide derived from SV40 T-antigen were only moderately active.

135 e vector, pZ402, that contains a mutation in SV40 T-antigen which blocks its ability to interact with

136 by exchanging the wt T-antigen for a mutant SV40 T-antigen, which is unable to bind with p53.