1 increase in the phosphorylation state of the Smad2 protein.

2 minish TGF-beta-triggered phosphorylation of Smad2 protein.

3 to the Smad2 promoter, and reduces levels of Smad2 protein.

4  expression of TGF-betaRI, TGF-betaRIII, and SMAD2 proteins.

5                  The corresponding Smad3 and Smad2 protein amounts were also decreased respectively b

6 igher ratio of phosphorylated Smad2 to total Smad2 protein and higher in vivo Smad2 reporter activity

7 ated kinase 1 (ERK1) increases the amount of Smad2 protein and leads to enhanced transcriptional acti

8  EBNA1 induces a lower steady-state level of SMAD2 protein as a consequence of increased protein turn

9                    No significant changes in SMAD2 protein expression and phosphorylation in either c

10                           By down-regulating Smad2 protein expression, EBNA1 apparently disables TGF-

11 La cells using small interfering RNA reduces Smad2 protein expression; this decrease is at least part

12 d Smad2/3 phosphorylation and elevated total Smad2 protein level were observed in Sulf1 siRNA-transfe

13 ein-Barr nuclear antigen-1 (EBNA1) decreased Smad2 protein levels and that this was responsible for P

14                             The elevation of Smad2 protein levels was because of increased half-life

15                                The amount of Smad2 protein was increased by transfection with a const

16 (DPC4), the downstream mediator of Smad3 and Smad2 proteins, with antisense oligodeoxynucleotide, als