ライフサイエンスコーパス: Spemann organizer

1 development and for Nodal expression in the Spemann organizer.

2 a known executer of cell migration from the Spemann organizer.

3 network giving rise to the formation of the Spemann organizer.

4 f Hensen's node, the avian equivalent of the Spemann organizer.

5 and Wnt inhibitors secreted dorsally in the Spemann organizer.

6 m, and mesendoderm, a tissue specific to the Spemann organizer.

7 xposed to the BMP-inhibiting activity of the Spemann organizer.

8 bryo functionally analogous to the amphibian Spemann organizer.

9 ndependent of the patterning activity of the Spemann Organizer.

10 ction of dorsal mesodermal cells to form the Spemann organizer.

11 lation and is necessary for formation of the Spemann organizer.

12 sal-ventral axis, from the blood through the Spemann organizer.

13 ts indicate that signaling activity from the Spemann Organizer alone may not be sufficient for dorsov

14 4, is expressed at the gastrula stage in the Spemann organizer and at later stages in the notochord a

15 athway and is necessary for formation of the Spemann organizer and dorsoanterior development in Xenop

16 l-related, are required for induction of the Spemann organizer and establishment of the body plan.

17 oxD3 is required for Nodal expression in the Spemann organizer and this function is essential for dor

18 ior mesoderm in response to signals from the Spemann organizer and underlying dorsoanterior endoderm.

19 l for beta-catenin-mediated formation of the Spemann organizer, and that Siamois acts prior to noggin

20 its RNA product becomes concentrated in the Spemann organizer at early gastrula stage.

21 at genes controlling cellular changes in the Spemann organizer at gastrulation might be reactivated i

22 gs, one of which, Xrgs4a, was expressed as a Spemann organizer component.

23 , it is expressed and regulated as a typical Spemann organizer component.

24 nes included several previously unrecognized Spemann organizer components.

25 Smad10 appears to function downstream of the Spemann organizer, consistent with a role in mediating o

26 or signaling pathways, thus establishing the Spemann organizer domain.

27 zed Xenopus embryos and was expressed in the Spemann organizer during early gastrulation.

28 signaling, leading to reduced expression of Spemann organizer effector genes and inducing head and a

29 ier nodal-related signals in endoderm and by Spemann-organizer factors that repress signalling by BMP

30 Unexpectedly, we found that blocking Spemann organizer formation by UV treatment or beta-Cate

31 rect transcriptional responses necessary for Spemann organizer formation.

32 A hallmark of Spemann organizer function is its expression of Wnt anta

33 R-1BX causes dorsoanterior deficits, reduced Spemann organizer gene expression, and inhibition of can

34 r the years, the molecular dissection of the Spemann organizer has proven to be a very fruitful sourc

35 hat is related to Frizzled, expressed by the Spemann organizer in frog embryos and can bind to and an

36 t-5A induced axis duplication and an ectopic Spemann organizer in the presence of hFz5, a member of t

37 The Spemann organizer induces neural tissue, dorsalizes meso

38 The results strengthen the view that the Spemann organizer is a source of secreted inhibitory fac

39 ADMP transcription in the Spemann organizer is activated at low BMP levels.

40 The Spemann organizer is an essential signaling center in Xe

41 The Spemann organizer is largely responsible for organizing

42 , the functional equivalent of the amphibian Spemann organizer is the dorsal shield.

43 pus, all mesoderm, with the exception of the Spemann organizer, is originally specified as ventral ty

44 Signals released by the Spemann organizer of the amphibian gastrula can directly

45 al-related 3 gene (Xnr3) is expressed in the Spemann organizer of the embryo and encodes a member of

46 Angptl4 is expressed in the Spemann organizer of Xenopus embryos and acts as a Wnt a

47 t inhibitor in human cancer cells and in the Spemann organizer of Xenopus embryos.

48 is highly expressed in the deep cells of the Spemann organizer prior to dorsal lip formation and in t

49 noggin is expressed in the Spemann organizer region of the Xenopus embryo and can p

50 nown for regulating cellular dynamics in the Spemann organizer, regulates delamination of neuroblasts

51 ons that inhibit or promote formation of the Spemann organizer signaling center.

52 ventrally restricted even in the absence of Spemann organizer signaling.

53 vo, and that in the absence of ventral BMPs, Spemann organizer signals are not required for brain for

54 We find that Xtwn is able to activate the Spemann organizer-specific gene goosecoid (gsc) via dire

55 F proteins in wnt signaling and identify the Spemann organizer-specific gene Xnr3 as a direct target

56 independent manner, whereas a panel of other Spemann organizer-specific genes did not respond to beta

57 The Spemann organizer stands out from other signaling center

58 The most famous example is the Spemann organizer that sets up embryonic axes in amphibi

59 ne in the axis running equatorially from the Spemann organizer-the so--called "dorsal/ventral axis"--

60 din (Chd) is an abundant protein secreted by Spemann organizer tissue during gastrulation.

61 Transplantation of Spemann organizer tissue showed that Chordin diffused ov

62 tg-x is expressed in the dorsal mesendoderm (Spemann organizer tissue) of gastrula stage embryos and

63 "left-right coordinator" interacts with the Spemann organizer to coordinate the evolutionarily conse

64 ctions as a transcriptional repressor in the Spemann organizer to maintain the expression of Nodal-re

65 Similar to experiments performed with the Spemann organizer, transplantation of the cumulus is abl

66 Chordin protein secreted by the dorsal Spemann organizer was found to diffuse along a narrow re

67 , encodes a secreted factor expressed in the Spemann organizer, where it functions to oppose the vent

68 al signals are required for formation of the Spemann organizer, which is essential for germ layer pat