ライフサイエンスコーパス: Src family

1 sites, including those that are dependent on Src family and FGFR kinase activity.

2 ent study, we show that CLEC-2 signaling via Src family and Syk tyrosine kinases promotes platelet ad

3 d, proximal cysteine (Cys277) found in three Src-family and six unrelated kinases.

4 Src-family and Syk kinases determine the structure of th

5 hanced neutrophil integrin signaling through Src-family and Syk kinases, whereas autoimmunity resulte

6 bosutinib, and saracatinib that target ABL, SRC-family, and numerous other kinases.

7 Nonreceptor tyrosine kinases of the Src family are large multidomain allosteric proteins tha

8 yrosine kinase library screen identified the SRC family as Y80-SOCS1 kinases.

9 uding the p160 steroid receptor coactivator (SRC) family composed of SRC-1 (NCOA1), SRC-2 (TIF2/GRIP1

10 oved multikinase inhibitor that also targets Src family, dramatically attenuated the spontaneous and

11 By using an MT1-MMP Y573A mutant or the Src family inhibitor PP2, we observed that the previousl

12 ed MFL epithelial cells was prevented by the SRC family inhibitor, SI-2.

13 rs successfully predicted TERT repression by Src-family inhibitor SU6656 and lack of repression by ER

14 g the tyrosine phosphorylation of C-Raf with Src family inhibitors blocks growth, basal dimerization,

15 Treatment of intact ECs with Src family inhibitors induced cytoplasmic localization o

16 dings show that SOCS1 phosphorylation by the SRC family inhibits its tumor-suppressive activity, indi

17 SRC1, another highly conserved member of the SRC family, interacts with RORgammat to regulate Th17 di

18 member of the steroid receptor coactivator (SRC) family, is recruited by transcription factors to re

19 izing cellular dynamics, we demonstrate that Src family isoforms produce very different phenotypes, e

20 Finally, we demonstrated that JAM-C controls Src family kinase (SFK) activation in LSC and that LIC w

21 Moreover, we present in vivo evidence that Src family kinase (SFK) activity is critical for PCP reg

22 the autophosphorylation site tyrosine in the SRC family kinase (SFK) FYN as well as Tyr142 in beta-ca

23 ro model of dormancy to evaluate the role of Src family kinase (SFK) in regulating this dormant-to-pr

24 of intracellular calcium but is sensitive to SRC family kinase (SFK) inhibition, suggestive of channe

25 Accordingly, inhibitors such as the SRC family kinase (SFK) inhibitor dasatinib reduced pPLC

26 tivation was completely abolished by the pan-Src family kinase (SFK) inhibitor, PP2, or when Syk is i

27 uced H2O2 is detected by the redox-sensitive Src family kinase (SFK) Lyn within the responding blood

28 mutation in the inhibitory SH2 domain of the SRC family kinase (SFK) LYN.

29 lar permeability attributable to loss of the Src family kinase (SFK) Lyn.

30 We tested the hypothesis that regulation of SRC family kinase (SFK) signaling by the scaffold protei

31 tment of neutrophils through redox-regulated Src family kinase (SFK) signaling in neutrophils.

32 alternative signaling activation mechanisms, Src family kinase (SFK) signaling is sufficient to trans

33 This reflects a mechanosensitive Src family kinase (SFK) signaling pathway that is activa

34 ined that CRKL signaling was associated with SRC family kinase (SFK) signaling, specifically with YES

35 nding macrophages by directly activating the Src family kinase (SFK) Src42A,(3) which in turn phospho

36 identified the concomitant activation of an Src family kinase (SFK), hematopoietic cell kinase (HCK)

37 educed GPVI expression and signaling via the Src family kinase (SFK)-Syk-PLCgamma2 pathway, and fibri

38 ne lipid rafts, leading to the activation of Src Family Kinase (SFK)/hemopoietic cell kinase (Hck) an

39 e carcinoma is associated with activation of SRC family kinase (SRC, YES, FYN) activity and loss of c

40 We identified Src family kinase activation mediated by mu-receptors as

41 These effects require Src family kinase activation, a classic LRP1-mediated Tr

42 that often overexpress SOCS1 also displayed SRC family kinase activation, constitutive phosphorylati

43 cription and secretion through inhibition of Src family kinase activation, particularly Lck, downstre

44 induces CaM phosphorylation at Tyr(99) by a Src family kinase and that phosphorylated CaM activates

45 or tyrosine kinases and EGF receptor, with a Src family kinase as a required intermediate.

46 Previous studies with various Src family kinase biosensors showed that the nuclear kin

47 signals through an evolutionarily conserved Src family kinase cascade to drive cytoskeletal rearrang

48 of Eps8 aimed to identify specific FGFR and Src family kinase dependent phosphosites and co-associat

49 ess (0.1-0.4 kPa), and such ILP formation is Src family kinase dependent.

50 tion increased receptor association with the Src family kinase Fgr and shifted signals from the adapt

51 The Src family kinase Fgr was identified as a downstream eff

52 In this study, the participation of the Src family kinase Fyn in the production of TNF after sti

53 he slit diaphragm and transduce signals in a Src family kinase Fyn-mediated tyrosine phosphorylation-

54 motif of ADAP, a known docking site for the Src family kinase Fyn.

55 gh formation of a signaling complex with the Src family kinase Fyn.

56 PGD is phosphorylated at tyrosine (Y) 481 by Src family kinase Fyn.

57 cells, and these genes include seven of nine Src family kinase genes, FGFR1, FGFR2, ITK, NTRK1, NTRK2

58 The Src family kinase Hck, Wiskott-Aldrich-syndrome protein,

59 lly disordered SH4 and Unique domains of the Src family kinase Hck.

60 Aberrant activation of the SRC family kinase hematopoietic cell kinase (HCK) trigge

61 thermore, MCR-independent phosphorylation of Src family kinase induces IgF1 receptor phosphorylation,

62 rylation is compromised in the presence of a Src family kinase inhibitor and when the SH3 domains of

63 igh levels of pY128Cas are more sensitive to SRC family kinase inhibitor Dasatinib.

64 Here, we sought to repurpose the Src family kinase inhibitor oncology compound, AZD0530,

65 regulated kinase (ERK1/2) was blocked by the Src family kinase inhibitor PP2, indicating that the act

66 , and cerebrospinal fluid penetration of the Src family kinase inhibitor saracatinib in patients with

67 nical trials using single agent dasatinib, a SRC family kinase inhibitor, have failed in sarcomas.

68 SRC family kinase inhibitors potentiated the SOCS1-p53 p

69 eased SOCS1 phosphorylation may benefit from SRC family kinase inhibitors.

70 rotein HER-2 increased the activation of the Src family kinase LCK and cytokine-induced STAT-5 signal

71 ng to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulate al

72 Src family kinase Lck plays critical roles during T cell

73 The Src Family kinase Lck sets a critical threshold for T ce

74 respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell a

75 cancer cells feature high expression of the Src family kinase Lyn that has been implicated in the pa

76 g, they did so by opposite regulation of the Src family kinase Lyn.

77 onocytes and that inhibition of the MAPK and Src family kinase pathways blocked the ability of CD4 li

78 C-2 receptor clustering, followed by Syk and Src family kinase phosphorylation, determined by the clu

79 The latter event is mediated by Lyn, a Src family kinase previously found to be overexpressed,

80 ng the underlying actin cytoskeleton through Src family kinase signaling and m-Tor-dependent protein

81 cones responses involve the potentiation of Src family kinase signaling, a common effector of both p

82 moattraction, or by pharmacological block of Src family kinase signaling, consistent with receptor re

83 hosphorylation of the SH2-kinase linker by a SRC family kinase such as LYN proto-oncogene, SRC family

84 We have previously demonstrated that the Src family kinase Yes, the Yes-associated protein (YAP)

85 c studies showed that these TKIs inhibit the Src family kinase Yes1, which was found to be essential

86 er kinetics of Erk1/2 activation through the src family kinase(s)-Syk signaling pathway.

87 2)R-cGMP downstream signaling molecules Src (Src family kinase), ERK (extracellular signal-related ki

88 orylation of Syk, Akt, and ERK, but not SFK (Src family kinase), was significantly reduced in RhoG-de

89 leading to integrin activation via the SFK (Src family kinase)-Syk (spleen tyrosine kinase)-PLCgamma

90 5beta1 integrin and the acylated form of the Src family kinase, Fyn, to lipid rafts.

91 siRNA-mediated suppression of Fyn, a Src family kinase, inhibited VSM cell motility.

92 Delta;Y567F/Y567F) knock-in mice lacking the SRC family kinase-binding site on KIT (pY567) exhibited

93 estricts TGF-beta1 secretion in a Cdc42- and Src family kinase-dependent manner and independently of

94 In stiff matrices, prolactin increased SRC family kinase-dependent phosphorylation of focal adh

95 presence of epidermal growth factor (EGF) by Src family kinase-mediated phosphorylation on c-Abl-Tyr4

96 Blockade of Src family kinase-mediated WASp Tyr-291/Tyr-293 phosphor

97 ptor type-protein tyrosine phosphatase alpha-Src family kinase-Rap1 pathway as responsible for recrui

98 yrosine phosphorylation is controlled by the Src family kinase.

99 been shown to confer enhanced sensitivity to SRC-family kinase (SFK) inhibitors in other malignancies

100 CD8 associates with the Src-family kinase (SFK) Lck, which, in turn, initiates t

101 Here we report that the Src-family kinase (SFK) regulator CD148 has a unique and

102 ation through receptor tyrosine kinase (RTK)/SRC-family kinase (SFK) signaling or mutant NRAS, which

103 Together, these findings suggest that Src-family kinase activation, NMDAR stimulation, and lik

104 These results support a model in which Src-family kinase binding induces conformational changes

105 arget peptide from an unrelated protein, the Src-family kinase Fyn.

106 s with the SH3 or the SH3-SH2 domains of the Src-family kinase Hck.

107 We further hypothesized that src-family kinase inhibition would improve barrier funct

108 sed the effect of TNF-alpha, with or without src-family kinase inhibitor SU6656, on barrier propertie

109 t; 0.25 or 2.5 mug/0.5 mul/hemisphere), PP2 (Src-family kinase inhibitor; 6.25 or 62.5 ng/0.5 mul/hem

110 Our previous work showed that the src-family kinase Lck is a targetable mediator of BCR si

111 In this article, we show that the Src-family kinase LCK, but not FYN, associates with NTB-

112 e tyrosine-phosphorylated by Pyk2, bound the Src-family kinase Lyn and linked TLR9 to a Src-kinase Sy

113 Upon Fc receptor activation, Src-family kinase signaling leads to segregation of Fcga

114 trated by independent association of the Lyn Src-family kinase with an intracellular immunoreceptor t

115 orthologue of Syk, and Src42A, a Drosophila Src-family kinase, and is dependent on Nox activity.

116 PPARgamma by inhibiting the activity of the Src-family kinase, Fyn.

117 Thus, extracellular actin detection via a Src-family kinase-dependent cascade is an ancient means

118 nduced CLEC-2 immunodepletion occurs through Src-family kinase-dependent receptor internalization in

119 se activation, NMDAR stimulation, and likely Src-family kinase-mediated NR2B subunit-containing NMDAR

120 hermore, the trophic factor S100beta induces Src-family kinase-mediated tyrosine phosphorylation of h

121 d DC activation occurred within minutes in a Src-family-kinase- and CD18-integrin-dependent manner.

122 Here we report that Src family kinases (SFK) and focal adhesion kinase (FAK)

123 The Src family kinases (SFK) and insulin-like growth factor-

124 tion of type-1 TNF receptors, recruitment of Src family kinases (SFK) and SFK-dependent phosphorylati

125 ustion through TICAM2 mediated activation of Src family kinases (SFK) and STAT1, as the application o

126 Focal adhesion kinase (FAK) and Src family kinases (SFK) are known to play critical role

127 n of these differences is that inhibition of Src family kinases (SFK) blocks TCR but not BCR signalin

128 Here we show the role of Src family kinases (SFK) in mouse and human pDCs.

129 Src family kinases (SFK) integrate signal transduction f

130 ORF4 protein (E4orf4) subverts signaling by Src family kinases (SFK) to perturb cellular morphology,

131 ER2 are activated through phosphorylation by Src family kinases (SFK).

132 d by PDGF, reactive oxygen species (ROS) and Src family kinases (SFKs) act downstream of PDGFRs to en

133 Src family kinases (SFKs) activation is required for int

134 engagement of LFA-1 led to the activation of SRC family kinases (SFKs) and SFK inhibition blocked cyt

135 The SRC family kinases (SFKs) and the receptor tyrosine kina

136 Src family kinases (SFKs) are a group of nonreceptor tyr

137 Src family kinases (SFKs) are involved in both NMDA-medi

138 The Src family kinases (SFKs) c-Src and Yes mediate vascular

139 ally, we found that different members of the Src family kinases (SFKs) can promote RIP2 tyrosine phos

140 oblastoma (GBM), the EGF receptor (EGFR) and Src family kinases (SFKs) contribute to an aggressive ph

141 Here we investigate how flaviviruses exploit Src family kinases (SFKs) for exit from infected cells.

142 The Src family kinases (SFKs) Lck, Hck, and Fgr directly pho

143 Src family kinases (SFKs) play a central role in mediati

144 The Src family kinases (SFKs) Src, Lyn, and Fyn are essentia

145 tyrosine phosphorylation indicated that, the Src family kinases (SFKs) were found to phosphorylate CD

146 The interactions of Src family kinases (SFKs) with the plasma membrane are c

147 This process was mediated by Src family kinases (SFKs), and nuclear EGFR had a role i

148 d this, we identified the involvement of the Src family kinases (SFKs), based upon the ability of SFK

149 ion of the C-terminal inhibitory tyrosine of SRC family kinases (SFKs), implicating CD148 as a critic

150 induced by IGF-1 can occur in cells lacking Src family kinases (SFKs), indicating that an unknown ki

151 embrane protein that acts as a substrate for SRC family kinases (SFKs), is overexpressed in a subset

152 r of the group of tyrosine kinases named the Src family kinases (SFKs), is overexpressed, associated

153 telet activation signals in conjunction with Src family kinases (SFKs), spleen tyrosine kinase (Syk),

154 PECAM-1 transduces forces to activate src family kinases (SFKs), which phosphorylate and trans

155 downregulated the expression and activity of Src family kinases (SFKs).

156 ctivation of kinases, Syk acts downstream of Src family kinases (SFKs).

157 ition and substrate recognition of the eight Src family kinases (SFKs).

158 urn is required to activate VEGFR2-recruited SRC family kinases (SFKs).

159 ial benefit of inhibitors for PI3K, Syk, and Src family kinases among these patients.

160 CD38, via Src family kinases and adapters, interacts with a MAPK s

161 TrkA was transactivated by Src family kinases and extracellular signal-regulated ki

162 sites depends on the direct interaction with Src family kinases and is upstream of the activation by

163 e co- or posttranslational myristoylation of Src family kinases and other oncogenic proteins, thereby

164 resulted in the following: 1) activation of Src family kinases and Syk revealed by their recruitment

165 activation was dependent on PKA and required Src family kinases and the Rap1 exchanger C3G.

166 etwork revealed decreased phosphorylation of Src family kinases and their targets.

167 e function of Csk as a negative regulator of Src family kinases appears to have arisen with the emerg

168 Src family kinases are required for normal PEAK1 localiz

169 Src family kinases are required for the generation of th

170 Src family kinases are thought to be major signaling eff

171 cence pathway and suggest that inhibition of SRC family kinases as personalized treatment in patients

172 Pharmacological inhibition of Src family kinases by SKI-606 (bosutinib) induces C/EBPd

173 ylation of a neighboring tyrosine residue by Src family kinases disrupts COP1 binding, thereby stabil

174 Inhibition of Src family kinases efficiently reduces the interaction o

175 Three major Src family kinases found in T cells (Lck, Fyn, and Lyn)

176 splaying high potency and selectivity toward SRC family kinases have been developed by combining liga

177 Mice lacking the Src family kinases Hck, Fgr, and Lyn in the hematopoieti

178 THrP elevated Y418 phosphorylation levels in Src family kinases in CD11b(+)Gr1(+) cells via osteoblas

179 ovide pharmacological evidence for a role of Src family kinases in CVP development.

180 CDCP1 is phosphorylated by Src family kinases in its full-length and cleaved states

181 ving cells, providing evidence for a role of Src family kinases in regulating growth factor induced A

182 morphology changes, which are independent of SRC family kinases in Src-/-, Yes-/-, Fyn-/- (SYF) mouse

183 osignaling and control of RhoA and implicate Src family kinases in the regulation of p115 RhoGEF.

184 demonstrate that YY1 is a target of multiple Src family kinases in vitro and in vivo.

185 nd is therefore capable of signaling without SRC family kinases or stimulation of the T cell receptor

186 Although Src family kinases participate in leukocyte function in

187 urs via a novel, sequential process in which Src family kinases phosphorylate the C-terminal ITIM, th

188 In the second phase, Src family kinases phosphorylate tyrosyl residues within

189 We show that Src family kinases play a critical role in myeloid cell-

190 er, the identification of YY1 as a target of Src family kinases provide key insights into the inhibit

191 -alphavbeta3 coupling altered recruitment of Src family kinases to adhesion complexes and impaired me

192 entified activated ephrin (EPH) receptor and Src family kinases upon NF2 loss.

193 Moreover, the activatory phosphorylation of Src family kinases was considerably delayed as well as t

194 Instead, Src family kinases were required for the generation of t

195 cellent selectivity over other TEC, EGFR and Src family kinases, (ii) desirable ADME, excellent in vi

196 nd treatment with dasatinib, an inhibitor of Src family kinases, also mimics the effects of versican.

197 ultimerization of DCC, activation of FAK and Src family kinases, and increases in exocytic vesicle fu

198 at the tyrosine residue is phosphorylated by Src family kinases, and that Src-activation limits surfa

199 This response required the NMDA-R, LRP1, Src family kinases, and Trk receptors.

200 Furthermore, TNFalpha, via SRC family kinases, increases pro-proliferative NOTCH2 s

201 he PSGL-1-L-selectin complex signals through Src family kinases, ITAM domain-containing adaptor prote

202 Finally, inhibition of Src family kinases, known to be involved in HB-EGF proce

203 Specifically, Src family kinases, NCK1 and Vav1, bound to the Tyr(P)(1

204 In addition to abrogating myristoylation of Src family kinases, PCLX-001 also promotes their degrada

205 he signaling through spleen tyrosine kinase, Src family kinases, phosphatidylinositol-3-kinase, and p

206 rosine residues that, when phosphorylated by Src family kinases, potentiate NMDAR activity.

207 wo GEFs are further regulated by FAK/ERK and Src family kinases, respectively.

208 signaling pathways mediated by RhoA/ROCK and Src Family Kinases, respectively.

209 Nef binds to the Src homology 3 domains of Src family kinases, resulting in kinase activation impor

210 3BP2 is required for optimal activation of Src family kinases, small GTPase Rac2, neutrophil supero

211 This in turn activates the Src family kinases, spleen tyrosine kinase and PLCgamma2

212 gnificant homology with other members of the Src family kinases, which may lead to unintended off-tar

213 Phosphorylation of paxillin by Src family kinases, which regulates adhesion turnover, i

214 ivating components in the network, including Src family kinases, whose inhibition affects only a subs

215 ested that this occurs through inhibition of Src family kinases.

216 ed production of ROS that was independent of Src family kinases.

217 le phosphorylation and activation of PI3K by Src family kinases.

218 ng the C-terminal inhibitory tyrosine of the src family kinases.

219 and provide insights into transformation by Src family kinases.

220 ells phosphorylates SLP-76 in the absence of SRC family kinases.

221 yrosine phosphorylation on FcRgamma chain or Src family kinases.

222 osphorylating the inhibitory tyrosine of the Src family kinases.

223 inding region of M2 and its interaction with Src family kinases.

224 could be attributed to reduced activation of Src family kinases.

225 its NPXY domains through phosphorylation by Src family kinases.

226 g Abl localization and Abl/Arg activation by Src family kinases.

227 SRC (proto-oncogene tyrosine-protein kinase Src) family kinases (SFKs), can be found in a significan

228 The corolla amplified active phosphorylated Src-family kinases (pSFK), LAT and PLC-gamma over T cell

229 ase (Csk), the primary negative regulator of Src-family kinases (SFK), plays a crucial role in contro

230 le of phosphoinositide 3-kinases (PI3Ks) and Src-family kinases (SFKs) in these responses using human

231 increased expression of c-Cbl, Vav1, and the Src-family kinases (SFKs) Lyn and Fgr.

232 haride-induced cell migration, activation of Src-family kinases (SFKs), and phosphorylation of focal

233 The activity of Src-family kinases (SFKs), which phosphorylate immunorec

234 tering of receptors, which in turn activates Src-family kinases (SFKs).

235 cell antigen receptor (TCR) is initiated by Src-family kinases (SFKs).

236 ound to be associated with the inhibition of Src-family kinases (SFKs).

237 factor-beta (TGF-beta), RhoA/Rho-kinase and Src-family kinases (SrcFK) have independently been impli

238 Amongst these are the Src-family kinases (SrcFKs), a multi-functional group of

239 analysis showed that SHP2 activates several SRC-family kinases and downstream targets, most of which

240 ion of integrins and involves stimulation of Src-family kinases and focal adhesion kinase, as well as

241 The synthesis of ROS by oxLDL/CD36 required Src-family kinases and protein kinase C (PKC)-dependent

242 DNGR-1 is phosphorylated by Src-family kinases and recruits the tyrosine kinase Syk

243 the specific requirement of HCK p59 and FGR src-family kinases for FCRL4-mediated immunomodulatory a

244 -based cells express increased levels of the src-family kinases HCK and FGR.

245 his study, we investigate the roles of these src-family kinases in FCRL4-mediated immunoregulation of

246 Thus, Src-family kinases in the DH may similarly control conte

247 encodes a tyrosine phosphatase that inhibits Src-family kinases responsible for Ag receptor signaling

248 either the SH3 or tandem SH3-SH2 domains of Src-family kinases reveal distinct dimer conformations o

249 activation and intracellular localization of SRC-family kinases, especially FYN and LYN.

250 c-Src is a tyrosine kinase belonging to the Src-family kinases.

251 r for C-terminal SRC kinase, an inhibitor of SRC-family kinases.

252 host cell effectors, including Hck and other Src-family kinases.

253 inding affinities of Gleevec between the two Src-family kinases.

254 s activity does not appear to be mediated by Src-family kinases.

255 ation, and Integrin beta1 phosphorylation by Src-family kinases.

256 gage cytoplasmic signaling molecules such as Src-family kinases.

257 omain regulatory interaction exists in other Src-family kinases.

258 ique and often contradictory roles played by Src-family-kinases (SFKs) in regulating cell physiology,

259 models, mainly because of the redundancy of Src family members and the importance of BCR signaling f

260 aracterize the molecular associations of the SRC family of coactivators with other protein complexes

261 his study, we investigated the activation of Src family of cytoplasmic tyrosine kinases (SFKs) and tw

262 ecent experiments have demonstrated that the Src family of kinases plays an important role in the reg

263 ade of phosphorylated proteins including the SRC family of kinases.

264 late neurogenesis.SIGNIFICANCE STATEMENT The Src family of nonreceptor tyrosine kinases acts in signa

265 The SRC family of proteins is important during pregnancy, es

266 nt procedure to test the hypothesis that the Src family of tyrosine kinases (SFK) in the dorsal hippo

267 The Src family of tyrosine kinases (SFKs) regulate numerous

268 rthermore, in vitro studies suggest that the Src family of tyrosine kinases critically regulates glut

269 In addition, we found that members of the Src family of tyrosine kinases were required for CVB ent

270 al Src kinase (CSK), a negative regulator of Src family of tyrosine kinases.

271 Fyn is a member of the Src-family of nonreceptor protein-tyrosine kinases.

272 , including several oncogenes of the Ras and Src families, palmitoylation is indispensable for protei

273 was blocked in cultured microglia by PP2, a Src family protein tyrosine kinase inhibitor.

274 1), and this inhibition is attenuated by the Src-family protein tyrosine kinase (SFK).

275 -3'-kinase, protein tyrosine kinases (PTKs), Src family PTK, focal adhesion kinase, Rho GTPase Rac1,

276 addition, it highlights a potential role for Src family signaling in this progenitor subtype of HCC.

277 erential downstream kinase signaling through SRC family-TNK2 or JAK kinases and differential sensitiv

278 We identified an IL-2-JAK-independent SRC family Tyr-kinase-controlled signaling network that

279 Interactions of LCK proto-oncogene, SRC family tyrosine kinase (LCK), and the IL-2-inducible

280 naling pathway, including LCK proto-oncogene SRC family tyrosine kinase (LCK), LYN proto-oncogene SRC

281 ly tyrosine kinase (LCK), LYN proto-oncogene SRC family tyrosine kinase (LYN), zeta chain of T-cell r

282 RC family kinase such as LYN proto-oncogene, SRC family tyrosine kinase (LYN).

283 face expression of TrkB that is inhibited by Src family tyrosine kinase and A2A receptor antagonists.

284 The protein Lck (p56(Lck)) is a Src family tyrosine kinase expressed at all stages of th

285 a TCR-associated complex, which includes the Src family tyrosine kinase Lck.

286 rough its downstream, intracellular Dab1 and Src family tyrosine kinase signaling cascade, is essenti

287 The SRC family tyrosine kinase YES1 is upregulated in rhabdo

288 We identified an Src family tyrosine kinase, hematopoietic cell kinase (H

289 Here, we determined that FYN, a Src family tyrosine kinase, interacts with the C-termina

290 phosphorylated forms of BCR-signaling nodes (Src family tyrosine kinase, spleen tyrosine kinase [SYK]

291 Protein phosphatase 2A (PP2A), YAP, Src family tyrosine kinases, Shc, phosphatidylinositol 3

292 Signaling is proximally mediated by Src family tyrosine kinases, the most abundant being Lyn

293 ponses can be mimicked through inhibition of Src family tyrosine kinases.

294 0) and Tyr(129), which are phosphorylated by Src family tyrosine kinases.

295 tase inhibition, and negatively regulated by Src-family tyrosine kinase activity, which restricts the

296 Deletion of lyn, a Src-family tyrosine kinase expressed by B, myeloid, and

297 Src-family tyrosine kinase Fyn and serine-threonine prot

298 ITAM receptors engage Src-family tyrosine kinases (SFKs) to initiate phagocyto

299 Activation of Src-family tyrosine kinases on the Golgi is essential fo

300 Inhibiting the kinases of the SRC family, which are downstream of PGRMC1, blocked the