ライフサイエンスコーパス: Src homology domain

1 tion, is tightly regulated by two inhibitory Src homology domains.

2 Small Src homology domain 2 (SH2) and 3 (SH3) adapter proteins

3 Src homology domains [i.e., Src homology domain 2 (SH2) and Src homology domain 3 (S

4 LC-gamma2-deficient cells reconstituted with Src homology domain 2 (SH2) domain mutant PLC-gamma2 did

5 ontaining a functional point mutation in the Src homology domain 2 (SH2) led to more rapid dephosphor

6 derived from TrkA (TAT-pQYP) that bound the Src homology domain 2 (SH2) of PLCgamma.

7 resulted in the tyrosine phosphorylation of Src homology domain 2 (SH2)-containing phosphatase-2 (SH

8 of BCR-mediated signaling via recruitment of Src homology domain 2 (SH2)-containing phosphatases.

9 ine phosphorylation and association with the Src homology domain 2 (SH2)-containing protein tyrosine

10 By contrast, SOCS-2 and cytokine-inducible Src homology domain 2 (SH2)-containing protein up-regula

11 er in a pathway downstream of EGL-15 and the Src homology domain 2 (SH2)/SH3-adaptor protein SEM-5/GR

12 factor receptor binding protein 2 (Grb2) and Src homology domain 2 containing (Shc) TbetaR-II, thereb

13 tory function of CEACAM1, was dependent upon src homology domain 2 containing phosphatase 1 activity,

14 lasmid or a small interference RNA targeting src homology domain 2 containing phosphatase 1.

15 the protein kinase A (PKA) pathway activates Src homology domain 2 containing protein tyrosine phosph

16 The two SH2 (Src homology domain 2) domains present in phospholipase

17 ion and VEGFR-2 deactivation, the latter via Src homology domain 2-containing (SH2-containing) tyrosi

18 B cells require the inositol 5-phosphatase, Src homology domain 2-containing inositol 5-phosphatase

19 ing protein tyrosine phosphatase (SHP) 2 and Src homology domain 2-containing inositol phosphatase 1

20 n of SIRP-alpha and downstream activation of Src homology domain 2-containing phosphatase-1.

21 We observed that ICAM-1 interacts with Src homology domain 2-containing phosphatase-2 (SHP-2),

22 ion of both the receptor and the phosphatase Src homology domain 2-containing protein tyrosine phosph

23 rosine-phosphorylated CTLA-4, and associated Src homology domain 2-containing protein tyrosine phosph

24 g binding to DCIR induced phosphorylation of Src homology domain 2-containing protein tyrosine phosph

25 is the binding site for both SOCS-3 and for Src homology domain 2-containing tyrosine phosphatase 2

26 endent on protein tyrosine phosphatase SHP2 (Src homology domain 2-containing tyrosine phosphatase 2)

27 Additionally, when immobilized Src homology domains 2 and 3 (SH2 and SH3, respectively)

28 pendent protein kinase (RIIDD(2)) and to the Src-homology domain 2 (SH2) of growth factor receptor-bo

29 The Src-homology domain 2 (SH2)-containing cytoplasmic tyros

30 r(P)(19)) may function as a docking site for Src homology domain-2 (SH2) domain containing proteins d

31 ar sequence of FGFRL1 consists of a putative Src homology domain-2 (SH2)-binding motif adjacent to a

32 ressing both heme oxygenase-1 (HO-1) and the Src homology domain-2 containing tyrosine phosphatase-1

33 Here we demonstrate noncanonical Src homology domain 3 (SH3) binding site motifs in the i

34 is mediated by an interaction of the second src homology domain 3 (SH3) domain of ponsin with the pr

35 proline rich, the hypothesis that it targets Src homology domain 3 (SH3) domains was tested, but muta

36 In eukaryotes, the Src homology domain 3 (SH3) is a very important motif in

37 An extensive search and analysis for Src homology domain 3 (SH3) ligand motifs revealed a myr

38 g mutant Myo5 proteins with deletions of the src homology domain 3 (SH3) or both TH2 and SH3 domains

39 Antennapedia-mediated delivery of Hck Src homology domain 3 (SH3), a domain that binds to the

40 e (GST) fusion proteins encoding the unique, Src homology domain 3 (SH3), and SH2 domains of Fyn, Hck

41 following either the loss or mutation of its Src homology domain 3 (SH3), resulting in both increased

42 mains [i.e., Src homology domain 2 (SH2) and Src homology domain 3 (SH3)] play a critical role in lin

43 evalence of modular protein domains, such as Src homology domain 3 and 2 (SH3 and SH2), among importa

44 l interfering RNA or myristoylated cortactin Src homology domain 3 blocking peptide attenuated ROS pr

45 cruitment of IRSp53 effector proteins to its Src homology domain 3 by promoting 14-3-3 binding in the

46 One class I ligand for Src homology domain 3 docking, found in the N terminus (

47 in Kalirin-9, with its Sec14p, spectrin, and Src homology domain 3 motifs, is essential for regulatin

48 -terminal and central regions of WRN and the Src homology domain 3 of c-Abl.

49 of cAMP-dependent PKA, adapter protein Grb2, Src homology domain 3 of tyrosine kinases Fyn and Abl, a

50 a potential interaction motif for the Noxa1 Src homology domain 3, caused up-regulation of basal and

51 nvolved in protein-protein interactions with Src homology domain 3-containing proteins.

52 This domain is one of the rare examples of Src homology domain 3-like folds in bacterial proteins,

53 Clear, unbiased electron density for the Src homology domain 3-like third domain, which is often

54 otyrosine-binding (PTB) domain and potential Src-homology domain 3 (SH3) binding sites.

55 the native state ensemble of the C-terminal src homology domain-3 (C-SH3) from Caenorhabditis elegan

56 ntramolecular interactions of the PLC-gamma1 Src homology domains and/or by positioning it for phosph

57 mulations to show how both myristoyl and the Src homology domains are required to impose the full inh

58 toylation consensus sequence and SH3 and SH2 Src homology domains, but lacks a tyrosine kinase domain

59 The Src homology domain containing phosphatase 2 (SHP2) and

60 at the cytoplasmic tail of CEACAM1 bound the src homology domain-containing phosphatase 1 and adaptor

61 development, whereas a tyrosine phosphatase Src homology domain-containing tyrosine phosphatase (Shp

62 In this study, we provide evidence that the Src-homology domain-containing adaptor Nck1 negatively r

63 terization of protein modules exemplified by Src Homology domains has revolutionized our understandin

64 Src homology domains [i.e., Src homology domain 2 (SH2)

65 se results fit a model which postulates that Src homology domain interactions are a molecular determi

66 Tyrosine kinase activity, a determinant of Src homology domain interactions, has a prominent effect

67 sented here suggest that, although cbl lacks src homology domains, it represents a novel intermediate

68 line-phenylalanine repeats, and proline-rich Src homology domain ligand sites.

69 minal catalytic domain (cGAP), or N-terminal Src homology domains (nGAP).

70 s with nanomolar affinity for the N-terminal Src homology domain of SHP2, good selectivity, stability

71 involve phosphotyrosine adapter molecules or src-homology domains of p85alpha, and extend to other st

72 The first 10 residues within the Src homology domain (SH)-4 domain of the Src family kina

73 intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displ

74 Intramolecular interactions between the Src homology domains (SH2 and SH3) and the catalytic dom

75 PI-3 kinase activation required a putative Src-homology domain (SH2) binding motif in the MyD88 Tol

76 etween the PH (pleckstrin homology) and SH2 (Src homology) domains that binds to IRbeta.

77 Tyr-783 in the beta1 tail, and that the Arg Src homology domain then engages this phosphorylated reg

78 tion of two C-terminal Grb10 motifs (BPS and Src homology domains) with receptor phosphotyrosine resi