ライフサイエンスコーパス: Src-family kinase

1 gulated proliferative response by activating Src family kinase.

2 yrosine phosphorylation is controlled by the Src family kinase.

3 ed production of ROS that was independent of Src family kinases.

4 le phosphorylation and activation of PI3K by Src family kinases.

5 ng the C-terminal inhibitory tyrosine of the src family kinases.

6 and provide insights into transformation by Src family kinases.

7 ells phosphorylates SLP-76 in the absence of SRC family kinases.

8 yrosine phosphorylation on FcRgamma chain or Src family kinases.

9 osphorylating the inhibitory tyrosine of the Src family kinases.

10 inding region of M2 and its interaction with Src family kinases.

11 osphorylating the inhibitory tyrosine of the src family kinases.

12 d cortactin were identified as substrates of Src family kinases.

13 s suggest a role of GD3 in the regulation of Src family kinases.

14 could be attributed to reduced activation of Src family kinases.

15 its NPXY domains through phosphorylation by Src family kinases.

16 g Abl localization and Abl/Arg activation by Src family kinases.

17 ested that this occurs through inhibition of Src family kinases.

18 c-Src is a tyrosine kinase belonging to the Src-family kinases.

19 r for C-terminal SRC kinase, an inhibitor of SRC-family kinases.

20 host cell effectors, including Hck and other Src-family kinases.

21 inding affinities of Gleevec between the two Src-family kinases.

22 s activity does not appear to be mediated by Src-family kinases.

23 ation, and Integrin beta1 phosphorylation by Src-family kinases.

24 gage cytoplasmic signaling molecules such as Src-family kinases.

25 tinib, a clinical Bcr-Abl inhibitor, targets Src-family kinases.

26 omain regulatory interaction exists in other Src-family kinases.

27 erimentally observed association of BCR with Src-family kinases (10-20 s).

28 Pharmacologic inhibition of src family kinases abolished Vav1 phosphorylation by oxL

29 We identified Src family kinase activation mediated by mu-receptors as

30 These effects require Src family kinase activation, a classic LRP1-mediated Tr

31 cal reagents, PP2 and Dasatinib, which block Src family kinase activation, blocked scattered growth o

32 that often overexpress SOCS1 also displayed SRC family kinase activation, constitutive phosphorylati

33 cription and secretion through inhibition of Src family kinase activation, particularly Lck, downstre

34 Together, these findings suggest that Src-family kinase activation, NMDAR stimulation, and lik

35 The second-stage binding requires Src family kinase activity to initiate CD8 binding to th

36 of this inhibitory circuit was dependent on Src-family kinase activity and consequent to biased BCR

37 Saracatinib, a specific inhibitor of Src family kinases, administered at low doses during the

38 nd treatment with dasatinib, an inhibitor of Src family kinases, also mimics the effects of versican.

39 ial benefit of inhibitors for PI3K, Syk, and Src family kinases among these patients.

40 induces CaM phosphorylation at Tyr(99) by a Src family kinase and that phosphorylated CaM activates

41 CD38, via Src family kinases and adapters, interacts with a MAPK s

42 myristic acid analog known to interact with Src family kinases and an inhibitor of cyclin dependent

43 TrkA was transactivated by Src family kinases and extracellular signal-regulated ki

44 lusive interaction between SRC but not other Src family kinases and FLT3-ITD, which is mediated by th

45 sites depends on the direct interaction with Src family kinases and is upstream of the activation by

46 e co- or posttranslational myristoylation of Src family kinases and other oncogenic proteins, thereby

47 ls through a signaling pathway that involves Src family kinases and p38 MAPK.

48 resulted in the following: 1) activation of Src family kinases and Syk revealed by their recruitment

49 activation was dependent on PKA and required Src family kinases and the Rap1 exchanger C3G.

50 etwork revealed decreased phosphorylation of Src family kinases and their targets.

51 analysis showed that SHP2 activates several SRC-family kinases and downstream targets, most of which

52 ion of integrins and involves stimulation of Src-family kinases and focal adhesion kinase, as well as

53 The synthesis of ROS by oxLDL/CD36 required Src-family kinases and protein kinase C (PKC)-dependent

54 DNGR-1 is phosphorylated by Src-family kinases and recruits the tyrosine kinase Syk

55 ultimerization of DCC, activation of FAK and Src family kinases, and increases in exocytic vesicle fu

56 required for TGFbeta1-mediated activation of Src family kinases, and Src inhibition blocked both pY65

57 at the tyrosine residue is phosphorylated by Src family kinases, and that Src-activation limits surfa

58 This response required the NMDA-R, LRP1, Src family kinases, and Trk receptors.

59 orthologue of Syk, and Src42A, a Drosophila Src-family kinase, and is dependent on Nox activity.

60 d DC activation occurred within minutes in a Src-family-kinase- and CD18-integrin-dependent manner.

61 e function of Csk as a negative regulator of Src family kinases appears to have arisen with the emerg

62 Src family kinases are required for normal PEAK1 localiz

63 Src family kinases are required for the generation of th

64 Src family kinases are thought to be major signaling eff

65 or tyrosine kinases and EGF receptor, with a Src family kinase as a required intermediate.

66 cence pathway and suggest that inhibition of SRC family kinases as personalized treatment in patients

67 These results support a model in which Src-family kinase binding induces conformational changes

68 Delta;Y567F/Y567F) knock-in mice lacking the SRC family kinase-binding site on KIT (pY567) exhibited

69 Previous studies with various Src family kinase biosensors showed that the nuclear kin

70 e not accompanied by the expected decline of Src family kinases but were accompanied by Akt-mammalian

71 Pharmacological inhibition of Src family kinases by SKI-606 (bosutinib) induces C/EBPd

72 signals through an evolutionarily conserved Src family kinase cascade to drive cytoskeletal rearrang

73 of Eps8 aimed to identify specific FGFR and Src family kinase dependent phosphosites and co-associat

74 ess (0.1-0.4 kPa), and such ILP formation is Src family kinase dependent.

75 endogenous ROS activate TrkB signaling by a Src family kinase-dependent but brain-derived neurotroph

76 estricts TGF-beta1 secretion in a Cdc42- and Src family kinase-dependent manner and independently of

77 ion of macrophage Vav in vitro in a CD36 and Src family kinase-dependent manner.

78 In stiff matrices, prolactin increased SRC family kinase-dependent phosphorylation of focal adh

79 Thus, extracellular actin detection via a Src-family kinase-dependent cascade is an ancient means

80 nduced CLEC-2 immunodepletion occurs through Src-family kinase-dependent receptor internalization in

81 ylation of a neighboring tyrosine residue by Src family kinases disrupts COP1 binding, thereby stabil

82 Inhibition of Src family kinases efficiently reduces the interaction o

83 2)R-cGMP downstream signaling molecules Src (Src family kinase), ERK (extracellular signal-related ki

84 activation and intracellular localization of SRC-family kinases, especially FYN and LYN.

85 tion increased receptor association with the Src family kinase Fgr and shifted signals from the adapt

86 The Src family kinase Fgr was identified as a downstream eff

87 the specific requirement of HCK p59 and FGR src-family kinases for FCRL4-mediated immunomodulatory a

88 Three major Src family kinases found in T cells (Lck, Fyn, and Lyn)

89 In this study, the participation of the Src family kinase Fyn in the production of TNF after sti

90 he slit diaphragm and transduce signals in a Src family kinase Fyn-mediated tyrosine phosphorylation-

91 gh formation of a signaling complex with the Src family kinase Fyn.

92 PGD is phosphorylated at tyrosine (Y) 481 by Src family kinase Fyn.

93 motif of ADAP, a known docking site for the Src family kinase Fyn.

94 arget peptide from an unrelated protein, the Src-family kinase Fyn.

95 5beta1 integrin and the acylated form of the Src family kinase, Fyn, to lipid rafts.

96 PPARgamma by inhibiting the activity of the Src-family kinase, Fyn.

97 cells, and these genes include seven of nine Src family kinase genes, FGFR1, FGFR2, ITK, NTRK1, NTRK2

98 splaying high potency and selectivity toward SRC family kinases have been developed by combining liga

99 r 3 uses templated catalysis to redirect the Src family kinase Hck to phosphorylate hDM2, a negative

100 The Src family kinase Hck, Wiskott-Aldrich-syndrome protein,

101 lly disordered SH4 and Unique domains of the Src family kinase Hck.

102 Mice lacking the Src family kinases Hck, Fgr, and Lyn in the hematopoieti

103 s with the SH3 or the SH3-SH2 domains of the Src-family kinase Hck.

104 -based cells express increased levels of the src-family kinases HCK and FGR.

105 Aberrant activation of the SRC family kinase hematopoietic cell kinase (HCK) trigge

106 cellent selectivity over other TEC, EGFR and Src family kinases, (ii) desirable ADME, excellent in vi

107 on neutrophils, P-selectin on platelets, and Src family kinases in both cell types.

108 THrP elevated Y418 phosphorylation levels in Src family kinases in CD11b(+)Gr1(+) cells via osteoblas

109 ovide pharmacological evidence for a role of Src family kinases in CVP development.

110 Interestingly, it also positively regulates Src family kinases in hematopoietic and endothelial cell

111 CDCP1 is phosphorylated by Src family kinases in its full-length and cleaved states

112 ving cells, providing evidence for a role of Src family kinases in regulating growth factor induced A

113 morphology changes, which are independent of SRC family kinases in Src-/-, Yes-/-, Fyn-/- (SYF) mouse

114 The possible roles of Src family kinases in the enhanced malignant properties

115 osignaling and control of RhoA and implicate Src family kinases in the regulation of p115 RhoGEF.

116 demonstrate that YY1 is a target of multiple Src family kinases in vitro and in vivo.

117 his study, we investigate the roles of these src-family kinases in FCRL4-mediated immunoregulation of

118 Thus, Src-family kinases in the DH may similarly control conte

119 Furthermore, TNFalpha, via SRC family kinases, increases pro-proliferative NOTCH2 s

120 thermore, MCR-independent phosphorylation of Src family kinase induces IgF1 receptor phosphorylation,

121 siRNA-mediated suppression of Fyn, a Src family kinase, inhibited VSM cell motility.

122 We further hypothesized that src-family kinase inhibition would improve barrier funct

123 rylation is compromised in the presence of a Src family kinase inhibitor and when the SH3 domains of

124 igh levels of pY128Cas are more sensitive to SRC family kinase inhibitor Dasatinib.

125 Here, we sought to repurpose the Src family kinase inhibitor oncology compound, AZD0530,

126 The Src family kinase inhibitor PP2 blocked injury-induced t

127 regulated kinase (ERK1/2) was blocked by the Src family kinase inhibitor PP2, indicating that the act

128 , and cerebrospinal fluid penetration of the Src family kinase inhibitor saracatinib in patients with

129 nical trials using single agent dasatinib, a SRC family kinase inhibitor, have failed in sarcomas.

130 leles exhibited a greater sensitivity to the Src family kinases inhibitor dasatinib in response to co

131 sed the effect of TNF-alpha, with or without src-family kinase inhibitor SU6656, on barrier propertie

132 imulated with antigen in the presence of the src-family kinase inhibitor, PP2.

133 t; 0.25 or 2.5 mug/0.5 mul/hemisphere), PP2 (Src-family kinase inhibitor; 6.25 or 62.5 ng/0.5 mul/hem

134 SRC family kinase inhibitors potentiated the SOCS1-p53 p

135 Pretreatment with pan-Src family kinase inhibitors, PP2 and dasatinib, abolish

136 eased SOCS1 phosphorylation may benefit from SRC family kinase inhibitors.

137 he PSGL-1-L-selectin complex signals through Src family kinases, ITAM domain-containing adaptor prote

138 Finally, inhibition of Src family kinases, known to be involved in HB-EGF proce

139 rotein HER-2 increased the activation of the Src family kinase LCK and cytokine-induced STAT-5 signal

140 ng to regulate T cell lineage commitment and SRC family kinase LCK and STAT5 signaling to regulate al

141 Src family kinase Lck plays critical roles during T cell

142 The Src Family kinase Lck sets a critical threshold for T ce

143 respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell a

144 fts function in the phosphoregulation of the Src family kinase Lck.

145 Our previous work showed that the src-family kinase Lck is a targetable mediator of BCR si

146 In this article, we show that the Src-family kinase LCK, but not FYN, associates with NTB-

147 ncreased activity of the negative regulatory Src family kinase Lyn and reduced activities of the posi

148 cancer cells feature high expression of the Src family kinase Lyn that has been implicated in the pa

149 g, they did so by opposite regulation of the Src family kinase Lyn.

150 e tyrosine-phosphorylated by Pyk2, bound the Src-family kinase Lyn and linked TLR9 to a Src-kinase Sy

151 presence of epidermal growth factor (EGF) by Src family kinase-mediated phosphorylation on c-Abl-Tyr4

152 Blockade of Src family kinase-mediated WASp Tyr-291/Tyr-293 phosphor

153 se activation, NMDAR stimulation, and likely Src-family kinase-mediated NR2B subunit-containing NMDAR

154 hermore, the trophic factor S100beta induces Src-family kinase-mediated tyrosine phosphorylation of h

155 Specifically, Src family kinases, NCK1 and Vav1, bound to the Tyr(P)(1

156 e with ActApo, including p38, JNK, PI3K-Akt, Src family kinases, NFkappaB p65, and AP1 transcription

157 Among Src family kinases only Yes, not Fyn or Src, was functio

158 tein that can function by the recruitment of Src family kinases or by competition with phosphatases.

159 nd is therefore capable of signaling without SRC family kinases or stimulation of the T cell receptor

160 Although Src family kinases participate in leukocyte function in

161 onocytes and that inhibition of the MAPK and Src family kinase pathways blocked the ability of CD4 li

162 In addition to abrogating myristoylation of Src family kinases, PCLX-001 also promotes their degrada

163 he signaling through spleen tyrosine kinase, Src family kinases, phosphatidylinositol-3-kinase, and p

164 urs via a novel, sequential process in which Src family kinases phosphorylate the C-terminal ITIM, th

165 In the second phase, Src family kinases phosphorylate tyrosyl residues within

166 C-2 receptor clustering, followed by Syk and Src family kinase phosphorylation, determined by the clu

167 We show that Src family kinases play a critical role in myeloid cell-

168 rosine residues that, when phosphorylated by Src family kinases, potentiate NMDAR activity.

169 The latter event is mediated by Lyn, a Src family kinase previously found to be overexpressed,

170 Increased activity of SRC family kinases promotes tumor invasion and metastasi

171 lly, phospho-specific staining for Zap70 and Src family kinase proteins suggests that sensing of subs

172 er, the identification of YY1 as a target of Src family kinases provide key insights into the inhibit

173 The corolla amplified active phosphorylated Src-family kinases (pSFK), LAT and PLC-gamma over T cell

174 ptor type-protein tyrosine phosphatase alpha-Src family kinase-Rap1 pathway as responsible for recrui

175 wo GEFs are further regulated by FAK/ERK and Src family kinases, respectively.

176 signaling pathways mediated by RhoA/ROCK and Src Family Kinases, respectively.

177 encodes a tyrosine phosphatase that inhibits Src-family kinases responsible for Ag receptor signaling

178 Additionally, inhibition of Src family kinases resulted in increased cellular retent

179 Nef binds to the Src homology 3 domains of Src family kinases, resulting in kinase activation impor

180 either the SH3 or tandem SH3-SH2 domains of Src-family kinases reveal distinct dimer conformations o

181 er kinetics of Erk1/2 activation through the src family kinase(s)-Syk signaling pathway.

182 Finally, we demonstrated that JAM-C controls Src family kinase (SFK) activation in LSC and that LIC w

183 Ls) to open the paracellular pathway through Src family kinase (SFK) activation.

184 Moreover, we present in vivo evidence that Src family kinase (SFK) activity is critical for PCP reg

185 the autophosphorylation site tyrosine in the SRC family kinase (SFK) FYN as well as Tyr142 in beta-ca

186 ro model of dormancy to evaluate the role of Src family kinase (SFK) in regulating this dormant-to-pr

187 of intracellular calcium but is sensitive to SRC family kinase (SFK) inhibition, suggestive of channe

188 Accordingly, inhibitors such as the SRC family kinase (SFK) inhibitor dasatinib reduced pPLC

189 s study, we show that the pyrrolo-pyrimidine Src family kinase (SFK) inhibitor PP2 effectively promot

190 tivation was completely abolished by the pan-Src family kinase (SFK) inhibitor, PP2, or when Syk is i

191 was inhibited in the presence of PP2, a pan-src family kinase (SFK) inhibitor, suggesting that c-Cbl

192 e AR by an alpha7 agonist was inhibited by a Src family kinase (SFK) inhibitor.

193 Previously, we found that the Src family kinase (SFK) Lyn functions as a redox sensor

194 uced H2O2 is detected by the redox-sensitive Src family kinase (SFK) Lyn within the responding blood

195 mutation in the inhibitory SH2 domain of the SRC family kinase (SFK) LYN.

196 lar permeability attributable to loss of the Src family kinase (SFK) Lyn.

197 We tested the hypothesis that regulation of SRC family kinase (SFK) signaling by the scaffold protei

198 tment of neutrophils through redox-regulated Src family kinase (SFK) signaling in neutrophils.

199 alternative signaling activation mechanisms, Src family kinase (SFK) signaling is sufficient to trans

200 This reflects a mechanosensitive Src family kinase (SFK) signaling pathway that is activa

201 ined that CRKL signaling was associated with SRC family kinase (SFK) signaling, specifically with YES

202 nding macrophages by directly activating the Src family kinase (SFK) Src42A,(3) which in turn phospho

203 resulted in increased phosphorylation of the SRC family kinase (SFK) YES, increased expression of WNT

204 identified the concomitant activation of an Src family kinase (SFK), hematopoietic cell kinase (HCK)

205 domain triggered PEAR1 phosphorylation in a src family kinase (SFK)-dependent manner.

206 crophages is, in addition, contributed to by Src family kinase (SFK)-dependent pathways.

207 glioblastoma, promotes tumorigenesis through Src family kinase (SFK)-dependent phosphorylation of Doc

208 educed GPVI expression and signaling via the Src family kinase (SFK)-Syk-PLCgamma2 pathway, and fibri

209 ne lipid rafts, leading to the activation of Src Family Kinase (SFK)/hemopoietic cell kinase (Hck) an

210 Here we report that Src family kinases (SFK) and focal adhesion kinase (FAK)

211 The Src family kinases (SFK) and insulin-like growth factor-

212 tion of type-1 TNF receptors, recruitment of Src family kinases (SFK) and SFK-dependent phosphorylati

213 ustion through TICAM2 mediated activation of Src family kinases (SFK) and STAT1, as the application o

214 Focal adhesion kinase (FAK) and Src family kinases (SFK) are known to play critical role

215 n of these differences is that inhibition of Src family kinases (SFK) blocks TCR but not BCR signalin

216 Here we show the role of Src family kinases (SFK) in mouse and human pDCs.

217 Src family kinases (SFK) integrate signal transduction f

218 ORF4 protein (E4orf4) subverts signaling by Src family kinases (SFK) to perturb cellular morphology,

219 ER2 are activated through phosphorylation by Src family kinases (SFK).

220 been shown to confer enhanced sensitivity to SRC-family kinase (SFK) inhibitors in other malignancies

221 CD8 associates with the Src-family kinase (SFK) Lck, which, in turn, initiates t

222 Here we report that the Src-family kinase (SFK) regulator CD148 has a unique and

223 ation through receptor tyrosine kinase (RTK)/SRC-family kinase (SFK) signaling or mutant NRAS, which

224 ase (Csk), the primary negative regulator of Src-family kinases (SFK), plays a crucial role in contro

225 demonstrate the activation of PLCgamma by a Src family kinase (SFK1) during NE assembly.

226 d by PDGF, reactive oxygen species (ROS) and Src family kinases (SFKs) act downstream of PDGFRs to en

227 Src family kinases (SFKs) activation is required for int

228 hese receptors lacking the binding sites for Src family kinases (SFKs) and phosphatidylinositol-3-kin

229 We found increased phosphorylation of Src family kinases (SFKs) and putative Src substrates in

230 engagement of LFA-1 led to the activation of SRC family kinases (SFKs) and SFK inhibition blocked cyt

231 e, we report that RUNX1 is phosphorylated by Src family kinases (SFKs) and that this occurs on multip

232 The SRC family kinases (SFKs) and the receptor tyrosine kina

233 Src family kinases (SFKs) are a group of nonreceptor tyr

234 Src family kinases (SFKs) are involved in both NMDA-medi

235 both fibroblast growth factor receptors and SRC family kinases (SFKs) but does not affect the abilit

236 The Src family kinases (SFKs) c-Src and Yes mediate vascular

237 ally, we found that different members of the Src family kinases (SFKs) can promote RIP2 tyrosine phos

238 oblastoma (GBM), the EGF receptor (EGFR) and Src family kinases (SFKs) contribute to an aggressive ph

239 Here we investigate how flaviviruses exploit Src family kinases (SFKs) for exit from infected cells.

240 The Src family kinases (SFKs) Lck, Hck, and Fgr directly pho

241 Src family kinases (SFKs) play a central role in mediati

242 The Src family kinases (SFKs) play essential roles in collag

243 The Src family kinases (SFKs) Src, Lyn, and Fyn are essentia

244 tyrosine phosphorylation indicated that, the Src family kinases (SFKs) were found to phosphorylate CD

245 The interactions of Src family kinases (SFKs) with the plasma membrane are c

246 This process was mediated by Src family kinases (SFKs), and nuclear EGFR had a role i

247 Anoxia or exogenous NMDA activated Src family kinases (SFKs), as measured by increased phos

248 d this, we identified the involvement of the Src family kinases (SFKs), based upon the ability of SFK

249 ion of the C-terminal inhibitory tyrosine of SRC family kinases (SFKs), implicating CD148 as a critic

250 induced by IGF-1 can occur in cells lacking Src family kinases (SFKs), indicating that an unknown ki

251 embrane protein that acts as a substrate for SRC family kinases (SFKs), is overexpressed in a subset

252 r of the group of tyrosine kinases named the Src family kinases (SFKs), is overexpressed, associated

253 , and subsequent TSAd-mediated activation of Src family kinases (SFKs), SFKs engage the receptor tyro

254 telet activation signals in conjunction with Src family kinases (SFKs), spleen tyrosine kinase (Syk),

255 PECAM-1 transduces forces to activate src family kinases (SFKs), which phosphorylate and trans

256 ER stress coincided with the inhibition of Src family kinases (SFKs), which was exacerbated by PTP1

257 downregulated the expression and activity of Src family kinases (SFKs).

258 ctivation of kinases, Syk acts downstream of Src family kinases (SFKs).

259 phorylation of the tyrosines in the ITAMs by Src family kinases (SFKs).

260 ition and substrate recognition of the eight Src family kinases (SFKs).

261 urn is required to activate VEGFR2-recruited SRC family kinases (SFKs).

262 SRC (proto-oncogene tyrosine-protein kinase Src) family kinases (SFKs), can be found in a significan

263 Multiple SRC-family kinases (SFKs) are commonly activated in carc

264 le of phosphoinositide 3-kinases (PI3Ks) and Src-family kinases (SFKs) in these responses using human

265 increased expression of c-Cbl, Vav1, and the Src-family kinases (SFKs) Lyn and Fgr.

266 haride-induced cell migration, activation of Src-family kinases (SFKs), and phosphorylation of focal

267 The activity of Src-family kinases (SFKs), which phosphorylate immunorec

268 cell antigen receptor (TCR) is initiated by Src-family kinases (SFKs).

269 CP1 might function through the activation of Src-family kinases (SFKs).

270 ound to be associated with the inhibition of Src-family kinases (SFKs).

271 tering of receptors, which in turn activates Src-family kinases (SFKs).

272 ique and often contradictory roles played by Src-family-kinases (SFKs) in regulating cell physiology,

273 ng the underlying actin cytoskeleton through Src family kinase signaling and m-Tor-dependent protein

274 cones responses involve the potentiation of Src family kinase signaling, a common effector of both p

275 moattraction, or by pharmacological block of Src family kinase signaling, consistent with receptor re

276 quitination of Ag.BCR complexes occurs by an Src family kinase signaling-dependent mechanism that is

277 n-like growth factor receptor signaling, and SRC family kinase signaling.

278 Upon Fc receptor activation, Src-family kinase signaling leads to segregation of Fcga

279 In addition, phosphorylation of Src family kinases significantly increased after stimula

280 3BP2 is required for optimal activation of Src family kinases, small GTPase Rac2, neutrophil supero

281 This in turn activates the Src family kinases, spleen tyrosine kinase and PLCgamma2

282 e carcinoma is associated with activation of SRC family kinase (SRC, YES, FYN) activity and loss of c

283 factor-beta (TGF-beta), RhoA/Rho-kinase and Src-family kinases (SrcFK) have independently been impli

284 Amongst these are the Src-family kinases (SrcFKs), a multi-functional group of

285 hosphorylation of the SH2-kinase linker by a SRC family kinase such as LYN proto-oncogene, SRC family

286 leading to integrin activation via the SFK (Src family kinase)-Syk (spleen tyrosine kinase)-PLCgamma

287 ithin RECs by elevating ROS, which activated Src-family kinases that stimulated the extracellular sig

288 -alphavbeta3 coupling altered recruitment of Src family kinases to adhesion complexes and impaired me

289 entified activated ephrin (EPH) receptor and Src family kinases upon NF2 loss.

290 Moreover, the activatory phosphorylation of Src family kinases was considerably delayed as well as t

291 orylation of Syk, Akt, and ERK, but not SFK (Src family kinase), was significantly reduced in RhoG-de

292 fic contribution of c-Src, one member of the Src family kinases, was demonstrated using c-Src-deficie

293 Rac1/WAVE2 and Cdc42/WASP pathways, whereas Src family kinases were required for proper WASP tyrosin

294 Instead, Src family kinases were required for the generation of t

295 gnificant homology with other members of the Src family kinases, which may lead to unintended off-tar

296 Phosphorylation of paxillin by Src family kinases, which regulates adhesion turnover, i

297 ivating components in the network, including Src family kinases, whose inhibition affects only a subs

298 trated by independent association of the Lyn Src-family kinase with an intracellular immunoreceptor t

299 We have previously demonstrated that the Src family kinase Yes, the Yes-associated protein (YAP)

300 c studies showed that these TKIs inhibit the Src family kinase Yes1, which was found to be essential