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1 engineering of secondary metabolite BGCs in Streptomyces.
2 ested, with the most notable exception being Streptomyces.
3 ted availability of the biochemical tools in Streptomyces.
4 r ion balance and coordinated development in Streptomyces.
5 influenced the contemporary biogeography of Streptomyces.
6 been widely reported in bacteria but none in Streptomyces.
7 and B, indolosesquiterpenoids isolated from Streptomyces.
8 eterologous expression of gene clusters from Streptomyces.
9 by the actinobacterial members of the genus Streptomyces.
10 the Frankia and other actinobacteria such as Streptomyces.
11 d cell envelope stress response in the genus Streptomyces.
12 microbial-resistant pathogens more than soil Streptomyces.
13 bacteria, including the antibiotic-producing Streptomyces.
16 Thal, also known as ThdH, from the bacterium Streptomyces albogriseolus at 2.55 angstrom resolution.
17 tures of tryptophan 6-halogenase (Thal) from Streptomyces albogriseolus using stopped-flow, rapid-que
18 me, hydroxyethylphosphonate dioxygenase from Streptomyces albus (SaHEPD), and find that it displays t
20 gene cluster was heterologously expressed in Streptomyces albus J1074 setting the stage for convenien
22 -membered metagenomic library constructed in Streptomyces albus, the species that exhibited the highe
24 we characterize reciprocal inhibition among Streptomyces and Fusarium populations from prairie soil,
28 s in the prolific antibiotic-producing genus Streptomyces and provide strong evidence that antibiotic
31 t only to bacterial PNPases from E. coli and Streptomyces antibioticus, but also PNPase from human mi
32 in that patterns of genetic diversity within Streptomyces are consistent with genome surfing, and we
33 tagonistic interactions between Fusarium and Streptomyces are driven by resource competition, and sup
41 metabolites, and provide global control over Streptomyces' arsenal of signaling and antagonistic comp
42 lase-mediated ICL unhooking was described in Streptomyces as a means of self-resistance to the genoto
44 is a potent antitumor antibiotic produced by Streptomyces atroolivaceus S-140, featuring an unusual 1
46 ) annotated to perform housekeeping roles in Streptomyces avermitilis Biochemical experiments define
47 ed in the transcriptome of a pure culture of Streptomyces avermitilis, suggesting for the first time
49 nthesis genes among virtually all species of Streptomyces bacteria (and genes for the biosynthesis of
53 has long been thought that the life cycle of Streptomyces bacteria encompasses three developmental st
54 rack the movement of an endophytic strain of Streptomyces bacteria throughout a managed strawberry ec
57 from the chalcomycin biosynthetic pathway in Streptomyces bikiniensis These studies provided a basis
60 myces bacteria among flowers and plants, and Streptomyces can move into the plant vascular bundle fro
64 ine biosynthetic pathway first discovered in Streptomyces cattleya While fluoroacetate has long been
66 D, X2 and X0beta, produced by the bacterium Streptomyces CBR38; and the macrolides elaiophylin, efom
67 A and efomycin G, produced by the bacterium Streptomyces CBR53.These metabolites were found at the i
69 red as a previously unreported metabolite of Streptomyces chromofuscus ATCC49982, and the gene cluste
71 gna unguiculata PLD, as well as the PLD from Streptomyces chromofuscus, cabbage, or peanuts, and no P
72 sequence of beta-lactam antibiotic-producing Streptomyces clavuligerus ATCC 27 064 is completed, whic
73 pentalenene synthase (Uniprot: B5GLM7) from Streptomyces clavuligerus was used in an automated compu
75 interaction between vancomycin and VanS from Streptomyces coelicolor (VanS(SC)), a model Actinomycete
76 of a cellulose-active family AA10 LPMO from Streptomyces coelicolor A3(2) (ScLPMO10C, also known as
77 member of the prodiginine group produced by Streptomyces coelicolor A3(2) and other actinobacteria.
79 ning RpfA function using the model bacterium Streptomyces coelicolor and have uncovered unprecedented
80 We describe here mutant alleles of ftsZ in Streptomyces coelicolor and Streptomyces venezuelae that
81 C-terminal HNH nuclease domain, Sco5333 from Streptomyces coelicolor and Tbis1 from Thermobispora bis
84 non-covalent inhibitors and GlgE, a variant Streptomyces coelicolor GlgEI (Sco GlgEI-V279S) was made
85 ucture resembles that of M. tuberculosis and Streptomyces coelicolor GlgEs, reported before, with eac
86 ructure, based on the cocrystal structure of Streptomyces coelicolor IHF duplex DNA, a bona fide rela
87 nd native mass spectrometry demonstrate that Streptomyces coelicolor NsrR (ScNsrR), previously report
88 ulating the nitrosative stress response like Streptomyces coelicolor NsrR, Sven6563 binds to a conser
89 Antibiotic production is coordinated in the Streptomyces coelicolor population through the use of di
91 e lipoprotein signal peptidase (lsp) gene in Streptomyces coelicolor results in growth and developmen
92 of this methodology to Bacillus subtilis and Streptomyces coelicolor revealed heterogeneity in chemic
94 d produced simocyclinone heterologously in a Streptomyces coelicolor strain engineered for improved a
95 onally, the macrodomain protein SCO6735 from Streptomyces coelicolor This protein is a member of an u
96 rt dynamics at the TNC of small laccase from Streptomyces coelicolor using paramagnetic NMR and elect
98 we confirmed that both aerobic prokaryotic (Streptomyces coelicolor) and eukaryotic (Homo sapiens) F
99 he distantly related Pgl system described in Streptomyces coelicolor, are widely distributed in ~10%
101 allowed for rapid heterologous expression in Streptomyces coelicolor, leading to the identification a
103 n B, oxytetracycline and avermectin B(1a) in Streptomyces coelicolor, Streptomyces venezuelae, Strept
104 ents of the transcriptome and translatome of Streptomyces coelicolor, the model antibiotic-producing
110 cal for normal growth and differentiation in Streptomyces, connecting ionic stress to development.
112 we show that new optimized derivatives from Streptomyces-derived griselimycin are highly active agai
118 ll biological approach, we show that the two Streptomyces dynamins specifically localize to sporulati
119 including formation of Bacillus endospores, Streptomyces exospores, and metabolically latent Mycobac
121 ng the composition of the growth medium, and Streptomyces explorer cells can communicate this explora
122 ovel antimicrobials, particularly the strain Streptomyces fildesensis So13.3, which first draft genom
125 sociated niches have selected some symbiotic Streptomyces for increased cellulose degrading activity
126 s the homologous P450 from tylosin-producing Streptomyces fradiae (TylHI) exhibits a high degree of s
127 For instance, in the antibiotic producer Streptomyces fradiae, a layered network of TetRs regulat
129 assess the distinct evolutionary lineages of Streptomyces from insect microbiomes as a source of new
130 of biosynthetic clusters by Lsr2 may protect Streptomyces from the inappropriate expression of specia
132 robials, yet discovery campaigns focusing on Streptomyces from the soil largely rediscover known comp
135 translational regulatory elements in GC-rich Streptomyces genomes is essential to elucidating the com
136 omain searches for TA pairs in the sequenced Streptomyces genomes, we identified two putative relBE l
137 We then applied decRiPPter to mine 1,295 Streptomyces genomes, which led to the identification of
140 rce for antibiotics discovery and members of Streptomyces genus have historically been studied as nat
143 ), a clinically relevant antitumor agent, by Streptomyces globisporus that negative feedback can exte
144 the polyketide natural product Aurodox from Streptomyces goldiniensis is able to block the pathogene
145 nucleoside blasticidin S (BS) isolated from Streptomyces griseochromogenes was the first non-mercuri
146 surprisingly, the eukaryote-like enzyme from Streptomyces griseus IleRS lacks this capacity; at the s
147 tiviral mechanism developed in the bacterium Streptomyces griseus SgrAI is a type II restriction endo
148 ense of NADPH, similar to its counterpart in Streptomyces griseus We obtained the crystal structure o
154 d the dimeric geometry from its hypothesized Streptomyces homologue CprB, which is a gamma-butyrolact
156 biosynthetic gene cluster in extremotolerant Streptomyces huasconensis HST28(T) from Salar de Huasco,
157 However, it is structurally more similar to Streptomyces hygroscopicus VldE, a GDP-valienol-dependen
159 s that drive plant biomass deconstruction in Streptomyces, including acquisition and selective retent
165 ass degrading genes (CAZy) are widespread in Streptomyces, key enzyme families are enriched in highly
167 t of the sporulation process, completing the Streptomyces life cycle by facilitating dispersal of spo
170 o it is not surprising that bacteria such as Streptomyces lividans can activate many of the available
171 nd PepN2, two neighboring PepN homologs from Streptomyces lividans were purified in E. coli but displ
173 o use KcsA (a K(+) channel from the bacteria Streptomyces lividans) as a surrogate because it lacks a
175 e desertomycin amidinohydrolase gene dstH in Streptomyces macronensis led to the accumulation of dese
176 tigation of another family member, EncP from Streptomyces maritimus, thereby expanding the biocatalyt
179 ates were treated with transglutaminase from Streptomyces mobaraensis and tyrosinase from Trichoderma
180 tion of microbial transglutaminase (TG) from Streptomyces mobaraensis in different types of restructu
181 second step with the less specific MTG from Streptomyces mobaraensis, a successful bio-orthogonal la
182 tion of microbial transglutaminase (TG) from Streptomyces mobaraensis, and bovine and porcine fibrino
184 for the nogalamycin monooxygenase (NMO) from Streptomyces nogalater As with flavin, dithranol oxidati
186 OlvS(A) encoded in the olv gene cluster from Streptomyces olivaceus NRRL B-3009 catalyzes the rearran
187 ally the same number of P450s in the genome, Streptomyces P450s are much more diverse than those of M
190 Cs and variable distribution patterns in the Streptomyces phylogeny, even among very closely related
191 cally abundant and geographically widespread Streptomyces phylogroups from our culture collection.
192 igate the key roles of type II TA systems in Streptomyces physiology and environmental stress respons
195 anipulation in the PTM-PTN dual overproducer Streptomyces platensis SB12029, revealing two genes, ptm
196 gase derived from a GH20 hexosaminidase from Streptomyces plicatus in which the catalytic acid/base g
198 ce for local adaptation between Fusarium and Streptomyces populations as indicated by significantly g
200 migatus, which is activated by the bacterium Streptomyces rapamycinicus during the bacterial-fungal i
201 se-binding lectin (SL2-1) from the bacterium Streptomyces rapamycinicus was identified by analysis of
202 ory network that controls differentiation in Streptomyces, repressing a large regulon of developmenta
203 which depend on a type IV secretion system, Streptomyces requires only TraB protein to transfer the
204 rs-e.g., from Photorhabdus luminescens TT01, Streptomyces resistomycificus, Streptoccocus sp. GMD2S,
206 consisting of orthogonal promoter sequences, Streptomyces ribosome binding sites, and yeast selectabl
208 epsipeptide derived from the soil saprotroph Streptomyces roseosporus, and its antibiotic properties
209 Collectively, these results suggest that in Streptomyces, Rpfs have a structural rather than signali
211 oral microbiome signature (Pseudoxanthomonas-Streptomyces-Saccharopolyspora-Bacillus clausii) highly
212 Here we report the crystal structure of Streptomyces sahachiroi AlkZ (previously Orf1), a bacter
214 zyme from the plant pathogen 87.22 strain of Streptomyces scabies Scabin shares nearly 40% sequence i
215 ce of a large and diverse number of P450s in Streptomyces secondary metabolism contributes to antibio
217 unexpectedly both abundant and widespread in Streptomyces Seven of 11 systematically selected T1PKS m
219 rectly cloned the skt gene cluster using the Streptomyces site-specific integration vector pSET152.
221 the marginolactone azalomycin F in mangrove Streptomyces sp. 211726 has shown that only nineteen ext
222 gates), were characterized as metabolites of Streptomyces sp. AD-23-14 isolated from the Rock Creek u
223 ), and tetranactin (3) in a crude extract of Streptomyces sp. AMC 23 in the precursor ion scan mode.
225 inamide construction in the marine bacterium Streptomyces sp. CNB-091, which involves a novel intermo
226 to identify nigericin in a crude extract of Streptomyces sp. Eucal-26 by means of precursor ion scan
228 9 (GenBank accession no. KU901725; 1313 bp), Streptomyces sp. Kz-28 (GenBank accession no. KY000534;
229 8 (GenBank accession no. KY000534; 1378 bp), Streptomyces sp. Kz-32 (GenBank accession no. KY000536;
230 GenBank accession no. KY000536; 1377 bp) and Streptomyces sp. Kz-67 (GenBank accession no. KY000540;
231 ene cluster for herbicidin A biosynthesis in Streptomyces sp. L-9-10 as well as its verification by h
232 identification of the cytochrome P450, NzeB (Streptomyces sp. NRRL F-5053), which catalyzes both inte
233 been isolated from laboratory cultures of a Streptomyces sp. obtained from a tropical marine sedimen
238 d the close relationship between CLI2509 and Streptomyces sp. SPB78, which was previously implicated
240 been isolated from laboratory cultures of a Streptomyces sp. Svetamycins A-D, F, and G are cyclic de
243 th MS-based molecular networking analysis of Streptomyces sp.QL37, elucidated 24 other rearranged and
245 s study, we examined a collection of diverse Streptomyces species for the best innate ability to hete
247 ted with primary metabolism in nonpathogenic Streptomyces species have been recruited as basic elemen
251 logous proteins are widely distributed among Streptomyces species, and their apparent substrate promi
252 nowledge about phylogenetic relationships of Streptomyces species, genome-wide diversity and distribu
253 a class of polyether ionophores produced by Streptomyces species, was investigated by accurate-mass
261 h-throughput transcriptional assay format in Streptomyces spp. by leveraging eGFP, inserted both at a
263 l species, and that at least for the case of Streptomyces, strain de-replication based on SSU gene se
264 lts highlight the potential of the Antarctic Streptomyces strains as a promising source of novel anti
265 activity of organic extracts from Antarctic Streptomyces strains was evaluated by disk diffusion ass
268 those governing sporulation of Bacillus and Streptomyces, suggesting that Myxococcus evolved a highl
269 rD3 genes from the apramycin gene cluster in Streptomyces tenebrarius were expressed in E. coli and t
272 mental behaviours in bacteria, here, causing Streptomyces to deviate from its classically-defined lif
274 During sporulation, the filamentous bacteria Streptomyces undergo a massive cell division event in wh
275 for conjugative plasmid transfer in mycelial Streptomyces Unlike other conjugative systems, which dep
278 vitro and in vivo experiments with WhiD from Streptomyces venezuelae (SvWhiD), which differs from S.
281 tion of this site, which is conserved in the Streptomyces venezuelae GlgE enzyme, did not affect the
283 GT1 family glycosyltansferase, Sv0189, from Streptomyces venezuelae ISP5230 (ATCC 10721) was charact
285 n the jadomycin biosynthetic gene cluster of Streptomyces venezuelae ISP5230, affects both chloramphe
288 leles of ftsZ in Streptomyces coelicolor and Streptomyces venezuelae that perturb cell division in su
289 es that c-di-GMP controls spore formation in Streptomyces venezuelae through sequestering the sporula
290 n (MTM) and pikromycin (PKM), co-produced by Streptomyces venezuelae, represent minimalist macrolide
291 avermectin B(1a) in Streptomyces coelicolor, Streptomyces venezuelae, Streptomyces rimosus and Strept
292 application of genome-wide approaches using Streptomyces venezuelae, which is capable of fairly sync
294 3(2), this strain is more closely related to Streptomyces violaceoruber ISP5049 than to the type stra
296 aenorhabditis elegans and the bacterial prey Streptomyces, which have evolved a powerful defense: the
297 he best studied representatives of the genus Streptomyces, which is the largest genus within the Acti
298 ed the feasibility of these affinity tags in Streptomyces, which will be widely employed to explore t
299 omycetes, which include members of the genus Streptomyces, with their bacterial cellular dimensions b
300 Vibrio cyclitrophicus, Escherichia coli and Streptomyces yokosukanensis, which has distinct genetic