ライフサイエンスコーパス: T antigen

1 ells transformed with simian virus 40 (SV40) T antigen.

2 n small T antigen (sTAg) and truncated large T antigen.

3 origin-binding domain of virus-encoded large T antigen.

4 ernatively spliced 57kT forms of MCPyV large T antigen.

5 genome has undergone mutations in the large T antigen.

6 tent expression of large T antigen and small T antigen.

7 D patients were transformed using SV40 large T antigen.

8 of the role of simian virus 40 (SV40) small t antigen.

9 sion in mice that express the Polyoma middle T antigen.

10 MCC tumors that fail to express MCPyV large T antigen.

11 xpresses small T antigen and truncated large T antigen.

12 nd in only 1 of 56 tumors positive for large T antigen.

13 arrying the gene encoding the polyoma middle T antigen.

14 ion between PNA and glycoproteins containing T antigen.

15 methylation, and John Cunningham (JC) virus T antigen.

16 an essential step in unwinding origin DNA by T antigen.

17 mune response to peptides encoding BKV large T antigen.

18 cificity for conserved epitopes of JCV large T antigen.

19 Golgi, resulting in the formation of sialyl-T antigen.

20 ncy was the principal carcinogenic effect of T-antigen.

21 y of MCCs, may drive tumorigenesis via viral T antigens.

22 ost tumors express the MCPyV large and small T antigens.

23 mian virus 40 (SV40) large (T) and small (t) T antigens.

24 y test both tumor-derived and wild type (WT) T antigens.

25 r MUC1 carrying one or more Tn, T, or sialyl-T antigens.

26 spect to the early gene products, the tumor (T) antigens.

27 imeric reporters containing the entire BPCV1 T antigen 3' UTR undergo negative regulation when coexpr

28 eased in proportion to the reduction in p68N-T antigen affinity, confirming that p68-T antigen intera

29 Other polyomavirus-encoded large T antigens also increase the levels of CBP/p300 and sust

30 delayed in NHAs, and the expression of SV40 T antigen alters the cellular environment, which impacts

31 subunits as well as for the localization of T antigen and damage-signaling proteins to viral replica

32 nd viral oncogenes, including the SV40 large T antigen and human papilloma virus 16 E6-antigen.

33 mmortalized with temperature-sensitive large T antigen and human telomerase reverse transcriptase (OS

34 ing partner of the mouse polyoma virus large T antigen and later shown to possess tumor suppressor-li

35 of a kinase activity associated with middle T antigen and our serendipitous discovery that this acti

36 On the other hand, SVST complements large T antigen and Ras for the transformation of human mammar

37 It is predicted to encode the large T antigen and small T antigen early proteins and the VP1

38 yomavirus and persistent expression of large T antigen and small T antigen.

39 The fraction of cells expressing SV40 large T antigen and the levels of T antigen mRNA were reduced

40 helicases, such as the simian virus 40 large T antigen and the papillomavirus E1 protein, are active

41 hromosomes of MCC tumors and expresses small T antigen and truncated large T antigen.

42 rocytes, which instead expressed early viral T antigens and exhibited apoptotic death.

43 les, specifically the simian virus 40 (SV40) T antigens and oncogenic Ras(12V), affect fatty acid met

44 n increase in unsialylated core 1 O-glycans (T-antigens) and Tn-antigens.

45 cin origin, with terminal fucose, the sialyl T-antigen, and N-linked oligosaccharides identified as p

46 me or all of the functions of the SV40 small T antigen, another well-characterized oncoprotein, in tw

47 cture of the hexameric helicase of JCV large T antigen (apo) and its use to drive the structure-based

48 tly focused on a few epitopes within variant TS antigens appear to neither contribute to, nor detract

49 ons of full-length and truncated MCPyV large T antigen are unknown.

50 criptase (hTERT) plus SV40 large T and small T antigens are transformed by either oncogenic Ras (H-Ra

51 These results indicate that MCPyV T antigens are tumorigenic in vivo, consistent with thei

52 We further show that the BKPyV large T antigen, as well as large T antigens from related poly

53 ecule and ensemble assays to show that large T antigen assembled on the SV40 origin unwinds DNA effic

54 Reliable detection of TES antigen at 10 and 30 pg/mL level was demonstrated in

55 s long-terminal region-driven polyoma middle T antigen breast cancer model.

56 By binding YAP, small t antigen brings it together with protein phosphatase 2A

57 JCV large T antigen, but not VP1 capsid protein, was expressed in

58 ere positive for early SV40 transcript large T antigen, but only 4 of the 14 cases exhibited late vir

59 uch as retinoblastoma (RB1) by mutated viral T antigens, but the molecular pathogenesis of MCPyV-nega

60 loping antibodies capable of detecting large T antigen by immunohistochemistry.

61 In contrast, expression of the MCPyV large T antigen C-terminal 100 residues could inhibit the grow

62 how that the oncogenes simian virus 40 large T antigen, c-Myc, and cyclin E induce spatial reorganiza

63 However, we have observed that SV40 large T antigen can induce cell proliferation and transformati

64 The two small T antigens can target different proteins for dephosphory

65 ated a novel mouse hepatocellular SV40 large T-antigen carcinoma cell line, MHT that maintains the ab

66 The analysis of the mechanisms by which T antigen carries out its many functions has proved to b

67 erse transcriptase (hTERT) and/or SV40 large T antigen cDNA vectors, and antibiotic-resistant cells w

68 d anthracyclines were studied in CEA424/SV40 T-antigen (CEA/Tag) transgenic mice, which develop gastr

69 tion of p53 and Rb proteins using SV40 large T antigen completely rescued necrotic cell death.

70 he hexameric replicative helicase SV40 large T antigen, constituting a simple primosome that is activ

71 On its own, small t antigen controls cell survival and differentiation.

72 Our results suggest that the SV40 T antigen could be a valuable tool to dissect cellular a

73 MCPyV large T antigen could bind to Rb but was unable to bind to p53

74 arious models are proposed to illustrate how T antigen could separate the central origin.

75 progeny than the wild type, suggesting that T antigen-CUL7-directed proteolysis facilitates virus pr

76 standards sequenced in this study with large T antigen deletions were cultured in cell lines immortal

77 Mice expressing MCPyV T antigens developed hyperplasia, hyperkeratosis, and ac

78 ogenesis using an orthotopic, polyoma middle-T antigen-driven model in Foxp3(DTR) knockin mice.

79 form core 1 Galbeta1-3GalNAcalpha1-Ser/Thr (T antigen) during mucin type O-glycan biosynthesis.

80 cted to encode the large T antigen and small T antigen early proteins and the VP1, VP2, and VP3 struc

81 untranslated region (UTR) of the BPCV1 large T antigen early transcript and identified a functional m

82 The large tumor antigen (T antigen) encoded by simian virus 40 is an amazing mole

83 Verhaegen et al. report MCPyV small T-antigen-expressing transgenic mice that now provide in

84 3 in the two MCC specimens that lacked large T antigen expression and in only 1 of 56 tumors positive

85 nvestigated any potential link between MCPyV T antigen expression and the highly metastatic nature of

86 rnative mechanisms of negative regulation of T antigen expression between the BPCVs and the polyomavi

87 agic acid and spiperone also inhibited large T antigen expression by BK virus and JC virus, two impor

88 These miRNAs negatively regulate T antigen expression by directing small interfering RNA

89 e have low mutation burden and require viral T antigen expression for tumor growth.

90 vel monoclonal antibody detected MCPyV large T antigen expression in 56 of 58 (97%) unique MCC tumors

91 Ectopic T antigen expression results in the immortalization and

92 As a consequence of T antigen expression, B cells develop normally but, upon

93 an important role in regulating viral large-T-antigen expression and limiting the replication of arc

94 d from the late strand regulates viral large-T-antigen expression and limits the replication capacity

95 The biosensor was used to evaluate the T-antigen expression in serum samples and was able to di

96 rcentage of BKV infected cells and the large T-antigen expression were significantly decreased in HRP

97 BKV by immunofluorescent analysis and large T-antigen expression which suggested BKV infection by We

98 ols, which was not due to the suppression of T-antigen expression.

99 taining mutations in the C terminus of large T antigen fail to replicate efficiently or form plaques

100 sX abundance, (b) the fibronectin, collagen, T-antigen (FCT) region of the genome, which contains the

101 he deletion of the C terminus of MCPyV large T antigen found in MCC serves not only to disrupt viral

102 the BKPyV large T antigen, as well as large T antigens from related polyomaviruses, is alone capable

103 These residues are well conserved in the T antigens from the polyomaviruses, indicating that the

104 acid reading frame of opposing-strand large T antigen gene.

105 major capsid protein gene VP1, and the large T antigen gene.

106 to other polyomaviruses, MCPyV encodes early T antigen genes, viral oncogenes required for MCC tumor

107 utations were detected in both VP1 and large T antigen genes.

108 , rescues the minerva mutant's migration and T-antigen glycosylation defects.

109 These data indicate that T antigen has a mechanism to specifically unwind the cen

110 68 (p68N) that physically interacts with the T antigen helicase domain.

111 cture of p68N and map its interface with the T antigen helicase domain.

112 ise molecular interactions between the viral T antigen, host replication proteins, including DNA poly

113 xP-flanked stop cassette, and the SV40 large T-antigen (iAST).

114 T-antigen immortalization of cells allowed cell growth.

115 Comparisons of polyoma and SV40 small T antigens implicate Abeta in the control of differentia

116 We report that small T antigen in complex with MYCL and the EP400 complex act

117 gland tumors induced by polyomavirus middle T antigen in JNK2(-/-) mice were more sensitive to CDDP

118 the results of their efforts to express SV40 T antigen in mature B cells of mice.

119 re effective than full-length and 57kT large T antigen in promoting the growth of human and mouse fib

120 abel-free profiling of the cancer-associated T antigen in serum samples.

121 e novo by overprinting of the second exon of T antigen in the common ancestor of a large clade of mam

122 e used transgenic mice expressing SV40 large T antigen in their prostatic neuroendocrine cells, under

123 a viral oncogene that cooperates with middle T antigen in transformation.

124 inase expression induced expression of MCPyV T antigens in stratified squamous epithelial cells and M

125 the oncogenic activity of MCC tumor-derived T antigens in vivo, a conditional, tissue-specific mouse

126 Here we show that T-antigen in Drosophila melanogaster macrophages is invo

127 growth factor alpha, but not simian virus 40 T-antigen, increase the rate of hepatocyte growth under

128 PP2A Abeta/Akt interaction by polyoma small T antigen increased turnover of Akt Ser-473 phosphorylat

129 s required for A3B induction by polyomavirus T antigen indicating a shared molecular mechanism.

130 polyomavirus (MCPyV)-derived truncated large T antigens induced ATOH1 expression in fibroblasts, whic

131 suggest an important role of UNC5B in small-T antigen-induced mitotic catastrophe that also requires

132 sformation of many cell types in culture and T antigen induces neoplasia when expressed in rodents.

133 p68N-T antigen affinity, confirming that p68-T antigen interaction is vital for primosome function.

134 For small T antigens, interaction with PP2A is needed for each of

135 Polyomavirus small t antigen is a viral oncogene that cooperates with middl

136 genic mice in which expression of SV40 large T antigen is driven by UPK II promoter.

137 Although SV40 large T antigen is essential, it is not sufficient for cellula

138 T antigen is required for viral DNA replication, transcr

139 m) in which an increase in the expression of T antigen is well-known.

140 l cell polyomavirus (MCPyV) expressing viral T antigens is a common feature of most Merkel cell carci

141 rant display of the truncated core1 O-glycan T-antigen is a common feature of human cancer cells that

142 he knockdown of Sox2 in MCV(+) MCCs mimicked T antigen knockdown by inducing MCC cell growth arrest a

143 uding HES6, SOX2, ATOH1, and KRT20 Of these, T antigen knockdown directly inhibited Sox2 and Atoh1 ex

144 Single-cell RNA sequencing revealed that T antigen knockdown inhibited cell cycle gene expression

145 as downregulated by the MCPyV early gene, as T antigen knockdown rescued the level of NDRG1.

146 ce that express a fragment of the SV40 small t antigen known to inhibit protein phosphatase 2A (PP2A)

147 Higher macrophage T-antigen levels require an atypical major facilitator s

148 large probasin promoter directed SV40-large T-antigen (LPB-Tag) expressing mouse prostate, mPIN form

149 T antigen (ST) and a truncated form of large T antigen (LT) and usually contains wild-type p53 (TP53)

150 protein phosphatase 2A (PP2A), and the large T antigen (LT) binds pRb, p107, p130, and p53.

151 monstrated that simian virus 40 (SV40) large T antigen (LT) binds to the Bub1 kinase, a key regulator

152 t the co-crystal structure of the SV40 Large-T Antigen (LT) hexameric helicase bound to its origin ds

153 pended on the coexpression of the SV40 large T antigen (LT) in the cells.

154 Simian virus 40 (SV40) large T antigen (LT) is a multifunctional protein that is impo

155 Simian virus 40 (SV40) large T antigen (LT), for example, targets p53 directly, but m

156 inding and helicase domains of the MCV large T antigen (LT), suggesting a selective pressure to remov

157 t expression of simian virus 40 (SV40) large T antigen (LT), without a viral origin, is sufficient to

158 iated DDR pathways accumulate in MCPyV large T antigen (LT)-positive nuclear foci in cells infected w

159 t-antigen (ST) collaborates with SV40 large T-antigen (LT) and activated rasv12 to promote transform

160 ens, pharmacologic interference of the large T antigen (LTA) may represent an effective therapeutic a

161 Phylogenetic trees based on large T-antigen (LTA) allow separation of subtype I into subgr

162 e prostate model that is driven, in part, by T antigen-mediated functional inactivation of p53.

163 Here we found that SV40 T antigen-mediated transformation inhibits HCMV infectio

164 enesis in ovariectomized polyomavirus middle T-antigen mice.

165 use mammary tumor virus-polyoma virus middle T antigen (MMTV-PyMT)-induced breast cancer to conduct s

166 the mouse mammary tumor virus-polyoma middle T-antigen model.

167 the Mouse Mammary Tumor Virus-Polyoma Middle T-Antigen mouse.

168 ssing SV40 large T antigen and the levels of T antigen mRNA were reduced in infected human and monkey

169 locks tumor formation in both polyoma middle T antigen (MT) and HER2/Neu transgenic models of breast

170 re we characterize YAP as a target of middle T antigen (MT) important for transformation.

171 The gene coding for middle T antigen (MT) is the murine polyomavirus oncogene most

172 Middle T antigen (MT) is the primary polyomavirus oncogene resp

173 reast cancer driven by either polyoma middle T antigen (MT) or HER2 is p110alpha dependent.

174 d differentiation and cooperates with middle T antigen (MT) to transform primary cells in vitro and i

175 Middle T antigen (MT), the oncogene of polyomavirus, can drive

176 Middle T antigen (MT), the principal oncoprotein of murine poly

177 ialyl Lewis-X (sLe(X)) and the di-sialylated T-antigen (NeuAcalpha2,3Galbeta1,3(NeuAcalpha2,6)GalNAc)

178 cal monopartite NLSs, such as c-myc and SV40 T-antigen NLSs.

179 H was independently associated with JC virus T antigen (odds ratio [OR] = 1.93; P = .0077), body mass

180 ALTO is evolutionarily related to the middle T antigen of murine polyomavirus despite almost no seque

181 ic C subunit, in a manner similar to that of T antigens of the small DNA tumor viruses.

182 As in other polyomaviruses, the large T-antigen of MCV recognizes the viral origin of replicat

183 e studies uncover the action of polyomavirus T antigens on cellular CBP/p300 and suggest that additio

184 rmine that Minerva increases the presence of T-antigen on proteins in pathways previously linked to c

185 While the impact of MCV and viral T-antigens on MCC development has been extensively inves

186 in HER2/neu mice, but not in polyoma middle T-antigen oncomice.

187 cells on activation of either polyoma middle T antigen or ErbB2 signaling.

188 d in cells immortalized by either SV40 large T antigen or p53-null mutation, whereas alpha3beta1-depe

189 vity because of the expression of SV40 large T-antigen or because of a mutation in the TP53 gene.

190 of PP2A with okadaic acid, fostriecin, small T antigen, or PP2A knockdown abrogated rapamycin-induced

191 two highly constrained regions of the large T antigen ORF provided a start codon and C-terminal hydr

192 the 2.9 A crystal structure of the MCV large T-antigen origin binding domain (OBD) in complex with a

193 1 and minimal intrarenal expression of SV40-T antigen (P < 0.001).

194 ntigen, suggesting a functional link between T antigen-p68 interaction and primosome activity.

195 of p68 residues in the interface diminished T antigen-p68 interaction, confirming the interaction si

196 Here, we report the detailed large T antigen-p68 interface, as revealed in a co-crystal str

197 ell lines show oncogene addiction to the MCV T antigens, pharmacologic interference of the large T an

198 case domains of simian virus 40 (SV40) large T antigen play a critical role in DNA replication.

199 ferences between SVST and polyomavirus small T antigen (POLST) in their effects on differentiation, t

200 prototypical NLS from simian virus 40 large T-antigen preferentially at the major NLS binding site.

201 sis on the cell-cell modules that complement T-antigen-presenting cell interaction, provides a fundam

202 ns with the unique T. cruzi trans-sialidase (TS) antigen protect against gastric and systemic T. cruz

203 isms were detected in the VP1, VP2 and Large T Antigen proteins, suggesting potential functional effe

204 Using the MMTV-Polyoma Middle T antigen (PyMT) mouse model of human ductal carcinoma,

205 The polyomavirus middle T antigen (PyMT) oncogene activates the cellular nonrece

206 mary tumor virus (MMTV)-Polyoma virus middle T antigen (PyMT) or MMTV-c-Neu transgenic mice.

207 mmary tumorigenesis using the polyoma middle T antigen (PyMT) transgenic mouse model.

208 metastatic breast cancer, the polyoma middle T antigen (PyMT) transgenic mouse.

209 In the polyoma middle T-antigen (PyMT) transgenic mouse model of breast cancer

210 have utilized the murine polyomavirus small T antigen (PyST) as a tool to study UNC5B-mediated apopt

211 Murine polyomavirus small t antigen (PyST) regulates cell cycle, cell survival, ap

212 Polyoma small T antigen (PyST), an early gene product of the polyoma v

213 Like all polyomavirus T antigens, PyST functions largely via its interactions

214 Polyoma virus middle T antigen (PyVmT) is a powerful viral oncogene; however,

215 ncluding the widely used polyomavirus middle-T antigen (PyVmT) model, which provides an opportunity t

216 ctively, due to large deletions in the large T antigen region.

217 of miRNA-mediated negative regulation of the T antigens remains uncertain.

218 suppressor p53 and pRb in urothelium by SV40 T antigen resulted in urothelial carcinoma, resembling h

219 nslocation strand, suggesting that the large T antigen ring can open to bypass bulky adducts.

220 g peptide (LPLMRKAYL), encoded by 2 relevant T-antigens (small T and large T) and previously shown to

221 is the most sensitive method to quantify the TES antigen so far.

222 Fabpi-TAg mice expressing large T-antigen solely in villi had ectopic enterocyte prolife

223 MCV-positive MCC expresses small T antigen (ST) and a truncated form of large T antigen (

224 The MWPyV small T antigen (ST) binds protein phosphatase 2A (PP2A), and

225 ecently demonstrated that polyomavirus small T antigen (ST) binds YAP, a major effector of Hippo sign

226 We have previously shown that SV40 small t antigen (st) cooperates with deregulated cyclin E to a

227 SV40 small t antigen (ST) has been reported to be necessary and suf

228 Merkel cell polyomavirus (MCV) small T antigen (sT) is the main oncoprotein for the developme

229 t of regulatory B subunits by the SV40 Small T antigen (ST) or mutation/deletion of PP2A subunits alt

230 Coexpression of SV40 small t antigen (st), but not other tested oncogenes, efficien

231 e of the functions of the polyomavirus small T antigens (ST) are shared by the E6 and E7 oncoproteins

232 SV40 small t-antigen (ST) collaborates with SV40 large T-antigen (L

233 ress putative polyomavirus oncoprotein small T antigen (sTAg) and truncated large T antigen.

234 nds directly to the hexameric viral helicase T antigen, suggesting a functional link between T antige

235 es immortalized using simian virus 40 (SV40) T antigen, suggesting the possibility of transcomplement

236 hereas immortalization induced by SV40 large T antigen supported fibroblast proliferation in the abse

237 SV40 small T antigen (SVST) has received considerable attention bec

238 Simian virus 40 (SV40) large T antigen (SVT) interferes with normal cell regulation a

239 promoter to target expression of SV40 large T-antigen (T-Ag) in the undifferentiated murine embryoni

240 domain (OBD) of simian virus 40 (SV40) large T-antigen (T-Ag) is essential for many of T-Ag's interac

241 rototypical replicative helicase, SV40 large T-antigen (T-ag), was investigated.

242 nity binding element for the viral initiator T-antigen (T-ag).

243 o address this question, we knocked down MCV T-antigen (TA) expression in MCV-positive MCC cell lines

244 r suppressor p53 (fused to Gal4BD) and large T antigen (TAg) (fused to VP16) was visualized in vivo b

245 the input virus nor the expression of large T antigen (TAg) alone is sufficient to trigger the activ

246 lleles, including the simian virus 40 (SV40) T antigen (TAg) and oncogenic H-Ras, inhibit HCMV infect

247 Simian virus 40 large T antigen (TAg) contributes to cell transformation, in p

248 and emphasized the importance of functional T antigen (Tag) for efficient replication.

249 Simian virus 40 large T antigen (TAg) transforms cells in culture and induces

250 seeding of tumorigenic hepatocytes from SV40 T antigen (Tag) transgenic MTD2 mice into the livers of

251 on, persistent overexpression of viral large T antigen (TAg), and malignancy, yet little is known abo

252 origin and flanking sequences, to which BKV T antigen (Tag), cellular proteins, and small regulatory

253 duced activation of the oncogenic SV40 large T antigen (TAg).

254 In agreement, expression of large tumor T antigens (TAg) encoded by polyomaviruses in mammalian

255 feron gamma (IFNgamma) induction of the SV40 T-antigen (TAg) was assayed by immunohistochemistry and

256 In addition, T antigen targets multiple cellular pathways, including

257 Mutations in the C terminus of large T antigen that disrupt binding to the host protein FAM11

258 ns result in expression of a truncated large T antigen that retains the Rb binding or LXCXE motif but

259 ng discovered provides a collection of novel T antigens that, like simian virus 40, can be used to di

260 sis of the common core 1 O-glycan structure (T-antigen), the precursor structure for most mucin-type

261 ormation assay that also includes SV40 large T antigen, the catalytic subunit of cellular telomerase,

262 By contrast, large T antigen, the replicative DNA helicase of the simian vi

263 lization via genetic influences such as SV40 T-antigen, thus limiting our knowledge of the events tha

264 evels of SnoN cooperated with polyoma middle T antigen to accelerate the formation of aggressive mult

265 te (TRAMP) model of PCa that uses SV40 large T antigen to induce PCa, loss of Foxm1 decreased tumor g

266 ggest that additional mechanisms are used by T antigens to induce cell immortalization and transforma

267 defined oncogenic driver antigen (SV40 large T-antigen) to follow the activation and differentiation

268 BPCV1 miRNA is not encoded antisense to the T antigen transcripts but rather lies in a separate, pro

269 preserving the reading frame of the opposing T antigen transcripts.

270 , but were the cell line 661W, a mouse SV-40 T antigen transformed photoreceptor cell line.

271 selectively induces apoptosis of SV40 large T-antigen transformed cells and significantly reduces co

272 contrast to the half-life of simian virus 40 T antigen-transformed cells.

273 In contrast, T-antigen-transformed REF52 and p53+/+ HCT116 tumor cell

274 hrelinomas induced by a tissue-specific SV40 T-antigen transgene.

275 MATERIALS AND C3(1) Sv-40 large T antigen transgenic mice (n = 23) were studied with ins

276 eighted (DW)-MRI in the polyoma virus middle T antigen transgenic mouse model of breast cancer.

277 by using mammary tumour virus-polyoma middle T-antigen transgenic (PyMT) mice as a model of inherited

278 ination is a secondary occurrence, following T antigen-triggered oligodendroglial apoptosis.

279 Mice expressing Polyoma middle T antigen under the mouse mammary tumor virus promoter w

280 mouse prostate (TRAMP) mice express the SV40 T-antigen under the control of the probasin promoter, an

281 Stimulation with TD antigens under inflammatory conditions induces plasma

282 e, and Tregs are produced in the presence of TD antigens under tolerance conditions.

283 Unexpectedly, large T antigen unwinds DNA past a DNA-protein crosslink on th

284 died these mutants to gain insights into how T antigen unwinds the origin.

285 these controversies, we detected MCPyV large T antigen using immunohistochemistry with two distinct a

286 selective detection of the cancer-associated T antigen, using the lectin from Arachis hypogaea (peanu

287 The occurrence of T- and sialyl T-antigen varied in bovine and ovine reproductive tract

288 on induced by Merkel cell polyomavirus small T antigen viral oncoprotein.

289 In support of this, wild-type T antigen was able to specifically unwind a 31-bp DNA co

290 While large T antigen was expressed to higher levels in adar1(-/-) c

291 Furthermore, MCPyV-truncated large T antigen was more effective than full-length and 57kT l

292 aperone, since simian immunodeficiency virus T antigen was previously shown to contain a J domain; ho

293 ombination, transforming growth factor alpha/T-antigen, was sufficient to direct cell autonomous grow

294 However, JCV proteins (VP1 or T antigen) were detected mainly in the brains of 23/24 H

295 al oncoprotein, simian virus 40 (SV40) large T-antigen, which is frequently used to immortalize cells

296 his work shows how this association of small t antigen with YAP is important for its effects on cell

297 MWPyV is a widespread human virus expressing T antigens with low transforming potential.

298 roteins, by replacing SV40 large T and small T antigens with sh-p53, mutant CDK4 (CDK4(R24C)), and sh

299 to plasma cells in response to T-dependent (TD) antigens within germinal centers (GCs).

300 In contrast, tolerance induction by TD antigens without costimulation triggers the developme