ライフサイエンスコーパス: T-cell clone

1 (TCR) isolated from a hemophilia A subject's T-cell clone.

2 rophil autoantibodies, and 6 of 47 (12.8%) a T-cell clone.

3 amma production and proliferation by the CD4 T-cell clone.

4 l receptor interaction with a tumor-specific T-cell clone.

5 n and IFN-gamma expression in plaque-derived T cell clones.

6 ed in Ca(2+) signaling in some lymphomas and T cell clones.

7 gorithm that detected significantly expanded T cell clones.

8 ertoire but does not eliminate self-reactive T cell clones.

9 f both CD244 and TIM-3, but not PD-1, on CD8 T cell clones.

10 pare iNOS-dependent and iNOS-independent CD4 T cell clones.

11 d expansion of alloreactive and autoreactive T cell clones.

12 d their ability to stimulate CD1b-restricted T cell clones.

13 on of PKCtheta mutants in antigen-stimulated T cell clones.

14 m expansion and contraction of infected CD4+ T cell clones.

15 for their ability to stimulate human CD4(+) T cell clones.

16 X peptide-stimulated PBMCs, and IFX-specific T cell clones.

17 tiviral capacity of some HIV-specific CD8(+) T-cell clones.

18 resistance to infection present in some CD4 T-cell clones.

19 cal T cell, BDC-2.5, and other ChgA-specific T-cell clones.

20 with either indirect or direct alloreactive T-cell clones.

21 ficity, thereby avoiding the need to isolate T-cell clones.

22 , in combination with either direct/indirect T-cell clones.

23 o compared with virus-specific cytotoxic CD8 T-cell clones.

24 the selection of weakly self-reactive, naive T-cell clones.

25 and evade lysis by HLA-restricted cytotoxic T-cell clones.

26 tly higher activation of HIV-specific CD8(+) T-cell clones.

27 ) DCs in elicitation of HCMV-specific CD8(+) T-cell clones.

28 s a large number of distinct HTLV-1-infected T-cell clones.

29 igen-driven expansion of a limited number of T-cell clones.

30 to assess the functional capacity of derived T-cell clones.

31 with macrophages and expanded populations of T-cell clones.

32 is decreased in peripherally expanded naive T-cell clones.

33 cells is sufficient to identify predominant T-cell clones.

34 glia-alpha1a- and DQ2.5-glia-omega1-reactive T-cell clones.

35 hemokine secretion than "ineffective" CD8(+) T-cell clones.

36 nsulin reactive, MHC class-I-restricted CD8+ T cell clone (1E6) that can recognize over 1 million dif

37 n an individual clone basis, 14 of 53 CD4(+) T-cell clones (26%) recognized 6 distinct but overlappin

38 tection of atabecestat metabolite-responsive T-cell clones activated via a pharmacological interactio

39 CD4(+) T-cell clones activated with the DIAT metabolite were de

40 ence of proteasomal processing and immediate T cell clone activation upon stimulation with FLUX in so

41 his potential promiscuity, reactivity of the T cell clones against 400 randomly selected HLA-A*0201-b

42 Wherever tested, all CD8(+) T cell clones against these novel lytic cycle epitopes r

43 TCR) is the individual identity card of each T cell clone and can help to follow single specificities

44 Autoantigen-reactive CD4(+) memory T cell clones and an APS-derived, pathogenic monoclonal

45 drug-specific responses from in vitro primed T cell clones and clones from hypersensitive patients we

46 f T1D patient-derived beta cell-autoreactive T cell clones and lines, but, when screening for pathoge

47 s (DeltaNPM1) and then generate high-avidity T cell clones and retrovirally transduced T cell populat

48 e and memory T cell libraries, combined with T cell cloning and TCR sequencing, to dissect the human

49 We isolated the corresponding T-cell clone and characterized the recognized epitope as

50 cinoma cell line stimulates a tumor-specific T-cell clone and elicits antigen-specific cells in vivo,

51 7)-RLGL-WE14 tetramers bind to ChgA-specific T-cell clones and easily detect ChgA-specific T cells in

52 expression was detected in IL-17-expressing T-cell clones and in CD161(+) T helper type 17 cells ex

53 Mechanistic experiments using human T-cell clones and lines are providing a clinically relev

54 Multiple T-cell clones and polyclonal lines having different avid

55 s at earlier time-points in Bet v 1-specific T-cell clones and promoted less IL-5 production in T cel

56 ty by the adoptive transfer of mHAg-specific T-cell clones and the challenges for the broad applicati

57 e kinetics of activation of Bet v 1-specific T-cell clones and the polarization of naive T cells.

58 apies has required the isolation of specific T-cell clones and their clonotypic TCRs.

59 nitoring the fate and function of individual T cell clones, and the adoptive transfer of protective e

60 tumoral responses and whether tumor-resident T cell clones are amplified following treatment.

61 Infected T cell clones are detected at low frequencies in the lon

62 the hypothesis that to maintain homeostasis, T cell clones are expelled from the repertoire, reducing

63 Although high- and low-affinity CD8(+) T cell clones are recruited into the primary response, t

64 We show that PPI-specific CD8 T-cell clones are mainly reliant upon cytotoxic degranul

65 previously published chlamydia-specific CD8 T-cell clones are MHC class II restricted.

66 HIV-1 latency model using autologous CD8(+) T cell clones as biosensors of antigen presentation, nei

67 However, none of the 75 expanded T cell clones assayed contained intact virus.

68 so confirmed the presence of GVHD-associated T-cell clones at the site of the disease.

69 The diabetogenic CD4 T cell clone BDC-2.5, originally isolated from a NOD mou

70 the target Ag for a highly diabetogenic CD4 T cell clone BDC-5.2.9.

71 e target antigen for the highly diabetogenic T-cell clone BDC-5.2.9.

72 the target antigen for the diabetogenic CD4 T-cell clone BDC-5.2.9.

73 Insulin epitopes recognized by diabetogenic T cell clones bind poorly to the class II I-A(g7) molecu

74 y expressed GATA3, nonetheless, a portion of T-cell clones both GATA3 and RAR-related orphan receptor

75 an CD1a mediates foreign Ag recognition by a T cell clone, but the nature of possible TCR interaction

76 The extent of fluctuation of dominant CD8(+) T-cell clones, but not of CD4(+) counterparts, correlate

77 Isolation of T cell clones by limiting dilution from tumor-infiltrati

78 e hypothesized that distinct GVHD-associated T-cell clones can be identified during the disease progr

79 une system is its ability to generate B- and T-cell clones capable of recognizing and neutralizing sp

80 We identified an expanded T cell clone carrying an intact provirus that matched a

81 These data show that HTLV-1-infected T-cell clones carrying key oncogenic driver mutations ca

82 For 3 distinct T-cell clones, CD79b specificity was confirmed through C

83 to cause diabetes; and 3) individual CD8(+) T-cell clones chose their cytotoxic weaponry by a yet un

84 g the model to address expansion of multiple T cell clones competing for antigen, we find that higher

85 ethod, no reactivity was observed by the CD8 T-cell clone, confirming no semidirect alloreactivity.

86 In addition, in total, 663 T-cell clones (containing at least 91 unique clones expr

87 We report that a highly expanded CD4(+) T-cell clone contains an intact provirus.

88 onal tissues, and absolute numbers of unique T-cell clones correlated with respective T-cell counts.

89 ers, an unlabeled influenza peptide reactive T cell clone could be detected at a frequency of 0.1% in

90 owed that a subset of Chlamydia-specific CD4 T cell clones could terminate replication in epithelial

91 In 6 of 8 patients, a malignant T-cell clone could be identified in lesional skin, and a

92 annexin A2-specific Vdelta2(neg) gammadelta T-cell clones could be derived from peripheral blood mon

93 with MM is associated with the large CD8(+) T cell clone count 21 d after treatment and agnostic to

94 ntial TH1 cytokine secretion patterns from a T cell clone cultured under TH1 or TH2 inducing conditio

95 nd that the immunodominance of high-affinity T cell clones declined during the chronic infection phas

96 the topography of the expanding CMV-specific T-cell clones, deep sequencing allowed us, for the first

97 measurements of three of these self-reactive T cell clones demonstrated a normal off-rate but a slow

98 alysis of a set of 10 HLA-A*02:01-restricted T cell clones demonstrated that staining with pMHC multi

99 f 14 brain-infiltrating, JCV-specific CD4(+) T cell clones demonstrated that these cells use an unexp

100 d on TCR/CD8:pMHC avidity, as tumor-reactive T cell clones derived from patients vaccinated with the

101 Using a panel of diabetogenic CD4 T cell clones derived from the NOD mouse, we recently id

102 from HA-1Hneg/HLA-A*02:01pos donors and one T-cell clone derived from an HA-1Hpos/HLA-A*02:01pos don

103 16 unique HA-1H-specific T-cell clones, five T-cell clones derived from HA-1Hneg/HLA-A*02:01pos donor

104 a PmpG(303-311)-specific multifunctional Th1 T cell clone, designated PmpG1.1, from an immune C57BL/6

105 or ablates antigenicity with a wide range of T cell clones despite significantly improving peptide bi

106 However, the expansion of T cell clones did not derive from pre-existing tumor-inf

107 cell markers (Foxp3(+) CD25(+)) and cultured T cell clones did not express a cytokine profile that in

108 sured by allospecific CD4 (indirect) and CD8 T-cell clones (direct) when cells were used.

109 T cell clones directed against the HLA-A*0201-binding WT

110 T-cell clones directed against the HLA*02:01-restricted

111 KK10-stimulated "effective" CD8(+) T-cell clones displayed significantly more rapid TCR sig

112 Finally, IL-10-producing drug-specific T cell clones downregulated the response of autologous e

113 -term fitness advantage to a small number of T-cell clones (e.g., by an increased division rate or de

114 The WE14 responses of three NOD-derived CD4 T-cell clones, each with different T-cell receptors (TCR

115 From a CD8(+) T cell clone established by stimulation of HLA-A2(+) CD8

116 hat cotransfer of MPO431-439-specific CD8(+) T cell clones exacerbated disease mediated by MPO-specif

117 ode of action, a HERV-K(HML-2)-specific CD8+ T cell clone exhibited comprehensive elimination of cell

118 T-cell clones expressing CCR4 and CCR9 migrated toward C

119 Of the 16 unique HA-1H-specific T-cell clones, five T-cell clones derived from HA-1Hneg/

120 nable monitoring of pathogenic or protective T cell clones following HSCT and cellular therapies.

121 e immune response selectively expands B- and T-cell clones following antigen recognition by B- and T-

122 parameter to rapidly demark cytotoxic CD8(+) T cell clones for further TCR evaluation.

123 escribe how to isolate carbohydrate-specific T cell clones (for which we propose the designation 'Tca

124 otal T cells and of cells of an autoreactive T-cell clone found in inflamed organs, while maintaining

125 tetramer from a synovial Vdelta1 gammadelta T cell clone from a Lyme arthritis patient.

126 immunological synapses (IS) in self-reactive T cell clones from patients with multiple sclerosis and

127 thermore, we demonstrated that MiHA-specific T cell clones from patients with selective GVL reactivit

128 T cell clones from single cell cloning of DRB1*0401/MOG(

129 o characterize in detail JCV-specific CD4(+) T cell clones from the infected tissue during acute vira

130 terized 24 unique proinsulin-specific CD4(+) T cell clones from the peripheral blood of 17 individual

131 ta repertoires, 30-33% of IFN-gamma(+)CD4(+) T cell clones from three M. tuberculosis-infected macaqu

132 its primary CD8(+) T cell responses that, by T cell cloning from infectious mononucleosis (IM) patien

133 tivity to wheat, rye, and barley peptides as T-cell clones from adults with celiac disease.

134 Jug r 2-specific T-cell clones from allergic subjects mainly expressed GA

135 rom one effective and two ineffective CD8(+) T-cell clones from an elite controller into TCR-expressi

136 About half of the generated T-cell clones from children and adults reacted to unknow

137 uten peptide recognition was similar between T-cell clones from children and adults.

138 either HLA-A2 or HLA-B7 were used to isolate T-cell clones from HLA-A*0201 and B*0702-negative indivi

139 gainst gluten by generating T-cell lines and T-cell clones from intestinal biopsies of adults and chi

140 activity was observed for individual CD8(+) T-cell clones from mice bearing BPTF-silenced tumors.

141 racterize atabecestat(metabolite)-responsive T-cell clones from patients with liver injury.

142 l receptor beta (TCRB) gene sequencing of 15 T-cell clones from the severe HA subject revealed that a

143 lls, we isolated and characterized 53 CD4(+) T-cell clones from within the residual pancreatic islets

144 ed two functions of cognate antigen-specific T cell clones: gamma interferon (IFN-gamma) production a

145 ils the antigen specificity and phenotype of T-cell clones generated from patients with AX-Clav-induc

146 CD4(+) T cell clones, generated from HLA-DRB1*15:01 transgenic

147 T cell clones identified by their clonotypic sequence as

148 ct of DM on stimulation of the two groups of T cell clones implies differences in DQ2 presentation pa

149 the TCR sequences of the proinsulin-specific T cell clones in pancreatic lymph node samples compared

150 ought (typically between 104 and 105 HTLV-1+ T cell clones in the body of an asymptomatic carrier or

151 tumoral TCR repertoire revealed expansion of T cell clones in the setting of neoantigen loss.

152 e recognition by an HLA-DR-restricted CD4(+) T-cell clone in response to cognate antigen presented by

153 blood draws, indicating persistence of this T-cell clone in the peripheral blood.

154 nd rapid expansion or enrichment of relevant T-cell clones in <2 weeks, and is applicable for T-cell

155 de 2-3 irAEs also had expansion of >/=55 CD8 T-cell clones in blood samples collected before the onse

156 We identified T-cell clones in GI biopsies in a heterogeneous group of

157 concentrations and phenotypes of individual T-cell clones in response to primary and secondary yello

158 ers of NK cells (83% vs 50% of patients) and T-cell clones in the blood (83% vs 30% of patients).

159 ed by marked proliferation of a few dominant T-cell clones in the tumor.

160 1) to EBNA1- and LMP1-specific CD4+ and CD8+ T-cell clones in vitro.

161 rget for three NOD-derived, diabetogenic CD4 T-cell clones, including the well-known BDC-2.5.

162 RIM5alpha transduction of virus-specific CD4 T-cell clones increased and prolonged their ability to s

163 eptor obtained from a hemophilia A subject's T-cell clone, into expanded human FoxP3(+) Tregs.

164 A T cell clone is able to distinguish Ags in the form of p

165 The BDC2.5 T cell clone is highly diabetogenic, but the transgenic

166 The repertoire of alloreactive T cell clones is distinct for every donor-recipient pair

167 ving a large number of sufficiently abundant T cell clones is important for adequate protection again

168 y de novo priming of newly pathogenic CD8(+) T-cell clones is an alternate mechanism responsible for

169 gen recognized by an HLA-E-restricted CD8(+) T cell clone isolated from an Mtb latently infected indi

170 confirmed that 17% (range, 13%-33%) of CD8+ T cell clones isolated from 4 vaccinated patients by lim

171 High-avidity CD8+ T cell clones isolated from healthy donors killed CBFB-M

172 We found that diabetes-inducing CD4 T cell clones isolated from nonobese diabetic mice recog

173 Tetramer-positive T-cell clones isolated from T1D subjects that responded

174 Forty-two of 104 tetramer(pos) T-cell clones, isolated from 16 of 17 UCB samples, showe

175 c protein-specific Tim-3(+) encephalitogenic T-cell clone (LCN-8), we found that conditioned medium f

176 hed recognition by the H-2D(b)/Trh4-specific T cell clone LnB5.

177 Aspergillus-specific T-cell clones mainly exhibited a T-helper cell 1 phenoty

178 s that targeting of specific epitopes and/or T-cell clones may be a promising approach to achieve tol

179 An MR1-restricted T cell clone mediated in vivo regression of leukemia and

180 ercome this limitation, we isolated a CD8(+) T-cell clone (MEL5) with an enhanced ability to recogniz

181 Using a dye dilution-based T cell cloning method, we generated and characterized 24

182 isolated six nonredundant, antigen-specific T-cell clones, most of which reacting to their target HI

183 (koff) of tumor-specific vaccine-induced CD8 T cell clones (n = 139) derived from seven melanoma pati

184 PBMC and T-cell clones (n = 570, 84% CD4(+)) from blood of pipera

185 e had reconstituted from an epidermal CD8(+) T cell clone of an HLA-C*06:02-positive psoriasis patien

186 t a single patient-derived autoimmune CD8(+) T cell clone of pathogenic relevance in human type I dia

187 hly polymorphic Tp2(49-59) epitope by CD8(+) T cell clones of defined TRB genotype.

188 Further, T cell clones of tetramer-sorted memory cells of healthy

189 ized in the context of the DQ2.3 molecule by T-cell clones of a DQ8/DQ2.5 heterozygous celiac disease

190 g, except for five patients (6%) with minute T-cell clones of uncertain significance accounting for 5

191 The self-HLA-restricted WT1-specific T cell clones only recognized the WT1 peptide.

192 We demonstrate that a subset of T cell clones possesses a heightened capacity to form TR

193 esults suggested that expansion of >/=55 CD8 T-cell clones preceded the development of severe irAEs.

194 HIP-reactive T-cell clones produced Th1-associated cytokines and prol

195 However, different T cell clones proliferate at different rates, and some T

196 E-VLD-specific and one NY-eso-1-SLL-specific T-cell clone provoked interferon-gamma production and/or

197 requirement for expansion of many individual T cell clones, rather than merely expansion of the entir

198 ogous HLA-DR-restricted and Bet v 1-specific T-cell clones reactive with epitopes in different region

199 PPD-specific T cell clones readily trafficked to the airway or lung a

200 were further characterized, and specific CD8 T-cell clones recognized both peptide-pulsed target cell

201 In melanoma patients, T cell clones recognizing naturally processed cancer ant

202 s patient-derived preproinsulin-specific CD8 T-cell clones recognizing either an HLA-A2 (A*0201) or H

203 tometric cluster analysis of multiple CD8(+) T-cell clones recognizing the identical HLA-B*2705-restr

204 siveness of effective and ineffective CD8(+) T-cell clones recognizing the identical HLA-B*2705-restr

205 The 20.1 mAb stimulated Vgamma2Vdelta2 T cell clones regardless of their functional phenotype o

206 Recognition by the CD8(+) T cell clone required N-terminal O-linked mannosylation

207 These T-cell clones respond weakly to the peptide WE14, a natu

208 that recognized the cross-reactive epitope, T cell clones responded robustly to cashew, hazelnut and

209 Experiments with T-cell clones revealed that AgmTRIM5alpha could reproduc

210 Effective and ineffective CD8(+) T-cell clones segregated based on responses to HIV-1-inf

211 ytometry-based unbiased analysis followed by T cell cloning, several findings were made.

212 Emerging T-cell clones should be monitored in patients with AIE w

213 ontrols and infectious cases; however, these T cell clones show very little overlap between subjects.

214 er, a patient-derived PPI(3-11)-specific CD8 T-cell clone shows a proinflammatory phenotype and kills

215 kdown of Cbl-b in human CD8(+)CD28- effector T cell clones similarly restored IL-2 production and pro

216 rly clonal dynamics imprint the hierarchy of T cell clone sizes with implications for pathogen defens

217 CTL system model based on a CD8(+)/CD103(-) T cell clone specific of a lung tumor-associated Ag, we

218 nals triggered by the stimulation of the 1G4 T cell clone specific to the tumor epitope NY-ESO-1(157-

219 T-cell clones specific for dominant alpha- or omega-glia

220 CD4(+) T-cell clones specific to LANA, a protein expressed in a

221 We identified and enumerated unique CD8(+) T cell clones specifically induced by this vaccine throu

222 entified TCR sequences from the autoreactive T cell clones, suggesting possible pathogenic TCRs that

223 his study was to generate clozapine-specific T cell clones (TCC) and characterize pathways of T cell

224 Two VZV-specific CD4 T cell clones (TCC), recovered from the eye of a VZV uve

225 co-culture experiments with Bet v 1-specific T-cell clones (TCCs).

226 Using T cell cloning techniques, a modest increase in the freq

227 ining serial dilutions of CD4(+) T cells and T cell-cloning technologies, we are able to demonstrate

228 tetramers that bind to most insulin-specific T-cell clones tested.

229 We isolated a new KS20-reactive Th1 CD4 T cell clone that rapidly transfers diabetes.

230 rthermore, we identified autoreactive CD4(+) T cell clones that can cross-react with HLA-DR-derived s

231 Medicine, Yost et al., 2019 report that the T cell clones that dominate the intra-tumoral T cell lan

232 le biopsies demonstrated a limited number of T cell clones that emerged at 3 months after vector admi

233 Self-reactive T cell clones that escape negative selection are either

234 reporting the identity of activated effector T cell clones that expand in response to the YFV 2 weeks

235 ockade derives from a distinct repertoire of T cell clones that may have just recently entered the tu

236 pid in vivo expansion of neoantigen-specific T cell clones that were reactive to mutant neopeptides f

237 Furthermore, EATL arose from a single T-cell clone that had been present for several years in

238 mplexes (pMHCs), we examined the ILA1 CD8(+) T-cell clone that responds to a peptide sequence derived

239 proliferation of peripherally expanded naive T-cell clones that accumulate with age.

240 FOXP3, allowing the comparison of autologous T-cell clones that do or do not express FOXP3.

241 Identification of specific antigens and T-cell clones that drive the disease will be the first s

242 h this route, we discovered that preinfusion T-cell clones that expressed the IL7 receptor (IL7R) and

243 We isolated T-cell clones that recognized dominant peptides and asse

244 tion of the MEL5 clone, but not other CD8(+) T-cell clones that recognized HLA A*0201-AAGIGILTV poorl

245 In particular, large naive T-cell clones that were distinct from memory clones were

246 We identified three sets of T-cell clones that were either frequently involved in GV

247 e of this study was to characterize distinct T-cell clones that were frequently and exclusively invol

248 inherent uncertainty in the number of B- and T-cell clones that will be missing from a blood or tissu

249 s recognized by other Chlamydia-specific CD4 T cell clones, the PmpG(303-311) epitope persisted on sp

250 nts for both the number and the abundance of T cell clones.) The causes of this observation are incom

251 scriptomics, the ability to track individual T cell clones through paired sequencing of the T cell re

252 t that the maintenance of large CMV-reactive T cell clones throughout life does not compromise the un

253 igating the mechanism used by a panel of CD4 T cell clones to control Chlamydia replication in epithe

254 and stimulates carbohydrate-specific CD4(+) T cell clones to produce interleukins 2 and 4-cytokines

255 entropy underpinned the ability of the HA1.7 T-cell clone to cross-react with HA(306-318) presented b

256 e performed with Tc1 clones and a CD8gamma13 T-cell clone to determine whether either influenced bact

257 Transfer of an MPO(409-428)-specific CD4(+) T-cell clone to Rag1(-/-) mice induced focal necrotizing

258 ll line showed that a Chlamydia-specific CD4 T cell clone was able to inhibit C. muridarum replicatio

259 The TCR from this high affinity T cell clone was rarely identified in ex vivo evaluation

260 functional avidity and specificity of these T cell clones was analyzed in-depth.

261 One T-cell clone was isolated from the same patient on two d

262 The presence of neutrophil autoantibodies or T-cell clone was not associated with any specific clinic

263 rprise, an adoptively transferred CD8gamma13 T-cell clone was remarkably proficient at preventing chl

264 ack of focused TCR-peptide binding, the ILA1 T-cell clone was still cross-reactive.

265 abacavir/abacavir analogue-responsive CD8(+) T-cell clones was measured using IFN-gamma ELIspot.

266 bjects and in 12 of 50 independently derived T cell clones, was TCRBV12-4.

267 Using a high affinity tumor-specific T cell clone, we identified a panel of mimotope vaccines

268 luding 7 L) new epitopes using memory CD8(+) T cell clones, we looked in HLA-matched IM patients and

269 by using well-characterized UCP-specific CD4 T cell clones, we showed that hTERT processing and prese

270 By genomic sequencing of these T-cell clones, we identified a gene encoding a dominant

271 of the 70 most frequent putative pathogenic T cell clones were alphabeta T cells.

272 re in these monkeys indicated that identical T cell clones were capable of recognizing wild-type (WT)

273 Autoreactive T cell clones were detected in the periphery of Foxn1 co

274 d by IFX-specific T cells, T cell lines, and T cell clones were evaluated at the mRNA and protein lev

275 illing of different T. parva-specific CD8(+) T cell clones were found to be significantly correlated

276 ELVHFL) or MAGE-A3: 271-279 (FLWGPRALV), and T cell clones were generated.

277 t (i) on average, approximately 2,000 CD8(+) T cell clones were induced by YF-17D, (ii) 5 to 6% of th

278 n the active-TGFbeta was limited or when new T cell clones were recruited into the epidermis, antigen

279 E-S)) tetramer(+) cells confirmed that these T cell clones were responsive to both the native and the

280 Jug r 2-specific T-cell clones were also generated, and mRNA transcriptio

281 blood mononuclear cells and Bet v 1-specific T-cell clones were compared.

282 Several T-cell clones were cross-reactive, especially clones tha

283 amenable to augmentation, HIV-specific CD8+ T-cell clones were derived from HIV-reactive CD28+CD8+ T

284 tide, and only 44% of Art v 125-36 -specific T-cell clones were detected by the tetramer.

285 IL-17(+)FoxP3(+) and IL-17(+) CD4(+) T-cell clones were generated by limiting dilution.

286 T-cell clones were generated from 4 hypersensitive patie

287 Drug-specific T-cell clones were generated from immediate hypersensiti

288 110 AX-specific and 96 Clav-specific T-cell clones were generated from seven patients with po

289 ed protein derivative of tuburculin-specific T-cell clones were generated.

290 The CD79b-specific T-cell clones were highly reactive against CD79b-express

291 Small T-cell clones were often observed in T- and NK-cell tumo

292 Most (87%) top expanded lesional T-cell clones were shared with nonlesional tissues, and

293 MART-1(26-35)-specific CD8 T cell clones, which differed in their trogocytosis capa

294 st aggressive of these represented by AI4, a T cell clone with promiscuous Ag-recognition characteris

295 y functional diversity within tumor-specific T cell clones with identical TCR specificity.

296 In summary, IL-17-producing alphabeta T cell clones with psoriasis-specific antigen receptors

297 cuspid CAS valves contains numerous expanded T cell clones with varying degrees of additional polyclo

298 Pen m 1-specific T-cell clones, with specificity for regions highly conse

299 Finally, both donor and recipient T cell clones within the rejecting kidney suggested lymp

300 In contrast, permanence of naive T cell clones would be determined by their affinity for