ライフサイエンスコーパス: T-cell differentiation

1 d priming in identifying novel regulators of T cell differentiation.

2 hibit tumour growth and stimulate regulatory T cell differentiation.

3 and a transcription program associated with T cell differentiation.

4 eleven translocation (TET)2 regulates CD8(+) T cell differentiation.

5 T cell expansion and favored central memory T cell differentiation.

6 ith previously unappreciated roles in CD8(+) T cell differentiation.

7 change dynamically as cells progress through T cell differentiation.

8 ynamic transcriptome necessary for efficient T cell differentiation.

9 ession, and a subsequent role in guiding CD8 T cell differentiation.

10 , suggesting that infected cells can undergo T cell differentiation.

11 nt mice, was not sufficient to normalize CD8 T cell differentiation.

12 positive histone modifications during memory T cell differentiation.

13 a progressive and selective model of CD4(+) T cell differentiation.

14 n produce significantly different results in T cell differentiation.

15 re SCC and correlated with increasing CD8(+) T cell differentiation.

16 DC) and the consequence of that in DC-driven T cell differentiation.

17 CMV) infection, paralleling antigen-specific T cell differentiation.

18 itatively, to promote robust effector CD8(+) T cell differentiation.

19 tch signaling pathway during effector CD8(+) T cell differentiation.

20 tabolic reprogramming that supports effector T cell differentiation.

21 ption factors NFAT and AP-1 promote effector T cell differentiation.

22 mulation in a subset of proteins critical to T cell differentiation.

23 nd two key transcription factors involved in T cell differentiation.

24 ivation for survival and to prevent terminal T cell differentiation.

25 labor among DC subsets in regulating CD8(+) T cell differentiation.

26 ibit Ag-specific T cell priming and regulate T cell differentiation.

27 t stimulus-dependent alternative pathways of T cell differentiation.

28 in 1 (BLIMP1) is a master regulator of B and T cell differentiation.

29 suggesting that it is associated with early T cell differentiation.

30 dex for investigating human and mouse CD8(+) T cell differentiation.

31 unx3, a nuclear factor crucial for cytotoxic T cell differentiation.

32 ortant role in T cell development and mature T cell differentiation.

33 egulatory network that shapes the balance of T cell differentiation.

34 nd silencing of Cd4 and Cd8 during alphabeta T cell differentiation.

35 s to resist M. tuberculosis infection-driven T cell differentiation.

36 (IL)-2 and IL-21 dichotomously shape CD8(+) T cell differentiation.

37 were ineffective in driving encephalitogenic T cell differentiation.

38 ing Langerhans cell and inducible regulatory T cell differentiation.

39 ses in the spleen and their consequences for T cell differentiation.

40 ily conserved role for lncRNAs during CD8(+) T cell differentiation.

41 ping of cell proteomes that permits effector T cell differentiation.

42 cteristics of the intermediate states in the T cell differentiation.

43 and surface-bound signals that help to guide T cell differentiation.

44 ons and epigenetic reprogramming that drives T cell differentiation.

45 whether co-stimulatory pathways also control T cell differentiation.

46 RNA processing and splicing factors to drive T cell differentiation.

47 o natural killer T cell (NKT) and gammadelta T-cell differentiation.

48 ed CD25 in controlling IL-2 availability and T-cell differentiation.

49 while retaining the ability to enhance naive T-cell differentiation.

50 e induction of tolerogenic regulatory CD4(+) T-cell differentiation.

51 shown to restrict T-cell function and impact T-cell differentiation.

52 BAC in coordinating the signals required for T-cell differentiation.

53 endogenous PU.1 allows precocious access to T-cell differentiation.

54 been implicated in the regulation of CD4(+) T-cell differentiation.

55 assembly of complexes that broadly influence T-cell differentiation.

56 sion patterns conducive to IFN signaling and T-cell differentiation.

57 tigen (Ag)-presenting pDCs directly regulate T-cell differentiation.

58 nd other genes that are essential for normal T-cell differentiation.

59 n factor whose ectopic expression can arrest T-cell differentiation.

60 enes in mDCs impact their ability to promote T-cell differentiation.

61 immunology based on its ability to influence T-cell differentiation.

62 scriptional program that promotes regulatory T-cell differentiation.

63 rks active during fetal and adult gammadelta T-cell differentiation.

64 usly uncharacterized gene, fam49ab, inhibits T-cell differentiation, a phenotype that can be rescued

65 e association of transcriptional pathways of T cell differentiation, acquisition of effector function

66 terestingly, the rate of naive-to-memory CD8 T cell differentiation after a peptide-coated dendritic

67 repress PD-1 during the early stages of CD8 T cell differentiation after acute infection with lympho

68 lls (APCs) and donor T cells, culminating in T-cell differentiation along pathogenic type-1 and type-

69 hat PPARgamma in addition to regulating CD4+ T cell differentiation also plays a major role controlli

70 ght into the mechanisms of CD4(+) and CD8(+) T cell differentiation and a foundation for mechanistic

71 itis virus (LCMV) strains, we uncovered that T cell differentiation and acquisition of a chronic or e

72 lls and T cells reveals strong signatures of T cell differentiation and activation that correlate pos

73 , whereas enforced EBF1 expression inhibited T cell differentiation and caused rapid loss of Gata3 mR

74 g phagocyte microbicidal capacity to driving T cell differentiation and cytotoxic activity.

75 ogocytosis-mediated signaling impacts CD4(+) T cell differentiation and effector cytokine production

76 While the transcriptional control of CD8 T cell differentiation and effector function following T

77 e discuss recent insights into memory CD8(+) T cell differentiation and exhaustion and the associatio

78 ion, CD28-YMFM CAR-T cells exhibited reduced T cell differentiation and exhaustion as well as increas

79 logy, as well as how metabolic changes drive T cell differentiation and fate.

80 TOs provide a robust tool for studying human T cell differentiation and for the future development of

81 posure to an AhR ligand directly alters CD4+ T cell differentiation and function later in life.

82 MHC class II (MHCII)-influenced CD4(+) T cell differentiation and function play critical roles

83 lar immunotherapies in cancer, and to direct T cell differentiation and function towards non-pathogen

84 To study the role of Ikaros in CD4 T cell differentiation and function, an Ikaros condition

85 vealed critical roles for mTOR in regulating T cell differentiation and function.

86 p'n'collar homology (Bach)2 in orchestrating T cell differentiation and function.

87 n important role for these structures in the T cell differentiation and function.

88 bolic pathways can alter or prevent effector T cell differentiation and function.

89 d early role for NR4A3 in programming CD8(+) T cell differentiation and function.

90 tigen presentation, cytokine modulation, and T cell differentiation and has emerged as a promising th

91 of how environmental-driven cues can impact T cell differentiation and have implications for autoimm

92 n family cytokines involved in regulation of T cell differentiation and homeostasis.

93 glucosamine may be an important modulator of T cell differentiation and immune homeostasis.

94 a growth factor; it lays the foundation for T cell differentiation and immunological memory.

95 Thus, induction of Fas signaling enhanced T cell differentiation and impaired antitumor immunity,

96 n important regulator of effector and memory T cell differentiation and induces a population of stem

97 Notch is a critical regulator of T cell differentiation and is activated through proteoly

98 Mechanisms for human memory T cell differentiation and maintenance have largely been

99 helper cell responses, and promoting memory T cell differentiation and maintenance.

100 nges, including histone methylation, control T cell differentiation and memory formation, though the

101 cts lupus development by regulating effector T cell differentiation and promoting TFHs at the expense

102 mediate human TCR-alphabeta and -gammadelta T cell differentiation and provide a mechanistic insight

103 ors, revealing early compartmentalization of T cell differentiation and regulation.

104 lation as a key regulator and determinant of T cell differentiation and suggest that checkpoint block

105 y which aerobic glycolysis promotes effector T cell differentiation and suggest that LDHA may be targ

106 s strongly induced CD4(+)Foxp3(+) regulatory T cell differentiation and suppressed Th1 and Th17 diffe

107 Determining factors in T cell differentiation and survival include antigen reco

108 mmune responses occur, are known to regulate T cell differentiation and survival.

109 bcellular localization and for balancing CD8 T cell differentiation and survival.

110 y a key mechanism of DC-mediated coupling of T cell differentiation and trafficking that orchestrates

111 role for LDH in modulating cytokine-mediated T cell differentiation and underscore the therapeutic po

112 lasts resulted in impaired follicular helper T cell differentiation and, consequently, in reduced num

113 tor Thpok is required for intrathymic CD4(+) T cell differentiation and, together with its homolog LR

114 endent circuitry promotes both memory CD4(+) T cells' differentiation and functional fitness, two pre

115 alignant state accompanied with an arrest in T-cell differentiation and acquisition of somatic Notch1

116 that Ndfip1 is progressively induced during T-cell differentiation and activation in vivo and that i

117 ng from the T-cell receptor (TCR) conditions T-cell differentiation and activation, requiring exquisi

118 the role of upstream PI3K isoforms in CD8(+) T-cell differentiation and assessed the potential use of

119 s unravel a new pathway orchestrating CD4(+) T-cell differentiation and demonstrate that NAD(+) may s

120 eated exposure to antigen, delaying effector T-cell differentiation and exhaustion.

121 , we assessed the long-term effect of CD8(+) T-cell differentiation and function in 131 patients who

122 e transcriptional programs that regulate CD8 T-cell differentiation and function in the context of vi

123 s with factors important for effector CD4(+) T-cell differentiation and function, including IRF8 and

124 ing is a highly conserved pathway pivotal to T-cell differentiation and function, rendering it a targ

125 e the polyamine spermidine as a modulator of T-cell differentiation and function.

126 ly expressed E3 ubiquitin ligase involved in T-cell differentiation and in a wide range of inflammato

127 sitive regulator that is essential for naive T-cell differentiation and in vivo T-cell responses to a

128 mportance of epigenetic regulation of CD8(+) T-cell differentiation and the likely role that transcri

129 emature defects in mTEC-dependent regulatory T-cell differentiation and thymocyte maturation, which p

130 of NFATc1 activity is vital in facilitating T-cell differentiation and to prevent Notch3-induced T-a

131 d B cell proliferation, antibody production, T cell differentiation, and cytokine production, which c

132 dings shed new light on the role of IL-21 in T cell differentiation, and have relevant implications f

133 TOR pathway is a key driver of murine CD4(+) T cell differentiation, and induction of regulatory T (T

134 ults in the dysregulation of splicing during T cell differentiation, and knockdown of hnRNP L or hnRN

135 la carte cytokine secretion profiles, biased T cell differentiation, and local delivery of non-native

136 tory T cell generation, restraining effector T cell differentiation, and potentiating memory T cell d

137 etermine the effect on clinical progression, T cell differentiation, and T cell migration from the in

138 to nucleosomal regulation of transcription, T cell differentiation, and the inflammatory response an

139 has been shown to have profound influence on T cell differentiation, and use of distinct AhR ligands

140 s of transcription activation and inhibiting T-cell differentiation, and have clinical potential as a

141 olved in the regulation of immune responses, T-cell differentiation, and immunity.

142 ated protein kinase important for apoptosis, T-cell differentiation, and inflammatory responses.

143 The JAK-STAT pathway critically regulates T-cell differentiation, and STAT1 is postulated to regul

144 However, current models for memory CD8(+) T cell differentiation are derived from pathogen-free la

145 how changes in metabolite flux contribute to T cell differentiation are less established.

146 contribute to effector versus memory CD8(+) T cell differentiation are poorly understood.

147 y 5-8 cell divisions, unusually rapid memory T cell differentiation as measured by phenotype and mito

148 ction and that this led to biased helper CD4 T cell differentiation as well as impaired antibody resp

149 replication drove increased effector CD8(+) T cell differentiation, as expected.

150 ate the utility of this collection in CD4(+) T cell differentiation assays revealing the potential of

151 rize this phenotype, we used in vitro CD4(+) T cell-differentiation assays and show that NLRX1-defici

152 T cell maturation confirmed early arrest of T cell differentiation at the T cell progenitor stage in

153 f in vitro functional assays measuring naive T-cell differentiation, B-cell/T-cell cocultures, and re

154 mutant models, allowed overcoming of B- and T-cell differentiation blocks and thymic epithelial cell

155 ation of IL-12 and IL-23 was able to restore T cell differentiation both in vitro and in vivo in the

156 -) mice have normal Th1, Th2, and regulatory T cell differentiation but show defective Th17 different

157 en implicated in the very earliest stages of T cell differentiation, but members of a family of Ras a

158 Mechanistically, DOT1L controlled CD8(+) T cell differentiation by ensuring normal T cell recepto

159 CD4(+) T-cell differentiation by primary human B cells was inve

160 ursors and gradually decreases during normal T-cell differentiation, differences in ABT-199 sensitivi

161 isms by which CD4(+) T cells regulate CD8(+) T cell differentiation during chronic infection remain e

162 mouse norovirus (MNV) to investigate CD8(+) T cell differentiation during chronic infection.

163 ming the basis for a refined model of CD8(+) T cell differentiation during CMV infection.

164 hes to examine the requirements of genes for T cell differentiation during infection are time consumi

165 of how "CD4(+) T cell help" regulates CD8(+) T cell differentiation during persistent infection and h

166 ed a unique role for A2aRs in regulating CD4 T cell differentiation during vaccination.

167 ns in T cells to examine genes that regulate T cell differentiation during viral infection, and that

168 e a new mechanism that controls intrahepatic T-cell differentiation during atherosclerosis developmen

169 nct contributions of these parameters to CD4 T-cell differentiation during infection.

170 urn significantly associated with CD8 memory T-cell differentiation (effector memory, naive, and T-be

171 Thus, ADAP regulates CD8 T cell differentiation events following acute pathogen c

172 Now, multiple additional T cell differentiation fates are recognized with distinc

173 his demonstrated a trajectory of myeloid and T cell differentiation from the periphery inward.

174 efects, which were manifest at all stages of T-cell differentiation from early thymic pre-T cells to

175 stablish a high-resolution map of gammadelta T-cell differentiation from the fetal and adult thymus u

176 regulator of mTOR signaling, which regulates T cell differentiation, function, and trafficking.

177 Understanding intrathymic T cell differentiation has been greatly aided by the dev

178 L-23 has been well studied in the context of T cell differentiation; however, its role in the differe

179 to understand the mechanisms underlying Th17 T cell differentiation in both mouse and human.

180 ntifies miR-210 as an important regulator of T cell differentiation in hypoxia, which can limit immun

181 pathogens in the periphery elicits effector T cell differentiation in local lymph nodes followed by

182 Thus, the cytokine acts to control cytotoxic T cell differentiation in lymphoid and peripheral organs

183 , TLR ligands, on effector and memory CD8(+) T cell differentiation in mice.

184 ining transcriptional networks direct CD4(+) T cell differentiation in the lymphoid organs and tissue

185 s animal development; for example, mammalian T cell differentiation in the thymus and neuroblast spec

186 ITK-Syk oncogene expression induces terminal T cell differentiation in the thymus by activating Blimp

187 reveals how TCF-1 exerts central control of T cell differentiation in the thymus by normally repress

188 e transcription factor ThPOK promotes CD4(+) T cell differentiation in the thymus.

189 The drivers and the specification of CD4(+) T cell differentiation in the tumor microenvironment and

190 fore, examined cytokine signaling and CD4(+) T cell differentiation in these cohorts to characterize

191 educes Th17 skewing and increases regulatory T cell differentiation in vitro when cultured in RPMI 16

192 -3 protein acutely at specific points during T cell differentiation in vitro.

193 layers of fate decisions that inform CD4(+) T cell differentiation in vivo.

194 complications and a skewed follicular helper T-cell differentiation in defined monogenic immunodefici

195 ered resistance to infection, and influenced T-cell differentiation in response to a de novo viral in

196 demonstrate alterations in markers of CD8(+) T-cell differentiation in response to this metabolite.

197 ages of T-cell development in the thymus and T-cell differentiation in the periphery.

198 Spermidine modulates CD4(+) T-cell differentiation in vitro, preferentially committi

199 out spermidine treatment, to evaluate CD4(+) T-cell differentiation in vitro.

200 latory molecules involved in proinflammatory T cell differentiation, including cluster of differentia

201 Naive CD4(+) T cell differentiation into distinct subsets of T helper

202 Infections induce pathogen-specific T cell differentiation into diverse effectors (Teff) tha

203 ts a role for these receptors in skewing CD8 T cell differentiation into effector and memory cells an

204 mat, GATA3 and others is essential for naive T cell differentiation into effector T cells.

205 ain receptors was essential for naive CD4(+) T cell differentiation into HA1-specific Th17.

206 drug treatment caused a striking bias of CD4 T cell differentiation into Th1 cells and substantially

207 Our study indicates that ABCG1 regulates T cell differentiation into Tregs, highlighting a pathwa

208 cept of strict fate commitment during CD4(+) T-cell differentiation into distinct subsets.

209 Dendritic cells (DCs) direct CD4(+) T-cell differentiation into diverse helper (Th) subsets

210 the small intestine and colon, and inhibits T-cell differentiation into Th1 cells under different cy

211 e report that Jmjd3 ablation promotes CD4(+) T-cell differentiation into Th2 and Th17 cells in the sm

212 s are constitutively unmethylated throughout T cell differentiation, irrespective of their activation

213 Because T cell differentiation is finely tuned by multiple posit

214 Cytotoxic T cell differentiation is guided by epigenome adaptation

215 eutic option, but the role of IL-21 in human T cell differentiation is incompletely understood.

216 CD8 T cell differentiation is orchestrated by dynamic metabo

217 At issue is whether the state of T cell differentiation is specified by initial condition

218 The skewing of T-cell differentiation is concomitant with changes in th

219 ome increasingly clear that pathogenic donor T-cell differentiation is initiated by both professional

220 hough our understanding of miRNA function in T-cell differentiation is still rudimentary, the availab

221 n-1 (Blimp-1), a critical regulator of B and T cell differentiation, is highly expressed in memory CD

222 arget of rapamycin pathway influences CD4(+) T cell differentiation; low levels favor regulatory T ce

223 od; however, one key regulator of memory CD8 T cell differentiation, mammalian target of rapamycin ki

224 We examined the requirement of the T cell differentiation marker killer cell lectin-like re

225 To assess T-cell differentiation, mDCs were cocultured with naive

226 In this study, using in vitro T cell differentiation models, we demonstrate that CQ ac

227 a key regulatory role of Id2 during effector T cell differentiation necessary to limit IL-10 producti

228 for traditional biological concepts, such as T cell differentiation or cell cycle regulation, in exis

229 nses both in vitro and in vivo by regulatory T-cell differentiation or directly inhibiting T-cell-med

230 T cell differentiation originally was considered a dicho

231 By computationally reconstructing T cell differentiation paths, we identified protein expr

232 consistent with an effect of GSK-J4 on Th17 T cell differentiation pathways directly related to prol

233 em and suggests that leptin signaling during T cell differentiation plays a crucial role in T cell pe

234 the active form of vitamin D3, during CD8(+) T-cell differentiation prevents IL-4-induced conversion

235 activation imprints unique and long lasting T-cell differentiation programs.

236 CD4 T cell differentiation (proliferation and epigenetic rem

237 f rapamycin (mTOR) are central regulators of T cell differentiation, proliferation, metabolism, and s

238 including those involved in proinflammatory T cell differentiation, prolonged monocyte major histoco

239 ogical inhibition of regulators that mediate T cell differentiation promotes the differentiation of a

240 BACH2 functions as a pervasive regulator of T cell differentiation, promoting development of CD4(+)

241 n methods ultimately inform models of memory T cell differentiation, protection, and vaccine translat

242 We developed a stage-specific T cell differentiation protocol to validate genetic corr

243 cell receptor signaling (PTPRN2, RLTPR), and T-cell differentiation (RARA).

244 both constitutively expressed during CD8(+) T cell differentiation, regulated the formation of termi

245 genetic mechanisms and any normal purpose in T cell differentiation remain unclear.

246 tudied, but how they influence memory CD8(+) T cell differentiation remains poorly defined.

247 How MyD88 regulates helper T-cell differentiation remains largely unknown, however.

248 he effect of hypercholesterolemia on hepatic T-cell differentiation remains unknown.

249 gical processes, but its in vivo function in T-cell differentiation remains unknown.

250 T cell differentiation requires appropriate regulation o

251 -cell differentiation, with a leaky block in T-cell differentiation resulting in an oligoclonal T-cel

252 .0001), with the latter independently of the T cell differentiation state.

253 This indicates that CD4 T cell differentiation status differentially affects LRA

254 rs is modulated by conditions such as CD4(+) T cell differentiation, stimulation, tissue location, or

255 T cell differentiation studies revealed a reduction of b

256 critically important molecules required for T cell differentiation, such as JAK2 and IL12RB2, are re

257 (CD134), provides essential signals driving T cell differentiation, survival, and memory in part thr

258 between Trib1 and effector versus exhausted T cell differentiation that can be targeted to improve a

259 f19-PRC2 as a pivotal axis regulating CD8(+) T cell differentiation, thereby paving new ways for pote

260 Anti-TIM-3 drives CD8 T cell differentiation through activation of the mTORC1

261 nt during Ag stimulation directly influences T cell differentiation through mTORC1.

262 Herein, we provide an updated perspective on T cell differentiation through the lens of recent advanc

263 cate KLF2 is pivotal for coordinating CD4(+) T cell differentiation through two distinct and compleme

264 We show that NAD(+) regulates CD4(+) T-cell differentiation through tryptophan hydroxylase-1

265 ing strength is a dominant factor regulating T-cell differentiation, thymic development, and cytokine

266 s, suppressed T cell activation, and altered T cell differentiation to suppressive regulatory phenoty

267 ifferent sources converges to match effector T cell differentiation to the demands of an infection.

268 e loss of aPKC unexpectedly increased CD8(+) T cell differentiation toward a short-lived, terminal ef

269 Skewing T cell differentiation toward a Th2-dominated phenotype

270 ZIKV infection was characterized by a CD4 T cell differentiation toward effector cells and by a lo

271 beta signaling axis that ultimately enhances T cell differentiation toward Th1.

272 immune dysregulation had a skewed memory CD4 T-cell differentiation toward a CXCR3(+)CCR6(-) TH1 phen

273 es of MS, although the factors that regulate T-cell differentiation toward pathogenic T helper-1/T he

274 ymus across the life span and to reconstruct T cell differentiation trajectories and T cell receptor

275 and PD-1 and CTLA-4 expression, and blocked T cell differentiation, until the cells quickly disappea

276 s of ACC1 did not compromise effector CD8(+) T cell differentiation upon listeria infection but did r

277 ivity and flexibility and improve memory CD8 T cell differentiation, useful attributes for T cells us

278 roviding clear evidence that B7-H1 modulates T cell differentiation via a novel receptor.

279 ts identify Jmjd3 as an epigenetic factor in T-cell differentiation via changes in histone methylatio

280 Overall, T cell differentiation was enhanced in sites of viral pe

281 The regulation of CD4+ T cell differentiation was mediated at least in part thr

282 T-cell differentiation was assessed by using intracellul

283 ng the cytokine that is important for B- and T-cell differentiation was knocked into its respective m

284 menn syndrome (OS) patient, similar impaired T-cell differentiation was observed, due to increased si

285 erminal centers (GCs), and follicular B- and T-cell differentiation was reduced, whereas the number o

286 TH1, TH17, and CD8(+) memory T-cell differentiation was significantly reduced, and T

287 ding a transcription repressor essential for T cell differentiation, was deleted in over one-half of

288 (RORgamma), known to drive inflammation and T cell differentiation, was upregulated during pancreati

289 m, whereby the androgen milieu modulates CD4 T-cell differentiation, was ascertained as we found that

290 To study the spectrum of T cell differentiation, we have analyzed an infection wi

291 in TCR signal strength could regulate CD8(+) T cell differentiation, we investigated the transcriptio

292 S1PR1 was progressively downregulated during T cell differentiation whereas S1PR2 expression remained

293 Overexpression of NR4A1 inhibits effector T cell differentiation, whereas deletion of NR4A1 overco

294 the bioenergetic and biosynthetic demands of T-cell differentiation, whether metabolism might control

295 bit an imbalance in effector and memory CD8+ T cell differentiation, which impairs the formation of m

296 tivation blocks immunosuppressive regulatory T cell differentiation, which is a potential therapeutic

297 no factors seemed as dominantly required for T cell differentiation, which may represent a fall-back

298 press the Ealpha enhancer at early stages of T cell differentiation, while their decommission is requ

299 actors (TFs) are known to play a key role in T cell differentiation, with mice deficient for the TF T

300 ly found that EGR2 promotes peripheral naive T-cell differentiation, with delayed T-cell receptor-ind