ライフサイエンスコーパス: T-cell epitope

1 ing high levels of the I-E(k)-restricted hLa T cell epitope.

2 J8 does not contain a dominant GAS-specific T cell epitope.

3 uing that the methyl lysines are part of the T cell epitope.

4 hemical properties and shared the same major T-cell epitope.

5 y processed ligands, cancer neoantigens, and T cell epitopes.

6 T cell reactivity revealed a large number of T cell epitopes.

7 roves comprehensive identification of CD8(+) T cell epitopes.

8 ly directed against immunodominant conserved T cell epitopes.

9 o include the most common forms of potential T cell epitopes.

10 this process, we also identified nine other T cell epitopes.

11 lly determined and computer-predicted CD4(+) T cell epitopes.

12 hampered by the lack of defined RSV-specific T cell epitopes.

13 atrix for identification of disease-relevant T cell epitopes.

14 d to identify novel RSV-specific CD4 and CD8 T cell epitopes.

15 s but contains conserved, immunodominant CD8 T cell epitopes.

16 HRV A-specific and three HRV C-specific CD8 T cell epitopes.

17 a T cell immune response are referred to as T cell epitopes.

18 imal and dominant SARS-CoV-2-specific CD8(+) T cell epitopes.

19 the immunogenicity and response magnitude to T cell epitopes.

20 n vaccine- versus infection-generated CD4(+) T cell epitopes.

21 were immunized with a pool of virus-derived T-cell epitopes.

22 ion and the clinical relevance of identified T-cell epitopes.

23 rrelates with the presence of immunodominant T-cell epitopes.

24 ability to sensitize and is devoid of major T-cell epitopes.

25 des, defining a large number of discrete CD4 T-cell epitopes.

26 been speculation that H7N9 will have few CD4 T-cell epitopes.

27 -A2-, HLA-B0702-, and HLA-B08-restricted CD8 T-cell epitopes.

28 Like Api g 1, Mal d 1 lacked dominant T-cell epitopes.

29 nal approach to test for selection in CD8(+) T-cell epitopes.

30 tion of novel, pathophysiologically relevant T-cell epitopes.

31 p120 enhanced responses to the dominant CD4+ T-cell epitopes.

32 ong DR04:01 restricted Pooideae grass-pollen T-cell epitopes.

33 ype and function, and TCR reactivity to many T-cell epitopes.

34 confirmed that mutant peptides can serve as T-cell epitopes.

35 phenotype and recognized a broad variety of T-cell epitopes.

36 tocompatibility complex (MHC) class I and II T-cell epitopes.

37 ons in both identified immunodominant CD8(+) T-cell epitopes.

38 t v 1 into fragments containing all relevant T-cell epitopes.

39 correlate to a decreased production of known T-cell epitopes.

40 to filter peptide epitopes, we identified 41 T cell epitopes (5 HLA class I, 36 HLA class II) and 6 B

41 A*02:01-restricted SARS-CoV-2-specfic CD8(+) T cell epitopes, A2/S(269-277) and A2/Orf1ab(3183-3191)

42 virus was discovered in 2019, we mapped 142 T cell epitopes across the SARS-CoV-2 genome to facilita

43 omprehensive identification of unique CD4(+) T-cell epitopes across the 4 DENV serotypes allows the t

44 monstrate that the HLA-DRB1*15:01-restricted T cell epitope alpha3136-146 can induce T cell responses

45 ed a HLA-DRB1*15:01-restricted alpha3(IV)NC1 T cell epitope (alpha3136-146) with four critical residu

46 Three previously identified dominant T cell epitopes (Amb a 1 176-191, 200-215, and 344-359)

47 We identified GPC and NP regions containing T cell epitopes and HLA haplotypes from LF survivors and

48 of HLA class II restriction across multiple T cell epitopes and HLA types.

49 s that contribute to the conservation of CD8 T cell epitopes and how rapidly the virus will evolve in

50 table of training predictors able to predict T cell epitopes and peptides eluted from human EBV-trans

51 a), engineered to express several autologous T cell epitopes and sequences derived from the circumspo

52 Yet, cashew-specific T cell epitopes and T cell cross-reactivity amongst cash

53 amino acids encompassed by both antibody and T cell epitopes and were central to globally circulating

54 equence epitope previously identified as CD8 T-cell epitope and a second epitope that we previously i

55 the mosaic method chooses the most frequent T-cell epitopes and combines them to form a synthetic an

56 cluded HN3-T20, which was modified to remove T-cell epitopes and contains a PE domain II truncation.

57 ings identify immunodominant human norovirus T-cell epitopes and demonstrate that it is feasible to g

58 es to 50 frequently recognized Amb a-derived T-cell epitopes and homologous peptides from western rag

59 with the human genome, the links between the T-cell epitopes and low immunogenicity of H7 HA remains

60 e antibodies bind gluten peptides related to T-cell epitopes and many have higher reactivity to deami

61 ogenicity by eliminating known and predicted T-cell epitopes and maximizing the content of human pept

62 The new immunotoxin has a 93% decrease in T-cell epitopes and should have improved efficacy in pat

63 ffinity is widely used to identify candidate T cell epitopes, and an affinity of 500 nM is routinely

64 BV infection, identified HDV-specific CD8(+) T-cell epitopes, and characterized HDV-specific CD8(+) T

65 largely by the targeting of specific CD8(+) T-cell epitopes, and we identify eight epitopes that are

66 CD8 T cell memory in a mouse model where CD8 T cell epitopes are clearly defined.

67 The CD4 T cell epitopes are derived from HCMV structural protein

68 e CD4 and CD8 T cell responses, whereas DENV T cell epitopes are found primarily in nonstructural pro

69 Mutations in T cell epitopes are implicated in hepatitis C virus (HCV

70 f computational approaches that predict what T cell epitopes are likely to be recognized in a given i

71 T cell epitopes are mostly nonmodified peptides, althoug

72 Which, and how many, T cell epitopes are required and suffice to perpetuate a

73 However, T-cell epitopes are difficult to identify and predict.

74 at recognized these minimally cross-reactive T-cell epitopes are present in Grass-pollen-allergic sub

75 Some identified T-cell epitopes are promiscuous and recognizable by the

76 these data identify for the first time a Tg T cell epitope as a spontaneous target in ISAT.

77 Definitive identification of pathogenic T cell epitopes as is now known in celiac disease and re

78 This technique identified novel CD4(+) T-cell epitopes as well as a novel B-cell epitope, Meu10

79 ptide of Phl p 1 devoid of allergen-specific T cell epitopes, as recognized by BALB/c mice, was fused

80 The TYKW mutant retained T-cell epitopes, as evident from its lymphoproliferative

81 ied a class of hidden self-antigens known as T cell epitopes associated with impaired peptide process

82 n shown that MHC-Ilo tumors produce a set of T cell epitopes associated with impaired peptide process

83 T cell epitopes associated with impaired peptide process

84 T cell epitope-based oral immunotherapy is effective in

85 articular interest are mutated tumor antigen T-cell epitopes, because neoepitope-specific T cells oft

86 We therefore sought to identify common T cell epitopes between Lassa fever survivors from Sierr

87 tides predicted to contain I-A(b)-restricted T-cell epitopes but not identified in WT mice.

88 nt on presentation of both CD4(+) and CD8(+) T cell epitopes by the same dendritic cell population.

89 T cell epitope candidates are commonly identified using

90 lso incorporating molecular adjuvant and CD4 T cell epitope cargo.

91 lergen immunotherapy using synthetic peptide T-cell epitopes (Cat-PAD) from the major cat allergen Fe

92 After identification of T cell epitope-containing parts on each of the 3 parenta

93 ergen Bet v 1 and recombinant hypoallergenic T-cell epitope-containing Bet v 1 fragments in patients

94 taneously optimize proteins for both reduced T cell epitope content and high-level function.

95 were able to identify a MHCII-restricted CD4 T cell epitope, corresponding to amino acids 37-47 in th

96 e to Bla g 7 and Ani s 3, indicating lack of T-cell epitope cross-reactivity.

97 s-like particle (VLP) containing a universal T cell epitope (CuMV(TT) ) using a semi-crossover design

98 virus containing a tetanus toxoid universal T-cell epitope (CuMVTT).

99 Here, we overcome a lack of T cell epitope data to construct swine epitope predictor

100 pes (T regulatory cell epitopes) are natural T cell epitopes derived from immunoglobulin G (IgG) that

101 ss allergen peptides, comprising 7 synthetic T-cell epitopes derived from Cyn d 1, Lol p 5, Dac g 5,

102 HRV-specific CD8 T cell epitopes describe here are expected to elicit CD8

103 cell lines for identifying CD8(+) and CD4(+) T-cell epitopes, determining the ability of vaccine-indu

104 the consensus sequence in the corresponding T-cell epitope did not expand in vitro.

105 However, conventional CD8 T cell epitope discovery methods are labor intensive and

106 inding peptides is an essential component of T cell epitope discovery, something that ultimately shou

107 Q-MS will not only find broad application in T-cell epitope discovery but also inform vaccine design

108 Traditional methods of T-cell epitope discovery use overlapping short peptides

109 development of immunogens to overcome HIV-1 T-cell epitope diversity, identification of correlates o

110 Helper T-cell epitope dominance in human immunodeficiency virus

111 ducing non-sense mutations may still present T cell epitopes downstream of the premature termination

112 gence of escape mutations in multiple CD8(+) T cell epitopes during the course of infection.

113 ction, and a large number of M. tuberculosis T cell epitopes enabled us to identify pMHC ligands for

114 ory T cells and identify a novel HLA-DR7/ HY T cell epitope, encoded by RPS4Y, a potential new therap

115 ch consists of screening for likely dominant T-cell epitopes, establishing antigen-specific memory T-

116 , even in human influenza virus NP, sites in T-cell epitopes evolve more slowly than do nonepitope si

117 We identify two immunodominant SpCas9 T cell epitopes for HLA-A*02:01 using an enhanced predic

118 dictions identified a priori potential B and T cell epitopes for SARS-CoV-2.

119 import of the OVA peptide SIINFEKL, a CD8(+) T cell epitope frequently used to study cross-presentati

120 (MCMV) recombinants expressing a single CD8 T cell epitope from HSV-1 fused to different MCMV genes,

121 oncogene and expresses an immunodominant CD8 T cell epitope from MHV-68.

122 NLPs loaded with the AhR agonist ITE and a T cell epitope from myelin oligodendrocyte glycoprotein

123 atis strain expressing a heterologous CD4(+) T cell epitope from ovalbumin (OVA) consisting of OVA re

124 Surprisingly, a well-characterized T cell epitope from the flagellar protein FliC afforded

125 We identified immunodominant CD8(+) T cell epitopes from IBVs that were protective in mice a

126 hat in pandemic situations, inclusion of CD4 T cell epitopes from seasonal viruses have the potential

127 aracterization of conserved HRV-specific CD8 T cell epitopes from species A (HRV A) and C (HRV C), th

128 y 10 potential HLA-A*02:01-restricted CD8(+) T cell epitopes from the 718-aa sequence of VP11/12.

129 y 10 potential HLA-A*02:01-restricted CD8(+) T cell epitopes from the HSV-1 gB amino acid sequence.

130 chimeric peptide composed of a cytotoxic CD8 T-cell epitope from CMV pp65 and a tetanus T-helper epit

131 vaccine that is selectively based on CD8(+) T-cell epitopes from ASYMP individuals.

132 d 10 potential HLA-A*02:01-restricted CD8(+) T-cell epitopes from the 693-amino-acid sequence of the

133 T-cell epitopes from timothy grass (Phleum pratense) wer

134 d on MSP1 (PvRMC-MSP1) that includes defined T cell epitopes genetically fused to PvMSP119.

135 The USA-specific vaccine comprised 6 CD8+ T cell epitopes (GILGFVFTL, FMYSDFHFI, GMDPRMCSL, SVKEKD

136 The majority (68%) of T cell epitopes harbored no detectable escape mutations.

137 lity of currently available tools to predict T cell epitopes has not been comprehensively evaluated.

138 Naturally processed T cell epitopes have been discovered by elution from HLA

139 cently described, so far no PVM-specific CD4 T cell epitopes have been identified within the C57BL/6

140 Although multiple AQP4 T-cell epitopes have been identified in WT C57BL/6 mice,

141 overlapping peptides, we identified multiple T cell epitopes hosted in the N-terminal parts of the al

142 lgorithms and provide new clues to improving T-cell epitope identification.

143 A pool of the most dominant T cell epitopes identified in the present study and from

144 e important contribution of this H7-specific T cell epitope in determining the immunogenicity of an i

145 peptides were shown to encompass strong CD4 T cell epitopes in B. pseudomallei-exposed individuals a

146 ass II alleles for immunodominant Gag CD4(+) T cell epitopes in clade C virus infection, constructed

147 capacity of HLA-C to present immunodominant T cell epitopes in HIV-infected individuals, indicating

148 Most vaccines and basic studies of T cell epitopes in Mycobacterium tuberculosis emphasize

149 DR and -DQ loci accurately predicted Ara h 2 T cell epitopes in peanut-allergic subjects, suggesting

150 ruhugu and rustrela viruses and two putative T cell epitopes in the capsid protein of the rubella and

151 We identified all reactive T cell epitopes in the HIV-1 proteome for each participa

152 VIII using, as input, the number of putative T cell epitopes in the infused protein and the competenc

153 Insulin B6-23, a highly immunogenic CD4 T-cell epitope in patients with T1D, bound to both DQ6 a

154 affecting presentation of the immunodominant T-cell epitope in vitro.

155 To eliminate widespread T-cell epitopes in any biotherapeutic and thereby mitiga

156 genicity reduction, and we use it to disrupt T-cell epitopes in GFP and Pseudomonas exotoxin A withou

157 h prior immunoinformatic analysis identified T-cell epitopes in H7 hemagglutinin (HA) which potential

158 h was used to identify HLA-restricted CD4(+) T-cell epitopes in Jug r 2.

159 ent of substitutions that alter human CD8(+) T-cell epitopes in NP of human versus swine influenza vi

160 sing human cells, we identified eight helper T-cell epitopes in PE38, a portion of the bacterial prot

161 Identification of potential T-cell epitopes in the peanut major allergens is essenti

162 sed to identify and validate 5 myelin CD8(+) T cell epitopes, including 2 newly described determinant

163 We identified 5 new CD4 and 5 new CD8 T cell epitopes, including a CD8 T cell epitope within t

164 We identified 12 CD8-positive (CD8(+)) T cell epitopes, including epitopes common to both Niger

165 a mixture of these two immunodominant CD4(+) T cell epitopes induced a robust antiviral CD4(+) T cell

166 upport the possibility of incorporating FliC T cell epitopes into vaccination programs targeting both

167 The T cell epitope is naturally processed from alpha3(IV)NC1

168 onditional; the accumulation of mutations in T cell epitopes is limited, and the rate of accumulation

169 ology, the discovery and characterization of T-cell epitopes is a critical aspect of type 1 diabetes

170 However, identifying tumor-specific T-cell epitopes is a major challenge.

171 es and controls allergic inflammation at the T-cell epitope level is critical for the design of new a

172 T cell epitopes localized to conserved molecular regions

173 ptide representing immunodominant RSV CD8(+) T cell epitope M282-90, a TLR agonist (polyinosinic-poly

174 aking this the most comprehensive dataset of T cell epitopes mapped in a complex pathogen.

175 Of note, 50% (5/10) of CD8(+) T cell epitopes mapped within the gamma-gliadins.

176 ted T cells were determined by a novel CD154 T cell epitope mapping assay.

177 The complexity and importance of T cell epitope mapping have motivated the development of

178 T cell epitope mapping unveiled a 13-residue sequence co

179 promoter, the polypeptide context of a CD8(+)T cell epitope may determine whether classical or inflat

180 peptide, homologous to an immunodominant MPO T-cell epitope (MPO(409-428)), can induce anti-MPO autoi

181 immunogens fused to an immunodominant CD4(+) T cell epitope of the secreted Ag 85B protein of BCG.

182 Thus, sequence homology between T cell epitopes of 2 self-proteins and a related order o

183 s that contribute to the conservation of CD8 T cell epitopes of IAV.

184 The high degree of conservation of CD8 T cell epitopes of influenza A virus (IAV) may allow for

185 Identifying T cell epitopes of islet autoantigens is important for u

186 Two vaccines expressing CD4(+) and CD8(+) T cell epitopes of melanoma-associated Ags (MAAs) by a c

187 T cell epitopes of Met e 1 were first identified based o

188 ) T cells that target RV is largely unknown, T cell epitopes of RV capsid proteins were analyzed, and

189 A mix of hypoallergenic peptides containing T cell epitopes of the most important HDM allergens was

190 mmune control and a means to identify CD8(+) T cell epitopes of topological importance for rational i

191 We sought to identify the immunodominant T cell epitopes of tropomyosin, the major shrimp allerge

192 termined by mass spectrometry and related to T-cell epitopes of Amb a allergens (group 1, 3, 4, 5, 8

193 ssing and MHC protein binding for all helper T-cell epitopes of an antigen.

194 Modeling predicted masking of major IgE and T-cell epitopes of BLG by ligand binding.

195 We analyzed the T-cell epitopes of Mal d 1, the nonsensitizing Bet v 1 h

196 T-cell epitopes of multiple allergens/isoallergens are i

197 , we identified a broad landscape of 83 CD8+ T-cell epitopes of MuV, 41 of which were confirmed based

198 e defined the immunodominant, HLA-restricted T-cell epitopes of OprF.

199 berculosis is likely due to the depletion of T-cell epitopes on commensal gut non-tuberculosis mycoba

200 ormed to map experimentally validated CD8(+) T cell epitopes onto the distribution of DENV genome seq

201 the previously identified thyroglobulin (Tg) T cell epitope p2549-2560 containing thyroxine at positi

202 ognize an HLA-A*0201-presented wild-type p53 T-cell epitope, p5365-73(RMPEAAPPV).

203 A CD8(+) T cell epitope peptide from OVA (CSIINFEKL) and CpG were

204 Mice treated with the T cell epitope peptide mixture demonstrated an ameliorat

205 Known gluten T cell epitope peptides were enriched by DQ2.5, whereas

206 MHC-class II-based T cell epitope prediction algorithms for HLA-DR and -DQ

207 T cell epitope prediction tools and associated vaccine d

208 Most T cell epitope prediction tools are based on machine lea

209 ata shows significant promise for developing T cell epitope prediction tools for pigs.

210 l currently publicly available computational T cell epitope prediction tools to identify these major

211 idual endolysosomal proteases as well as the T-cell epitope presentation in BMDCs.

212 eptibility factor for many diseases, culprit T cell epitopes presented by disease-associated MHC mole

213 collagen, alpha3(IV)NC1, but critical early T cell epitopes presented by this human MHC class II mol

214 nes that deliver different CD8(+) and CD4(+) T-cell epitopes presented by MHC class I and class II al

215 ated with Lyme arthritis (LA), we identified T-cell epitopes presented in vivo by human leukocyte ant

216 ope diversities exhibit equivalent levels of T cell epitope promiscuity.

217 This comprehensive characterization of HDV T-cell epitopes provides important information that will

218 gning vaccine antigens to optimize potential T-cell epitope (PTE) coverage.

219 ries only in C-terminal truncation of the p6 T cell epitope, raising the possibility of selection by

220 ammed to achieve distinct patterns of CD8(+) T cell epitope recognition.

221 ntify B. melitensis MHC-II-restricted CD4(+) T cell epitopes recognized by the human immune response,

222 The specific T cell epitopes recognized in an individual are determin

223 ublished dataset that systematically defined T cell epitopes recognized in vaccinia virus (VACV) infe

224 station in the retina as part of the CNS and T-cell epitopes recognized by the allogeneic T cells wer

225 ector prime boosting increased the number of T-cell epitopes recognized.

226 Several distinct T-cell epitope regions along the allergen were identifie

227 pe and function of HSV-specific human CD4(+) T cell epitopes remain to be fully elucidated.

228 nfection but, surprisingly, HRV-specific CD8 T cell epitopes remain yet to be identified.

229 Mutations within T cell epitopes represent a common mechanism of viral es

230 xperiments, they contained allergen-specific T cell epitopes required for tolerance induction, and up

231 experimentally validated HCMV-specific B and T cell epitopes, respectively, from available epitope re

232 ected by mucoid PA, and they showed a narrow T-cell epitope response and a relative reduction in Th1

233 orm of brain cancer generates an immunogenic T cell epitope restricted by a common HLA subtype, there

234 nes, and relatively few optimal HIV-1 CD8(+) T cell epitopes restricted by HLA-C alleles have been de

235 Our analysis included recently identified T cell epitopes restricted through HLA-C, whose presenta

236 In total, 15 PVM-specific CD8(+) T-cell epitopes restricted by H-2D(b) and/or H-2K(b) wer

237 Here we define HLA-restricted CD4(+) T-cell epitopes resulting from natural infection with de

238 hat is a homolog of a highly immunogenic EBV T cell epitope (SELEIKRY) presented by HLA-B*18:01.

239 bserved for IgE reactivity and influenced by T cell epitope sequence conservation.

240 Some T-cell epitope sequences in EBNA3 genes show extensive v

241 We identified 6 CD8(+) T-cell epitopes; several were restricted by multiple HLA

242 ant virus population within samples harbored T-cell epitopes similar to the reference BKV strain that

243 ealed that all the infection-elicited CD4(+) T cell epitope specificities are also elicited by protei

244 Some T cell epitopes, such as p6, are able to bind diverse HL

245 ts with a polymorphic region overlapping two T cell epitopes, suggesting that variability in C-PfCSP

246 190A) are localized in class I/II-restricted T-cell epitopes, suggesting a role in HBV escape from T-

247 ined mutations occurred at sites enriched in T-cell epitopes, suggesting they promote viral immune es

248 e reasons, a cataloging and appraisal of the T-cell epitopes targeted in type 1 diabetes was complete

249 DP alleles can be classified into functional T cell epitope (TCE) groups.

250 ated this question in nonpermissive HLA-DPB1 T-cell epitope (TCE) mismatches reflected by numerical f

251 Our results indicate that CD4 T cell epitopes that are 17 amino acids in length result

252 T cell component consists of 6 CD8 and 6 CD4 T cell epitopes that are conserved among HCMV strains.

253 e observations: 1) SERCA2a contains multiple T cell epitopes that induce varying degrees of myocardit

254 hows a nonuniform distribution of HBV CD8(+) T cell epitopes that is influenced by the presence of IF

255 nsively studied in mice, no recognized human T cell epitopes that might provide new approaches to cla

256 tion of a wide array of VACV-derived, CD8(+) T cell epitopes that share homology with other poxviruse

257 ity of NetMHCpan to predict antiviral CD8(+) T cell epitopes that we identified with a traditional ap

258 synthesized and evaluated candidate mutated T cell epitopes that were identified using a major histo

259 were identified as minimally cross-reactive T-cell epitopes that do not show cross-reactivity to Phl

260 BV reproducibly selects substitutions in CD8 T-cell epitopes that functionally act as immune escape m

261 Identification of specific HLA alleles and T-cell epitopes that influence the course of BK polyomav

262 We identified a set of "type 2" T-cell epitopes that were recognized at 10-fold-lower le

263 Therefore, in the quest for T cell epitopes, the prediction of peptide binding to MH

264 alone and also linked with the measles virus T cell epitope to produce a chimeric peptide vaccine.

265 en studied, in part due to the lack of known T cell epitopes to vaccine viruses.

266 ntaining the tetanus toxin-derived universal T-cell epitope tt830-843 (CuMV(TT)) was used to immunize

267 lected strongly binding alleles to the MHC-I T-cell epitopes using molecular docking and the complexe

268 In addition, CD4 T cell epitope vaccination of immunocompetent mice reduc

269 ve panel of 467 HLA-A*0201-restricted CD8(+) T cell epitopes was predicted from the entire HSV-1 geno

270 edicted peptide, distinct from the predicted T-cell epitope, was identified from ClpC.

271 peptide array identified putative novel CD8 T cell epitopes, we validated the method by IFN-gamma EL

272 Although these substitutions targeted T-cell epitopes, we demonstrate that reduced conformatio

273 Though the initial CD4 T cell epitopes were 15 amino acids in length, synthesis

274 s showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the p

275 n addition, five previously unidentified CD4 T cell epitopes were discovered, including epitopes in t

276 ions of the PvCSP predicted to contain human T cell epitopes were genetically fused to an immunodomin

277 Six major Met e 1 T cell epitopes were identified.

278 le alpha3IV-NC1 domain, three immunodominant T cell epitopes were identified.

279 monstrated that the core and envelope CD8(+) T cell epitopes were not uniformly distributed in the li

280 While PVM-specific CD8 T cell epitopes were recently described, so far no PVM-s

281 All CD8 T cell epitopes were reported to induce cytotoxic activi

282 Five novel CD8 T cell epitopes were revealed within the RSV fusion (F)

283 All non-synonymous mutations in reactive T cell epitopes were tested for their effect on the size

284 Multiple Ana o 1 and Ana o 2 T cell epitopes were then identified.

285 servation of epitopes, low-level variants in T-cell epitopes were detected in 77.7% (14/18) of patien

286 Multiple Jug r 2 T-cell epitopes were identified.

287 B27 from three chlamydial proteins for which T-cell epitopes were predicted.

288 rt on the first VZV/HSV-1 cross-reactive CD4 T cell epitope, which is HLA-DR promiscuous and immunopr

289 ssays revealed that CCNB1 contained many CD4 T cell epitopes, which are differentially recognized by

290 The identified CD8+ T-cell epitopes will help to further characterize MuV-sp

291 us, immune responses can be augmented toward T cell epitopes with low functional avidity by increasin

292 epitope that we previously identified as CD4 T-cell epitope with increased binding to HLA-DQ8trans up

293 rived MHC class I and MHC class II candidate T-cell epitopes with potential antigen-specific cross-re

294 presented that predicts and scores antitumor T-cell epitopes, with a focus on tolerability and avoida

295 d 5 new CD8 T cell epitopes, including a CD8 T cell epitope within the G protein that was previously

296 potential to present a greater number of CD8 T cell epitopes within a single animal can delay immune

297 c T cell responses, but, to date, only a few T cell epitopes within these proteins have been identifi

298 ified multiple polyfunctional CD4-restricted T-cell epitopes within a highly conserved region of memb

299 hed presentation of MHC-Ia-restricted CD8(+) T cell epitopes without impacting presentation of peptid

300 ing peptides represent an important class of T cell epitopes, yet their prevalence remains underestim