ライフサイエンスコーパス: T-cell leukaemia

1 , and ectopic expression of which results in T cell leukaemia.

2 lated from a chromosomal breakpoint in human T-cell leukaemia.

3 ate that sustained Zeb2 expression initiates T-cell leukaemia.

4 a range of human diseases including AIDS and T-cell leukaemias.

5 tion, predisposition to cancer, particularly T cell leukaemia and lymphoma, and premature ageing.

6 predisposition to some tumours, particularly T cell leukaemia and lymphoma.

7 Adults with T cell leukaemias and lymphomas, collectively called T c

8 discovered via chromosomal translocations in T-cell leukaemia and shown normally to be essential for

9 nduces a high incidence of myeloid or B- and T-cell leukaemia and the proviral integration sites in t

10 rotein LMO2 is expressed aberrantly in acute T-cell leukaemias as a result of the chromosomal translo

11 us Type 1 (HTLV-1) infection to lethal Adult T-cell Leukaemia (ATL); a progression that is more likel

12 Notably, reactivation of PTEN mainly reduced T-cell leukaemia dissemination but had little effect on

13 The development of T-cell leukaemia following the otherwise successful trea

14 , activated by chromosomal translocations in T-cell leukaemias, is normally expressed in haematopoies

15 sly, PTEN expression in the PTEN-null Jurkat T cell leukaemia line was shown to cause reduced prolife

16 or, in Japanese patients with relapsed adult T-cell leukaemia-lymphoma and other peripheral T-cell ly

17 Patients with adult T-cell leukaemia-lymphoma have few treatment options aft

18 -2, documented diagnosis of aggressive adult T-cell leukaemia-lymphoma or other peripheral T-cell lym

19 Of 13 assessable patients (nine with adult T-cell leukaemia-lymphoma, four with other peripheral T-

20 usly treated patients with aggressive, adult T-cell leukaemia-lymphoma.

21 lly, some H3K9M mice succumbed to aggressive T cell leukaemia/lymphoma, while H3K36M mice exhibited d

22 32%] were female) and 22 patients with adult T-cell leukaemia/lymphoma (66.5 years [54.0-73.0]; 15 [6

23 linically linked to the development of adult T-cell leukaemia/lymphoma (ATL), an aggressive blood can

24 oup and 11 [50%] of 22 patients in the adult T-cell leukaemia/lymphoma group), anaemia (25 [19%] and

25 The primary endpoint for patients with adult T-cell leukaemia/lymphoma was the safety and tolerabilit

26 h either peripheral T-cell lymphoma or adult T-cell leukaemia/lymphoma, aged 18 years or older with a

27 ripheral T-cell lymphoma, 14 (16%) had adult T-cell leukaemia/lymphoma, and 19 (21%) had B-cell non-H

28 ciated with malignant disease--namely, adult T-cell leukaemia/lymphoma.

29 gamulizumab, for mycosis fungoides and adult T-cell leukaemia/lymphoma.

30 ma) and the modified 2009 criteria for adult T-cell leukaemia/lymphoma.

31 n patients with relapsed or refractory adult T-cell leukaemia/lymphoma.

32 ll lymphoma and 15 (68%) patients with adult T-cell leukaemia/lymphoma; nine (7%) patients and one (5

33 vs 16 deaths; 41%, 26-65; p=0.018) and adult T-cell leukaemia or lymphoma (45 deaths; 20%, 11-38 vs 1

34 tin America, with a high prevalence of adult T-cell leukaemia or lymphoma and extranodal natural kill

35 and third most frequent subtypes were adult T-cell leukaemia or lymphoma and extranodal natural kill

36 The observed proportion of people with adult T-cell leukaemia or lymphoma was higher in Peru (158 [39

37 ations were seen among the 114 patients with T-cell leukaemia (p=0.61, 0.35, and 0.53, respectively).

38 Some T cell leukaemia patients have chromosomal abnormalities

39 rare, sporadic leukaemia similar to a mature T-cell leukaemia seen in some patients with Ataxia Telan

40 disordered transcription factor activated in T cell leukaemia that is difficult to target.

41 Human T cell leukaemia virus type 1 (HTLV-1) and human immunod

42 and downstream of the splice donor in human T cell leukaemia virus type 1 (HTLV-1) was inserted into

43 ruses human immunodeficiency virus and human T-cell leukaemia virus are resistant to human complement

44 The human T-cell leukaemia virus type 1 (HTLV-1) subtype c is ende

45 Extending these findings to T cell leukaemia, we show that lineage-determining trans

46 more common among European individuals) and T cell leukaemia (which is more common among Japanese in

47 t enforced expression of Lmo1 and Lmo2 cause T cell leukaemias with long latency and that Lmo2 expres