ライフサイエンスコーパス: T-cell receptor gene

1 n of progenitor cells harboring a transgenic T-cell receptor gene.

2 ein-Barr virus (EBV) positive, with germline T-cell receptor gene.

3 which is the assembly of immunoglobulin and T cell receptor genes.

4 , juxtaposing them to regulatory elements of T cell receptor genes.

5 single-cell polymerase chain reaction of the T-cell receptor genes.

6 essary to form functional immunoglobulin and T-cell receptor genes.

7 permutation of immunoglobulin and, probably, T-cell receptor genes.

8 that juxtapose it to regulatory elements of T-cell receptor genes.

9 ymphoma 1) locus with regulatory elements of T-cell receptor genes.

10 rkably similar to that of immunoglobulin and T-cell receptor genes.

11 ates rearrangement of the immunoglobulin and T-cell receptor genes.

12 segments into functional immunoglobulin and T-cell receptor genes.

13 from excised DNA during the rearrangement of T-cell-receptor genes.

14 R) analysis of rearranged immunoglobulin and T-cell receptor genes (allele-specific oligonucleotide [

15 nsertion hypervariable regions of rearranged T-cell receptor genes allows the same identification of

16 T cell receptor gene analysis is a sensitive method for

17 cell clones through paired sequencing of the T cell receptor genes and high-dimensional single-cell s

18 eptors on lymphocytes (immunoglobulin genes, T cell receptor genes and NK receptor genes [4] [5] [6]

19 e showing associations with polymorphisms of T cell receptor genes and other immune-relevant loci and

20 Analysis of phenotype, rearrangements in T-cell receptor genes, and chromosome alterations by hig

21 Antibody and T cell receptor genes are assembled from gene segments b

22 Functional immunoglobulin and T cell receptor genes are produced in developing lymphoc

23 Immunoglobulin and T-cell-receptor genes are assembled from component gene

24 ting gene 1 (Rag1) and Rag2 are required for T cell receptor gene assembly and thymocyte maturation,

25 B and T cell receptor gene assembly by V(D)J recombination is

26 Immunoglobulin and T cell receptor gene assembly depends on V(D)J recombina

27 Assembly of functional Ig and T cell receptor genes by V(D)J recombination depends on

28 ly similar to that of the immunoglobulin and T cell receptor gene clusters, and can potentially provi

29 zation similar to that of immunoglobulin and T cell receptor gene clusters.

30 e, surpassing that of the immunoglobulin and T cell receptor genes combined.

31 that the split nature of immunoglobulin and T-cell-receptor genes derives from germline insertion of

32 -2 gene and a broad repertoire of rearranged T-cell receptor genes, develop the ability to produce T

33 J recombination assembles immunoglobulin and T cell receptor genes during lymphocyte development thro

34 In contrast, T-cell receptor genes exhibited a germline (unrearranged

35 in polymyositis an overexpression of certain T-cell receptor gene families among the autoinvasive T-c

36 Assembly of immunoglobulin and T cell receptor genes from separate gene segments [V(D)J

37 ecular process, assembles immunoglobulin and T cell receptor genes from V, D, and J coding segments.

38 immune system to assemble immunoglobulin and T-cell receptor genes from the preexisting gene segments

39 The process of assembling immunoglobulin and T-cell receptor genes from variable (V), diversity (D),

40 ral virologic control by sequencing viruses, T cell receptor genes, HIV integration sites, and cellul

41 initiates the assembly of immunoglobulin and T cell receptor genes in a reaction known as V(D)J recom

42 combination assembles and diversifies Ig and T cell receptor genes in developing B and T lymphocytes.

43 bulin genes in immature B lymphocytes and of T cell receptor genes in immature T lymphocytes and are

44 ncoded by all of the rearranged antibody and T cell receptor genes in one person-the 'genome' of the

45 l-known rearrangements of immunoglobulin and T-cell receptor genes in lymphocytes (a commonly used re

46 The variable domains of Ig and T-cell receptor genes in vertebrates are assembled from

47 ned from a T-cell nucleus carried rearranged T-cell-receptor genes in all tissues.

48 g suggests a fundamental role for TNFSF15, a T-cell receptor gene involved in T-cell maturation, in t

49 ious generative events that occur when a new T-cell receptor gene is created.

50 and (ii) a mapping of the immunoglobulin and T cell receptor gene libraries to the genome, which are

51 nctions within rearranged immunoglobulin and T cell receptor gene loci can only be introduced after t

52 on of a proto-oncogene by translocation of a T-cell-receptor gene, may not be applicable to the main

53 eic hematopoietic stem cell transplantation, T cell receptor gene-modified T cells, chimeric antigen

54 h is required for the assembly of the Ig and T-cell receptor genes of the immune system.

55 The thymus is the key organ of T cell receptor gene rearrangement and T-cell maturation

56 This study investigated levels of T cell receptor gene rearrangement excision circles (TRE

57 on/single-strand conformational polymorphism/T cell receptor gene rearrangement.

58 T-cell receptor gene rearrangement and flow cytometry re

59 ressively with age, thymopoiesis with active T-cell receptor gene rearrangement continued normally wi

60 Normal T-cell receptor gene rearrangement in T-cell progenitors

61 T-cell receptor gene rearrangement studies with Southern

62 merase chain reaction-based investigation of T-cell receptor gene rearrangement to detect clonality.

63 e have genetic defects in immunoglobulin and T cell receptor gene rearrangements and are devoid of ci

64 cytometry, examination of blood smears, and T cell receptor gene rearrangements), and performed musc

65 acilitates examination of immunoglobulin and T cell receptor gene rearrangements, and initial studies

66 clonality of mutants as does analysis of the T-cell receptor gene rearrangements themselves.

67 uantitative PCR of clonal immunoglobulin and T-cell receptor gene rearrangements, real-time quantitat

68 ntitative PCR analysis of immunoglobulin and T-cell receptor gene rearrangements.

69 late the thymus, as evidenced by oligoclonal T-cell-receptor gene rearrangements.

70 arly stage, lack of Ku70 was compatible with T cell receptor gene recombination and the development o

71 Quantitative next generation sequencing of T-cell receptor genes revealed distinct oligoclonal CD4(

72 MAIT cell T-cell receptor gene segment usage differed between the

73 tides at the junctions of rearranging Ig and T cell receptor gene segments, thereby generating antige

74 rearrangement of different immunoglobulin or T cell receptor gene segments.

75 inase recognizes a pair of immunoglobulin or T-cell receptor gene segments flanked by recombination s

76 The rearrangement of antibody and T-cell receptor gene segments is indispensable to the ve

77 unrearranged (germ line) immunoglobulin and T-cell receptor gene segments often precedes V(D)J recom

78 postvaccination (as defined by their unique T cell receptor gene sequence) and by tracking clones th

79 tocompatibility complex, immunoglobulin, and T cell receptor genes stands in strong support of the hy

80 e apoptotic thymocytes have rearranged their T-cell receptor genes, suggesting that they are differen

81 ate to the thymus where they rearrange their T-cell receptor genes (TCR) and undergo selection on the

82 DP cells rearrange the T cell receptor gene Tcra to generate T cell receptors w

83 The four T cell receptor genes (Tcra, Tcrb, Tcrg, Tcrd) are assem

84 rs or the pursuit of immunotherapies such as T cell receptor gene therapy or adoptive transfer, may b

85 e target antigens is required to ensure that T-cell receptor gene therapy will result in preferential

86 Moreover, although using different T-cell receptor genes, they were all restricted to HLA-D

87 ements that involve the translocation of one T cell receptor gene to either chromosome 14q32 or Xq28.

88 he TIL 1383I TCR an attractive candidate for T-cell receptor gene transfer-based immunotherapy.

89 ism in a proof-of-concept experiment where a T-cell receptor gene was expressed in yeast.

90 This is reminiscent of immunoglobulin and T-cell receptor genes, which undergo DNA rearrangements

91 Furthermore, we isolated a number of cognate T cell receptor genes with tumor reactivity.