ライフサイエンスコーパス: T-cell-specific

1 lpha and IL-6R associations were found to be T cell specific.

2 we found that the increase in Treg cells in T cell-specific A20-deficient mice was already observed

3 Furthermore, T cell-specific ABCG1 deficiency led to a 30% increase i

4 -deficient mice fed a high-cholesterol diet, T cell-specific ABCG1 deficiency protected against ather

5 T cell specific ablation of IL-1R1 decreased tumor-elici

6 T cell-specific ablation of CD83 expression resulted in

7 T cell-specific ablation of Dot1L resulted in loss of na

8 Notably, T cell-specific ablation of IL-10 produced pathologies t

9 Here, we have shown that the T cell-specific ablation of MyD88 in mice impairs not on

10 Here we showed that T cell-specific ablation of the common interleukin-6 (IL

11 In the thymus, T cell-specific ablation of the Roquin paralogs leads to

12 In peripheral organs, T cell-specific ablation of Vps34 had a profound impact

13 IL-7Ralpha transgenesis or T-cell-specific ablation of Gfi-1 restored IL-7Ralpha ex

14 In vivo, T-cell-specific ablation of murine Gclc prevented autoim

15 Using mice with T-cell-specific ablation of Raptor/mTORC1 or Rictor/mTOR

16 mation induced SPTLC2 expression, and murine T-cell-specific ablation of Sptlc2 impaired antiviral-T-

17 Here we show that T-cell-specific ablation of the kinase TBK1 promotes T-c

18 T cell-specific abrogation of type I IFN signaling showe

19 These data demonstrate that T cell-specific activation of Nrf2 protects from IR-indu

20 IL-2-inducible T cell kinase (ITK) with the T cell-specific adapter protein (TSAD) promotes LCK-medi

21 The T cell-specific adaptor protein (TSAd), encoded by the S

22 Upon T cell-specific alpha-CD3, alpha-CD28 stimulation, MAIT

23 Here we show that T cell-specific and activation-dependent alternative spl

24 /kg body weight), alone or combined with the T-cell-specific antibody anti-T-cell receptor (TCR) (0.5

25 ophagy to T-cell allo-immunity, we generated T-cell-specific Atg5 knock-out mice.

26 T cell-specific augmentation of Nrf2 significantly incre

27 ver, an animal model that could recapitulate T cell-specific autoimmune responses by initiating and s

28 knowledge, a quantitative framework bridging T cell-specific biology with concepts developed for inte

29 T cell-specific Blimp-1-deficient mice, a model of aller

30 In addition, we showed that in T cell-specific Blimp-1-deficient mice, deletion of Blim

31 1 were used and abolished in mice with a CD8 T cell-specific Bmal1 deletion.

32 of the T-cell receptor pathway and reside at T-cell-specific boundaries of repressive and active chro

33 cell reprogramming by introducing individual TS cell-specific 'CAG' factors (Cdx2, Arid3a and Gata3),

34 sing macrophage-specific (CD14) but not CD4+ T cell-specific (CD3) antibodies, suggesting that M-trop

35 Cardiac function significantly declined in T-cell-specific CD4-Cre(+/)(-)CD73(flox/flox) mice ident

36 e aortic constriction (TAC) using global and T-cell-specific CD73(-)(/-) mice.

37 egulatory cytokines, and this is restored by T-cell-specific CEACAM1 expression.

38 SATB1 is an important T-cell specific chromatin organizer in cutaneous T-cell

39 R insulators predicted here show evidence of T-cell-specific chromatin barrier and gene regulatory ac

40 Here we report that mice with a T-cell-specific conditional knockout of HGK (T-HGK cKO)

41 trated that a promoter variant is causal for T cell-specific control of HLA-DQB1 expression.

42 Regulation of the gene encoding the T cell-specific coreceptor CD4 in helper and cytotoxic T

43 Thus, the phenotype of T cell-specific Coronin 1a deletion resembles the phenot

44 d by the deletion of Coronin 1a Furthermore, T cell-specific Coronin 1a knock-out mice were largely r

45 this research question, we have generated a T cell-specific Coronin 1a knock-out mouse (Coro1a(fl/fl

46 gE concentrations in the blood of sensitized T cell-specific Cyp27b1-KO mice support a lymphocyte-dri

47 T cell-specific deficiency in TRAF3 resulted in a two- t

48 T cell-specific deficiency of the genome organizer Satb1

49 We further show that T-cell-specific deficiency of Fabp4 and Fabp5 (Fabp4/Fab

50 We show that T cell-specific deletion and early pharmaceutical inhibi

51 T cell-specific deletion of acetyl coenzyme A carboxylas

52 Mice with T cell-specific deletion of Atf7ip have impaired Th17 di

53 anticancer functions in vivo, and mice with T cell-specific deletion of Atg5 have reduced tumour out

54 ) and regulatory (Treg) cells, and mice with T cell-specific deletion of Blimp1 (Blimp1CKO mice) spon

55 T cell-specific deletion of Gfi1 results in aberrant exp

56 Moreover, bone marrow chimeric mice with CD4 T cell-specific deletion of IL-10 increased PF4/heparin-

57 al TCR activation, as mice engineered with a T cell-specific deletion of IRAP fail to develop efficie

58 T cell-specific deletion of Lis1 resulted in depletion o

59 Mice harboring a T cell-specific deletion of Pdpn developed exacerbated E

60 In addition, we studied AAI in mice with a T cell-specific deletion of recombination signal-binding

61 In this study, we found that mice with a T cell-specific deletion of Shp1 had normal iNKT cell nu

62 T cell-specific deletion of talin in Tln1(fl/fl)Cd4(Cre)

63 Evaluation of mice with a T cell-specific deletion of the gene encoding the negati

64 Here, we used inducible and CD4 T cell-specific deletion of the gene encoding the TGF-be

65 Classical p38 signals were reduced after T cell-specific deletion of the guanine nucleotide excha

66 In this study, we demonstrate that T cell-specific deletion of the IL-6 receptor alpha chai

67 ion mediated by its RING domain: mice with a T cell-specific deletion of the ROQUIN RING domain have

68 Here, we generate mice with a T cell-specific deletion of the scaffold protein A kinas

69 ressing a point mutant thereof, or mice with T cell-specific deletion of the transcription factor RUN

70 T cell-specific deletion of the tumor suppressor PTEN in

71 Mice with a T cell-specific deletion of Twist1 demonstrate increased

72 In this study, we show that T-cell specific deletion of Pak2 gene in mice resulted i

73 drug targets, we have generated mice with a T-cell specific deletion.

74 ns in T cells, we generated mice harboring a T-cell-specific deletion of A(2A)R.

75 T-cell-specific deletion of dynamin 2, an essential comp

76 Mice with T-cell-specific deletion of GATA3 did not develop coliti

77 zenesulfonic acid to control mice, mice with T-cell-specific deletion of GATA3, and mice with deletio

78 We report here that T-cell-specific deletion of mTOR results in dramatically

79 In this study, mice with T-cell-specific deletion of the dominant murine AT(1) re

80 Assessment of regulatory T cell-specific demethylated region methylation status i

81 Regulatory T cell-specific demethylation region (TSDR) demethylatio

82 We generated mice with T-cell-specific disruption of the geranylgeranyltransfer

83 Mice with T cell-specific dynamin 2 deficiency had profound lympho

84 T cell-specific enhancement of ERK signaling was only su

85 epitopes of walnut have been studied, CD4(+) T cell-specific epitopes for walnut remain uncharacteriz

86 We note an over-representation of T cell-specific eQTLs among susceptibility alleles for a

87 T cell-specific Etv5-deficient and littermate control mi

88 Here, we report that T cell-specific expression of a Bcl2 BH3 mutant transgen

89 Conversely, mice with T cell-specific expression of a transgene encoding miR-1

90 We found that T cell-specific expression of Bim during early/cortical,

91 In this study, we show that T cell-specific expression of the ITK-Syk oncogene in mi

92 Major Peak are required to recapitulate the T-cell specific expression of Bcl11b in stable reporter

93 ed the addition of the Major Peak to exhibit T-cell specific expression.

94 st generated Kras(G12D) transgenic mice with T-cell-specific expression of the pan-Notch inhibitor, d

95 e transcriptional start sites of B-cell- and T-cell-specific factors.

96 ats can be readily optimized to redirect CAR-T cells (specific for the corresponding FITC or PNE) to

97 Finally, T cells specific for 5GHPV3 encoded antigens were detect

98 In this study, we identified T cells specific for 6 Pol epitopes present in the immun

99 howed that induction of airway memory CD4(+) T cells specific for a conserved epitope shared by SARS-

100 In adoptive transfer experiments, maternal T cells specific for a fetal alloantigen proliferate aft

101 reagents to understand how endogenous CD4(+) T cells specific for a house dust mite (HDM) allergen fo

102 outline an immunotherapy in which endogenous T cells specific for a noncancer antigen are retargeted

103 ient with metastatic cholangiocarcinoma, CD4 T cells specific for a peptide from a mutated region of

104 g TRAPeS with transcriptome analysis of CD8+ T cells specific for a single epitope from Yellow Fever

105 We demonstrate that memory CD8 T cells specific for a single immunodominant epitope (S4

106 this study indicate that a high frequency of T cells specific for a single myelin Ag, rather than inc

107 Here we present a strategy to render T cells specific for a tumor in the absence of a truly t

108 also gives critical insight into how CD4(+) T cells specific for Ag expressed in the liver are recru

109 In support of this hypothesis, we detected T cells specific for all 20 amino acid variants at the p

110 nterferon-gamma (IFN-gamma)-producing CD8(+) T cells specific for all four TAA in the periphery as we

111 mic preference by tracking polyclonal CD4(+) T cells specific for an MHC class II-bound peptide from

112 ients of OT-I T cell receptor transgenic CD8 T cells specific for an ovalbumin (OVA) peptide, IL-1 re

113 mmune system, but the low frequency of naive T cells specific for any one pathogen means dependence o

114 and lacking SIINFEKL enabled coinflation of T cells specific for both SIINFEKL and nonrecombinant Ag

115 In mice, CD4+ T cells specific for cardiac alpha myosin heavy chain (a

116 We show how the same approach of CAR T cells specific for CD30 (CD30.CAR-Ts) can be used to t

117 The proportion of memory and CD20(+) CD8(+) T cells specific for certain myelin but not influenza ep

118 rgence of ACPAs in the absence of detectable T cells specific for citrullinated antigens: ACPAs could

119 ART on restoring pre-existing memory CD4(+) T cells specific for common copathogens is still unclear

120 Inducing memory CD8(+) T cells specific for conserved antigens from influenza A

121 accination induced readily detectable CD4(+) T cells specific for conserved portions of hemagglutinin

122 by HSV-specific CD8 T cells compared to CD8 T cells specific for control viruses, Epstein-Barr virus

123 the presence of a broad repertoire of naive T cells specific for cryptic H1-HA peptides and demonstr

124 ted that the administration of donor-derived T cells specific for cytomegalovirus or Epstein-Barr vir

125 from the blood is significantly enriched for T cells specific for cytomegalovirus-pp65 (immunodominan

126 Surprisingly, we found that CD4 T cells specific for different epitopes exhibited distin

127 t & Microbe, Moguche et al. (2017) show that T cells specific for different immunodominant vaccine an

128 sus, suggesting a way to characterize CD4(+) T cells specific for disease-driving antigens in multipl

129 rategies are not effective in the absence of T cells specific for displayed tumor antigens.

130 The phenotype and function of CD8(+) T cells specific for each epitope were compared in HLA-A

131 ed target cells so poorly relative to CD8(+) T cells specific for early lytic cycle antigens.

132 T cells specific for EBV antigens have also produced com

133 Donor T cells specific for either determinant from AQP4(-/-),

134 Casp11(-/-) T cells specific for endogenous Ags were more readily de

135 ins unclear whether it can effectively prime T cells specific for endogenous antigens expressed by po

136 ress HIV-1 replication more effectively than T cells specific for epitopes in other proteins.

137 ll expansions in magnitude, activated CD4(+) T cells specific for epitopes in the latent antigen EBNA

138 Moreover, donor naive T cells specific for exogenous and self/tumor antigens p

139 In blood samples from controls, CD4(+) T cells specific for FlaX, A4-fla2, or YidX had a T-help

140 this molecular strategy to render cytotoxic T cells specific for fungi.

141 Here we studied polyclonal CD4(+) T cells specific for green fluorescent protein expressed

142 adenovirus 35 fiber (Ad5F35GFP) viruses and T cells specific for HLA-A*01-restricted LTDLGQNLLY, HLA

143 CD4(+) T cells specific for human CMV (HCMV) are elevated in HI

144 nal analyses and functional assays of CD4(+) T cells specific for human immunodeficiency virus (HIV)

145 We isolated circulating CD4(+) T cells specific for immunoglobulin-derived neoantigens

146 -specific CD4 T cells was similar to that of T cells specific for known immunogenic therapeutic prote

147 hallenge of KSHV-infected B cells with CD4(+)T cells specific for LANA, a protein expressed in all KS

148 correlated with the frequency of circulating T cells specific for leukemia-associated antigens, indic

149 laque psoriasis harbour CD4(+) and/or CD8(+) T cells specific for LL37, an antimicrobial peptide (AMP

150 T cells specific for LMP as well as nonviral tumor-assoc

151 CD4(+) memory T cells specific for measles are maintained nearly exclu

152 We found that A(2A)R-proficient CD8(+) T cells specific for melanoma cells displayed a relative

153 Using TCR-redirected CD8+ T cells specific for MHC-I-restricted HBV epitopes, we s

154 Importantly, CD4(+) T cells specific for mycobacterial ribosomes accumulate

155 ional capacity, and memory profile of CD4(+) T cells specific for Mycobacterium tuberculosis and CMV

156 The adoptive transfer of T cells specific for native tumor antigens (TAs) is an i

157 KL epitope inflated and profoundly dominated T cells specific for nonrecombinant (i.e., MCMV-derived)

158 Moreover, when the virus encoded SIINFEKL, T cells specific for nonrecombinant Ags displayed a phen

159 transgenic mice had fewer peripheral CD8(+) T cells specific for NRP-V7 than control mice.

160 It is also unclear whether CD4+ T cells specific for one epitope are more protective tha

161 fic for one epitope are more protective than T cells specific for other epitopes.

162 ransfer into coinfected mice, transgenic CD8 T cells specific for OVA(257-264) failed to proliferate

163 entral memory, and/or effector memory CD4(+) T cells specific for overlapping peptides spanning the e

164 tileukemic effects can be delivered by donor T cells specific for particular minor histocompatibility

165 CD8(+) T cells specific for pp65, IE1, and IE2 are present at h

166 The host retains memory T cells specific for previous infections throughout the

167 Using G9Calpha(-/-)CD8(+) T cells specific for proinsulin, we studied the mechanis

168 required to produce Abs, we wondered whether T cells specific for RLN2 might be already present in th

169 We found that CD4(+) T cells specific for Salmonella peptide:MHC class II (MH

170 ed the number and function of endogenous CD4 T cells specific for segmented filamentous bacterium (SF

171 ntigens are generally weak, and high avidity T cells specific for self-antigens are deleted in the th

172 Clonal deletion of T cells specific for self-antigens in the thymus has bee

173 These results show that self-HLA-restricted T cells specific for self-antigens such as MiHA in MiHAp

174 However, the CD8 T cells specific for self-TAs had a lower functional avi

175 nstrated that the clonal abundance of CD4(+) T cells specific for self-tumor antigen positively corre

176 However, CD8(+) T cells specific for subdominant epitopes lose functiona

177 nctionality throughout latency, while CD8(+) T cells specific for subdominant epitopes undergo functi

178 In ISAT, activated CD4+ T cells specific for T4p2553 are detected before the dis

179 Transduced ANS8 CAR T cells specific for the A2 domain proliferated in respo

180 In this study, we identified CD4+ T cells specific for the Aspergillus proteins Crf1 and c

181 igens, and we described Th as well as CD8(+) T cells specific for the autoallergen Hom s 2, the alpha

182 induces high levels of antibodies and CD4(+) T cells specific for the circumsporozoite protein (CSP).

183 tentially the result of cross-recognition by T cells specific for the common cold coronaviruses.

184 ross-recognition of the novel coronavirus by T cells specific for the common cold coronaviruses.METHO

185 ether with engineered RMS-directed cytotoxic T cells specific for the fetal acetylcholine receptor.

186 In vitro expansion studies suggested that T cells specific for the HCoV-NL63 spike protein in this

187 +) T cells while sparing more differentiated T cells specific for the human herpesviruses cytomegalov

188 n against the parasite is mediated by CD8(+) T cells specific for the immunodominant CSP-derived epit

189 In the C57BL/6 mouse, CD8(+) T cells specific for the immunodominant epitope from gly

190 Using retrogenic CD8(+) T cells specific for the M. tuberculosis Ag TB10.4 (EsxH

191 ticle, we explore the contribution of CD8(+) T cells specific for the major antigenic epitope for HSV

192 Antibodies and T cells specific for the major birch pollen allergen Bet

193 study, we use a transgenic mouse model with T cells specific for the merozoite surface protein (MSP)

194 ity of these mice to expand epitope-specific T cells specific for the model antigen ovalbumin express

195 We have previously shown that T cells specific for the peptide epitope LTDLGQNLLY were

196 When mice were infected with these viruses, T cells specific for the SIINFEKL epitope inflated and p

197 peptide pools.CONCLUSIONHDs have circulating T cells specific for the spike proteins of HCoV-NL63, HC

198 cytotoxic effect on tumor cells, whereas CAR-T cells specific for the tumor antigen GD2 (GD2.CAR-T ce

199 Because T cells specific for these antigens are present with low

200 T cells specific for these antigens expanded in patients

201 Unfortunately, the avidity of T cells specific for these antigens is limited by centra

202 We then determined that chronic CD8 T cells specific for these epitopes were more likely pre

203 proteins and reduce the impact of the CD8(+) T cells specific for these epitopes.

204 CD4 T cells specific for these HLA class II molecules recogn

205 However, the frequency of expanded T cells specific for these last two epitopes was variabl

206 class II tetramers, we verified that memory T cells specific for these modified epitopes were detect

207 T cells specific for these modified self-antigens then p

208 h)1 phenotype; a larger proportion of CD4(+) T cells specific for these proteins in patients with CD

209 n assay to measure the antiviral capacity of T cells specific for this and other peptide epitopes in

210 ong lipid Ags tested, and polyfunctional CD4 T cells specific for this lipid simultaneously expressed

211 Taken together, we demonstrate that T cells specific for three peptide epitopes, from both s

212 flected by the presence of infiltrating CD8+ T cells specific for tumor antigens within the tumor mic

213 The frequency of CD4(+) T cells specific for U1-70(131-150):I-E(k) (without phos

214 The number of T cells specific for various antigens can vary dramatica

215 single sample, and detect low-frequency CD8 T cells specific for virus- or cancer-restricted antigen

216 driven cancers is to elicit cytotoxic CD8(+) T cells specific for virus-derived peptides.

217 In immunized mice, CD4 T cells specific for vWFA2 were detected, and their indu

218 f interferon gamma (IFN-gamma)-producing CD4 T cells specific for VZV glycoprotein E and all other st

219 The number (fold difference from PRE) of T-cells specific for CMV pp65 (2.6), EBV LMP2A (2.5), an

220 at is overexpressed on tumor vasculature and T-cells specific for the tumor antigens gp100 (PMEL), TR

221 We previously identified a T cell-specific Gata3 enhancer (Tce1) lying 280 kb downs

222 T cell-specific gene ablation of Notch1 and Notch2 impai

223 d when using the CD4Cre transgenic model for T cell-specific gene manipulation, particularly when lun

224 re transgenic model has been widely used for T cell-specific gene manipulation.

225 Bcl11b is a T-cell specific gene in hematopoiesis that begins expres

226 ression program is followed by activation of TS cell-specific genes by CAG factors.

227 udies leveraging pharmacologic inhibition or T cell specific genetic deletion of signaling components

228 T domains, was originally characterized as a T cell-specific genome organizer whose aberrant overexpr

229 T-cell-specific GLK-transgenic mice develop spontaneous

230 for physiological T cell responses by using T cell-specific Gpx4-deficient mice.

231 In vivo, T-cell-specific GR deletion in pregnant animals undergoi

232 T cell-specific Grb2(fl/fl) Lckcre(tg) Grb2-deficient mi

233 Using T cell-specific IL-4/IL-13-deficient mice and basophil-d

234 llergic asthma was assessed weekly in CD4(+) T cell-specific IL-4Ralpha-deficient BALB/c mice (Lck(cr

235 in T cells (IL-6R-cKO), we demonstrated that T cell-specific IL-6R signaling is essential for viral c

236 use model for crescentic GN, in mice lacking T cell-specific IL-6Ra.

237 dentification of gp120 glycopeptide-induced, T cell-specific immune responses offers a foundation for

238 f CD4(+) T cells and B cells, but not CD8(+) T cells; specific increases in the total numbers of Th1

239 e followed the fates of CCR2(-/-) T cells in T cell-specific inflammatory models.

240 ression of its targets, we characterized its TS cell-specific interactome using mass spectrometry.

241 However, recent studies in mice with T cell-specific Irf8 disruption under direction of the L

242 Using mice with either T cell-specific loss or constitutive activation of TGF-b

243 Using T cell-specific loss-of-function experiments, we find th

244 Mice with T-cell-specific loss of the tumor suppressor gene PTEN e

245 l role of miR-17-92 in TH17 differentiation: T cell-specific miR-17-92 deficiency reduced TH17 differ

246 Altogether, these data indicate that T cell-specific miRNAs play pivotal roles in regulating

247 Using T cell-specific murine lines genetically altered in expr

248 T cell-specific NIK ablation reduced the frequency of ef

249 genes appeared to normalize rapidly, whereas T cell-specific normalization occurred over six weeks.

250 Here we show that T cell-specific Notch deficiency in mice prevented house

251 Mice with T cell-specific over-expression of Bcl-2, that blocks mu

252 e have demonstrated that, although mice with T cell-specific overexpression of miR-27 harbor dysregul

253 In contrast, T cell-specific overexpression of PDPN resulted in profo

254 T cell-specific pan-Notch blockade prolonged heart allog

255 In this study, we evaluate a T-cell-specific PET agent, [18F]F-AraG, as an imaging bi

256 However, T cell-specific PKM2 deletion impairs Th17 cell differen

257 THEMIS, a T cell-specific protein with high expression in CD4(+)CD

258 e selection is enabled by the ability of the T-cell-specific protein Themis to specifically attenuate

259 T-cell-specific PRR-knockout mice had a significant decr

260 T-cell-specific PTPN2 deficiency prevented tumours formi

261 reatic beta-cells and the onset of diabetes, T-cell-specific PTPN2 deficiency was also accompanied by

262 This explains the T-cell-specific Rac1-targeting therapeutic action of 6-T

263 cells through the generation and analysis of T cell-specific RASA1 and NF1 double-deficient mice.

264 fully retained allografts while maintaining T cell-specific responses against microbial pathogens.

265 c role of Shp1, we characterized mice with a T cell-specific Shp1 deletion (Shp1fl/fl CD4-cre).

266 , CD8+ effector, CD4+ memory, and regulatory T-cell-specific signatures.

267 ted transgenic mice with constitutively high T cell-specific Smad7 expression.

268 Gag p24 and Nef CD8+ T cell-specific soluble virus inhibition was common amon

269 Compared with WT animals, mice with T cell-specific Stim1 deletion died prematurely during t

270 ferentially express the transcription factor T-cell-specific T-box transcription factor (T-bet), whic

271 cid-related orphan receptor Cv2 (RORCv2) and T-cell-specific T-box transcription factor (Tbet).

272 we show that mice expressing a constitutive T-cell-specific ThPOK transgene (ThPOK(const) mice) deve

273 , and exhaustion status of TG-resident CD8(+)T cells specific to 40 epitopes derived from HSV-1 gB, g

274 Using human CD8(+) T cells specific to a lung tumor-associated Ag, we show

275 V susceptibility and phenotypes of human CD4 T cells specific to Ad5 and CMV, two viruses that have b

276 CD8(+) T cells specific to caspase-cleaved antigens derived fro

277 with expansion of IFN-gamma-producing CD4(+) T cells specific to ColV and KAT, but not ColII.

278 rossreactive neutralizing antibodies, CD8(+) T cells specific to conserved viral epitopes correlated

279 surrounding normal breast tissue to identify T cells specific to each, as well as their abundance in

280 transendothelial migration of CD8+ effector T cells specific to graft antigens and that both steps o

281 CMV persistence did not further erode memory T cells specific to LCMV.

282 hibited reduced frequency and numbers of CD8 T cells specific to Mycobacterium bovis bacille Calmette

283 ore, SLIT enhanced proportions of regulatory T cells specific to RGP.

284 Further, CD8(+) T cells specific to sporozoite surface-expressed CSP and

285 CD4(+) T cells specific to the HCMV proteins studied were predo

286 MHC in the presence of naive TCR transgenic T cells specific to the MHC class II-peptide combination

287 n of lymphocytes and proliferation of CD8(+) T cells specific to tumor-associated antigens, resulting

288 ells (20%-90%, averaging over 50%) of CD4(+) T cells specific to viral antigens in adults who had nev

289 ators with memory precursor cells, including T cell-specific transcription factor 1 (TCF1), but it is

290 However, the expression of Foxp3, regulatory T cell-specific transcription factor, was enhanced in th

291 tosis and markedly lower islet expression of T cell-specific transcription factor-1 (TCF1, encoded by

292 yeloid and dendritic cell potential is lost, T-cell specific transcription factors subsequently induc

293 activates transcription in partnership with T-cell-specific transcription factor 1 (Tcf-1).

294 report that Bcl11b, previously considered a T-cell-specific transcription factor, acted directly ups

295 TS cells by direct binding and regulation of TS cell-specific transcription factors including Elf5 an

296 and sufficient for critical aspects of Gata3 T cell-specific transcriptional activity.

297 CD4-driven T cell-specific transgenic overexpression of mir-146a an

298 cells were hypoproliferative, yet mice with T cell-specific Usp9x deletion had elevated numbers of a

299 Mice with a T cell-specific UTX deletion had fewer Tfh cells, reduce

300 Whole-body VDR KO, T cell-specific VDR (T-VDR) KO, B cell-specific VDR (B-V