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1 ion, despite a systemic increase in FoxP3(+) T regulatory cells.
2 d no GVHD with expanded donor and host Foxp3 T regulatory cells.
3 t expansion of Th17 cells and a reduction in T regulatory cells.
4 DO1 represents an effective tool to generate T regulatory cells.
5 olecule present on a subset of human natural T regulatory cells.
6 of CD8(+) T effector cells to CD4(+)FoxP3(+) T regulatory cells.
7 rinsic, with no detectable effects on Th1 or T regulatory cells.
8 r gut homeostasis and maintenance of colonic T regulatory cells.
9 survival, function, and expansion of type 1 T regulatory cells.
10 t barrier integrity and increased intestinal T regulatory cells.
11 suppressor cells, tolerogenic monocytes, and T regulatory cells.
12 nhancing the development of Foxp3(+)-induced T regulatory cells.
13 L-2 induces organ pathology and expansion of T regulatory cells.
14 g dependent and IL-2-nano-APC did not affect T regulatory cells.
15 ntiation, and downregulates the induction of T regulatory cells.
16 of IRIS was not influenced by the levels of T regulatory cells.
17 insic unresponsiveness and the activation of T regulatory cells.
18 e IFN-gamma production by expanding FoxP3(+) T regulatory cells.
19 educed CD73 expression in Th17 and inducible T regulatory cells.
20 d function of DEPTOR within recipient CD4(+) T regulatory cells.
21 heir nodes, males had a higher percentage of T regulatory cells.
22 cytes and in increased thymic and peripheral T regulatory cells.
23 ted T conventional cells into CD4(+)Foxp3(+) T regulatory cells.
24 is mediated by both conventional and induced T regulatory cells.
25 This profile was not observed for natural T regulatory cells.
26 igration of purified CD4(+)CD25(+)CD127(dim) T regulatory cells.
27 ss the endothelial barrier at the expense of T regulatory cells.
28 ctions in differentiated CD4(+) T helper and T regulatory cells.
29 NAs, compared with wild-type mice, and fewer T-regulatory cells.
30 d a relative bias toward suppressive Th2 and T-regulatory cells.
31 fferentiation, in particular T-helper 17 and T-regulatory cells.
32 e unique T-cell subset, composed of Foxp3(+) T-regulatory cells.
33 nd increased levels of CD4(+)CD25(+)Foxp3(+) T-regulatory cells.
34 and CD8(+) T-effector cells to CD4(+)CD25(+) T-regulatory cells.
35 DAA therapy increased patients' numbers of T-regulatory cells (1.5% +/- 0.18% before therapy vs 2.1
40 ntial for the development and maintenance of T regulatory cells and for activation-induced cell death
41 y increased the frequency of thymic Foxp3(+) T regulatory cells and Foxp3(-)FR4(hi)CD73(hi) anergic p
42 f food allergy through induction of IL-10(+) T regulatory cells and indirect stabilization of mast ce
44 ity of the vaccine to reduce infiltration of T regulatory cells and myeloid-derived suppressor cells.
45 h factor-beta (proTGFbeta) on the surface of T regulatory cells and platelets; however, whether GARP
49 on of AhR-KO mice resulted in an increase in T regulatory cells and transforming growth factor beta,
50 increased abundance of TAMs and intratumoral T-regulatory cells and decreased abundance of CD8(+) tum
51 levels of blood- and brain-resident Foxp3(+) T-regulatory cells and display an alteration in the infl
52 bers of myeloid-derived suppressor cells and T-regulatory cells and increased T-helper 1 and 17 respo
54 of Enterobacteriaceae, increased numbers of T-regulatory cells and levels of CX3CR1 protein and Il10
55 es revealed higher percentages of CD8(+) and T-regulatory cells and lower percentages of B cells.
58 follows: 1) induction of IL-10 and FOXP3(+) T regulatory cells, and 2) suppression of proinflammator
59 PDL1 and CTLA4, increased tumor-infiltrating T regulatory cells, and decreased natural killer (NK) ce
60 er, reduced numbers of CD4(+)CD25(+)Foxp3(+) T regulatory cells, and dysregulated NK cell and CD4(+)
62 conversion of CD4+CD25- T cells to CD4+CD25+ T regulatory cells, and KLF10 target gene expression.
64 mokine receptor type 5(+) (CCR5(+)) T cells, T regulatory cells, and T-helper 17 cells were unaltered
65 ry mechanisms, such as inhibitory receptors, T regulatory cells, and the anti-inflammatory cytokine,
66 ole in gut inflammation and the induction of T regulatory cells, and the short chain fatty acids (SCF
68 igh-dose allergen exposure models in humans, T regulatory cells are essential in the suppression of T
70 states include Th1, Th2, Th17, and Foxp3(+) T regulatory cells, as well as the more recently describ
71 ed the induction and maintenance of Foxp3(+) T regulatory cells, as well as their in vitro suppressiv
72 ) T-helper cells but not with an increase in T-regulatory cells, as observed in the vemurafenib-only
73 kines and Chemokines, (vi) Cellular markers (T regulatory cells, B regulatory cells and dendritic cel
76 ction was associated with increased adaptive T regulatory cells but not natural regulatory T cells in
78 jury by IL-33 correlated with an increase in T regulatory cells but with a decrease in macrophages, d
79 rkhead box P3 (FOXP3) is well-established in T-regulatory cells, but the function of transient FOXP3
80 contributes to the function of CD4(+)CD25(+) T regulatory cells by enhancing immune suppression, both
81 l focus on enhancing the clinical benefit of T-regulatory cells by increasing their number and streng
82 Dominant tolerance imposed by CD4(+)Foxp3(+) T regulatory cells can actively control autoaggressive T
84 ver, infiltrating T cells were predominantly T-regulatory cells (CD25+/Forkhead Box P3 [FoxP3+]).
85 erved an induction of regulatory cells (CD4+ T regulatory cells; CD8+ T suppressor cells) and of T me
86 g SMC showed greater increases in CD4+FOXP3+ T regulatory cells compared to children not receiving SM
87 ficantly reduced lamina propria CD4CD25Foxp3 T regulatory cells compared with chow-fed mice, whereas
89 utant mice demonstrate a twofold increase in T-regulatory cells, consistent with induction of immune
90 ddressed whether alteration in the levels of T regulatory cells contributed to the development of IRI
91 ter reports that adoptive immunotherapy with T-regulatory cells controls the alloreactivity of conven
92 characterized by increased allergen-specific T regulatory cells, decreased circulating Fel d 1 tetram
94 ation (dextran sodium sulphate treatment and T regulatory cell depletion using C57BL/6-FoxP3(DTR) mic
95 t improve antigen-specific T cell expansion, T regulatory cell depletion, or effector T cell function
97 ically regulate the acquisition of CD4+CD25+ T regulatory cell differentiation and function, an effec
98 d FOXP3 induction and inappropriate adaptive T regulatory cell differentiation results in vitro and i
102 s with MDS-PA have altered hematopoiesis and T regulatory cell distribution in the tumor microenviron
103 nse by augmenting both T-helper-1-driven and T-regulatory-cell-driven inflammatory responses in the l
104 cell subsets (Th1, Th2, Th17, and inducible T-regulatory cells), each of which has specialized funct
106 ding Th2 skewing and reduced IL-10-secreting T regulatory cells, exaggerated with additional allergen
109 A+ CD161+ effector memory T cells and IL17A+ T-regulatory cells; expansion of HLA-DR+CD56+ granulocyt
110 erapy with tolerogenic donor-specific type 1 T regulatory cells for patients with type 1 diabetes und
111 erance cannot occur in murine models lacking T regulatory cells, for which Foxp3+ is a key marker.
112 ioamnionitis clearly associated with reduced T regulatory cell frequencies and functional characteris
114 imited and important cell populations (e.g., T regulatory cells) from disease conditions or in diseas
115 A number of other gene defects that affect T regulatory cell function also give rise to IPEX-relate
117 spectrum of genetic defects that compromise T regulatory cell function underlies human disorders of
118 JNK phosphorylation plays a central role in T regulatory cell function with therapeutic implications
119 taining T cell homeostasis as well as normal T regulatory cell function, thereby controlling abnormal
121 logical functions, including cardiac growth, T-regulatory cell function, neuronal disorders, muscle d
123 l therapy, patients had increased numbers of T-regulatory cells, IgM+CD21-/low-memory B cells, CD4+CX
125 ls from patients with CD had increased IL1B+ T-regulatory cells, IL1B+ DCs and IL1B+ plasmacytoid DCs
127 shown that CD4(+) T-cells, especially CD4(+) T-regulatory cells, improve wound healing after MI, wher
128 us altering the ratio of donor T effector to T regulatory cells in favor of reducing the pathological
129 es showed intense peri-islet infiltration of T regulatory cells in long-term grafts and systemic depl
130 cterized TFR as CXCR5(+)CCR7(-) "follicular" T regulatory cells in lymphoid tissues of healthy rhesus
132 ed infiltration of activated macrophages and T regulatory cells in skin and digit joints as well as b
133 ter constitutive phosphorylation of STAT5 in T regulatory cells in spleen cells compared with mice tr
134 and highlight the key role for TGF-beta1 and T regulatory cells in the establishment and maintenance
136 with anti-CD40/CpG + IC/anti-CTLA-4 reduced T regulatory cells in the tumors and was effective again
138 ge, SHIV-immunized RM had significantly more T regulatory cells in the vagina than the unimmunized RM
139 IL-10 conversion of CD4 T cells to CD4 FoxP3 T regulatory cells in vitro, and DHA-treated M2 macropha
143 nd consequent induction of immunosuppressive T-regulatory cells in tumor tissue promote immune tolera
144 ivers, LSECs are active in the generation of T regulatory cells, in hepatic fibrosis LSECs induce an
145 tivation of CD4 T cells, as well as FOXP3(+) T regulatory cells, in response to YFV vaccination prece
146 CD4(+) T-cell lineages, Th1, Th2, Th17, and T-regulatory cells, in their gene expression profiles.
147 eficit in CD4(+) TCRbeta(+) Foxp3(+) CD25(+) T regulatory cells, increased IL-6 and IL-17 production
148 These data identify the critical role of CD8-T regulatory cell interactions in regulating the suppres
149 thogen recognition receptors in human FOXP3+ T regulatory cells is established, yet the function of t
150 hat the balance between T-helper (Th) 17 and T-regulatory cells is an important factor in toxoplasmos
151 n response to fetal tissue, and depletion of T regulatory cells led to an increase in fetal-specific
152 ions of solid organ transplantation and that T-regulatory cells may function toward maintenance of th
154 iate ratio of conventional T lymphocytes and T-regulatory cells, natural killer cells, gamma delta T
155 Naturally occurring Foxp3(+)CD4(+)CD25(+) T regulatory cell (nTreg)-mediated suppression of lung a
157 ctivity of CD4(+)CD25(+) naturally occurring T regulatory cells (nTregs) in wild-type (WT) hosts.
158 y elevated TGF-beta1 and high nasopharyngeal T regulatory cell numbers, is crucial for prolonged carr
159 not associated with differences in levels of T regulatory cells or baseline pro-inflammatory cytokine
160 numbers of IgM+CD21-/low memory B cells and T-regulatory cells (P = .03), and positive correlations
161 teronyssinus-induced CD4(+) CD25(+) FOXP3(+) T regulatory cell percentage, intracellular Foxp3 expres
162 oting FoxP3(+)RoRgammat(+)IL17(+) pathogenic T-regulatory cells (pgTreg), with a concomitant restorat
163 smokers' and nonsmokers' AM induced FoxP3(+) T regulatory cell phenotype responses in allogeneic admi
164 nitial experiment 1 protocol, lamina propria T regulatory cell phenotype was evaluated by Foxp3 expre
166 e into pathogenic Th1 and Th17 or protective T regulatory cells plays a pivotal role in the pathogene
167 included serum creatinine (SCr), peripheral T-regulatory cells (pTregs)(127/CD4+/25), and DSA for gr
171 epatitis infection with TGFbeta activity and T regulatory cell recruitment to establish a favorable m
173 Using reporter mice, we observed that these T regulatory cells released substantial amounts of IL-10
174 contrast to restoration of MDSCs, levels of T regulatory cells remained reduced in BRAFi-resistant t
175 med to investigate the efficacy, safety, and T regulatory cell response of vitamin D as an adjunct to
179 t induced expression of DEPTOR within CD4(+) T regulatory cells stabilizes Foxp3 expression, shifts m
180 d CD4(+) T cell responses and alterations in T regulatory cells (T(reg) cells) play a critical role i
185 tudies have identified an effector subset of T regulatory cells termed T follicular regulatory (Tfr)
186 in higher levels of class I in CD4(+)CD25(+) T regulatory cells than in conventional CD4(+)CD25(-) T
189 bundances of HLA-DR+CD38+ T cells, including T-regulatory cells that produce inflammatory cytokines;
190 higher expression of 24-hydroxylase than Th2/T regulatory cells, that was reverted by LOV or ROCK inh
191 ilar proportions of CD86(+) DCs and Foxp3(+) T regulatory cells, the SP-A(-/-) mice had elevated prop
192 ors to subvert proinflammatory signaling via T regulatory cells, thereby inducing anti-inflammatory e
193 vel, both mDCs and plasmacytoid DCs generate T regulatory cells through an IDO1/IDO2-dependent mechan
194 city may augment suppression of Th2 cells by T regulatory cells, through mechanisms that involve T ce
195 e product (WASP) serves an essential role in T regulatory cells to contain Th2 effector cell differen
196 newly identified inhibitory cytokine used by T regulatory cells to control T cell-driven immune respo
197 anism that involves IL-10 and CD4(+)FoxP3(+) T regulatory cells to dampen exaggerated mucosal inflamm
198 le of inducing in T lymphocytes, the pivotal T regulatory cell transcription factor forkhead box P3 (
199 l immunosuppression were observed, including T regulatory cell (Treg) co-localization with CD8 T cell
201 depleting and destabilizing the intratumoral T regulatory cell (Treg) population, the precise mechani
206 e possibility that simultaneous expansion of T regulatory cells (Treg) and T effector cells early pos
210 f Th2 responses in allergic disease, whereas T regulatory cells (Treg) have been shown to suppress pr
213 and preferentially induced the expansion of T regulatory cells (Treg) in vitro and in vivo Targeted
214 er, in the clinical setting, CD4(+) CD25(hi) T regulatory cells (Treg) present within the tumor micro
215 hanism involves the accumulation of FOXP3(+) T regulatory cells (Treg), a class of suppressive T cell
216 lockade reduced accumulation of intratumoral T regulatory cells (Treg), but it was insufficient to su
217 , the absolute cell number of CD4(+)Foxp3(+) T regulatory cells (Treg), essential for immune toleranc
220 recent advances in the fields of intestinal T-regulatory cell (Treg) and tolerogenic dendritic cell
223 rease the frequency of CD4(+)CD25(+)FoxP3(+) T-regulatory cells (Treg) relative to conventional T cel
224 cancer requires recruitment and expansion of T-regulatory cells (Treg) that promote escape from host
226 ively re-adding CD4(+) CD25(bright) T cells (T regulatory cells, Treg), their effect on drug-specific
228 effect of vitamin D on lung histology, AHR, T regulatory cells (Tregs) and BALF cytokines was examin
229 selective deficiency of DOCK8 in T cells or T regulatory cells (Tregs) and found that both have exag
230 functional imbalances in the frequencies of T regulatory cells (Tregs) and interleukin 17 (IL-17)/IL
231 minate immunosuppressive populations such as T regulatory cells (Tregs) and myeloid-derived suppresso
236 ng adoptive transfer models, we find that KO T regulatory cells (Tregs) are less efficient in suppres
237 Probiotic group coincided with higher ileal T regulatory cells (Tregs) before and after challenge, a
239 were resistant to killing by CD4(+)Foxp3(+) T regulatory cells (Tregs) compared with wild-type DCs.
240 itic cells (DCs), self-reactive T cells, and T regulatory cells (Tregs) contribute to maintaining mam
248 ntering SAg-mediated T cell activation using T regulatory cells (Tregs) might be beneficial in diseas
253 ogrammed cell death 1 (PD-1) is critical for T regulatory cells (Tregs) to maintain peripheral tolera
254 nsplantation, we reported that donor-derived T regulatory cells (Tregs), coinfused with conventional
257 use prevents autoimmune attack by recruiting T regulatory cells (Tregs), protecting mice from diabete
258 ically address the effects of type I IFNs on T regulatory cells (Tregs), we studied mixed bone marrow
273 nfection by bystander immune cells including T-regulatory cells (Tregs) and natural killer (NK) cells
277 ibular lymph node CD4(+) cells became robust T-regulatory cells (Tregs) in WT forkhead box P3 (Foxp3)
280 tress, regulating survival in murine natural T-regulatory cells (Tregs), an immune subset controlling
281 important in CD4 T-effector and/or Foxp3(+) T-regulatory cells (Tregs), and we found that B10.S-Eae5
283 nders had increased IL-10-producing FOXP3(+) T regulatory cells upon vaccination, only in hepatitis B
284 (+) T cells, the differentiation of Foxp3(+) T regulatory cells was suppressed, whereas Th17 cells we
285 tion of T-helper (Th1) cells, Th2 cells, and T-regulatory cells was determined by nuclear staining fo
291 c CD3(+) alphabeta TCR(+) cells and Foxp3(+) T regulatory cells were present in DKO mice but signific
296 n and muscle, elevated levels of CD3+ FoxP3+ T-regulatory cells were found in the skin and muscle obt
298 hanges, together with reduced recruitment of T regulatory cells, were associated with higher ratios o
299 MPL monotherapy was restored by depletion of T regulatory cells, whereas eliminating CD8(+) T cells a
300 pathology, 9142-primed mice also had splenic T regulatory cells with greater suppressive activity tha