ライフサイエンスコーパス: T-type calcium channel

1 that this channel is a low-voltage-activated T-type calcium channel.

2 selective blocker of low-voltage-activated, T-type calcium channels.

3 lcium transients due to strong expression of T-type calcium channels.

4 sect the contribution of genetic variants in T-type calcium channels.

5 of spinal pain neurons under the control of T-type calcium channels.

6 none or graded manner, due to recruitment of T-type calcium channels.

7 differentially inhibit Cav3 isoforms of the T-type calcium channels.

8 neurons are almost exclusively dependent on T-type calcium channels.

9 sufficiently hyperpolarized to de-inactivate T-type calcium channels.

10 logically distinct from L-, N-, P/Q-, R- and T-type calcium channels.

11 a low-threshold calcium current mediated by T-type calcium channels.

12 perpolarization "primes" (deinactivates) the T-type calcium channel, a depolarizing input will "trigg

13 Both forms of plasticity rely on T-type calcium channel activation to confer synapse spec

14 te to A-currents, thus potentially unmasking T-type calcium channel activity and membrane hyperexcita

15 e inhibits rebound activity independently of T-type calcium channels and A-type potassium channels.

16 aracterization of the subunit composition of T-type calcium channels and help determine their involve

17 This toxin distinguishes between alpha 1G T-type calcium channels and other types of voltage-gated

18 Cav3.2 T-type calcium channels and their dysregulation by the d

19 ogy in vivo showed that TTA-P2 (a blocker of T-type calcium channels) and gabapentin (inhibitor of tr

20 were consistent with the known properties of T-type calcium channels, and the voltage dependence was

21 pretreatment with the novel mixed N-type and T-type calcium channel antagonist 1-(6,6-bis(4-fluorophe

22 ient synthetic routes for the synthesis of a T-type calcium channel antagonist MK-8998 were developed

23 Using a selective T-type calcium channel antagonist, we describe a T-type

24 ry of a novel series of potent and selective T-type calcium channel antagonists is reported.

25 dependence was blocked by application of the T-type calcium channel antagonists Ni2+ and mibefradil.

26 sed by AMPA-R and NMDA-R antagonists but not T-type calcium channel antagonists.

27 Our results indicate that T-type calcium channels are critical regulators of a C.

28 quency band (0.75-1.5 Hz) only when thalamic T-type calcium channels are functionally active.

29 T-type calcium channels are important modulators of both

30 Low-threshold activated T-type calcium channels are present at the synapse, alth

31 s suggest that both alpha1A P/Q- and alpha1G T-type calcium channels are required for the dynamic con

32 T-type calcium channels are responsible for generating l

33 Low-voltage-activated (T-type) calcium channels are responsible for burst firin

34 the alpha1G subunit of the thalamus-enriched T-type calcium channel, are associated with absence seiz

35 We define T-type calcium channels as a target of Abeta-NgR signali

36 ene encoding Ca(v)3.2 low-voltage-activated, T-type calcium channels associated with bursting behavio

37 The effect of T-type calcium channel block was more pronounced after B

38 (100 nM), and by 26+/-3% (n=90 cells) by the T-type calcium channel blocker flunarizine (1 microM).

39 centration of nickel and by Z944, a specific T-type calcium channel blocker in advanced clinical deve

40 we demonstrated for the first time that the T-type calcium channel blocker ML218 acts similarly to m

41 c suppression of RT excitability via Z944, a T-type calcium channel blocker, and via C21 activation o

42 Ethosuximide, a T-type calcium channel blocker, eliminated busting in le

43 ility and burst firing, and selective triple T-type calcium channel blockers could offer a new way to

44 These T-type calcium channel blockers produced an insurmountab

45 In contrast to T-type calcium channel blockers that prevent all modes o

46 ives as potent, selective, brain-penetrating T-type calcium channel blockers.

47 ines as brain penetrant and selective triple T-type calcium channel blockers.

48 as potent, selective, and brain-penetrating T-type calcium channel blockers.

49 was unaltered in the presence of L-, R- and T-type calcium channel blockers.

50 The T-type calcium-channel blockers, nickel (3 micromol/l) a

51 In burst mode, dendritic T-type calcium channels boosted small synaptic inputs an

52 anic blocker to selectively block the native T-type calcium channel, but the potency and mechanism of

53 mutations in the CACNA1H gene (encoding the T-type calcium channel Ca(V)3.2) cause autosomal-dominan

54 We show that calcium spikes rely on the T-type calcium channel Ca-alpha1T and argue via analytic

55 e-activated calcium currents are mediated by T-type calcium channels Ca(V)3.1, Ca(V)3.2, and Ca(V)3.3

56 e found that pulvinar neurons expressed more T-type calcium channels (Ca(v) 3.2) and more small condu

57 block of this drug on the three recombinant T-type calcium channels (Ca(V)3.1, Ca(V)3.2, and Ca(V)3.

58 etinoic acid receptor beta 2 (RAR beta), and T-type calcium channel (CACNA1G) genes, and methylated i

59 1), retinoic acid receptor beta 2 (RARbeta), T-type calcium channel (CACNA1G), and multiple endocrine

60 d this area, we identified a gene encoding a T-type calcium channel, CACNA1G, as a target for hyperme

61 approved drug mibefradil, which inhibits the T-type calcium channel Cav3.2.

62 sion of L-type calcium channel (Cav1.2), not T-type calcium channel (Cav3.2), was up-regulated.

63 Pharmacological block of T-type calcium channels (Cav3), although not noticeably

64 at remains poorly understood with respect to T-type calcium channels (Cav3).

65 T-type calcium channels (Cav3.1 to Cav3.3) regulate low-

66 ut interestingly was a potent blocker of the T-type calcium channel, Cav3.1 (IC(50) = 1.05 muM).

67 The corresponding mutations affect the T-type calcium channel CCA-1 and symmetrically re-tune i

68 The robust E2 regulation of T-type calcium channels could be an important mechanism

69 zation-activated cation channel currents and T-type calcium channel currents may account for some of

70 cal blockers we showed that L-, P/Q-, R- and T-type calcium channels do not contribute to the spontan

71 CaV3.2 T-type calcium channels, encoded by CACNA1H, are express

72 tch between firing modes depends on Ca(v)3.1 T-type calcium channels enriched in thalamic relay neuro

73 Although 17beta-estradiol (E2) modulates T-type calcium channel expression and function, little i

74 ripts (alpha1G, alpha1H, and alpha1I) of the T-type calcium channel family (CaVT).

75 Other members of the T-type calcium channel family were also regulated by syn

76 Cav3 T-type calcium channels from great pond snail Lymnaea st

77 External pH (pH(o)) modifies T-type calcium channel gating and permeation properties.

78 models shows how a non-linear dependence of T-type calcium channel gating on GABA(B) receptor activi

79 lectively identify Cacna1g, one of the three T-type calcium channel genes, as a key component of a ge

80 The Ca(v)3.2 subtype of T-type calcium channels has been targeted for developing

81 cular cloning of low-voltage activated (LVA) T-type calcium channels has enabled the study of their r

82 nce of motor function and that modulation of T-type calcium channels has therapeutic potential for SC

83 w calcium antagonist that selectively blocks T-type calcium channels, has been shown to be an effecti

84 Low-voltage-activated (LVA) T-type calcium channels have a wide tissue distribution

85 ously, it was shown that mice lacking CaV3.1 T-type calcium channels have altered sleep/wake activity

86 the canonical rebound-related ion channels: T-type calcium channels, hyperpolarization-activated cat

87 regulates the expression of Cacna1h/Cav3.2 a T-type calcium channel implicated in autism and epilepsy

88 The aim was to investigate the role of the T-type calcium channel in HMSM by characterizing mRNA ex

89 tivity in vivo, supporting a contribution of T-type calcium channels in driving nociceptors' hyperexc

90 befradil completely and reversibly inhibited T-type calcium channels in freshly isolated rat cerebell

91 based on our biophysical characterization of T-type calcium channels in Purkinje cells suggests that

92 have identified a potential central role for T-type calcium channels in regulating body weight mainte

93 acologic inhibition or knockdown of Ca(v)3.1 T-type calcium channels in the auditory thalamus substan

94 believe to be a previously unknown role for T-type calcium channels in the regulation of sleep and w

95 The role of P/Q- and T-type calcium channels in the rhythmic oscillatory beha

96 alpha-adrenergic receptors and modulation of T-type calcium channels in the thalamus and was not due

97 inhibition of CaV3.2 low-voltage-activated (T-type) calcium channels in pain pathways.

98 I rats showed that the increased activity of T-type calcium channels induced by SCI contributes to dr

99 Here, we show that the increased activity of T-type calcium channels induced by the injury plays a ma

100 data suggest that the increased activity of T-type calcium channels induced by the injury plays a pr

101 increased activity of low voltage activated T-type calcium channels induced by the injury sustains t

102 is a useful tool for probing the effects of T-type calcium channel inhibition.

103 Conversely, ABT-639, a T-type calcium channel inhibitor that failed in Phase 2

104 k analysis showed trimethadione, a selective T-type calcium channel inhibitor, but not riluzole nor v

105 Cav3.2 T-type calcium channel is a major molecular actor of neu

106 more, we find that coexpression of TRPC5 and T-type calcium channels is sufficient to reconstitute a

107 Previous data have indicated that T-type calcium channels (low-voltage activated T-channel

108 The T-type calcium channel may play a role in this process.

109 their spontaneous activity, suggesting that T-type calcium channels may represent a pharmacological

110 Low voltage-activated (LVA), T-type, calcium channels mediate diverse biological func

111 The vulnerable population expresses a T-type calcium channel-mediated afterdepolarization (ADP

112 se in total firing and the ictal increase of T-type calcium channel-mediated burst firing of thalamoc

113 sociated with calpain-1 activation following T-type calcium channel opening, and resulted in the trun

114 ting sodium channel inactivation, inhibiting T-type calcium channels, or enhancing gamma-aminobutyric

115 This research expands our understanding of T-type calcium channel pharmacology and supports the sui

116 T-type calcium channels play a key role in neuronal exci

117 T-type calcium channels play essential roles in regulati

118 membrane potential allows activation of the T-type calcium channels, promoting rhythmic high-frequen

119 T-type calcium channels represent a key pathway for Ca(2

120 H channels determined impact of 1 variant on T-type calcium channel responsiveness to ethosuximide.

121 Our analysis with R- and T-type calcium channels revealed that differences in the

122 s of Ca(v)3.2 alone and in complex with four T-type calcium channel selective antagonists with overal

123 port the existence of a syntaxin-1A/Ca(v)3.2 T-type calcium channel signaling complex that relies on

124 +), using whole-cell recordings from alpha1G T-type calcium channels stably expressed in HEK 293 cell

125 t studies have highlighted the importance of T-type calcium channels (T-channels) in peripheral nocic

126 te a prominent role of low-voltage-activated T-type calcium channels (T-channels) in the firing activ

127 Recent studies indicate that T-type calcium channels (T-channels) in the thalamus are

128 e CaV3.1 isoform of low-voltage-activated or T-type calcium channels (T-channels) in this process.

129 usly documented that the Ca(V)3.3 isoform of T-type calcium channels (T-channels) is inhibited by cli

130 T-type calcium channels (T/Ca(v)3-channels) are implicat

131 ons in a hyperpolarized state for recruiting T-type calcium channels that are important for burst fir

132 We examined a homology model of the T-type calcium channel to look for possible routes of dr

133 tion of a potent and selective antagonist of T-type calcium channels, TTA-A2, to normal-weight animal

134 We previously proposed that T-type calcium channel (TTCC) expression may serve as a

135 INTERPRETATION: Four T-type calcium channel variants and 1 ABCB1 transporter

136 In T-type calcium channels, verapamil blocks with micromola

137 gene of the pore-forming alpha1G subunit for T-type calcium channel were used.

138 Although T-type calcium channels were first described in sensory

139 overexpressing the Cacna1g gene for alpha1G T-type calcium channels were generated with low and high

140 at estrogen regulates the mRNA expression of T-type calcium channels, which leads to increased functi

141 toxin (kurtoxin) that binds to the alpha 1G T-type calcium channel with high affinity and inhibits t

142 In current-clamp recordings, inhibition of T-type calcium channels with 1 mum TTA-P2 reduced both t