ライフサイエンスコーパス: TAP

1 TAP acrophase was able to assess eveningness.

2 TAP binding protein, related (TAPBPR), a widely expresse

3 TAP is a central component of the peptide-loading comple

4 TAP is a heterodimer formed by the association of two ha

5 TAP is freely available at opig.stats.ox.ac.uk/webapps/s

6 TAP of the UL28 protein from vFH476-infected cells, foll

7 TAP of UL28 complexes from cells infected with each doma

8 TAP plays an essential role in the antigen presentation

9 TAP shuttles proteasomal degradation products into the l

10 TAP translocates cellular peptides across the endoplasmi

11 TAP-1 showed high selectivity and sensitivity to HSNO in

12 TAP-seq permits routine analysis of thousands of CRISPR-

13 TAP/p32, similar to NAP-1, NLP, and Nph, facilitates nuc

14 the presence of Lambda-[Ru(TAP)2(dppz)](2+) (TAP = 1,4,5,8-tetraazaphenanthrene, dppz = dipyrido[3,2-

15 Lambda/Delta-[Ru(TAP)(2) (11-CN-dppz)](2+) (TAP=1,4,5,8-tetraazaphenanthrene, dppz=dipyridophenazine

16 ited-state quenching of [Ru(TAP)2(HAT)](2+) (TAP = 1,4,5,8-tetraazaphenanthrene, HAT= 1,4,5,8,9,12-he

17 alating photoreagent Ru[(TAP)(2)PHEHAT](2+) (TAP = 1,4,5,8-tetraazaphenanthrene; PHEHAT = 1,10-phenan

18 Ar(4)TAPs bearing various substituents in meso-phenyls and an

19 al tetraaryltetraanthra[2,3]porphyrins (Ar(4)TAPs) was developed.

20 Ru(II) complex [{Ru(TAP(2))}(2)(tpphz)](4+) (TAP = 1,4,5,8- tetraazaphenanthrene, tpphz = tetrapyrido

21 ccurs through the upregulation of Rab7 and a TAP-independent pathway that prime CTL responses.

22 A quantitative comparison between a TAP LPG and a non-TAP LPG was carried out to highlight t

23 molecule pulldown (SiMPull), we determined a TAP/tapasin ratio of 1:2, consistent with previous studi

24 accinated with viral constructs expressing a TAP inhibitor would develop insert-specific MHC-E-restri

25 e, single-blinded study compared 2 groups (a TAP block and PILA) with a standard anesthetic technique

26 AP affinity is imported into phagosomes in a TAP- and ATP-dependent manner, as expected.

27 all three viral ligands were presented in a TAP-dependent manner despite originating from different

28 ion, as evidenced by enhanced rejection of a TAP-deficient tumor in vivo.

29 t3 ligand, and induced the presentation of a TAP-independent peptide in human tumor cells.

30 erventions: Patients randomized to receive a TAP block with local anesthetics and dexamethasone, PILA

31 Herein, using a TAP-independent polyclonal vaccinia virus-polyspecific C

32 metrically assessed using the computer-aided TAP (Test Battery of Attentional Performance).

33 iously characterized histone chaperones, and TAP/p32 has no known function in chromatin metabolism.

34 animals with infundibular scarring (INF and TAP).

35 prioritize and implement interventions, and TAP resources; monthly webinars; state partner-led in-pe

36 inhibited the interaction between HDAg-L and TAP and blocked HDV virion assembly and secretion.

37 antioxidant capacity assessed using ORAC and TAP assays correlated with individual metabolites.

38 n the side chains of the antigen peptide and TAP.

39 e improved proportionally most in the PI and TAP groups in relation to the extent of RV dilation.

40 e cytosolic, characterized by proteasome and TAP dependency, or vacuolar, usually believed to be prot

41 uolar, usually believed to be proteasome and TAP independent.

42 by the HLA-B27 molecules was proteasome and TAP-independent and not restricted to Antigen-Presenting

43 r Ag uptake and employed the proteasome- and TAP-dependent cytosolic cross-presentation pathway, prev

44 The TAO and TAP TAVR groups were similar in terms of device success

45 molecules on the surface of both TAP(+) and TAP(-) cells.

46 morphic genes encoding classical class I and TAPs allows co-evolution, leading to a single dominantly

47 We find REST regulates both QNPs and TAPs, and importantly, ribosome biogenesis, cell cycle a

48 We apply TAP-seq to generate perturbation-based enhancer-target g

49 the chemically-synthesized nucleolin aptamer-TAP siRNA conjugate represents a broadly-applicable appr

50 The NXF1:NXT1 complex (also known as TAP:p15) is a general mRNA nuclear export factor that is

51 are found on the cell surface, with the B15 TAPs restricting the peptides available.

52 f receiving additional peptides from the B21 TAPs.

53 that the N-terminal 14 aa residues bestowed TAP-independent upregulation of HLA-E, whereas C region

54 tiation and reveals the interactions between TAP and RNAP holoenzyme responsible for transcription ac

55 Recent studies have indicated a link between TAP inhibition and induction of MHC-E-restricted T cells

56 exes or tumor or infected cells with blocked TAP molecules are able to present HLA class I ligands ge

57 ntrol T23D3 molecules on the surface of both TAP(+) and TAP(-) cells.

58 the chaperone tapasin organizes by bridging TAP to MHC class I and recruiting accessory molecules su

59 t with constitutive proteasome-dependent but TAP-independent peptide loading in the endocytic pathway

60 ucted not only by B cells but in addition by TAP-deficient T2-cells.

61 teps of substrate translocation catalyzed by TAP.

62 to present HLA class I ligands generated by TAP-independent processing pathways.

63 and release of HDV particles are mediated by TAP and Aly.

64 into dendritic cell phagosomes, mediated by TAP transporters recruited from the endoplasmic reticulu

65 at imposes the block in peptide transport by TAP.

66 nerated by the proteasome and transported by TAP meet MHC-I molecules for loading has been a matter o

67 we demonstrate that the molecular chaperone TAP-binding protein related (TAPBPR) associates with a b

68 Protamine chaperone TAP/p32 dissociates DNA-protamine complexes in vitro onl

69 Previous data show that chicken TAP genes have high allelic polymorphism, with peptide t

70 Here, we compared TAP function and interaction with tapasin of a range of

71 study, the host cellular RNA export complex TAP-Aly was found to form a complex with HDAg-L, but not

72 ology with the antigen translocation complex TAP, but is also able to restore antigen processing in h

73 demonstrate that a single heterodimeric core-TAP complex is active in peptide binding, which is tight

74 ancestral nucleobase, is mixed with a crude TAP+ribose reaction mixture, micrometer-length supramole

75 CT TAP restaging altered management in 6.7% of patients, wh

76 ged pre- and post-CRT with MR imaging and CT TAP were included.

77 omography of thorax, abdomen, and pelvis (CT TAP) to identify distant metastases.

78 T cell line, two conserved vaccinia-derived TAP-independent HLA-B*0702 epitopes were identified.

79 ve evolved strategies either to downregulate TAP expression or directly inhibit TAP activity.

80 ), and combined infundibular-PV dysfunction (TAP).

81 Each TAP inhibitor reduced surface expression of MHC-Ia molec

82 lled and randomly assigned to receive either TAP or sham blocks after caesarean section.

83 increase proteasome recruitment and enhance TAP-independent cross-presentation.

84 antigen supply to MHC I molecules in the ER, TAP assembles a macromolecular peptide-loading complex (

85 ed for immunotherapy against immune-escaped, TAP-deficient tumor cells expressing low levels of MHC-I

86 In evolution, TAP appeared together with effector cells of adaptive im

87 This study examines TAP block analgesic efficacy after caesarean section in

88 infrared excitation and emission of this FAP-TAPs provides a new spectral range for photosensitizer p

89 ir pretreatment performance in three of five TAP subtasks (vigilance, P < 0.001; shared attention: op

90 lective of individual peptide affinities for TAP, revealing the underlying mechanism of peptide-stimu

91 asymmetric ABC exporters in general, and for TAP in particular.

92 ndency is indirect and reflects the need for TAP to load HLA-A1 molecules with peptides in the endopl

93 assays, hyporesponsiveness was observed for TAP-deficient NK cells derived from four patients.

94 endogenous pathway by its independence from TAP and tapasin and its sensitivity to inhibitors of lys

95 generated, tagged Gli3 knock-in mouse (Gli3(TAP) ), we performed proteomic analyses and identified t

96 Here, the heterodimeric TAP complex was purified and reconstituted in nanodiscs

97 We observed that a peptide with high TAP affinity is imported into phagosomes in a TAP- and A

98 able to restore antigen processing in human TAP-deficient cells.

99 study, we determined the structure of human TAP bound to ICP47 by electron cryo-microscopy (cryo-EM)

100 cryo-electron microscopy structure of human TAP in complex with its inhibitor ICP47, a small protein

101 ation of an antigenic peptide bound to human TAP.

102 ophilus RNAP sigma(A) holoenzyme, a class II TAP-dependent promoter, and a ribotetranucleotide primer

103 MHC-I pathway, including immunoproteasomes, TAP, and ERAP1, whose transcriptional control was previo

104 In TAP-deficient mouse dendritic cells, cross-presentation

105 e in the presence of concomitant INF (54% in TAP versus 14% in PI; p = 0.03).

106 demonstrated that TEIPP-specific T cells in TAP-deficient mice have largely been deleted by central

107 Defects in TAP account for immunodeficiency and tumour development.

108 HLA-E ligand derived from the D8L protein in TAP-deficient vaccinia virus-infected cells.

109 lude that all three tapasin-binding sites in TAP cooperate to achieve high transporter stability and

110 Simvastatin (30 mg/kg) increased TAP activity on day 11 compared with the saline group.

111 nregulate TAP expression or directly inhibit TAP activity.

112 t viruses have evolved strategies to inhibit TAP so that they may go undetected by the immune system.

113 orm of CPXV012 that is capable of inhibiting TAP.

114 st bacterial factor identified that inhibits TAP function and MHC class I antigen presentation.

115 entation of the HLA-A1-restricted peptide is TAP dependent.

116 LCMS proteomic analysis of LAP-TAP-purified proteins from HeLa cells containing a tetra

117 the NLS failed to interact with full-length TAP.

118 nt with modulation of surface MHC-Ia levels, TAP inhibition diminished presentation of MHC-Ia-restric

119 ldren using a novel integrative measurement (TAP) derived from non-invasive assessments of wrist temp

120 strate that, in contrast to results in mice, TAP inhibition alone is insufficient for priming of MHC-

121 nd biochemical evidence that the Mex67-Mtr2 (TAP-p15) heterodimer, best characterized for its essenti

122 mutations of CRM1 (Exportin-1), MEX67/MTR2 (TAP/p15), and five nucleoporins cause accumulation of un

123 ative comparison between a TAP LPG and a non-TAP LPG was carried out to highlight the improvement of

124 However, individuals with nonfunctional TAP complexes or tumor or infected cells with blocked TA

125 Notably, TAP works as a molecular diode, translocating peptide su

126 both mRNAs is dependent on the cellular NXF1/TAP pathway, but it is unclear how they are recruited to

127 olvement of the nuclear export receptor NXF1/TAP in the nuclear export of gammaretroviral RNA transcr

128 Absence of TAP activity even increased the MHC-I presentation of th

129 es ATP binding to TAP and, thus, activity of TAP, thereby preventing the presentation of viral peptid

130 ism of peptide-stimulated ATPase activity of TAP.

131 Administration of TAP siRNA conjugated to a broad-range tumor-targeting nu

132 So far, neither the architecture of TAP nor the mechanism of viral inhibition has been eluci

133 However, the efficacy of TAP blocks in low-resourced settings where patients do n

134 Both the modeling and manufacturing of TAP LPGs were discussed.

135 selection, we combined homology modeling of TAP with experimental measurements to identify several T

136 Here, we present homology models of TAP built on the crystal structures of P-glycoprotein, A

137 in, which plugs the translocation pathway of TAP from the cytoplasmic side.

138 hat arise spontaneously from the reaction of TAP with the sugars.

139 mall hairpin RNA-mediated down-regulation of TAP or Aly reduced nuclear export of HDAg-L and assembly

140 (a) Chronotype objectively (7-day-rhythms of TAP) and subjectively measured (Munich-chronotype-self-r

141 +ribose reaction is a beta-ribofuranoside of TAP, which we term TARC.

142 The peptide binding site of TAP is located at the hydrophobic boundary of the cytoso

143 delineate different conformational states of TAP in a native subcellular membrane environment.

144 ructurally distinct conformational states of TAP.

145 also establishes the molecular structure of TAP to facilitate mechanistic studies of the antigen pre

146 to directly interact with the N terminus of TAP, whereas an HDAg-L mutant lacking the NLS failed to

147 Our studies highlight the potential of TAPs for single-dose treatment of Pf malaria in combinat

148 n contrast, the translocation specificity of TAPs from the low-expressing B21 haplotype is even more

149 Three tapasin binding sites on TAP have been described, two of which are located in the

150 By transferring an optimized TAP tag combined with state-of-the-art mass spectrometry

151 with state-of-the-art mass spectrometry, our TAP protocol enables the discovery of interactors for lo

152 a variant of the Taylor aggression paradigm (TAP) allowing to differentiate between reactive (provoke

153 We show that this paradoxical TAP-dependency is indirect and reflects the need for TAP

154 Models for peptide-TAP complexes were generated, which indicate bent confor

155 ied, revealing a complex scenario of peptide-TAP recognition.

156 no atomic-resolution information on peptide-TAP interactions has been obtained, hampering a mechanis

157 erase (ALT), and total alkaline phosphatase (TAP) were evaluated.

158 This targeted and activated photosensitizer (TAPs) approach enables protein inactivation, targeted ce

159 cacy of using a transversus abdominis plane (TAP) block in a randomized, double-blind, placebo-contro

160 Transversus abdominis plane (TAP) block provides 12-24 h of analgesia to the parietal

161 e efficacy of a transversus abdominis plane (TAP) block with dexamethasone sodium phosphate and prepe

162 er cladding mode near its turn-around point (TAP) was the strategy adopted to achieve good performanc

163 ed by the known contributions of polymorphic TAP variants to peptide selection, we combined homology

164 nd evaluation of the first fluorescent probe TAP-1 for HSNO detection.

165 e transporter associated with Ag processing (TAP) translocates proteasomally derived cytosolic peptid

166 e transporter associated with Ag processing (TAP).

167 nsporter associated with antigen processing (TAP) and class Ia has been documented in endothermic bir

168 nsporter associated with antigen processing (TAP) and MHC I to tapasin, which is responsible for MHC

169 nsporter associated with antigen processing (TAP) and then loaded onto the nascent MHC I molecules, w

170 nsporter associated with antigen processing (TAP) by single-turnover analyses at single-liposome reso

171 nsporter associated with antigen processing (TAP) complex, which transfers the peptide products of pr

172 nsporter associated with antigen processing (TAP) constitutes a focal element in the adaptive immune

173 nsporter associated with antigen processing (TAP) enables the flow of viral peptides generated in the

174 nsporter associated with antigen processing (TAP) into the endoplasmic reticulum, where they bind to

175 nsporter associated with antigen processing (TAP) is a 150 kDa heterodimeric ABC transport complex th

176 nsporter associated with antigen processing (TAP) is a member of the ATP binding cassette (ABC) trans

177 nsporter associated with antigen processing (TAP) is an ATP-binding cassette (ABC) transporter essent

178 nsporter associated with antigen processing (TAP) participates in immune surveillance by moving prote

179 nsporter associated with antigen processing (TAP) plays a critical role in the MHC class I antigen pr

180 nsporter associated with antigen processing (TAP) translocates the viral proteolytic peptides generat

181 nsporter associated with antigen processing (TAP), results in strongly decreased surface display of p

182 nsporter associated with antigen processing (TAP)-mediated transport of antigen peptides.

183 nsporter associated with antigen processing (TAP).

184 nsporter associated with antigen processing (TAP).

185 nsporter associated with antigen processing (TAP).

186 nsporter associated with antigen processing (TAP).

187 nsporter associated with antigen processing (TAP).

188 opyrimidine, TAP) and ribose, which produces TAP-ribose conjugates in high yield (60-90%).

189 studies using temporal analysis of products (TAP).

190 available the Therapeutic Antibody Profiler (TAP), a computational tool that builds downloadable homo

191 tiating into transit-amplifying progenitors (TAPs) and newborn neurons.

192 Tapasin is required to promote TAP stability, but through which binding site(s) it is a

193 by the HLA-A2 molecules required proteasome, TAP and professional APC.

194 y the two HLA-B27 molecules was proteasome-, TAP-, and APC-independent whereas the presentation by th

195 amin E. alpha-Tocopherol-associated protein (TAP) was found to be one of the major alpha-tocopherol b

196 lasmic reticulum, the transmembrane proteins TAP and tapasin that facilitate peptide binding to MHCI

197 es, our sequencing of affinity-purified Puf3-TAP associated mRNAs (RIP-seq) identified mRNAs encoding

198 d an optimized tandem affinity purification (TAP) approach from Arabidopsis thaliana toward Oryza sat

199 eloped a novel tandem-affinity purification (TAP) approach using hexahistidine and BirA-specific biot

200 ased approach, tandem affinity purification (TAP) followed with mass spectrometry (MS), we identified

201 re isolated by tandem-affinity purification (TAP) using recombinant viruses expressing either a full-

202 e based on the tandem affinity purification (TAP).

203 25 nm (for the determination of AMP, PG, PV, TAP and FFC), 240 nm (for OXA, CLO and DICLO) and 278 nm

204 e margin of safety, and a high success rate, TAP blocks remain under used in settings where patients

205 informed written consent, patients received TAP or sham blocks after caesarian section.

206 accessing the cellular mRNA export receptor TAP/NXF, which guides mRNA through the nuclear pore comp

207 n partners, including the transport receptor TAP of the host cell nuclear transport machinery, severa

208 In this study, we found that reduced TAP expression was significantly correlated with Her2/ne

209 Therefore, the frequently reported TAP dependence of cross-presentation of phagocytosed OVA

210 s-presentation of OVA-Le(X) neither required TAP-transporters nor Cathepsin-S and was still observed

211 The transapical route (TAP) is the current alternative but is associated with l

212 this work, we purified the complex with Rrp6-TAP, identified the co-purified proteins by mass spectro

213 inuclear photo-oxidizing Ru(II) complex [{Ru(TAP(2))}(2)(tpphz)](4+) (TAP = 1,4,5,8- tetraazaphenanth

214 we show that the complexes Lambda/Delta-[Ru(TAP)(2) (11-CN-dppz)](2+) (TAP=1,4,5,8-tetraazaphenanthr

215 d(TCGGCGCCGA) in the presence of Lambda-[Ru(TAP)2(dppz)](2+) (TAP = 1,4,5,8-tetraazaphenanthrene, dp

216 lds of guanine photo-oxidation by Lambda-[Ru(TAP)2(dppz)](2+) have been compared in 5'-{CCGGATCCGG}2

217 The excited-state quenching of [Ru(TAP)2(HAT)](2+) (TAP = 1,4,5,8-tetraazaphenanthrene, HAT

218 ctions of the intercalating photoreagent Ru[(TAP)(2)PHEHAT](2+) (TAP = 1,4,5,8-tetraazaphenanthrene;

219 t opig.stats.ox.ac.uk/webapps/sabdab-sabpred/TAP.php.

220 SAHA-TAP demonstrates cytotoxicity activity against various c

221 After incubation of SAHA-TAP with an HDAC, the thiol of a conserved HDAC cysteine

222 to the hydroxamic acid warhead (termed SAHA-TAP).

223 itations, we introduce targeted Perturb-seq (TAP-seq), a sensitive, inexpensive and platform-independ

224 xperimental measurements to identify several TAP residues that interact with peptides.

225 entation, is ATP-dependent but substantially TAP-independent.

226 Our objective was to describe how systematic TAP-CT affects the diagnosis and the management of IE.

227 I in complex with the peptide editor TAPBPR (TAP-binding protein-related), a tapasin homolog.

228 es reconstituted with purified, N-terminally TAP-tagged Drs2p, both ATPase and flippase activity were

229 , where N-N is 1,4,5,8-tetraazaphenanthrene (TAP), pyrazino[2,3-a]phenazine (pzph), or benzo[a]pyrazi

230 Collectively, these results confirm that TAP can import peptides into phagosomes, but they sugges

231 In addition, we demonstrate that TAP-seq can identify cell subtypes with only 100 sequenc

232 nce of our research is in demonstrating that TAP inhibition alone does not prime MHC-E-restricted T c

233 entation of long peptides, and indicate that TAP-dependency can no longer be used as a key criterion

234 The structure indicates that TAP stimulates isomerization through simple, adhesive, s

235 We propose that TAP/TPN complex formation is driven by hydrophobic inter

236 Here we show that TAP-independent presentation can be mediated by autophag

237 We show that TAP/p32 is required for the removal of Drosophila protam

238 The TAP block procedure is beneficial in reducing postoperat

239 The TAP translocates peptide Ags into the lumen of the endop

240 The TAP-CT findings slightly affected diagnosis and treatmen

241 ere we further advanced the workflow for the TAP approach and determined the infection-dependent inte

242 QoR-40 scores on postoperative day 1 for the TAP block group (median [interquartile range (IQR)], 178

243 es, and with all degrees of movement for the TAP group (appendix).

244 Results: The mean (SD) ages in the TAP block (n = 19), PILA (n = 24), and control (n = 23)

245 t reduction of opioid use in the PACU in the TAP block group (median [IQR], 0 [0-1.3]) when compared

246 studies elucidate structural changes in the TAP NBD in response to nucleotides and substrate, provid

247 The effects of the TAP block and PILA on pain in the postoperative care uni

248 reover, staining following inhibition of the TAP demonstrated that all three viral ligands were prese

249 I expression due to mutations in one of the TAP genes.

250 With time, the pain scores of the TAP group changed a little, whereas a decreasing trend c

251 deterioration was observed in animals of the TAP group.

252 TAP1/TAP2 complexes, but the location of the TAP peptide-binding pocket remains unknown.

253 A major product of the TAP+ribose reaction is a beta-ribofuranoside of TAP, whi

254 were asymptomatic and diagnosed only on the TAP-CT.

255 g/kg), 35 young healthy adults performed the TAP during functional magnetic resonance imaging (fMRI).

256 ient to form an annular belt surrounding the TAP complex.

257 ber of epitopes can be presented through the TAP-independent pathway, the precise mechanism for which

258 the trial and were randomized to undergo the TAP block procedure with either bupivacaine (n=24) or sa

259 eine residue is covalently appended with the TAP promoiety.

260 In addition, thiamphenicol (TAP) and florfenicol (FF), antibiotics with a structure

261 (CLO), dicloxacillin (DICLO), thiamphenicol (TAP), florfenicol (FFC) and chloramphenicol (CAP) were s

262 ng SIVmac239 Gag in addition to one of three TAP inhibitors: herpes simplex virus 2 ICP47, bovine her

263 es on HLA class I by generating them through TAP-independent processing pathways.

264 These TIPS-TAPs are either crystalline or amorphous, depending upon

265 ational arrest that precludes ATP binding to TAP and, thus, activity of TAP, thereby preventing the p

266 ptide transport by inhibiting ATP binding to TAP.

267 Similar to TAP deficiency in the absence of a regular CD8 T-cell co

268 se as a genetic determinant of resistance to TAPs.

269 thoracoabdominal-pelvic computed tomography (TAP-CT) may be helpful.

270 somal vacuoles, to which peptide transporter TAP and upregulated MHC class I (MHC I) are recruited.

271 ents like proteasome and peptide transporter TAP.

272 The structure shows that ICP47 traps TAP in an inactive conformation distinct from the normal

273 n scores at each time and type of treatment (TAP vs sham blocks) was assessed using general linear mo

274 midine nucleobase (2,4,6-triaminopyrimidine, TAP) and ribose, which produces TAP-ribose conjugates in

275 nucleobase mimics (2,4,6-triaminopyrimidine, TAP, and a cyanuric acid derivative, CyCo6) spontaneousl

276 malarial compounds, the triaminopyrimidines (TAPs), which emerged from a phenotypic screen against th

277 c cells, and HeLa cells expressing truncated TAP subunits.

278 lus transcription activator protein TTHB099 (TAP) [homolog of Escherichia coli catabolite activator p

279 tion from the tightly linked cluster of UAA, TAP, and LMP genes, the so-called class I region found i

280 a from 76 consecutive patients who underwent TAP TAVR at our site.

281 locked, as well as individuals with unusable TAP complexes, are able to present peptides on HLA class

282 Based on similar results obtained using TAP mutants that lack tapasin binding to either N-termin

283 her than SIINFEKL import into phagosomes via TAP.

284 r regression by dipalmitoylated peptides was TAP independent.

285 Apparently, this cross-presentation was TAP-independent, as it was conducted not only by B cells

286 Cancerous cells and infected cells in which TAP is blocked, as well as individuals with unusable TAP

287 ied the UL15, UL28, and UL33 subunits, while TAP of vFH499-infected cells confirmed previous findings

288 These data may explain why TAP-deficient individuals live normal life spans without

289 e classical MHC class I gene coevolving with TAP transporters, whereas class I genes are poorly expre

290 HDAg-L was found to colocalize with TAP and Aly in the nucleus.

291 The TAO approach, compared with TAP TAVR, was associated with lower combined bleeding an

292 yme-substrate trapping strategy coupled with TAP-TAG or orthogonal GST- purification followed by mass

293 is highly polymorphic, but co-evolution with TAP and class I genes remains unclear.

294 nto the ER membrane, where it interacts with TAP.

295 ICP27 binds viral mRNAs and interacts with TAP/NXF, providing a link to the cellular mRNA export pa

296 binds cellular mRNAs and also interacts with TAP/NXF.

297 ive binding mode via the PHEHAT ligand, with TAP-mediated hydrogen bonding capabilities.

298 fect is more extensive than in patients with TAP deficiency.

299 Indeed, mice vaccinated with TAP-inhibited autologous dendritic cells develop T cells

300 tered paracetamol-diclofenac with or without TAP blocks.